BR9911724A - Ciclosporina que tem um perfil de atividade melhorado - Google Patents

Ciclosporina que tem um perfil de atividade melhorado

Info

Publication number
BR9911724A
BR9911724A BR9911724-0A BR9911724A BR9911724A BR 9911724 A BR9911724 A BR 9911724A BR 9911724 A BR9911724 A BR 9911724A BR 9911724 A BR9911724 A BR 9911724A
Authority
BR
Brazil
Prior art keywords
cyclosporine
improved activity
activity profile
profile
improved
Prior art date
Application number
BR9911724-0A
Other languages
English (en)
Inventor
Roland M Wenger
Manfred Mutter
Thomas Ruckle
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of BR9911724A publication Critical patent/BR9911724A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Patente de Invenção: <B>''CICLOSPORINA QUE TEM UM PERFIL DE ATIVIDADE MELHORADO''<D>. A presente invenção trata de uma nova ciclosporina, de sua utilização farmacêutica, assim como de uma composição farmacêutica que a compreende.
BR9911724-0A 1998-07-01 1999-06-30 Ciclosporina que tem um perfil de atividade melhorado BR9911724A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140598 1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr) 1998-07-01 1999-06-30 Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (1)

Publication Number Publication Date
BR9911724A true BR9911724A (pt) 2001-03-20

Family

ID=4209677

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911724-0A BR9911724A (pt) 1998-07-01 1999-06-30 Ciclosporina que tem um perfil de atividade melhorado

Country Status (14)

Country Link
US (2) USRE40987E1 (pt)
EP (1) EP1091975B1 (pt)
JP (1) JP4350898B2 (pt)
CN (1) CN1218958C (pt)
AT (1) ATE312843T1 (pt)
AU (1) AU759480B2 (pt)
BR (1) BR9911724A (pt)
CA (1) CA2335903C (pt)
DE (1) DE69928938T2 (pt)
DK (1) DK1091975T3 (pt)
ES (1) ES2255275T3 (pt)
MX (1) MXPA00013019A (pt)
PT (1) PT1091975E (pt)
WO (1) WO2000001715A1 (pt)

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EP1809656A4 (en) * 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
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KR101309409B1 (ko) * 2004-10-01 2013-09-23 싸이넥시스, 인크. Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
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CA2623864C (en) * 2005-09-30 2014-12-16 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
KR20080059270A (ko) 2005-09-30 2008-06-26 싸이넥시스, 인크. Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물
AU2006306974B2 (en) * 2005-10-26 2011-09-22 Astellas Pharma Inc. New cyclic peptide compounds
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
WO2007136759A2 (en) 2006-05-19 2007-11-29 Scynexis, Inc. Method for the treatment and prevention of ocular disorders
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
CN101108178B (zh) * 2006-07-20 2010-09-15 复旦大学 一种亲环素a抑制剂在制备抗艾滋病药物中的应用
BRPI0719189A2 (pt) * 2006-10-12 2018-08-14 Univ Kyushu Nat Univ Corp uso de ciclosporinas modificadas
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
JP5801534B2 (ja) 2007-01-04 2015-10-28 デビオファーム インターナショナル ソシエテ アノニム ウールリッヒ型先天筋ジストロフィーの処置のための、非免疫抑制性シクロスポリン
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
US8603975B2 (en) * 2007-05-02 2013-12-10 Astellas Pharma Inc. Cyclic peptide compounds
AU2008304313B2 (en) 2007-09-26 2013-01-10 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) * 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
WO2010002428A2 (en) 2008-06-06 2010-01-07 Scynexis, Inc. Novel macrocyclic peptides
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8536114B2 (en) 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
NZ594755A (en) * 2009-01-30 2013-12-20 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c infection
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
KR20120106942A (ko) 2009-10-30 2012-09-27 베링거 인겔하임 인터내셔날 게엠베하 Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법
AU2010333656B2 (en) * 2009-12-18 2015-08-27 Boehringer Ingelheim International Gmbh HCV combination therapy
US8802666B2 (en) 2009-12-21 2014-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Inhibitors of cyclophilins and uses thereof
CN103153329A (zh) 2010-07-16 2013-06-12 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) * 2010-09-16 2012-03-22 1The Johns Hopkins University Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
MY165152A (en) 2010-12-15 2018-02-28 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
GB2515942A (en) 2011-10-21 2015-01-07 Abbvie Inc Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV
US8853176B2 (en) 2011-10-21 2014-10-07 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
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AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
SG11201601274QA (en) 2013-08-26 2016-03-30 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c
CN104744570A (zh) * 2013-12-31 2015-07-01 深圳先进技术研究院 一种环孢菌素的合成方法
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
US20230149504A1 (en) 2020-04-06 2023-05-18 Debiopharm International Sa Alisporivir for use in human viral infections

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Also Published As

Publication number Publication date
EP1091975A1 (fr) 2001-04-18
DE69928938D1 (de) 2006-01-19
WO2000001715A1 (fr) 2000-01-13
MXPA00013019A (es) 2003-07-14
AU4385699A (en) 2000-01-24
DE69928938T2 (de) 2006-08-17
EP1091975B1 (fr) 2005-12-14
CA2335903C (fr) 2009-11-10
CN1218958C (zh) 2005-09-14
PT1091975E (pt) 2006-05-31
JP2002519434A (ja) 2002-07-02
US6927208B1 (en) 2005-08-09
CA2335903A1 (fr) 2000-01-13
JP4350898B2 (ja) 2009-10-21
ES2255275T3 (es) 2006-06-16
DK1091975T3 (da) 2006-04-18
CN1308635A (zh) 2001-08-15
AU759480B2 (en) 2003-04-17
USRE40987E1 (en) 2009-11-17
ATE312843T1 (de) 2005-12-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: DEBIOPHARM S.A. (CH)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020090092713/RJ DE 01/10/2009.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 8O COMBINADO COM ART. 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]