USRE40987E1 - Cyclosporin with improved activity profile - Google Patents

Cyclosporin with improved activity profile Download PDF

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Publication number
USRE40987E1
USRE40987E1 US12/123,601 US12360199A USRE40987E US RE40987 E1 USRE40987 E1 US RE40987E1 US 12360199 A US12360199 A US 12360199A US RE40987 E USRE40987 E US RE40987E
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cyclosporin
thr
val
solution
coome
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Roland M. Wenger
Manfred Mutter
Thomas Rückle
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Debiopharm SA
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Debiopharm SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • the present invention relates to a novel cyclosporin (Cs), the pharmaceutical use thereof and to a pharmaceutical composition containing it.
  • Cyclosporins are a class of cyclic poly-N-methylated undecapeptides having several pharmacological activities; in particular, they are immunosuppressants, anti-inflammatories, anti-parasitic agents, drug resistance suppressors (anti-MDR) and anti-viral agents.
  • the first cyclosporin isolated from a fungal culture is cyclosporin A which is found in the natural state and which is represented by the following formula:
  • Cyclosporin A isolated 20 years ago from Tolypocladium inflatum has considerable immunosuppressive activity. It has revolutionised organ transplantation and is commonly used in the treatment of autoimmune diseases.
  • CsA Cyclosporin A
  • CsA results mainly in the selective suppression of the activation of T lymphocytes.
  • This immunosuppressive activity is explained by the fact that CsA binds to an intracellular proteic receptor cyclophilin A (CyP), forming a CyP-CsA complex which interacts with calcineurin (CaN) and thus inhibits its phosphatase activity.
  • CyP proteic receptor cyclophilin A
  • CaN calcineurin
  • the transcription of families of genes exhibiting precocious activation will be blocked (cf. O'Keefe, S. J; Tamura, J; Nature 1992, 357, 692-694).
  • the present invention provides the production of a novel cyclosporin with considerable HIV-1 (human immunodeficiency virus) inhibitory activity and not having the immunosuppressive activity of CsA.
  • the mode of infection of HIV type 1 is unique amongst the retroviruses because it requires the specific incorporation into its virion of the cellular protein CyP which interacts with the polyprotein Gag (cf. Eltaly Kara Franke, Bi-Xing Chem. Journal of Virology, September 1995, vol. 69 no. 9). It is well known that CyP binds to CsA and CaN in a ternary complex. However, the native function of CyP is to catalyse the isomerisation of peptidyl-prolyl bonds, a limiting and important step in the process allowing proteins to acquire a definitive three-dimensional structure. CyP also protects cells from thermal shocks or acts as a chaperone protein.
  • the product of the Gag gene of HIV-1 prohibits the formation of a ternary complex with CyP and CaN.
  • the HIV virus needs CyP in order to bind to the product of the Gag gene so as to form its own virions (cf. Franke, E. K; 1994 Nature 372, 359-362).
  • CsA there is direct competition with the polyprotein derived from the Gag gene of HIV-1 to bind the CyP. This CsA acts at two levels on the replication of the viral cycle. Firstly, at the level of translocation towards the core of the pre-integrated complex, then in the production of infectious viral particles.
  • Another patent WO 97/04005 uses the method of preparation of the patent EP 484 281 and the method developed by Seebach EP 194972 in order to produce derivatives in position 3 such as, for example, (D)-MeSer 3 -(4-OH)MeLeu 4 cyclosporin.
  • This substance has a better affinity for CyP but only has limited anti-HIV activity compared with the reference derivative MeIle 4 -Cs (NIM 811). The more hydrophilic nature of this substance prevents it penetrating the cells and the organism. This is reflected directly in the reduced anti-HIV activity of this substance (cf. Cristos Papageorgiou, J. J. Sanglier and RenéTraber—Bioorganic & Medicinal Chemistry Letters, Vol. 6, No. 1, pp. 23-26, 1996).
  • FIG. 1 shows the general structure of the novel cyclosporin according to the invention
  • FIGS. 2 and 3 show analysis spectra for NEtIle4-Cs
  • Table I shows affinity results of Cs derivatives for cyclophilin A in a competitive ELISA test
  • Table II shows the percentage protection during HIV infection of a CEM-SS cell line
  • TABLE III shows examples of cyclosporins with different groups R1, R2, R3 and R4.
  • the substances described in this invention have the dual advantage of retaining the same affinity for CyP as that observed with [(4-OH)MeLeu 4 ]-Cs or cyclosporin A whilst having anti-HIV activity which is identical to or greater than that of the reference derivatives (MeVal 4 -Cs or MeIle 4 -Cs) and appreciably greater than the anti-HIV activity of cyclosporin A or of (4-OH)MeLeu 4 -Cs.
  • the object of the invention is to provide a novel cyclosporin which does not have the immunosuppressive activity of CsA and has an improved profile of activity.
  • This new family of Cs is characterised by the formula (I): wherein:
  • the new cyclosporin molecule thus obtained offers the unexpected and surprising advantage of having much better stability towards metabolisation than all the other cyclosporins known hitherto.
  • This new molecule is much more resistant to the phenomena of oxidation and degradation which take place in the cell. Consequently, the “in vivo” life of this new N-alkyl as Cs is particularly prolonged.
  • this new N-alkyl aa 4 cyclosporin has high affinity for CyP and has anti-HIV activity which is equal to or greater than the best existing cyclosporins.
  • FIG. 1 represents the general structure of this novel cyclosporin.
  • the groups R1, R2, R3 and R4 will be largely described in Table III.
  • Table III Thus, by transforming these 4 key positions, it was possible to retain a very good affinity for cyclophilin and to prevent the formation of a ternary complex with CaN and, above all, to increase, in a particularly advantageous manner, its stability towards enzymatic oxidation and consequently its anti-HIV activity.
  • This novel cyclosporin is thus characterised principally by the presence, in position 4, of a residue with R>CH 3 and R ⁇ C 10 H 21 .
  • the substituent of nitrogen used will be, for example, ethyl, propyl, butyl or pentyl, but these examples are not limiting.
  • This novel cyclosporin is particularly active if the residue in position 4 is an N-ethylated amino acid (see drawings 2 and 3).
  • the invention also claims the pharmaceutical composition of the substance as described by formula (I). This may be combined with a pharmaceutically acceptable solution.
  • the pharmaceutical formulation thus produced makes it possible to increase the solubility in water or to keep the composition in the form of microemulsions in suspension in water.
  • the object of the present invention is also to provide a new medicinal product which may be used, for example, in the treatment and prevention of AIDS (acquired immunodeficiency syndrome).
  • AIDS immunodeficiency syndrome
  • the cyclosporin modified in position 4 by a residue Z, namely N-ethyl-valine will be used in particular for the production of a medicinal product intended for the treatment and prevention of AIDS.
  • the application for the prevention of AIDS is not limiting.
  • This substance may also be used, for example, for its anti-inflammatory properties.
  • CsA The process for the synthesis of CsA is described in: R. Wenger (Helv. Chim. Acta Vol. 67, p. 502-525 (1984)).
  • the process for opening protected cyclosporin A (OAc) is described in Peptides 1996.
  • the CsA molecule is treated with Meerwein's reagent (CH 3 ) 3 OBF 4 then cleaved by treatment with acid in methanol or hydrolysed by water in order to convert it to a linear peptide of 11 amino acid residues: H-MeLeu-Val-MeLeu-Ala-(D)Ala-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-Sar-OCH3.
  • the product is then used for the following synthesis routes without an additional purification step.
  • This substance is hydrolysed then activated and condensed with 1 corresponding amino acid in order to produce a new peptide with 11 residues, the starting product for the cyclisation and production of a novel cyclosporin with the desired properties.
  • the crude product (900 mg) is purified by chromatography [150 g of silica gel (0.4-0.63)], use of dichloromethane/methanol/triethylamine (17:3:0.05) as eluants) to eluate 700 mg (95%) of pure, deprotected undecapeptide (4).
  • the trimethyloxoformate is evaporated under vacuum and the remainder of the aqueous solution is diluted in 300 ml of water. This solution is then extracted 2 ⁇ with 100 ml of diethylether. The organic phase is then re-extracted 3 ⁇ with a 0.1 N aqueous solution of HCl. The combined aqueous phases are cooled to 0° C. then the pH is adjusted to 9 using (2N)NaOH. The solution then becomes cloudy. The aqueous suspension is extracted 4 ⁇ with 100 ml of diethylether. The combined organic phases are then dried with Na 2 SO 4 , filtered and the solvent is finally evaporated.
  • the results of Table 1 show the affinity of the derivatives of Cs for cyclophilin A in a competitive ELISA test described by Quesniaux in Eur. J. Immunology 1987, 17, 1359-1365.
  • Cs bound to BSA serum albumin
  • the concentration required to obtain 50% inhibition (IC 50 ) of the reference reaction in the absence of competitor is then calculated.
  • the results are expressed by the binding index BI which is the ratio of the IC 50 of the derivative and the IC 50 of CsA.
  • a binding index (BI) of 1.0 indicates that the compound tested binds as well as CsA.
  • a value lower than 1.0 indicates that the derivative binds better than CsA, and a value greater than 1.0 means that the derivative binds less well to CyP than CsA.
  • Cs is regarded as being immunosuppressive if its activity in the mixed lymphocyte reaction (MLR) is greater than 5%.
  • MLR mixed lymphocyte reaction
  • the reaction (MLR) is described by T. Meo in “Immunological Methods”, L. Lefkovits and B. Devis, Eds, Académie Prev. N.Y. pp: 227-239 (1979).
  • Spleen cells (0.5.10 6 ) originating from Balb/c mice (female, 8 to 10 weeks) are co-incubated for 5 days in the presence of treated spleen cells originating from CBA mice (females, 8 to 10 weeks). These cells were treated with mitomycin C or were irradiated at 2000 rads. The non-irradiated allogenic spleen cells exhibit a proliferative response in Balb/c cells which can be measured by incorporating a labelled precursor in the DNA. If the stimulator cells are irradiated (or treated with mitomycin C), the Balb/c cells no longer exhibit a proliferative response but retain their antigenicity.
  • the IC 50 calculated in the MLR test is compared with the IC 50 corresponding to CsA in a parallel experiment.
  • the IR index is thus found, this being the ratio of the IC 50 of the MLR test of the derivatives over the IC 50 of cyclosporin A.
  • a value of 1.0 for the IR means an activity similar to CsA.
  • a lower value means better activity and a value greater than 1.0 shows that the activity of the compound is lower than that of CsA.
  • Table II describes the percentage protection during infection with HIV of a CEM-SS cell line.
  • the protection of this line in the presence of a Cs derivative is compared with the infection of a line cultivated in the absence of Cs (reference control).
  • a mean value is established at a concentration of the derivative of 2 ⁇ 10 ⁇ 6 molar. This anti-HIV activity was measured by the NCI (National Cancer Institute) in Washington in the USA.

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US12/123,601 1998-07-01 1999-06-30 Cyclosporin with improved activity profile Expired - Lifetime USRE40987E1 (en)

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CH140598 1998-07-01
US09/720,923 US6927208B1 (en) 1998-07-01 1999-06-30 Cyclosporin with improved activity profile
PCT/IB1999/001232 WO2000001715A1 (fr) 1998-07-01 1999-06-30 Nouvelle cyclosporine ayant un profil d'activite ameliore

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EP (1) EP1091975B1 (pt)
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AU (1) AU759480B2 (pt)
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DE (1) DE69928938T2 (pt)
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Cited By (2)

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US20130267460A1 (en) * 2010-09-16 2013-10-10 The Johns Hopkins University Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection
US20160051625A1 (en) * 2009-01-30 2016-02-25 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection

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