HRP20000171B1 - Oral compositions of levosimendan - Google Patents

Oral compositions of levosimendan

Info

Publication number
HRP20000171B1
HRP20000171B1 HR20000171A HRP20000171A HRP20000171B1 HR P20000171 B1 HRP20000171 B1 HR P20000171B1 HR 20000171 A HR20000171 A HR 20000171A HR P20000171 A HRP20000171 A HR P20000171A HR P20000171 B1 HRP20000171 B1 HR P20000171B1
Authority
HR
Croatia
Prior art keywords
levosimendan
oral compositions
polymorphic form
crystalline polymorphic
demands
Prior art date
Application number
HR20000171A
Other languages
English (en)
Croatian (hr)
Inventor
Harjula Maarit
Larma Ilkka
Antila Saila
Lehtonen Lasse
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of HRP20000171A2 publication Critical patent/HRP20000171A2/hr
Publication of HRP20000171B1 publication Critical patent/HRP20000171B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HR20000171A 1997-09-26 2000-03-23 Oral compositions of levosimendan HRP20000171B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973804A FI973804A (fi) 1997-09-26 1997-09-26 Levosimendaanin oraalisia koostumuksia
PCT/FI1998/000753 WO1999016443A1 (en) 1997-09-26 1998-09-24 Oral compositions of levosimendan

Publications (2)

Publication Number Publication Date
HRP20000171A2 HRP20000171A2 (en) 2000-12-31
HRP20000171B1 true HRP20000171B1 (en) 2009-06-30

Family

ID=8549609

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000171A HRP20000171B1 (en) 1997-09-26 2000-03-23 Oral compositions of levosimendan

Country Status (36)

Country Link
US (1) US6355269B1 (xx)
EP (1) EP1014987B1 (xx)
JP (1) JP4493840B2 (xx)
KR (1) KR100762022B1 (xx)
CN (1) CN1149994C (xx)
AR (1) AR013519A1 (xx)
AT (1) ATE260659T1 (xx)
AU (1) AU732489B2 (xx)
BG (1) BG64746B1 (xx)
BR (1) BR9813213A (xx)
CA (1) CA2304702C (xx)
CZ (1) CZ294984B6 (xx)
DE (1) DE69822172T2 (xx)
DK (1) DK1014987T3 (xx)
EA (1) EA001647B1 (xx)
EE (1) EE03854B1 (xx)
ES (1) ES2217580T3 (xx)
FI (1) FI973804A (xx)
GE (1) GEP20032943B (xx)
HK (1) HK1032001A1 (xx)
HR (1) HRP20000171B1 (xx)
HU (1) HUP0003757A3 (xx)
ID (1) ID24486A (xx)
IL (1) IL134802A (xx)
MX (1) MXPA00002956A (xx)
MY (1) MY118156A (xx)
NO (1) NO320047B1 (xx)
NZ (1) NZ503207A (xx)
PL (1) PL190862B1 (xx)
PT (1) PT1014987E (xx)
RS (1) RS49708B (xx)
SI (1) SI1014987T1 (xx)
SK (1) SK283187B6 (xx)
TR (1) TR200000635T2 (xx)
WO (1) WO1999016443A1 (xx)
YU (1) YU17700A (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
DK1347747T3 (da) * 2000-12-22 2006-04-10 Baxter Int Fremgangsmåde til behandling af submikropartikelsuspensioner af farmaceutiske midler
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011465A0 (fi) * 2001-07-04 2001-07-04 Orion Corp Pyridatsinonijohdannaisen uusi käyttö
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
EP2454241B1 (en) 2009-07-14 2014-04-02 Cipla Limited Process for preparing levosimendan and intermediates for use in the process
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
EP4076398A4 (en) * 2019-12-16 2024-01-03 Tenax Therapeutics, Inc. LEVOSIMENDAN TO TREAT PULMONARY HYPERTENSION ACCOMPANIED BY HEART FAILURE BY MEANS OF PRESERVED EJECTION FRACTION (PH-HF-PEF)
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383449A2 (en) * 1989-02-11 1990-08-22 Orion-Yhtymà„ Oy Pyridazinone derivatives and processes for preparing the same
WO1992012135A1 (en) * 1991-01-03 1992-07-23 Orion-Yhtymä Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
WO1993021921A1 (en) * 1992-05-06 1993-11-11 Orion-Yhtymä Oy Anti-ischemic medicament
WO1997035841A2 (en) * 1996-03-27 1997-10-02 Orion-Yhtymä Oy Method for obtaining pure enantiomers of a pyridazinone derivative
WO1998001111A1 (en) * 1996-07-05 1998-01-15 Orion-Yhtymä Oy Transdermal compositions containing levosimendan

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383449A2 (en) * 1989-02-11 1990-08-22 Orion-Yhtymà„ Oy Pyridazinone derivatives and processes for preparing the same
WO1992012135A1 (en) * 1991-01-03 1992-07-23 Orion-Yhtymä Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
WO1993021921A1 (en) * 1992-05-06 1993-11-11 Orion-Yhtymä Oy Anti-ischemic medicament
WO1997035841A2 (en) * 1996-03-27 1997-10-02 Orion-Yhtymä Oy Method for obtaining pure enantiomers of a pyridazinone derivative
WO1998001111A1 (en) * 1996-07-05 1998-01-15 Orion-Yhtymä Oy Transdermal compositions containing levosimendan

Also Published As

Publication number Publication date
WO1999016443A1 (en) 1999-04-08
CN1271282A (zh) 2000-10-25
SK283187B6 (sk) 2003-03-04
BG64746B1 (bg) 2006-02-28
CN1149994C (zh) 2004-05-19
HUP0003757A2 (hu) 2001-05-28
EA200000360A1 (ru) 2000-10-30
JP4493840B2 (ja) 2010-06-30
PT1014987E (pt) 2004-06-30
RS49708B (sr) 2007-12-31
KR20010030679A (ko) 2001-04-16
MXPA00002956A (es) 2003-05-19
SI1014987T1 (en) 2004-08-31
IL134802A (en) 2004-01-04
FI973804A0 (fi) 1997-09-26
SK3842000A3 (en) 2000-09-12
CZ294984B6 (cs) 2005-04-13
IL134802A0 (en) 2001-04-30
PL339461A1 (en) 2000-12-18
TR200000635T2 (tr) 2000-09-21
EE200000187A (et) 2001-04-16
PL190862B1 (pl) 2006-02-28
DE69822172T2 (de) 2005-02-24
EP1014987B1 (en) 2004-03-03
CA2304702A1 (en) 1999-04-08
EA001647B1 (ru) 2001-06-25
NO20001585D0 (no) 2000-03-27
NZ503207A (en) 2001-04-27
ATE260659T1 (de) 2004-03-15
EE03854B1 (et) 2002-10-15
EP1014987A1 (en) 2000-07-05
NO320047B1 (no) 2005-10-17
KR100762022B1 (ko) 2007-09-28
DK1014987T3 (da) 2004-05-24
JP2001517702A (ja) 2001-10-09
DE69822172D1 (de) 2004-04-08
AR013519A1 (es) 2000-12-27
YU17700A (sh) 2002-10-18
FI973804A (fi) 1999-03-27
AU9350698A (en) 1999-04-23
CZ2000919A3 (cs) 2000-09-13
HK1032001A1 (en) 2001-07-06
BR9813213A (pt) 2000-08-29
CA2304702C (en) 2007-09-04
ES2217580T3 (es) 2004-11-01
HUP0003757A3 (en) 2001-07-30
ID24486A (id) 2000-07-20
NO20001585L (no) 2000-03-27
US6355269B1 (en) 2002-03-12
AU732489B2 (en) 2001-04-26
MY118156A (en) 2004-09-30
HRP20000171A2 (en) 2000-12-31
BG104250A (en) 2000-12-29
GEP20032943B (en) 2003-04-25

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Payment date: 20100827

Year of fee payment: 13

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