JP2002519434A5 - - Google Patents

Info

Publication number

JP2002519434A5

JP2002519434A5 JP2000558116A JP2000558116A JP2002519434A5 JP 2002519434 A5 JP2002519434 A5 JP 2002519434A5 JP 2000558116 A JP2000558116 A JP 2000558116A JP 2000558116 A JP2000558116 A JP 2000558116A JP 2002519434 A5 JP2002519434 A5 JP 2002519434A5

Authority

JP

Japan

Prior art keywords

thr

coome

cooh

phenyl

mebmt

Prior art date

1999-06-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 7
• 108010036949 Cyclosporine Proteins 0.000 description 7
• 229960001265 ciclosporin Drugs 0.000 description 7
• 229930182912 cyclosporin Natural products 0.000 description 7
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 5
• AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical group CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 description 4
• QHRMEJWWMGUKAM-LURJTMIESA-N (2s)-2-(ethylazaniumyl)-3-methylbutanoate Chemical compound CCN[C@@H](C(C)C)C(O)=O QHRMEJWWMGUKAM-LURJTMIESA-N 0.000 description 3
• 208000030507 AIDS Diseases 0.000 description 3
• 229930105110 Cyclosporin A Natural products 0.000 description 3
• 101100241859 Mus musculus Oacyl gene Proteins 0.000 description 3
• 125000000217 alkyl group Chemical group 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 3
• 239000008194 pharmaceutical composition Substances 0.000 description 3
• 239000003814 drug Substances 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1