AU2001259303A1 - Glycopeptide carboxy-saccharide derivatives - Google Patents
Glycopeptide carboxy-saccharide derivativesInfo
- Publication number
- AU2001259303A1 AU2001259303A1 AU2001259303A AU5930301A AU2001259303A1 AU 2001259303 A1 AU2001259303 A1 AU 2001259303A1 AU 2001259303 A AU2001259303 A AU 2001259303A AU 5930301 A AU5930301 A AU 5930301A AU 2001259303 A1 AU2001259303 A1 AU 2001259303A1
- Authority
- AU
- Australia
- Prior art keywords
- glycopeptide
- carboxy
- saccharide derivatives
- glycopeptide derivatives
- terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21341700P | 2000-06-22 | 2000-06-22 | |
US60213417 | 2000-06-22 | ||
PCT/US2001/013996 WO2001098327A2 (en) | 2000-06-22 | 2001-05-01 | Glycopeptide carboxy-saccharide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001259303A1 true AU2001259303A1 (en) | 2002-01-02 |
Family
ID=22795046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001259303A Abandoned AU2001259303A1 (en) | 2000-06-22 | 2001-05-01 | Glycopeptide carboxy-saccharide derivatives |
Country Status (7)
Country | Link |
---|---|
US (4) | US6620781B2 (en) |
EP (1) | EP1292611B1 (en) |
AT (1) | ATE388960T1 (en) |
AU (1) | AU2001259303A1 (en) |
DE (1) | DE60133198T2 (en) |
ES (1) | ES2302733T3 (en) |
WO (1) | WO2001098327A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2408008C (en) * | 2000-05-02 | 2011-01-18 | Theravance, Inc. | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin |
AU2001259298A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Polyacid glycopeptide derivatives |
SI1276759T1 (en) * | 2000-05-02 | 2008-12-31 | Theravance Inc | Reductive alkylation process on glycopeptides |
US6872804B2 (en) | 2000-06-22 | 2005-03-29 | Theravance, Inc. | Glycopeptide disulfide and thioester derivatives |
UA75083C2 (en) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Derivatives of glycopeptidephosphonates |
AU2001259816A1 (en) | 2000-06-22 | 2002-01-02 | Advanced Medecine, Inc. | Polyhydroxy glycopeptide derivatives |
ATE388960T1 (en) | 2000-06-22 | 2008-03-15 | Theravance Inc | GLYCOPEPTIDE DERIVATIVES WITH CARBOXY SACCHARIDES |
WO2002059354A2 (en) * | 2001-01-25 | 2002-08-01 | Tm Bioscience Corporation | Polynucleotides for use as tags and tag complements, manufacture and use thereof |
WO2008118784A1 (en) * | 2007-03-23 | 2008-10-02 | Targanta Therapeutics Corp. | Glycopeptide and lipoglycopeptide antibiotics with improved solubility |
JP2010095454A (en) * | 2008-10-14 | 2010-04-30 | Cyclochem:Kk | Antibacterial composition |
GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
US8901072B2 (en) | 2009-08-12 | 2014-12-02 | The Medicines Company | Glycopeptide and lipoglycopeptide antibiotics with improved solubility |
BR112015023044A8 (en) | 2013-03-15 | 2021-09-28 | Melinta Subsidiary Corp | Methods for treating infections in overweight and obese patients with the use of antibiotics |
CA2925005A1 (en) | 2013-09-23 | 2015-03-26 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Vancomycin-sugar conjugates and uses thereof |
CN107325159A (en) * | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | One class vancomycin derivatives, its preparation method, pharmaceutical composition and purposes |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US55464A (en) * | 1866-06-12 | Improved mode of starting cars | ||
US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
US4643987A (en) | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
NZ236393A (en) | 1989-12-13 | 1992-05-26 | Lilly Co Eli | N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions |
US5750509A (en) | 1991-07-29 | 1998-05-12 | Gruppo Lepetit S.P.A. | Amide derivatives of antibiotic A 40926 |
US5602112A (en) | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
EP0674528A4 (en) | 1992-12-02 | 1996-06-26 | Insite Vision Inc | Cyclodextrin and polymer based drug delivery system. |
RU2145609C1 (en) | 1994-01-28 | 2000-02-20 | Эли Лилли Энд Компани | Derivatives of glycopeptide or their salts, method of synthesis, pharmaceutical composition |
US5840684A (en) | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
US5919756A (en) | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
US5916873A (en) | 1997-04-17 | 1999-06-29 | Eli Lilly And Company | Teicoplanin derivatives |
JPH11113593A (en) * | 1997-09-17 | 1999-04-27 | Noguchi Inst | New complex glycopeptide and its production and intermediate therefor |
JP2002520422A (en) | 1998-07-14 | 2002-07-09 | プリンストン ユニバーシティ | Glycopeptide antibiotics, combinatorial library of glycopeptide antibiotics and method for producing the same |
SI1140993T1 (en) * | 1998-12-23 | 2003-12-31 | Theravance, Inc. | Glycopeptide derivatives and pharmaceutical compositions containing the same |
DE19911097A1 (en) | 1999-03-12 | 2000-09-14 | Basf Ag | Process for the preparation of solid dosage forms containing cyclodextrin |
CA2370782A1 (en) | 1999-04-02 | 2000-10-12 | The Trustees Of Princeton University | Desleucyl glycopeptide antibiotics and methods of making same |
AU2001259298A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Polyacid glycopeptide derivatives |
IL153514A0 (en) | 2000-06-21 | 2003-07-06 | Cubist Pharm Inc | Compositions and methods to improve the oral absorption of antimicrobial agents |
AU2001259816A1 (en) | 2000-06-22 | 2002-01-02 | Advanced Medecine, Inc. | Polyhydroxy glycopeptide derivatives |
AU2001259302A1 (en) | 2000-06-22 | 2002-01-02 | Yongqi Mu | Glycopeptide disulfide and thioester derivatives |
UA75083C2 (en) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Derivatives of glycopeptidephosphonates |
ATE388960T1 (en) | 2000-06-22 | 2008-03-15 | Theravance Inc | GLYCOPEPTIDE DERIVATIVES WITH CARBOXY SACCHARIDES |
-
2001
- 2001-05-01 AT AT01932807T patent/ATE388960T1/en not_active IP Right Cessation
- 2001-05-01 WO PCT/US2001/013996 patent/WO2001098327A2/en active Application Filing
- 2001-05-01 EP EP01932807A patent/EP1292611B1/en not_active Expired - Lifetime
- 2001-05-01 US US09/847,052 patent/US6620781B2/en not_active Expired - Lifetime
- 2001-05-01 AU AU2001259303A patent/AU2001259303A1/en not_active Abandoned
- 2001-05-01 DE DE60133198T patent/DE60133198T2/en not_active Expired - Lifetime
- 2001-05-01 ES ES01932807T patent/ES2302733T3/en not_active Expired - Lifetime
-
2003
- 2003-06-23 US US10/601,847 patent/US6903070B2/en not_active Expired - Lifetime
-
2005
- 2005-03-15 US US11/080,130 patent/US7157554B2/en not_active Expired - Lifetime
-
2006
- 2006-10-30 US US11/589,614 patent/US7265086B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20020028770A1 (en) | 2002-03-07 |
WO2001098327A2 (en) | 2001-12-27 |
WO2001098327A3 (en) | 2002-04-04 |
US20050159344A1 (en) | 2005-07-21 |
ATE388960T1 (en) | 2008-03-15 |
DE60133198D1 (en) | 2008-04-24 |
US7157554B2 (en) | 2007-01-02 |
EP1292611A2 (en) | 2003-03-19 |
US6903070B2 (en) | 2005-06-07 |
US6620781B2 (en) | 2003-09-16 |
EP1292611B1 (en) | 2008-03-12 |
US20040087494A1 (en) | 2004-05-06 |
ES2302733T3 (en) | 2008-08-01 |
US7265086B2 (en) | 2007-09-04 |
DE60133198T2 (en) | 2009-03-12 |
US20070042942A1 (en) | 2007-02-22 |
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