BRPI9914221B8 - derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos - Google Patents

derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI9914221B8
BRPI9914221B8 BRPI9914221A BR9914221A BRPI9914221B8 BR PI9914221 B8 BRPI9914221 B8 BR PI9914221B8 BR PI9914221 A BRPI9914221 A BR PI9914221A BR 9914221 A BR9914221 A BR 9914221A BR PI9914221 B8 BRPI9914221 B8 BR PI9914221B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compositions containing
derivatives
glycopeptide
glycopeptide derivatives
Prior art date
Application number
BRPI9914221A
Other languages
English (en)
Other versions
BR9914221A (pt
BR9914221B1 (pt
Inventor
M T Lam Bernice
Yang Guang
Kevin Judice J
Sheringham Linsell Martin
Leadbetter Michael
Ross Fatheree Paul
Gary Trapp Sean
Zhu Yan
Mu Yongqi
Original Assignee
Advanced Medicine Inc
Cumberland Pharmaceuticals Inc
Theravance Biopharma Antibiotics Ip Llc
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc, Cumberland Pharmaceuticals Inc, Theravance Biopharma Antibiotics Ip Llc, Theravance Inc filed Critical Advanced Medicine Inc
Publication of BR9914221A publication Critical patent/BR9914221A/pt
Publication of BR9914221B1 publication Critical patent/BR9914221B1/pt
Publication of BRPI9914221B8 publication Critical patent/BRPI9914221B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<b>derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos<d> são revelados derivados de compostos de glicopeptídeos tendo pelo menos um substituinte de fórmula: -r^ a^-y-r^ b^- (z) ~ x~ onde r^ a^, r^ b^, y, z, e x são como definido, e composições farmacêuticas contendo tais derivados de glicopeptídeos. os derivados de glicopeptídeos revelados são úteis como agentes antibacterianos.
BRPI9914221A 1998-12-23 1999-12-22 derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos BRPI9914221B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11372898P 1998-12-23 1998-12-23
US12931399P 1999-04-14 1999-04-14
US16402499P 1999-11-04 1999-11-04
US16997899P 1999-12-10 1999-12-10
PCT/US1999/030543 WO2000039156A1 (en) 1998-12-23 1999-12-22 Glycopeptide derivatives and pharmaceutical compositions containing the same

Publications (3)

Publication Number Publication Date
BR9914221A BR9914221A (pt) 2001-06-26
BR9914221B1 BR9914221B1 (pt) 2013-12-31
BRPI9914221B8 true BRPI9914221B8 (pt) 2021-05-25

Family

ID=27493926

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9914221A BRPI9914221B8 (pt) 1998-12-23 1999-12-22 derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos

Country Status (23)

Country Link
US (9) US6392012B1 (pt)
EP (1) EP1140993B1 (pt)
JP (1) JP4362017B2 (pt)
KR (1) KR100665204B1 (pt)
CN (1) CN1249081C (pt)
AT (1) ATE242783T1 (pt)
AU (1) AU768204B2 (pt)
BR (1) BRPI9914221B8 (pt)
CA (1) CA2336445C (pt)
CZ (1) CZ301184B6 (pt)
DE (1) DE69908819T2 (pt)
DK (1) DK1140993T3 (pt)
ES (1) ES2201825T3 (pt)
HK (1) HK1040721B (pt)
HU (1) HU230190B1 (pt)
IL (2) IL140093A0 (pt)
NO (1) NO326066B1 (pt)
NZ (1) NZ508594A (pt)
PL (1) PL198311B1 (pt)
PT (1) PT1140993E (pt)
SI (1) SI1140993T1 (pt)
WO (1) WO2000039156A1 (pt)
ZA (1) ZA200007222B (pt)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1140993T1 (en) * 1998-12-23 2003-12-31 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US6699836B2 (en) * 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
US6518243B1 (en) * 1999-04-02 2003-02-11 Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
WO2001057071A2 (en) * 2000-02-04 2001-08-09 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
WO2001083520A2 (en) * 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
US6831150B2 (en) 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
AU2001259303A1 (en) 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
WO2001098329A1 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
TWI275594B (en) * 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
DE60118737T2 (de) 2001-09-19 2006-10-19 The Procter & Gamble Company, Cincinnati Farbbedruckte Mehrschichtstruktur, ein damit hergestellter absorbierender Artikel und Verfahren zu deren Herstellung
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
US7652039B2 (en) 2002-05-17 2010-01-26 Sequella, Inc. Methods of use and compositions for the diagnosis and treatment of infectious disease
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
US6878686B2 (en) * 2002-05-24 2005-04-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2003106399A2 (en) 2002-06-17 2003-12-24 Theravance, Inc. PROCESS FOR PREPARING N-PROTECTED β-AMINO ALDEHYDE COMPOUNDS
SG149701A1 (en) * 2002-07-09 2009-02-27 Fasgen Llc Methods of treating microbial infections in humans and animals
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
WO2004045637A1 (en) * 2002-11-18 2004-06-03 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
WO2004113350A1 (en) * 2003-05-23 2004-12-29 Theravance, Inc. Cross-linked glycopeptide - cephalosporin antibiotics
EP1644382B1 (en) 2003-07-11 2008-03-05 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
DE102004055582A1 (de) 2004-11-18 2006-05-24 Bayer Cropscience Ag N-Heterocyclyl-phthalsäurediamide
BRPI0516657A (pt) 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
US8304597B2 (en) 2004-12-15 2012-11-06 The Procter And Gamble Company Method of using an absorbent article having a functional enhancement indicator
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
WO2007084507A2 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
BRPI0821947A2 (pt) 2007-12-26 2015-09-22 Shionogi & Co derivados de antibiótico de glicopetídeo glicosilatado
JP2011507959A (ja) * 2007-12-26 2011-03-10 レアド トヘラペウトイクス，インコーポレーテッド 抗菌薬としての新規半合成糖ペプチド
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
EP2688580A4 (en) * 2011-03-24 2015-03-25 Seachaid Pharmaceuticals Inc DERIVATIVES OF VANCOMYCIN
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
CA2925005A1 (en) * 2013-09-23 2015-03-26 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
US20170342110A1 (en) * 2014-12-25 2017-11-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN109072271A (zh) * 2016-01-15 2018-12-21 汉堡大学 用于制备鼠李糖基化类黄酮的方法
EP3408253A1 (en) * 2016-01-28 2018-12-05 Acatechol, Inc. Photo-cleavable primer compositions and methods of use
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
JP7210476B2 (ja) * 2017-05-22 2023-01-23 インスメッド インコーポレイテッド リポ‐グリコペプチド可切断性誘導体及びその使用
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
CN111620931B (zh) * 2020-06-12 2021-12-17 苏州博源医疗科技有限公司 万古霉素衍生物及其制备方法和应用
CN114213284B (zh) * 2022-01-04 2023-08-01 丽珠集团福州福兴医药有限公司 (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497802A (en) 1983-10-21 1985-02-05 Eli Lilly And Company N-Acyl glycopeptide derivatives
US4914187A (en) 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
GB8428619D0 (en) 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
GB8704847D0 (en) 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
FR2632185B1 (fr) * 1988-06-01 1992-05-22 Rhone Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc
GB8817397D0 (en) * 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
US5534420A (en) 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
DE68925806T2 (de) * 1988-12-27 1996-09-26 Lepetit Spa C63-Amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplaninen
IE64155B1 (en) * 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
CA2031803C (en) 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
AU647122B2 (en) 1990-05-28 1994-03-17 Gruppo Lepetit S.P.A. C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992017456A1 (en) 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivative and salt thereof
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
RU2125058C1 (ru) 1991-07-29 1999-01-20 Группо Лепетит С.П.А. Производное антибиотика а 40926, способы его получения, фармацевтическая композиция
TW457248B (en) 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
IT1282586B1 (it) 1996-02-08 1998-03-31 Chemical And Biolog Ind Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli
CA2249323A1 (en) 1996-03-21 1997-09-25 Transcell Technologies, Inc. Solid phase lipoglycopeptide library, compositions and methods
WO1997038702A1 (en) 1996-04-12 1997-10-23 Eli Lilly And Company Covalently-linked glycopeptide dimers
CA2251086C (en) 1996-04-12 2007-02-20 Eli Lilly And Company Glycopeptide compounds
WO1997040067A1 (en) 1996-04-23 1997-10-30 Biosearch Italia S.P.A. Improved chemical process for preparing amide derivatives of antibiotic a 40926
US5919756A (en) 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
US5952310A (en) 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5977063A (en) 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5919771A (en) 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US6518242B1 (en) * 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
AU3307399A (en) 1998-02-20 1999-09-06 Advanced Medicine, Inc. Novel antibacterial agents
WO1999056760A1 (en) 1998-05-01 1999-11-11 Eli Lilly And Company N1-modified glycopeptides
WO2000004044A1 (en) 1998-07-14 2000-01-27 Princeton University Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
SI1140993T1 (en) 1998-12-23 2003-12-31 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6878686B2 (en) * 2002-05-24 2005-04-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
EP1644382B1 (en) * 2003-07-11 2008-03-05 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Also Published As

Publication number Publication date
AU3127300A (en) 2000-07-31
US6444786B1 (en) 2002-09-03
HUP0400887A3 (en) 2012-09-28
IL140093A (en) 2006-06-11
US6455669B1 (en) 2002-09-24
CN1315961A (zh) 2001-10-03
CA2336445C (en) 2011-07-19
US20060241024A1 (en) 2006-10-26
DE69908819D1 (de) 2003-07-17
US20040204346A1 (en) 2004-10-14
EP1140993B1 (en) 2003-06-11
DE69908819T2 (de) 2004-05-06
IL140093A0 (en) 2002-02-10
US20050239690A1 (en) 2005-10-27
KR20010085857A (ko) 2001-09-07
HK1040721A1 (en) 2002-06-21
PT1140993E (pt) 2003-10-31
AU768204B2 (en) 2003-12-04
KR100665204B1 (ko) 2007-01-04
US20080103292A1 (en) 2008-05-01
CZ200122A3 (en) 2001-06-13
PL198311B1 (pl) 2008-06-30
NO20006323L (no) 2001-02-12
HK1040721B (zh) 2003-10-17
HU230190B1 (hu) 2015-09-28
US7723470B2 (en) 2010-05-25
CN1249081C (zh) 2006-04-05
WO2000039156A1 (en) 2000-07-06
ES2201825T3 (es) 2004-03-16
US8030445B2 (en) 2011-10-04
JP2002533472A (ja) 2002-10-08
US20090215982A1 (en) 2009-08-27
US6949681B2 (en) 2005-09-27
US20030060598A1 (en) 2003-03-27
NO20006323D0 (no) 2000-12-12
NO326066B1 (no) 2008-09-08
US6392012B1 (en) 2002-05-21
BR9914221A (pt) 2001-06-26
SI1140993T1 (en) 2003-12-31
US6962970B2 (en) 2005-11-08
JP4362017B2 (ja) 2009-11-11
DK1140993T3 (da) 2003-10-06
HUP0400887A2 (hu) 2004-08-30
CZ301184B6 (cs) 2009-12-02
BR9914221B1 (pt) 2013-12-31
US7101964B2 (en) 2006-09-05
US7351791B2 (en) 2008-04-01
ZA200007222B (en) 2002-03-06
NZ508594A (en) 2003-05-30
CA2336445A1 (en) 2000-07-06
PL348451A1 (en) 2002-05-20
ATE242783T1 (de) 2003-06-15
EP1140993A1 (en) 2001-10-10

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B25D Requested change of name of applicant approved
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/12/2013, OBSERVADAS AS CONDICOES LEGAIS.

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