YU17700A - Oralne kompozicije levosimendana - Google Patents
Oralne kompozicije levosimendanaInfo
- Publication number
- YU17700A YU17700A YU17700A YUP17700A YU17700A YU 17700 A YU17700 A YU 17700A YU 17700 A YU17700 A YU 17700A YU P17700 A YUP17700 A YU P17700A YU 17700 A YU17700 A YU 17700A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- levosimendan
- oral
- copositions
- polymorphic form
- useful
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Opisana je kompozicija za oralnu primenu koja sadrži suštinski čist kristalni polimorfni oblik (I) levosimendana kao aktivnu komponentu zajedno sa farmaceutski prihvatljivim nosačem. Polimorfni oblik (I) levosimendana se brzo absorbuje iz gastrointestinalnog trakta i koristan je u tretiranju kongestivnog srčanog oboljenja.[A composition for oral administration comprising substantially pure crystalline polymorphic form (I) of levosimendan as an active ingredient together with a pharmaceutically acceptable carrier is described. Polymorphic form (I) of levosimendan is rapidly absorbed from the gastrointestinal tract and is useful in the treatment of congestive heart disease.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI973804A FI973804A (fi) | 1997-09-26 | 1997-09-26 | Levosimendaanin oraalisia koostumuksia |
Publications (1)
Publication Number | Publication Date |
---|---|
YU17700A true YU17700A (sh) | 2002-10-18 |
Family
ID=8549609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU17700A YU17700A (sh) | 1997-09-26 | 2000-03-24 | Oralne kompozicije levosimendana |
Country Status (36)
Country | Link |
---|---|
US (1) | US6355269B1 (sh) |
EP (1) | EP1014987B1 (sh) |
JP (1) | JP4493840B2 (sh) |
KR (1) | KR100762022B1 (sh) |
CN (1) | CN1149994C (sh) |
AR (1) | AR013519A1 (sh) |
AT (1) | ATE260659T1 (sh) |
AU (1) | AU732489B2 (sh) |
BG (1) | BG64746B1 (sh) |
BR (1) | BR9813213A (sh) |
CA (1) | CA2304702C (sh) |
CZ (1) | CZ294984B6 (sh) |
DE (1) | DE69822172T2 (sh) |
DK (1) | DK1014987T3 (sh) |
EA (1) | EA001647B1 (sh) |
EE (1) | EE03854B1 (sh) |
ES (1) | ES2217580T3 (sh) |
FI (1) | FI973804A (sh) |
GE (1) | GEP20032943B (sh) |
HK (1) | HK1032001A1 (sh) |
HR (1) | HRP20000171B1 (sh) |
HU (1) | HUP0003757A3 (sh) |
ID (1) | ID24486A (sh) |
IL (1) | IL134802A (sh) |
MX (1) | MXPA00002956A (sh) |
MY (1) | MY118156A (sh) |
NO (1) | NO320047B1 (sh) |
NZ (1) | NZ503207A (sh) |
PL (1) | PL190862B1 (sh) |
PT (1) | PT1014987E (sh) |
RS (1) | RS49708B (sh) |
SI (1) | SI1014987T1 (sh) |
SK (1) | SK283187B6 (sh) |
TR (1) | TR200000635T2 (sh) |
WO (1) | WO1999016443A1 (sh) |
YU (1) | YU17700A (sh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9606474D0 (en) * | 1996-03-27 | 1996-06-05 | Orion Yhytmo Oy | Method for obtaining pure enantiomers of a pyridazinone derivative |
FI980901A (fi) * | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Levosimendaania säädellysti vapauttavia oraalisia koostumuksia |
FI980902A (fi) * | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Levosimendaanin stabiileja koostumuksia |
FI20000577A0 (fi) * | 2000-03-13 | 2000-03-13 | Orion Yhtymae Oy | Pyridatsinyylifenyylihydratsoneja |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
EP1642571A3 (en) * | 2000-12-22 | 2007-06-27 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
FI20010233A0 (fi) * | 2001-02-08 | 2001-02-08 | Orion Corp | Menetelmä sydämen vajaatoiminnan hoitoon |
FI20011465A0 (fi) * | 2001-07-04 | 2001-07-04 | Orion Corp | Pyridatsinonijohdannaisen uusi käyttö |
JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
CN100428937C (zh) * | 2003-10-30 | 2008-10-29 | 北京海合天科技开发有限公司 | 左西孟旦冷冻干燥组合物 |
AU2010272364B2 (en) * | 2009-07-14 | 2014-04-10 | Cipla Limited | Process for preparing levosimendan and intermediates for use in the process |
CN104418810A (zh) * | 2013-09-04 | 2015-03-18 | 北京博时安泰科技发展有限公司 | 一种左西孟旦的合成新路线 |
CN103554032A (zh) * | 2013-11-12 | 2014-02-05 | 江苏正大清江制药有限公司 | 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法 |
ITMI20132185A1 (it) * | 2013-12-23 | 2015-06-24 | Edmond Pharma Srl | Polimorfi di levosimendan |
CN104987310A (zh) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | 左西孟旦的合成工艺 |
CN111474289A (zh) * | 2019-10-31 | 2020-07-31 | 武汉嘉诺康医药技术有限公司 | 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法 |
CA3161960A1 (en) | 2019-12-16 | 2021-06-24 | Tenax Therapeutics, Inc. | Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef) |
CN111548310B (zh) * | 2020-05-12 | 2021-07-02 | 成都欣捷高新技术开发股份有限公司 | 一种左西孟旦钠晶型及其制备方法 |
CN111718299B (zh) * | 2020-07-23 | 2023-03-10 | 成都欣捷高新技术开发股份有限公司 | 一种左西孟旦钠晶型b及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
GB2266841A (en) * | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
GB9606474D0 (en) * | 1996-03-27 | 1996-06-05 | Orion Yhytmo Oy | Method for obtaining pure enantiomers of a pyridazinone derivative |
GB9614098D0 (en) * | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
-
1997
- 1997-09-26 FI FI973804A patent/FI973804A/fi not_active Application Discontinuation
-
1998
- 1998-09-21 MY MYPI98004329A patent/MY118156A/en unknown
- 1998-09-24 ID IDW20000565A patent/ID24486A/id unknown
- 1998-09-24 DE DE69822172T patent/DE69822172T2/de not_active Expired - Lifetime
- 1998-09-24 CA CA002304702A patent/CA2304702C/en not_active Expired - Fee Related
- 1998-09-24 PL PL339461A patent/PL190862B1/pl not_active IP Right Cessation
- 1998-09-24 NZ NZ503207A patent/NZ503207A/en unknown
- 1998-09-24 SK SK384-2000A patent/SK283187B6/sk not_active IP Right Cessation
- 1998-09-24 AU AU93506/98A patent/AU732489B2/en not_active Ceased
- 1998-09-24 IL IL13480298A patent/IL134802A/en not_active IP Right Cessation
- 1998-09-24 GE GEAP19985319A patent/GEP20032943B/en unknown
- 1998-09-24 EP EP98946480A patent/EP1014987B1/en not_active Expired - Lifetime
- 1998-09-24 CZ CZ2000919A patent/CZ294984B6/cs not_active IP Right Cessation
- 1998-09-24 BR BR9813213-0A patent/BR9813213A/pt not_active Application Discontinuation
- 1998-09-24 MX MXPA00002956A patent/MXPA00002956A/es not_active IP Right Cessation
- 1998-09-24 DK DK98946480T patent/DK1014987T3/da active
- 1998-09-24 KR KR1020007003095A patent/KR100762022B1/ko not_active IP Right Cessation
- 1998-09-24 TR TR2000/00635T patent/TR200000635T2/xx unknown
- 1998-09-24 EE EEP200000187A patent/EE03854B1/xx not_active IP Right Cessation
- 1998-09-24 ES ES98946480T patent/ES2217580T3/es not_active Expired - Lifetime
- 1998-09-24 JP JP2000513579A patent/JP4493840B2/ja not_active Expired - Fee Related
- 1998-09-24 SI SI9830645T patent/SI1014987T1/xx unknown
- 1998-09-24 CN CNB988094673A patent/CN1149994C/zh not_active Expired - Fee Related
- 1998-09-24 AT AT98946480T patent/ATE260659T1/de active
- 1998-09-24 PT PT98946480T patent/PT1014987E/pt unknown
- 1998-09-24 WO PCT/FI1998/000753 patent/WO1999016443A1/en not_active Application Discontinuation
- 1998-09-24 EA EA200000360A patent/EA001647B1/ru not_active IP Right Cessation
- 1998-09-24 RS YUP-177/00A patent/RS49708B/sr unknown
- 1998-09-24 HU HU0003757A patent/HUP0003757A3/hu unknown
- 1998-09-24 AR ARP980104780A patent/AR013519A1/es active IP Right Grant
- 1998-09-24 US US09/509,205 patent/US6355269B1/en not_active Expired - Fee Related
-
2000
- 2000-03-16 BG BG104250A patent/BG64746B1/bg unknown
- 2000-03-23 HR HR20000171A patent/HRP20000171B1/xx not_active IP Right Cessation
- 2000-03-24 YU YU17700A patent/YU17700A/sh unknown
- 2000-03-27 NO NO20001585A patent/NO320047B1/no not_active IP Right Cessation
-
2001
- 2001-04-10 HK HK01102520A patent/HK1032001A1/xx not_active IP Right Cessation
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