CN1249081C - 糖肽衍生物或含有它们的药物组合物 - Google Patents

糖肽衍生物或含有它们的药物组合物 Download PDF

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Publication number
CN1249081C
CN1249081C CNB99809434XA CN99809434A CN1249081C CN 1249081 C CN1249081 C CN 1249081C CN B99809434X A CNB99809434X A CN B99809434XA CN 99809434 A CN99809434 A CN 99809434A CN 1249081 C CN1249081 C CN 1249081C
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CN
China
Prior art keywords
hydrogen
substituted
cooh
alkyl
glycosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB99809434XA
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English (en)
Chinese (zh)
Other versions
CN1315961A (zh
Inventor
J·K·朱迪斯
P·R·法瑟里
B·M·T·兰姆
M·里德伯特
M·S·林塞尔
穆永琪
S·G·特莱普
杨光
朱严
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cumberland Pharmaceuticals Inc
Original Assignee
Shiwan Pharmaceutical
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiwan Pharmaceutical, Advanced Medicine Inc filed Critical Shiwan Pharmaceutical
Publication of CN1315961A publication Critical patent/CN1315961A/zh
Application granted granted Critical
Publication of CN1249081C publication Critical patent/CN1249081C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB99809434XA 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物 Expired - Lifetime CN1249081C (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11372898P 1998-12-23 1998-12-23
US60/113,728 1998-12-23
US12931399P 1999-04-14 1999-04-14
US60/129,313 1999-04-14
US16402499P 1999-11-04 1999-11-04
US60/164,024 1999-11-04
US16997899P 1999-12-10 1999-12-10
US60/169,978 1999-12-10

Publications (2)

Publication Number Publication Date
CN1315961A CN1315961A (zh) 2001-10-03
CN1249081C true CN1249081C (zh) 2006-04-05

Family

ID=27493926

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99809434XA Expired - Lifetime CN1249081C (zh) 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物

Country Status (23)

Country Link
US (9) US6392012B1 (https=)
EP (1) EP1140993B1 (https=)
JP (1) JP4362017B2 (https=)
KR (1) KR100665204B1 (https=)
CN (1) CN1249081C (https=)
AT (1) ATE242783T1 (https=)
AU (1) AU768204B2 (https=)
BR (1) BRPI9914221B8 (https=)
CA (1) CA2336445C (https=)
CZ (1) CZ301184B6 (https=)
DE (1) DE69908819T2 (https=)
DK (1) DK1140993T3 (https=)
ES (1) ES2201825T3 (https=)
HK (1) HK1040721B (https=)
HU (1) HU230190B1 (https=)
IL (2) IL140093A0 (https=)
NO (1) NO326066B1 (https=)
NZ (1) NZ508594A (https=)
PL (1) PL198311B1 (https=)
PT (1) PT1140993E (https=)
SI (1) SI1140993T1 (https=)
WO (1) WO2000039156A1 (https=)
ZA (1) ZA200007222B (https=)

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AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
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ES2302733T3 (es) * 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
WO2001098329A1 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
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US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
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TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
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TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
CN101404986B (zh) 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
TWI325323B (en) * 2002-05-24 2010-06-01 Theravance Inc Cross-linked glycopeptide-cephalosporin antibiotics
AU2003243574A1 (en) 2002-06-17 2003-12-31 Theravance, Inc. PROCESS FOR PREPARING N-PROTECTED Beta-AMINO ALDEHYDE COMPOUNDS
BRPI0312654A2 (pt) * 2002-07-09 2017-05-02 Fasgen Llc métodos de tratar infecções microbianas em seres humanos e animais
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US8778874B2 (en) 2004-11-29 2014-07-15 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
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US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007084507A2 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS
TW200808818A (en) * 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CA2710602A1 (en) * 2007-12-26 2009-07-09 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
CN101959900A (zh) 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
WO2012129493A1 (en) * 2011-03-24 2012-09-27 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
AU2014322817A1 (en) * 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
WO2016103284A1 (en) * 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CA3011208A1 (en) * 2016-01-15 2017-07-20 Universitat Hamburg Methods for the production of rhamnosylated flavonoids
US10696698B2 (en) * 2016-01-28 2020-06-30 ACatechol, Inc. Surface primer compositions and methods of use
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
IL270685B (en) * 2017-05-22 2022-09-01 Insmed Inc Cleavable derivatives of lipoglycopeptide and their uses
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
CN111620931B (zh) * 2020-06-12 2021-12-17 苏州博源医疗科技有限公司 万古霉素衍生物及其制备方法和应用
CN114213284B (zh) * 2022-01-04 2023-08-01 丽珠集团福州福兴医药有限公司 (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法
CN121270649A (zh) * 2024-07-03 2026-01-06 烟台新药创制山东省实验室 一类万古霉素衍生物、其制备方法、药物组合物和用途

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Also Published As

Publication number Publication date
US7723470B2 (en) 2010-05-25
CA2336445A1 (en) 2000-07-06
NO20006323D0 (no) 2000-12-12
WO2000039156A1 (en) 2000-07-06
EP1140993A1 (en) 2001-10-10
ES2201825T3 (es) 2004-03-16
US6444786B1 (en) 2002-09-03
IL140093A (en) 2006-06-11
BR9914221B1 (pt) 2013-12-31
US20090215982A1 (en) 2009-08-27
BR9914221A (pt) 2001-06-26
US20040204346A1 (en) 2004-10-14
NO20006323L (no) 2001-02-12
IL140093A0 (en) 2002-02-10
BRPI9914221B8 (pt) 2021-05-25
US6962970B2 (en) 2005-11-08
DE69908819D1 (de) 2003-07-17
US20080103292A1 (en) 2008-05-01
US20060241024A1 (en) 2006-10-26
HUP0400887A3 (en) 2012-09-28
HU230190B1 (hu) 2015-09-28
US20050239690A1 (en) 2005-10-27
CZ301184B6 (cs) 2009-12-02
ATE242783T1 (de) 2003-06-15
US6392012B1 (en) 2002-05-21
DK1140993T3 (da) 2003-10-06
SI1140993T1 (en) 2003-12-31
US8030445B2 (en) 2011-10-04
CN1315961A (zh) 2001-10-03
PL198311B1 (pl) 2008-06-30
US20030060598A1 (en) 2003-03-27
HUP0400887A2 (hu) 2004-08-30
CZ200122A3 (en) 2001-06-13
AU3127300A (en) 2000-07-31
US6455669B1 (en) 2002-09-24
EP1140993B1 (en) 2003-06-11
US7101964B2 (en) 2006-09-05
ZA200007222B (en) 2002-03-06
AU768204B2 (en) 2003-12-04
HK1040721B (en) 2003-10-17
JP4362017B2 (ja) 2009-11-11
US6949681B2 (en) 2005-09-27
NO326066B1 (no) 2008-09-08
NZ508594A (en) 2003-05-30
HK1040721A1 (en) 2002-06-21
PL348451A1 (en) 2002-05-20
CA2336445C (en) 2011-07-19
PT1140993E (pt) 2003-10-31
US7351791B2 (en) 2008-04-01
KR20010085857A (ko) 2001-09-07
JP2002533472A (ja) 2002-10-08
DE69908819T2 (de) 2004-05-06
KR100665204B1 (ko) 2007-01-04

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