IL139607A0 - Metabolites of ecteinascidin 743 - Google Patents

Metabolites of ecteinascidin 743

Info

Publication number
IL139607A0
IL139607A0 IL13960799A IL13960799A IL139607A0 IL 139607 A0 IL139607 A0 IL 139607A0 IL 13960799 A IL13960799 A IL 13960799A IL 13960799 A IL13960799 A IL 13960799A IL 139607 A0 IL139607 A0 IL 139607A0
Authority
IL
Israel
Prior art keywords
etm
ecteinascidin
metabolites
compounds
abbreviated
Prior art date
Application number
IL13960799A
Other languages
English (en)
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of IL139607A0 publication Critical patent/IL139607A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL13960799A 1998-05-11 1999-05-11 Metabolites of ecteinascidin 743 IL139607A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8502498P 1998-05-11 1998-05-11
PCT/US1999/010233 WO1999058125A1 (en) 1998-05-11 1999-05-11 Metabolites of ecteinascidin 743

Publications (1)

Publication Number Publication Date
IL139607A0 true IL139607A0 (en) 2002-02-10

Family

ID=22188976

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13960799A IL139607A0 (en) 1998-05-11 1999-05-11 Metabolites of ecteinascidin 743
IL139607A IL139607A (en) 1998-05-11 2000-11-10 Actinaskidine metabolites, their compositions and uses

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL139607A IL139607A (en) 1998-05-11 2000-11-10 Actinaskidine metabolites, their compositions and uses

Country Status (22)

Country Link
US (3) US6316214B1 (tr)
EP (1) EP1077698B1 (tr)
JP (2) JP4583598B2 (tr)
KR (1) KR100643092B1 (tr)
CN (3) CN100339375C (tr)
AT (1) ATE289810T1 (tr)
AU (1) AU759281B2 (tr)
BG (1) BG65235B1 (tr)
BR (1) BR9910419A (tr)
CA (1) CA2331593C (tr)
CZ (1) CZ302168B6 (tr)
DE (1) DE69923965T2 (tr)
ES (1) ES2239442T3 (tr)
HU (1) HUP0101960A3 (tr)
IL (2) IL139607A0 (tr)
NO (1) NO318081B1 (tr)
NZ (1) NZ508585A (tr)
PL (1) PL192409B1 (tr)
RU (1) RU2225864C2 (tr)
SK (1) SK285069B6 (tr)
TR (1) TR200003470T2 (tr)
WO (1) WO1999058125A1 (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200003470T2 (tr) 1998-05-11 2001-06-21 Pharama Mar, S.A. Ecteinascidin 743 Metabolitleri
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
BRPI0110024B8 (pt) 2000-04-12 2021-05-25 Pharma Mar Sa derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
EP1339713A2 (en) * 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
MXPA03003975A (es) * 2000-11-06 2004-02-12 Pharma Mar Sa Composiciones para tratamiento antitumoral, que contienen ecteinascidina 743.
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US7407327B2 (en) * 2003-03-21 2008-08-05 Seagate Technology Llc Method and system for withstanding shock in a spindle motor bearing
PT1689404E (pt) 2003-11-13 2008-12-15 Pharma Mar Sau Combinação de et-743 com pró-fármacos de fluorouracil para o tratamento do cancro
WO2006046079A1 (en) 2004-10-29 2006-05-04 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
WO2006094012A2 (en) * 2005-03-02 2006-09-08 The Trustees Of Columbia University In The City Of New York Pentacyclic alkaloid compounds and methods of use thereof
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2007092379A2 (en) * 2006-02-06 2007-08-16 Sears Barry D Sesamol derivatives as novel inhibitors of arachidonic acid formation
JP6382516B2 (ja) 2010-11-12 2018-08-29 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
JP2562162B2 (ja) * 1986-06-09 1996-12-11 ユニバーシティ・オブ・イリノイ エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
ES2108165T3 (es) 1992-06-19 1997-12-16 Hoechst Ag Compuestos policiclicos 31668p y 31668u, un procedimiento para su produccion y su uso como agentes antibioticos o antitumorales.
US5426108A (en) 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5809563A (en) * 1996-11-12 1998-09-15 Institute For The Development Of Emerging Architectures, Llc Method and apparatus utilizing a region based page table walk bit
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
PT1067933E (pt) * 1998-04-06 2007-11-15 Univ Illinois Ecteinascidinas semi-sintéticas
TR200003470T2 (tr) 1998-05-11 2001-06-21 Pharama Mar, S.A. Ecteinascidin 743 Metabolitleri
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
WO2001053299A1 (en) * 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
BRPI0110024B8 (pt) 2000-04-12 2021-05-25 Pharma Mar Sa derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
NZ508585A (en) 2002-11-26
NO318081B1 (no) 2005-01-31
AU759281B2 (en) 2003-04-10
EP1077698A1 (en) 2001-02-28
US7115743B2 (en) 2006-10-03
JP2010215656A (ja) 2010-09-30
HUP0101960A3 (en) 2003-03-28
EP1077698B1 (en) 2005-03-02
KR100643092B1 (ko) 2006-11-10
JP2002514597A (ja) 2002-05-21
CN1371279A (zh) 2002-09-25
SK17152000A3 (sk) 2001-07-10
CN1896064A (zh) 2007-01-17
DE69923965D1 (de) 2005-04-07
CN100339375C (zh) 2007-09-26
BR9910419A (pt) 2001-01-09
HUP0101960A2 (hu) 2001-11-28
PL344183A1 (en) 2001-10-08
CN100548988C (zh) 2009-10-14
EP1077698A4 (en) 2002-05-08
DE69923965T2 (de) 2006-04-06
RU2225864C2 (ru) 2004-03-20
PL192409B1 (pl) 2006-10-31
NO20005671D0 (no) 2000-11-10
CA2331593C (en) 2008-08-05
US20050261326A1 (en) 2005-11-24
TR200003470T2 (tr) 2001-06-21
CN1195514C (zh) 2005-04-06
NO20005671L (no) 2001-01-10
BG105023A (en) 2001-08-31
BG65235B1 (bg) 2007-09-28
CN1683299A (zh) 2005-10-19
CZ302168B6 (cs) 2010-11-24
AU4073799A (en) 1999-11-29
IL139607A (en) 2006-12-10
CZ20004183A3 (en) 2001-06-13
KR20010071237A (ko) 2001-07-28
US6316214B1 (en) 2001-11-13
US6867334B2 (en) 2005-03-15
JP4583598B2 (ja) 2010-11-17
US20020032326A1 (en) 2002-03-14
SK285069B6 (sk) 2006-05-04
ES2239442T3 (es) 2005-09-16
ATE289810T1 (de) 2005-03-15
CA2331593A1 (en) 1999-11-18
WO1999058125A1 (en) 1999-11-18

Similar Documents

Publication Publication Date Title
PL344183A1 (en) Metabolites of ecteinascidin 743
MXPA03001431A (es) Polimeros de un analogo de epotilona.
IL160440A (en) Dihydropteridinones, method for producing the same and the use thereof as medicaments
CL2004001072A1 (es) Compuestos derivados de trifluorofenil-triazolopirimidina; procedimiento de preparacion de los compuestos; compuestos intermediarios utiles como fungicidas.
MX9700564A (es) Derivados de benzoilo y sintesis de los mismos.
DK0397336T3 (da) Cellevækstinhibitoriske makrocycliske lactoner benævnte combretastatin D-1 og combretastatin D-2
NZ320580A (en) Tricyclic compounds, preparation and pharmaceutical compositions thereof
MX9602806A (es) Derivados del 1,2,4-oxadiazol y su uso como parasiticidas para animales.
UA27022C2 (uk) Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу
YU12000A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
BG106002A (en) Process for preparing pesticidal intermediates
IL121352A0 (en) Intermediates for the preparation of 2-imidazolin-5-ones
ZA986680B (en) Thiazolobenzoheterocycles their preparation and medicaments containing them
NO870423D0 (no) 5-substituert octahydroindolizin-analgetika-forbindelser og 7-keto-mellomprodukt.
DE50006244D1 (en) Neue substituierte 3-phenoxy- und 3-phenylalkyloxy-2-phenyl-propylamine
AU7020996A (en) UCK14 compounds
DE69706441D1 (de) Tetracyclische aromatische retinoide verbindungen, ihre herstellung und verwendung
GR3030190T3 (en) Benzoyl derivatives and synthesis thereof
AU4188700A (en) Pseudomycin natural products
DE69816095D1 (de) Herstellung von beta-mehtylcarbapenem-zwischenprodukten
IT1317000B1 (it) Uso di composti di origine naturale ad attivita' antiangiogenica.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed