WO2001098326A3 - Glycopeptide disulfide and thioester derivatives - Google Patents

Glycopeptide disulfide and thioester derivatives Download PDF

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Publication number
WO2001098326A3
WO2001098326A3 PCT/US2001/013995 US0113995W WO0198326A3 WO 2001098326 A3 WO2001098326 A3 WO 2001098326A3 US 0113995 W US0113995 W US 0113995W WO 0198326 A3 WO0198326 A3 WO 0198326A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycopeptide
disulfide
derivatives
thioester derivatives
thioester
Prior art date
Application number
PCT/US2001/013995
Other languages
French (fr)
Other versions
WO2001098326A2 (en
Inventor
Yongqi Mu
Original Assignee
Advanced Medicine Inc
Yongqi Mu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc, Yongqi Mu filed Critical Advanced Medicine Inc
Priority to AU2001259302A priority Critical patent/AU2001259302A1/en
Publication of WO2001098326A2 publication Critical patent/WO2001098326A2/en
Publication of WO2001098326A3 publication Critical patent/WO2001098326A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are disulfide and thioester derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
PCT/US2001/013995 2000-06-22 2001-05-01 Glycopeptide disulfide and thioester derivatives WO2001098326A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001259302A AU2001259302A1 (en) 2000-06-22 2001-05-01 Glycopeptide disulfide and thioester derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21314600P 2000-06-22 2000-06-22
US60/213,146 2000-06-22

Publications (2)

Publication Number Publication Date
WO2001098326A2 WO2001098326A2 (en) 2001-12-27
WO2001098326A3 true WO2001098326A3 (en) 2002-04-04

Family

ID=22793913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013995 WO2001098326A2 (en) 2000-06-22 2001-05-01 Glycopeptide disulfide and thioester derivatives

Country Status (2)

Country Link
AU (1) AU2001259302A1 (en)
WO (1) WO2001098326A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082971A2 (en) 2000-05-02 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
WO2001083520A2 (en) 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
ES2302733T3 (en) 2000-06-22 2008-08-01 Theravance, Inc. CARBOXI-SACARIDS DERIVATIVES OF GLUCOPEPTIDE.
UA75083C2 (en) 2000-06-22 2006-03-15 Тераванс, Інк. Derivatives of glycopeptidephosphonates
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004044A1 (en) * 1998-07-14 2000-01-27 Princeton University Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
WO2000059528A1 (en) * 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004044A1 (en) * 1998-07-14 2000-01-27 Princeton University Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
WO2000059528A1 (en) * 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NICOLAOU, K. C. ET AL: "Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria", ANGEW. CHEM., INT. ED. (2000), 39(21), 3823-3828, 27 October 2000 (2000-10-27), XP000967914, Retrieved from the Internet <URL:http://www3.interscience.wiley.com/cgi-bin/fulltext?ID=74500672&PLACEBO=IE.pdf> [retrieved on 20011120] *
SUNDRAM, UMA N. ET AL: "General and Efficient Method for the Solution- and Solid-Phase Synthesis of Vancomycin Carboxamide Derivatives", J. ORG. CHEM. (1995), 60(5), 1102-3, 10 March 1995 (1995-03-10), XP002183429 *
SUNDRAM, UMA N. ET AL: "Novel Vancomycin Dimers with Activity against Vancomycin-Resistant Enterococci", J. AM. CHEM. SOC. (1996), 118(51), 13107-13108, 25 December 1996 (1996-12-25), XP002037250 *

Also Published As

Publication number Publication date
AU2001259302A1 (en) 2002-01-02
WO2001098326A2 (en) 2001-12-27

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