DE69928938T2 - Neues cyclosporin mit verbesserter wirkung - Google Patents
Neues cyclosporin mit verbesserter wirkung Download PDFInfo
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- DE69928938T2 DE69928938T2 DE69928938T DE69928938T DE69928938T2 DE 69928938 T2 DE69928938 T2 DE 69928938T2 DE 69928938 T DE69928938 T DE 69928938T DE 69928938 T DE69928938 T DE 69928938T DE 69928938 T2 DE69928938 T2 DE 69928938T2
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- Prior art keywords
- cyclosporin
- thr
- val
- meleu
- solution
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- A61P37/00—Drugs for immunological or allergic disorders
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH140598 | 1998-07-01 | ||
| CH140598 | 1998-07-01 | ||
| PCT/IB1999/001232 WO2000001715A1 (fr) | 1998-07-01 | 1999-06-30 | Nouvelle cyclosporine ayant un profil d'activite ameliore |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69928938D1 DE69928938D1 (de) | 2006-01-19 |
| DE69928938T2 true DE69928938T2 (de) | 2006-08-17 |
Family
ID=4209677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69928938T Expired - Lifetime DE69928938T2 (de) | 1998-07-01 | 1999-06-30 | Neues cyclosporin mit verbesserter wirkung |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | USRE40987E1 (https=) |
| EP (1) | EP1091975B1 (https=) |
| JP (1) | JP4350898B2 (https=) |
| CN (1) | CN1218958C (https=) |
| AT (1) | ATE312843T1 (https=) |
| AU (1) | AU759480B2 (https=) |
| BR (1) | BR9911724A (https=) |
| CA (1) | CA2335903C (https=) |
| DE (1) | DE69928938T2 (https=) |
| DK (1) | DK1091975T3 (https=) |
| ES (1) | ES2255275T3 (https=) |
| MX (1) | MXPA00013019A (https=) |
| PT (1) | PT1091975E (https=) |
| WO (1) | WO2000001715A1 (https=) |
Families Citing this family (55)
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| AU759480B2 (en) | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
| WO2000046239A1 (fr) * | 1999-02-05 | 2000-08-10 | Debiopharm S.A. | Derives de cyclosporine et procede de preparation desdits derives |
| US6995139B2 (en) | 2001-04-20 | 2006-02-07 | Debiopharm S.A. | Cyclic undecapeptide pro-drugs and uses thereof |
| US7538084B2 (en) * | 2003-03-17 | 2009-05-26 | Amr Technology, Inc. | Cyclosporins |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| US20060035821A1 (en) * | 2004-08-16 | 2006-02-16 | Hunt Kevin W | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases |
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| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| DK1793844T3 (da) * | 2004-10-01 | 2011-03-21 | Debiopharm Sa | Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion |
| SI1802650T1 (sl) * | 2004-10-01 | 2012-03-30 | Scynexis Inc | Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c |
| US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
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| JP2008526816A (ja) * | 2005-01-10 | 2008-07-24 | デビオファーム ソシエテ アノニム | 心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用 |
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| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| EP2023918B1 (en) | 2006-05-19 | 2011-03-23 | Scynexis, Inc. | Cyclosporins for the treatment and prevention of ocular disorders |
| CN101502196A (zh) * | 2006-06-02 | 2009-08-05 | 克洛德·安妮·佩里西恩 | 激活电子的管理 |
| CN101108178B (zh) * | 2006-07-20 | 2010-09-15 | 复旦大学 | 一种亲环素a抑制剂在制备抗艾滋病药物中的应用 |
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| WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
| KR20100017547A (ko) * | 2007-05-02 | 2010-02-16 | 아스텔라스세이야쿠 가부시키가이샤 | 신규 시클릭 펩티드 화합물 |
| US8394763B2 (en) | 2007-09-26 | 2013-03-12 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
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| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
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| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| EP2376524B1 (en) | 2008-12-31 | 2017-03-15 | Cypralis Limited | Derivatives of cyclosporin a |
| KR20110111321A (ko) * | 2009-01-30 | 2011-10-10 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체 |
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| WO2012009715A2 (en) | 2010-07-16 | 2012-01-19 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| US9573978B2 (en) | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
| WO2012037485A2 (en) * | 2010-09-16 | 2012-03-22 | 1The Johns Hopkins University | Methods of inhibiting alphavirus replication and treating alphavirus infection |
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| JO3337B1 (ar) * | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
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| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
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| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
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| CN104744570A (zh) * | 2013-12-31 | 2015-07-01 | 深圳先进技术研究院 | 一种环孢菌素的合成方法 |
| US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
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| US4210581A (en) | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
| CH614931A5 (https=) | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| DE2819094A1 (de) | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| SE448386B (sv) | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| IE54936B1 (en) | 1980-02-14 | 1990-03-28 | Sandoz Ltd | A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| US4396542A (en) | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| DE3047662C2 (de) * | 1980-12-18 | 1985-02-21 | Karl M. Reich Maschinenfabrik GmbH, 7440 Nürtingen | Puffersystem bei Einschlaggeräten |
| US4384996A (en) | 1981-01-09 | 1983-05-24 | Sandoz Ltd. | Novel cyclosporins |
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| EP0290762B1 (en) | 1984-10-04 | 1993-05-12 | Sandoz Ag | Cyclosporins |
| EP0194972B1 (en) | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4814323A (en) | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
| DE3884470T2 (de) | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
| KR0148748B1 (ko) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| FI111730B (fi) | 1990-11-02 | 2003-09-15 | Novartis Ag | Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi |
| PL324531A1 (en) | 1995-07-17 | 1998-06-08 | Chem Ag C | Derivatives of cyclosporin effective against hiv virus |
| JP3089350B2 (ja) | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
| FR2757522B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757520B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent |
| FR2757521B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| AU759480B2 (en) | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| US7439277B2 (en) | 2005-05-19 | 2008-10-21 | Fina Technology, Inc. | In-situ preparation of hydroperoxide functionalized rubber |
-
1999
- 1999-06-30 AU AU43856/99A patent/AU759480B2/en not_active Expired
- 1999-06-30 ES ES99926684T patent/ES2255275T3/es not_active Expired - Lifetime
- 1999-06-30 CN CNB998081558A patent/CN1218958C/zh not_active Expired - Lifetime
- 1999-06-30 PT PT99926684T patent/PT1091975E/pt unknown
- 1999-06-30 AT AT99926684T patent/ATE312843T1/de active
- 1999-06-30 BR BR9911724-0A patent/BR9911724A/pt not_active Application Discontinuation
- 1999-06-30 DE DE69928938T patent/DE69928938T2/de not_active Expired - Lifetime
- 1999-06-30 DK DK99926684T patent/DK1091975T3/da active
- 1999-06-30 MX MXPA00013019A patent/MXPA00013019A/es active IP Right Grant
- 1999-06-30 JP JP2000558116A patent/JP4350898B2/ja not_active Expired - Lifetime
- 1999-06-30 EP EP99926684A patent/EP1091975B1/fr not_active Expired - Lifetime
- 1999-06-30 US US12/123,601 patent/USRE40987E1/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/IB1999/001232 patent/WO2000001715A1/fr not_active Ceased
- 1999-06-30 US US09/720,923 patent/US6927208B1/en not_active Ceased
- 1999-06-30 CA CA002335903A patent/CA2335903C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1308635A (zh) | 2001-08-15 |
| CN1218958C (zh) | 2005-09-14 |
| JP2002519434A (ja) | 2002-07-02 |
| ATE312843T1 (de) | 2005-12-15 |
| BR9911724A (pt) | 2001-03-20 |
| US6927208B1 (en) | 2005-08-09 |
| AU4385699A (en) | 2000-01-24 |
| JP4350898B2 (ja) | 2009-10-21 |
| ES2255275T3 (es) | 2006-06-16 |
| DK1091975T3 (da) | 2006-04-18 |
| CA2335903A1 (fr) | 2000-01-13 |
| CA2335903C (fr) | 2009-11-10 |
| MXPA00013019A (es) | 2003-07-14 |
| EP1091975A1 (fr) | 2001-04-18 |
| USRE40987E1 (en) | 2009-11-17 |
| WO2000001715A1 (fr) | 2000-01-13 |
| EP1091975B1 (fr) | 2005-12-14 |
| AU759480B2 (en) | 2003-04-17 |
| PT1091975E (pt) | 2006-05-31 |
| DE69928938D1 (de) | 2006-01-19 |
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