CN1249081C - 糖肽衍生物或含有它们的药物组合物 - Google Patents

糖肽衍生物或含有它们的药物组合物 Download PDF

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Publication number
CN1249081C
CN1249081C CNB99809434XA CN99809434A CN1249081C CN 1249081 C CN1249081 C CN 1249081C CN B99809434X A CNB99809434X A CN B99809434XA CN 99809434 A CN99809434 A CN 99809434A CN 1249081 C CN1249081 C CN 1249081C
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CN
China
Prior art keywords
hydrogen
substituted
cooh
alkyl
glycosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB99809434XA
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English (en)
Chinese (zh)
Other versions
CN1315961A (zh
Inventor
J·K·朱迪斯
P·R·法瑟里
B·M·T·兰姆
M·里德伯特
M·S·林塞尔
穆永琪
S·G·特莱普
杨光
朱严
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cumberland Pharmaceuticals Inc
Original Assignee
Shiwan Pharmaceutical
Advanced Medicine Inc
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Filing date
Publication date
Application filed by Shiwan Pharmaceutical, Advanced Medicine Inc filed Critical Shiwan Pharmaceutical
Publication of CN1315961A publication Critical patent/CN1315961A/zh
Application granted granted Critical
Publication of CN1249081C publication Critical patent/CN1249081C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB99809434XA 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物 Expired - Lifetime CN1249081C (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11372898P 1998-12-23 1998-12-23
US12931399P 1999-04-14 1999-04-14
US16402499P 1999-11-04 1999-11-04
US16997899P 1999-12-10 1999-12-10
US60/113,728 1999-12-10
US60/129,313 1999-12-10
US60/164,024 1999-12-10
US60/169,978 1999-12-10

Publications (2)

Publication Number Publication Date
CN1315961A CN1315961A (zh) 2001-10-03
CN1249081C true CN1249081C (zh) 2006-04-05

Family

ID=27493926

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99809434XA Expired - Lifetime CN1249081C (zh) 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物

Country Status (23)

Country Link
US (9) US6392012B1 (https=)
EP (1) EP1140993B1 (https=)
JP (1) JP4362017B2 (https=)
KR (1) KR100665204B1 (https=)
CN (1) CN1249081C (https=)
AT (1) ATE242783T1 (https=)
AU (1) AU768204B2 (https=)
BR (1) BRPI9914221B8 (https=)
CA (1) CA2336445C (https=)
CZ (1) CZ301184B6 (https=)
DE (1) DE69908819T2 (https=)
DK (1) DK1140993T3 (https=)
ES (1) ES2201825T3 (https=)
HK (1) HK1040721B (https=)
HU (1) HU230190B1 (https=)
IL (2) IL140093A0 (https=)
NO (1) NO326066B1 (https=)
NZ (1) NZ508594A (https=)
PL (1) PL198311B1 (https=)
PT (1) PT1140993E (https=)
SI (1) SI1140993T1 (https=)
WO (1) WO2000039156A1 (https=)
ZA (1) ZA200007222B (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69908819T2 (de) * 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
US6699836B2 (en) * 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
AU4054900A (en) * 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
AU2001238020A1 (en) * 2000-02-04 2001-08-14 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
US6770621B2 (en) 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
KR100856479B1 (ko) 2000-05-02 2008-09-04 세라밴스 인코포레이티드 환원성 알킬화 방법
JP4870314B2 (ja) 2000-05-02 2012-02-08 セラヴァンス， インコーポレーテッド シクロデキストリンを含むグリコペプチド抗生物質組成物
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
WO2001098329A1 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6620781B2 (en) * 2000-06-22 2003-09-16 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
ATE322975T1 (de) 2001-09-19 2006-04-15 Procter & Gamble Farbbedruckte mehrschichtstruktur, ein damit hergestellter absorbierender artikel und verfahren zu deren herstellung
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
CN101404986B (zh) 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
EP1507796B1 (en) * 2002-05-24 2012-05-02 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2003106399A2 (en) 2002-06-17 2003-12-24 Theravance, Inc. PROCESS FOR PREPARING N-PROTECTED β-AMINO ALDEHYDE COMPOUNDS
JP4493494B2 (ja) * 2002-07-09 2010-06-30 ファスゲン，インク． ヒトおよび動物における微生物感染症の治療方法
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
AU2003299561A1 (en) * 2002-11-18 2004-06-15 Vicuron Pharmaceuticals Inc. Compositions and methods for treating bacterial infections with protein-dalbavancin complexes
ES2335013T3 (es) 2003-05-23 2010-03-18 Theravance, Inc. Antibioticos de glucopeptido-cefalosporina reticulados.
EP1644382B1 (en) * 2003-07-11 2008-03-05 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
DE102004055582A1 (de) 2004-11-18 2006-05-24 Bayer Cropscience Ag N-Heterocyclyl-phthalsäurediamide
CA2588285A1 (en) 2004-11-29 2006-06-01 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US8304597B2 (en) 2004-12-15 2012-11-06 The Procter And Gamble Company Method of using an absorbent article having a functional enhancement indicator
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
WO2007084507A2 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CN101959849A (zh) * 2007-12-26 2011-01-26 利德治疗公司 作为抗菌剂的新型半合成糖肽
CN101959900A (zh) 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
US20140171357A1 (en) * 2011-03-24 2014-06-19 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
IN2013CH04314A (https=) * 2013-09-23 2015-08-28 Jawaharlal Nehru Ct For Advanced Scient Res Jncasr
US20170342110A1 (en) * 2014-12-25 2017-11-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
KR20210094657A (ko) * 2016-01-15 2021-07-29 함부르크대학교 람노실화된 플라보노이드의 제조 방법
CA3012176A1 (en) * 2016-01-28 2017-08-03 ACatechol, Inc. Photo-cleavable primer compositions and methods of use
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
GB2577420B (en) 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
CN111620931B (zh) * 2020-06-12 2021-12-17 苏州博源医疗科技有限公司 万古霉素衍生物及其制备方法和应用
CN114213284B (zh) * 2022-01-04 2023-08-01 丽珠集团福州福兴医药有限公司 (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法
CN121270649A (zh) * 2024-07-03 2026-01-06 烟台新药创制山东省实验室 一类万古霉素衍生物、其制备方法、药物组合物和用途

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497802A (en) 1983-10-21 1985-02-05 Eli Lilly And Company N-Acyl glycopeptide derivatives
US4914187A (en) 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
GB8428619D0 (en) 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
GB8704847D0 (en) * 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
FR2632185B1 (fr) * 1988-06-01 1992-05-22 Rhone Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc
GB8817397D0 (en) 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
US5534420A (en) 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
ATE134646T1 (de) * 1988-12-27 1996-03-15 Lepetit Spa C63-amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplanine
IE64155B1 (en) 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
CA2031803C (en) 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
AU647122B2 (en) 1990-05-28 1994-03-17 Gruppo Lepetit S.P.A. C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992017456A1 (fr) 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Derive d'acide amine et sel dudit derive
KR100242682B1 (ko) * 1991-07-29 2000-02-01 클라우디오 쿼르타 항생물질 a 40926의 아미드 유도체
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
MY128335A (en) 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
IT1282586B1 (it) 1996-02-08 1998-03-31 Chemical And Biolog Ind Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli
EP0934076A1 (en) 1996-03-21 1999-08-11 Intercardia, Inc. Solid phase lipoglycopeptide library, compositions and methods
JP4159110B2 (ja) 1996-04-12 2008-10-01 イーライ・リリー・アンド・カンパニー グリコペプチド化合物
AU2441697A (en) 1996-04-12 1997-11-07 Eli Lilly And Company Covalently-linked glycopeptide dimers
KR20000010589A (ko) 1996-04-23 2000-02-15 클라우디오 쿼르타 항생제a40926의아미드유도체의개선된화학적제조방법
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
US5977063A (en) 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5952310A (en) 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
FR2778184A1 (fr) 1998-02-20 1999-11-05 Advanced Medicine Inc Composes a liaisons multiples antibacteriens nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
WO1999056760A1 (en) 1998-05-01 1999-11-11 Eli Lilly And Company N1-modified glycopeptides
NZ509165A (en) 1998-07-14 2003-08-29 Univ Princeton Glycopeptide antobiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
DE69908819T2 (de) * 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
EP1507796B1 (en) 2002-05-24 2012-05-02 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
EP1644382B1 (en) 2003-07-11 2008-03-05 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Also Published As

Publication number Publication date
WO2000039156A1 (en) 2000-07-06
DE69908819D1 (de) 2003-07-17
KR20010085857A (ko) 2001-09-07
US20030060598A1 (en) 2003-03-27
US7351791B2 (en) 2008-04-01
US7101964B2 (en) 2006-09-05
ZA200007222B (en) 2002-03-06
BR9914221A (pt) 2001-06-26
PL348451A1 (en) 2002-05-20
CZ200122A3 (en) 2001-06-13
IL140093A (en) 2006-06-11
HUP0400887A3 (en) 2012-09-28
PT1140993E (pt) 2003-10-31
US6444786B1 (en) 2002-09-03
BRPI9914221B8 (pt) 2021-05-25
US6392012B1 (en) 2002-05-21
US20060241024A1 (en) 2006-10-26
AU768204B2 (en) 2003-12-04
US20090215982A1 (en) 2009-08-27
PL198311B1 (pl) 2008-06-30
HU230190B1 (hu) 2015-09-28
HK1040721B (en) 2003-10-17
HUP0400887A2 (hu) 2004-08-30
SI1140993T1 (en) 2003-12-31
DE69908819T2 (de) 2004-05-06
AU3127300A (en) 2000-07-31
US20040204346A1 (en) 2004-10-14
CA2336445A1 (en) 2000-07-06
BR9914221B1 (pt) 2013-12-31
HK1040721A1 (en) 2002-06-21
NO20006323D0 (no) 2000-12-12
NZ508594A (en) 2003-05-30
EP1140993B1 (en) 2003-06-11
US20080103292A1 (en) 2008-05-01
US7723470B2 (en) 2010-05-25
US6962970B2 (en) 2005-11-08
NO20006323L (no) 2001-02-12
ES2201825T3 (es) 2004-03-16
US8030445B2 (en) 2011-10-04
US6949681B2 (en) 2005-09-27
CZ301184B6 (cs) 2009-12-02
US20050239690A1 (en) 2005-10-27
CA2336445C (en) 2011-07-19
KR100665204B1 (ko) 2007-01-04
IL140093A0 (en) 2002-02-10
CN1315961A (zh) 2001-10-03
US6455669B1 (en) 2002-09-24
ATE242783T1 (de) 2003-06-15
EP1140993A1 (en) 2001-10-10
JP2002533472A (ja) 2002-10-08
JP4362017B2 (ja) 2009-11-11
NO326066B1 (no) 2008-09-08
DK1140993T3 (da) 2003-10-06

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