TR200003470T2 - Ecteinascidin 743 Metabolitleri - Google Patents
Ecteinascidin 743 MetabolitleriInfo
- Publication number
- TR200003470T2 TR200003470T2 TR2000/03470T TR200003470T TR200003470T2 TR 200003470 T2 TR200003470 T2 TR 200003470T2 TR 2000/03470 T TR2000/03470 T TR 2000/03470T TR 200003470 T TR200003470 T TR 200003470T TR 200003470 T2 TR200003470 T2 TR 200003470T2
- Authority
- TR
- Turkey
- Prior art keywords
- etm
- ecteinascidin
- metabolites
- combinations
- metaboism
- Prior art date
Links
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical class C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 102000018832 Cytochromes Human genes 0.000 abstract 1
- 108010052832 Cytochromes Proteins 0.000 abstract 1
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 229960000977 trabectedin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
Abstract
Ecteinascidin 743 hetabolitleri metaboizmasinin birkaç ürününün, insan sitokromu CYP A4 ile aritilmasi ve yapisinin açiklanmasi, saglanmistir. Bu bilesimler, "ETM" seklinde kisaltilmis olup, takiben sayisal deger yaklasik molekül agirligini gösterir. Üç bilesim, ETM 305, ETM 775 ve ETM 204, olarak belirlenmistir. Bu ecetinascidin metabolitlerinin yapilari ise ETM 305, ETM 204 ve ETM 775 olarak gösterilmistir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8502498P | 1998-05-11 | 1998-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200003470T2 true TR200003470T2 (tr) | 2001-06-21 |
Family
ID=22188976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03470T TR200003470T2 (tr) | 1998-05-11 | 1999-05-11 | Ecteinascidin 743 Metabolitleri |
Country Status (22)
Country | Link |
---|---|
US (3) | US6316214B1 (tr) |
EP (1) | EP1077698B1 (tr) |
JP (2) | JP4583598B2 (tr) |
KR (1) | KR100643092B1 (tr) |
CN (3) | CN100339375C (tr) |
AT (1) | ATE289810T1 (tr) |
AU (1) | AU759281B2 (tr) |
BG (1) | BG65235B1 (tr) |
BR (1) | BR9910419A (tr) |
CA (1) | CA2331593C (tr) |
CZ (1) | CZ302168B6 (tr) |
DE (1) | DE69923965T2 (tr) |
ES (1) | ES2239442T3 (tr) |
HU (1) | HUP0101960A3 (tr) |
IL (2) | IL139607A0 (tr) |
NO (1) | NO318081B1 (tr) |
NZ (1) | NZ508585A (tr) |
PL (1) | PL192409B1 (tr) |
RU (1) | RU2225864C2 (tr) |
SK (1) | SK285069B6 (tr) |
TR (1) | TR200003470T2 (tr) |
WO (1) | WO1999058125A1 (tr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1077698B1 (en) | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
CA2406080C (en) * | 2000-04-12 | 2011-11-29 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
JP2004529074A (ja) | 2000-11-03 | 2004-09-24 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | サフラマイシン、そのアナログ、およびその使用 |
CA2428160C (en) * | 2000-11-06 | 2009-10-13 | Pharma Mar, S.A. | Compositions for antitumor treatment containing ecteinascidin 743 |
GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0119243D0 (en) | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
US7407327B2 (en) * | 2003-03-21 | 2008-08-05 | Seagate Technology Llc | Method and system for withstanding shock in a spindle motor bearing |
RS50692B (sr) | 2003-11-13 | 2010-06-30 | Pharma Mar S.A.U. | Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera |
DE602005001833T2 (de) | 2004-10-29 | 2008-04-17 | Pharma Mar S.A., Sociedad Unipersonal | Zusammensetzungen enthaltend Ecteinascidin und einen Disaccharide |
US20090325971A1 (en) * | 2005-03-02 | 2009-12-31 | The Trustees Of Columbia University In The City Of New York | Pentacyclic Alkaloid Compounds and Methods of Use Thereof |
GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
WO2007092379A2 (en) * | 2006-02-06 | 2007-08-16 | Sears Barry D | Sesamol derivatives as novel inhibitors of arachidonic acid formation |
RU2743643C2 (ru) | 2010-11-12 | 2021-02-20 | Фарма Мар, С.А. | Комбинированная терапия противоопухолевым алкалоидом |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4273773A (en) | 1979-09-24 | 1981-06-16 | American Home Products Corporation | Antihypertensive tricyclic isoindole derivatives |
JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
WO1987007610A2 (en) | 1986-06-09 | 1987-12-17 | University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
ES2108165T3 (es) | 1992-06-19 | 1997-12-16 | Hoechst Ag | Compuestos policiclicos 31668p y 31668u, un procedimiento para su produccion y su uso como agentes antibioticos o antitumorales. |
US5426108A (en) | 1993-11-10 | 1995-06-20 | American Cyanamid Company | Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2 |
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
US5809563A (en) * | 1996-11-12 | 1998-09-15 | Institute For The Development Of Emerging Architectures, Llc | Method and apparatus utilizing a region based page table walk bit |
US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
BR9909488B1 (pt) * | 1998-04-06 | 2011-02-08 | ecteinascidinas semi-sintéticas e composição farmacêutica. | |
EP1077698B1 (en) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
AU783562B2 (en) * | 2000-01-19 | 2005-11-10 | Trustees Of Columbia University In The City Of New York, The | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
CA2406080C (en) | 2000-04-12 | 2011-11-29 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
1999
- 1999-05-11 EP EP99924169A patent/EP1077698B1/en not_active Expired - Lifetime
- 1999-05-11 CN CNB2005100544181A patent/CN100339375C/zh not_active Expired - Fee Related
- 1999-05-11 CN CNB2006100944780A patent/CN100548988C/zh not_active Expired - Fee Related
- 1999-05-11 DE DE69923965T patent/DE69923965T2/de not_active Expired - Lifetime
- 1999-05-11 HU HU0101960A patent/HUP0101960A3/hu unknown
- 1999-05-11 WO PCT/US1999/010233 patent/WO1999058125A1/en active IP Right Grant
- 1999-05-11 BR BR9910419-9A patent/BR9910419A/pt not_active IP Right Cessation
- 1999-05-11 CZ CZ20004183A patent/CZ302168B6/cs not_active IP Right Cessation
- 1999-05-11 AT AT99924169T patent/ATE289810T1/de not_active IP Right Cessation
- 1999-05-11 JP JP2000547976A patent/JP4583598B2/ja not_active Expired - Fee Related
- 1999-05-11 PL PL344183A patent/PL192409B1/pl not_active IP Right Cessation
- 1999-05-11 RU RU2000131178/04A patent/RU2225864C2/ru not_active IP Right Cessation
- 1999-05-11 AU AU40737/99A patent/AU759281B2/en not_active Ceased
- 1999-05-11 NZ NZ508585A patent/NZ508585A/xx unknown
- 1999-05-11 IL IL13960799A patent/IL139607A0/xx active IP Right Grant
- 1999-05-11 CN CNB998085200A patent/CN1195514C/zh not_active Expired - Fee Related
- 1999-05-11 US US09/309,947 patent/US6316214B1/en not_active Expired - Fee Related
- 1999-05-11 KR KR1020007012616A patent/KR100643092B1/ko not_active IP Right Cessation
- 1999-05-11 SK SK1715-2000A patent/SK285069B6/sk not_active IP Right Cessation
- 1999-05-11 CA CA002331593A patent/CA2331593C/en not_active Expired - Fee Related
- 1999-05-11 TR TR2000/03470T patent/TR200003470T2/tr unknown
- 1999-05-11 ES ES99924169T patent/ES2239442T3/es not_active Expired - Lifetime
-
2000
- 2000-11-10 IL IL139607A patent/IL139607A/en not_active IP Right Cessation
- 2000-11-10 NO NO20005671A patent/NO318081B1/no not_active IP Right Cessation
- 2000-12-05 BG BG105023A patent/BG65235B1/bg unknown
-
2001
- 2001-10-03 US US09/971,852 patent/US6867334B2/en not_active Expired - Fee Related
-
2004
- 2004-12-10 US US11/009,237 patent/US7115743B2/en not_active Expired - Fee Related
-
2010
- 2010-06-09 JP JP2010131960A patent/JP2010215656A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200003470T2 (tr) | Ecteinascidin 743 Metabolitleri | |
SV1997000009A (es) | Nuevas oxazolidinonas sustituidas ref. lea 31534-sv | |
TR199902372A2 (tr) | Sulfanilsilanlar. | |
DE3885534D1 (de) | Arylphosphorderivate, ihre Herstellung und Verwendung. | |
DE3769683D1 (de) | Farblose ketimine, ihre herstellung und ihre verwendung als vernetzungsmittel. | |
DK0675717T3 (da) | Anvendelse af 2-amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol (pramipexol) som lægemiddel med antidepressiv virknin | |
IT8022241A0 (it) | Vinil-3 cefalosporine, e loro preparazione. | |
IE801891L (en) | 4-alkyl-8-aminoalkylpsoralens | |
DE3586224D1 (de) | 3-carbonyl-1-aminoalkyl-1h-indole, verwendbar als analgetika und ihre herstellung. | |
DE3762879D1 (de) | Polysulfurierte olefin-zusammensetzungen, ihre herstellung und ihre verwendung als schmiermittelzusaetze. | |
DE3761138D1 (de) | Nitratderivate und ihre verwendung als gefaesserweiterer. | |
ATE286887T1 (de) | Antibakterielle mittel | |
ATE77367T1 (de) | 5-substituierte ornithin-derivate. | |
DE3685743T2 (de) | Anthracyclinderivate, ihre verwendung als antitumorsubstanzen und ihre herstellung. | |
DE68919259D1 (de) | N-Phenylimide, ihre Herstellung und Verwendung. | |
FI890370A (fi) | Foereningar med psykotrop inverkan, dessa innehaollande laekemedel och deras anvaendning vid behandling och profylax av stoerningar i det centrala nervsystemet. | |
DE59200365D1 (de) | Cyclische Isolongifolanon-Ketale, ihre Herstellung und ihre Verwendung. | |
DE58908912D1 (de) | Polytetrahydrofuranvinylether und ihre Herstellung. | |
TR200001135T2 (tr) | Dofetilid polimorfları. | |
AR023374A1 (es) | Derivados de 3-amino-3-arilpropano-1-ol. su preparacion y uso | |
DE3686632T2 (de) | Antibiotische derivate, ihre herstellung und verwendung. | |
BR9611904A (pt) | Dioxidos de ditiazol | |
DE68905889D1 (de) | Polysulfurierte olefin-zusammensetzung, ihre herstellung und ihre verwendung als schmiermittelzusaetze. | |
ES2053601T3 (es) | Agentes de biocontrol fundidos. | |
DE3872916T2 (de) | Herstellung und reinigung eines n,n-diethylaminophenols. |