JP2002510633A5 - - Google Patents

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Publication number
JP2002510633A5
JP2002510633A5 JP2000542009A JP2000542009A JP2002510633A5 JP 2002510633 A5 JP2002510633 A5 JP 2002510633A5 JP 2000542009 A JP2000542009 A JP 2000542009A JP 2000542009 A JP2000542009 A JP 2000542009A JP 2002510633 A5 JP2002510633 A5 JP 2002510633A5
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JP
Japan
Prior art keywords
mammalian
compound
pharmaceutical composition
excipient
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000542009A
Other languages
English (en)
Japanese (ja)
Other versions
JP4443043B2 (ja
JP2002510633A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/007471 external-priority patent/WO1999051238A1/en
Publication of JP2002510633A publication Critical patent/JP2002510633A/ja
Publication of JP2002510633A5 publication Critical patent/JP2002510633A5/ja
Application granted granted Critical
Publication of JP4443043B2 publication Critical patent/JP4443043B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2000542009A 1998-04-06 1999-04-05 半合成エクテイナシジン Expired - Fee Related JP4443043B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
US60/080,802 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (3)

Publication Number Publication Date
JP2002510633A JP2002510633A (ja) 2002-04-09
JP2002510633A5 true JP2002510633A5 (https=) 2006-05-25
JP4443043B2 JP4443043B2 (ja) 2010-03-31

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000542009A Expired - Fee Related JP4443043B2 (ja) 1998-04-06 1999-04-05 半合成エクテイナシジン

Country Status (27)

Country Link
US (1) US6124293A (https=)
EP (2) EP1067933B1 (https=)
JP (1) JP4443043B2 (https=)
KR (1) KR100603219B1 (https=)
CN (1) CN1157189C (https=)
AT (1) ATE370148T1 (https=)
AU (1) AU758100B2 (https=)
BG (1) BG65088B1 (https=)
BR (1) BR9909488B1 (https=)
CA (1) CA2327468C (https=)
CY (1) CY1106988T1 (https=)
CZ (1) CZ301083B6 (https=)
DE (1) DE69936845T2 (https=)
DK (1) DK1067933T3 (https=)
ES (1) ES2292237T3 (https=)
HU (1) HUP0104273A3 (https=)
IL (2) IL138856A0 (https=)
MX (1) MXPA00009840A (https=)
NO (1) NO328147B1 (https=)
NZ (1) NZ507350A (https=)
PL (1) PL196809B1 (https=)
PT (1) PT1067933E (https=)
RU (1) RU2217432C2 (https=)
SK (1) SK285669B6 (https=)
TR (1) TR200002921T2 (https=)
UA (1) UA59439C2 (https=)
WO (1) WO1999051238A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1339713A2 (en) 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EP1365808B1 (en) * 2000-11-06 2011-01-19 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
MX2007000360A (es) * 2004-07-09 2007-06-12 Pharma Mar Sa Marcadores moleculares de pronostico.
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
DK1827500T3 (da) * 2004-10-26 2009-08-31 Pharma Mar Sa Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
ME02395B (me) 2010-11-12 2016-09-20 Pharma Mar Sa Kombinovana terapija sa antitumorskim alkaloidima
CN107427512B (zh) * 2016-02-04 2021-10-08 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi
JP2023503318A (ja) 2019-11-21 2023-01-27 ファルマ、マール、ソシエダード、アノニマ ルルビネクテジン製剤で小細胞肺がんを処置する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
TW221441B (https=) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

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