DK1067933T3 - Semisyntetiske ecteinascidiner - Google Patents

Semisyntetiske ecteinascidiner

Info

Publication number
DK1067933T3
DK1067933T3 DK99916379T DK99916379T DK1067933T3 DK 1067933 T3 DK1067933 T3 DK 1067933T3 DK 99916379 T DK99916379 T DK 99916379T DK 99916379 T DK99916379 T DK 99916379T DK 1067933 T3 DK1067933 T3 DK 1067933T3
Authority
DK
Denmark
Prior art keywords
ecteinascidins
semisynthetic
bioactivities
boc
species
Prior art date
Application number
DK99916379T
Other languages
English (en)
Inventor
Kenneth L Rinehart
Jose J Morales
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of DK1067933T3 publication Critical patent/DK1067933T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Dental Preparations (AREA)
DK99916379T 1998-04-06 1999-04-05 Semisyntetiske ecteinascidiner DK1067933T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (1)

Publication Number Publication Date
DK1067933T3 true DK1067933T3 (da) 2007-12-27

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99916379T DK1067933T3 (da) 1998-04-06 1999-04-05 Semisyntetiske ecteinascidiner

Country Status (28)

Country Link
US (1) US6124293A (da)
EP (2) EP1067933B1 (da)
JP (1) JP4443043B2 (da)
KR (1) KR100603219B1 (da)
CN (1) CN1157189C (da)
AT (1) ATE370148T1 (da)
AU (1) AU758100B2 (da)
BG (1) BG65088B1 (da)
BR (1) BR9909488B1 (da)
CA (1) CA2327468C (da)
CY (1) CY1106988T1 (da)
CZ (1) CZ301083B6 (da)
DE (1) DE69936845T2 (da)
DK (1) DK1067933T3 (da)
ES (1) ES2292237T3 (da)
HK (1) HK1033651A1 (da)
HU (1) HUP0104273A3 (da)
IL (2) IL138856A0 (da)
MX (1) MXPA00009840A (da)
NO (1) NO328147B1 (da)
NZ (1) NZ507350A (da)
PL (1) PL196809B1 (da)
PT (1) PT1067933E (da)
RU (1) RU2217432C2 (da)
SK (1) SK285669B6 (da)
TR (1) TR200002921T2 (da)
UA (1) UA59439C2 (da)
WO (1) WO1999051238A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
TR200003470T2 (tr) * 1998-05-11 2001-06-21 Pharama Mar, S.A. Ecteinascidin 743 Metabolitleri
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
WO2001053299A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1339713A2 (en) * 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
MXPA03003975A (es) * 2000-11-06 2004-02-12 Pharma Mar Sa Composiciones para tratamiento antitumoral, que contienen ecteinascidina 743.
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
PT1689404E (pt) 2003-11-13 2008-12-15 Pharma Mar Sau Combinação de et-743 com pró-fármacos de fluorouracil para o tratamento do cancro
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
JP2007511509A (ja) * 2003-11-14 2007-05-10 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
NZ552607A (en) * 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
CN101068596A (zh) * 2004-09-29 2007-11-07 法马马私人股份有限公司 艾可特耐思地作抗炎药
US20090117176A1 (en) * 2004-10-26 2009-05-07 Pharma Mar, S.A. Sociedad Unipersonal Anticancer Treatments
WO2006046079A1 (en) 2004-10-29 2006-05-04 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
JP6382516B2 (ja) 2010-11-12 2018-08-29 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドを用いる、組み合わせの治療法
CA3011527A1 (en) * 2016-02-04 2017-08-10 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
CZ301083B6 (cs) 2009-11-04
BG65088B1 (bg) 2007-02-28
MXPA00009840A (es) 2002-04-24
KR20010074474A (ko) 2001-08-04
EP1876180A3 (en) 2009-12-16
NZ507350A (en) 2003-03-28
NO328147B1 (no) 2009-12-21
SK15012000A3 (sk) 2001-08-06
RU2217432C2 (ru) 2003-11-27
JP4443043B2 (ja) 2010-03-31
RU2000128058A (ru) 2004-02-20
DE69936845D1 (de) 2007-09-27
KR100603219B1 (ko) 2006-07-20
IL138856A0 (en) 2001-10-31
HK1033651A1 (en) 2001-09-14
NO20004978D0 (no) 2000-10-03
JP2002510633A (ja) 2002-04-09
PT1067933E (pt) 2007-11-15
NO20004978L (no) 2000-12-05
EP1067933B1 (en) 2007-08-15
BR9909488B1 (pt) 2011-02-08
CY1106988T1 (el) 2012-09-26
EP1067933A4 (en) 2002-12-18
CN1157189C (zh) 2004-07-14
PL343439A1 (en) 2001-08-13
TR200002921T2 (tr) 2001-02-21
EP1876180A2 (en) 2008-01-09
CA2327468C (en) 2008-05-06
ATE370148T1 (de) 2007-09-15
DE69936845T2 (de) 2008-05-08
US6124293A (en) 2000-09-26
EP1067933A1 (en) 2001-01-17
SK285669B6 (sk) 2007-06-07
HUP0104273A3 (en) 2003-12-29
UA59439C2 (uk) 2003-09-15
CZ20003650A3 (en) 2001-06-13
BG104902A (en) 2001-07-31
CA2327468A1 (en) 1999-10-14
CN1304309A (zh) 2001-07-18
BR9909488A (pt) 2000-12-26
WO1999051238A9 (en) 2000-01-27
WO1999051238A1 (en) 1999-10-14
ES2292237T3 (es) 2008-03-01
AU758100B2 (en) 2003-03-13
PL196809B1 (pl) 2008-02-29
IL138856A (en) 2007-07-24
AU3471399A (en) 1999-10-25
HUP0104273A2 (hu) 2002-03-28

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