DE69928938D1 - Neues cyclosporin mit verbesserter wirkung - Google Patents

Neues cyclosporin mit verbesserter wirkung

Info

Publication number
DE69928938D1
DE69928938D1 DE69928938T DE69928938T DE69928938D1 DE 69928938 D1 DE69928938 D1 DE 69928938D1 DE 69928938 T DE69928938 T DE 69928938T DE 69928938 T DE69928938 T DE 69928938T DE 69928938 D1 DE69928938 D1 DE 69928938D1
Authority
DE
Germany
Prior art keywords
improved effect
new cyclosporin
cyclosporin
new
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928938T
Other languages
English (en)
Other versions
DE69928938T2 (de
Inventor
M Wenger
Manfred Mutter
Thomas Ruckle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm SA filed Critical Debiopharm SA
Publication of DE69928938D1 publication Critical patent/DE69928938D1/de
Application granted granted Critical
Publication of DE69928938T2 publication Critical patent/DE69928938T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69928938T 1998-07-01 1999-06-30 Neues cyclosporin mit verbesserter wirkung Expired - Lifetime DE69928938T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140598 1998-07-01
CH140598 1998-07-01
PCT/IB1999/001232 WO2000001715A1 (fr) 1998-07-01 1999-06-30 Nouvelle cyclosporine ayant un profil d'activite ameliore

Publications (2)

Publication Number Publication Date
DE69928938D1 true DE69928938D1 (de) 2006-01-19
DE69928938T2 DE69928938T2 (de) 2006-08-17

Family

ID=4209677

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928938T Expired - Lifetime DE69928938T2 (de) 1998-07-01 1999-06-30 Neues cyclosporin mit verbesserter wirkung

Country Status (14)

Country Link
US (2) USRE40987E1 (de)
EP (1) EP1091975B1 (de)
JP (1) JP4350898B2 (de)
CN (1) CN1218958C (de)
AT (1) ATE312843T1 (de)
AU (1) AU759480B2 (de)
BR (1) BR9911724A (de)
CA (1) CA2335903C (de)
DE (1) DE69928938T2 (de)
DK (1) DK1091975T3 (de)
ES (1) ES2255275T3 (de)
MX (1) MXPA00013019A (de)
PT (1) PT1091975E (de)
WO (1) WO2000001715A1 (de)

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ES2267492T3 (es) * 1999-02-05 2007-03-16 Debiopharm S.A. Derivados de ciclosporina y procedimiento de preparacion de dichos derivados.
WO2002085928A2 (fr) 2001-04-20 2002-10-31 Debiopharm S.A. Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation
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GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
EP1809656A4 (de) * 2004-09-29 2009-03-25 Amr Technology Inc Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006038088A1 (en) * 2004-10-01 2006-04-13 Debiopharm Sa Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3-[etval]4-cyclosporin
KR101309409B1 (ko) * 2004-10-01 2013-09-23 싸이넥시스, 인크. Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
DK1853296T5 (da) * 2005-01-10 2013-03-18 Debiopharm Sa Anvendelse af et cyklisk undekapeptid til fremstilling af et lægemiddel til indgift ved myokardiale iskæmiepisoder
US8329658B2 (en) 2005-09-30 2012-12-11 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
JP5517454B2 (ja) 2005-09-30 2014-06-11 スシネキス インク Ｃ型肝炎感染の治療及び予防のための方法及び医薬組成物
ES2557477T3 (es) * 2005-10-26 2016-01-26 Astellas Pharma Inc. Nuevos compuestos peptídicos cíclicos
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
JP5377293B2 (ja) 2006-05-19 2013-12-25 スシネキス インク 眼疾患の治療及び予防方法
US20100194497A1 (en) * 2006-06-02 2010-08-05 Claude Annie Perrichon Management of active electrons
CN101108178B (zh) * 2006-07-20 2010-09-15 复旦大学 一种亲环素a抑制剂在制备抗艾滋病药物中的应用
CA2665415A1 (en) * 2006-10-12 2008-04-17 Novartis Ag Use of modified cyclosporins
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
US8450281B2 (en) 2007-01-04 2013-05-28 Debiopharm S.A. Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
KR20100017547A (ko) * 2007-05-02 2010-02-16 아스텔라스세이야쿠 가부시키가이샤 신규 시클릭 펩티드 화합물
CA2700536A1 (en) 2007-09-26 2009-04-02 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) * 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CN102307892A (zh) 2008-12-31 2012-01-04 西尼克斯公司 环孢菌素a的衍生物
CA2751210C (en) * 2009-01-30 2015-04-21 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
BR112012010110A2 (pt) 2009-10-30 2019-09-24 Boehringer Ingelheim Int regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina
US20130029904A1 (en) * 2009-12-18 2013-01-31 Boehringer Ingelheim International Gmbh Hcv combination therapy
EP2516387B1 (de) 2009-12-21 2018-02-21 Institut National de la Sante et de la Recherche Medicale (INSERM) Hemmer für cyclophiline zur prävention und/oder verwendung in der behandlung von viruskrankheiten oder infektionen
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012037485A2 (en) * 2010-09-16 2012-03-22 1The Johns Hopkins University Methods of inhibiting alphavirus replication and treating alphavirus infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
WO2012079172A1 (en) 2010-12-15 2012-06-21 Isotechnika Pharma Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
UY34401A (es) 2011-10-21 2013-05-31 Abbvie Inc Métodos para el tratamiento de hcv
DE202012012956U1 (de) 2011-10-21 2014-10-16 Abbvie Inc. Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen für die Verwendung zur Behandlung von HCV, umfassend Ribavirin aber nicht Interferon
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
EP2705856A1 (de) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
EP3038626A4 (de) 2013-08-26 2017-04-19 Enanta Pharmaceuticals, Inc. Cyclosporinanaloga zur prävention oder behandlung von hepatitis-c-infektionen
CN104744570A (zh) * 2013-12-31 2015-07-01 深圳先进技术研究院 一种环孢菌素的合成方法
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP4132558A1 (de) 2020-04-06 2023-02-15 Debiopharm International SA Alisporivir zur verwendung bei menschlichen virusinfektionen

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US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (de) 1975-11-04 1979-12-28 Sandoz Ag
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
AU548156B2 (en) 1980-02-14 1985-11-28 Novartis Ag Cyclo sporin
DE3047662C2 (de) * 1980-12-18 1985-02-21 Karl M. Reich Maschinenfabrik GmbH, 7440 Nürtingen Puffersystem bei Einschlaggeräten
US4384996A (en) 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
WO1986002080A1 (en) 1984-10-04 1986-04-10 Sandoz Ag Monoclonal antibodies to cyclosporings
EP0194972B1 (de) 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4814323A (en) 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
ES2059558T3 (es) 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
DE69124459T3 (de) 1990-11-02 2001-05-31 Novartis Ag Zyklosporine
IL122754A (en) 1995-07-17 2001-10-31 Chem Ag C History of cyclosporine, their preparation and the pharmaceutical preparations containing them
JP3089350B2 (ja) 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US7439277B2 (en) 2005-05-19 2008-10-21 Fina Technology, Inc. In-situ preparation of hydroperoxide functionalized rubber

Also Published As

Publication number Publication date
EP1091975A1 (de) 2001-04-18
DK1091975T3 (da) 2006-04-18
PT1091975E (pt) 2006-05-31
ES2255275T3 (es) 2006-06-16
BR9911724A (pt) 2001-03-20
CN1308635A (zh) 2001-08-15
CA2335903A1 (fr) 2000-01-13
CA2335903C (fr) 2009-11-10
MXPA00013019A (es) 2003-07-14
JP4350898B2 (ja) 2009-10-21
ATE312843T1 (de) 2005-12-15
DE69928938T2 (de) 2006-08-17
EP1091975B1 (de) 2005-12-14
AU759480B2 (en) 2003-04-17
US6927208B1 (en) 2005-08-09
AU4385699A (en) 2000-01-24
WO2000001715A1 (fr) 2000-01-13
USRE40987E1 (en) 2009-11-17
CN1218958C (zh) 2005-09-14
JP2002519434A (ja) 2002-07-02

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Legal Events

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8364 No opposition during term of opposition