DE69936845D1 - Halbsynthetische ectein-ascidine - Google Patents

Halbsynthetische ectein-ascidine

Info

Publication number
DE69936845D1
DE69936845D1 DE69936845T DE69936845T DE69936845D1 DE 69936845 D1 DE69936845 D1 DE 69936845D1 DE 69936845 T DE69936845 T DE 69936845T DE 69936845 T DE69936845 T DE 69936845T DE 69936845 D1 DE69936845 D1 DE 69936845D1
Authority
DE
Germany
Prior art keywords
synthetic
ectein
ascidine
bioactivities
boc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69936845T
Other languages
English (en)
Other versions
DE69936845T2 (de
Inventor
Kenneth L Rinehart
Jose J Morales
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois filed Critical University of Illinois
Publication of DE69936845D1 publication Critical patent/DE69936845D1/de
Application granted granted Critical
Publication of DE69936845T2 publication Critical patent/DE69936845T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Dental Preparations (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Saccharide Compounds (AREA)
DE69936845T 1998-04-06 1999-04-05 Halbsynthetische ectein-ascidine Expired - Lifetime DE69936845T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
US80802P 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (2)

Publication Number Publication Date
DE69936845D1 true DE69936845D1 (de) 2007-09-27
DE69936845T2 DE69936845T2 (de) 2008-05-08

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936845T Expired - Lifetime DE69936845T2 (de) 1998-04-06 1999-04-05 Halbsynthetische ectein-ascidine

Country Status (28)

Country Link
US (1) US6124293A (de)
EP (2) EP1067933B1 (de)
JP (1) JP4443043B2 (de)
KR (1) KR100603219B1 (de)
CN (1) CN1157189C (de)
AT (1) ATE370148T1 (de)
AU (1) AU758100B2 (de)
BG (1) BG65088B1 (de)
BR (1) BR9909488B1 (de)
CA (1) CA2327468C (de)
CY (1) CY1106988T1 (de)
CZ (1) CZ301083B6 (de)
DE (1) DE69936845T2 (de)
DK (1) DK1067933T3 (de)
ES (1) ES2292237T3 (de)
HK (1) HK1033651A1 (de)
HU (1) HUP0104273A3 (de)
IL (2) IL138856A0 (de)
MX (1) MXPA00009840A (de)
NO (1) NO328147B1 (de)
NZ (1) NZ507350A (de)
PL (1) PL196809B1 (de)
PT (1) PT1067933E (de)
RU (1) RU2217432C2 (de)
SK (1) SK285669B6 (de)
TR (1) TR200002921T2 (de)
UA (1) UA59439C2 (de)
WO (1) WO1999051238A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1077698B1 (de) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Ecteinascidinderivate
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
AU783562B2 (en) 2000-01-19 2005-11-10 Trustees Of Columbia University In The City Of New York, The Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
AU2002239565B2 (en) * 2000-11-03 2007-11-15 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
DK1365808T3 (da) * 2000-11-06 2011-05-16 Pharma Mar Sa Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
ATE406897T1 (de) 2003-11-13 2008-09-15 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (de) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Kombinationstherapie mit verwendung von et-743 und paclitaxel zur behandlung von krebs
EP1768671A2 (de) * 2004-07-09 2007-04-04 Pharma Mar, S.A. Verwendung von ecteinascidin bei der behandlung von krebs bei patienten mit niedrigen brca1-konzentrationen
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
ATE430586T1 (de) * 2004-10-26 2009-05-15 Pharma Mar Sa Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
RS58609B1 (sr) 2010-11-12 2019-05-31 Pharma Mar Sa Kombinovana terapija sa inhibitorom mitoze
MX2018009088A (es) * 2016-02-04 2018-09-03 Jiangsu Hengrui Medicine Co Composicion farmaceutica inyectable que incluye trabectedina para uso gastrointestinal externo y metodo para la fabricacion de la misma.
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
SK285669B6 (sk) 2007-06-07
KR20010074474A (ko) 2001-08-04
RU2217432C2 (ru) 2003-11-27
CA2327468A1 (en) 1999-10-14
IL138856A0 (en) 2001-10-31
NZ507350A (en) 2003-03-28
WO1999051238A9 (en) 2000-01-27
PL196809B1 (pl) 2008-02-29
CZ301083B6 (cs) 2009-11-04
SK15012000A3 (sk) 2001-08-06
PT1067933E (pt) 2007-11-15
ATE370148T1 (de) 2007-09-15
CZ20003650A3 (en) 2001-06-13
NO328147B1 (no) 2009-12-21
CN1304309A (zh) 2001-07-18
NO20004978D0 (no) 2000-10-03
KR100603219B1 (ko) 2006-07-20
CN1157189C (zh) 2004-07-14
DK1067933T3 (da) 2007-12-27
PL343439A1 (en) 2001-08-13
RU2000128058A (ru) 2004-02-20
IL138856A (en) 2007-07-24
TR200002921T2 (tr) 2001-02-21
DE69936845T2 (de) 2008-05-08
HUP0104273A3 (en) 2003-12-29
AU758100B2 (en) 2003-03-13
HK1033651A1 (en) 2001-09-14
JP4443043B2 (ja) 2010-03-31
EP1067933B1 (de) 2007-08-15
EP1067933A4 (de) 2002-12-18
CY1106988T1 (el) 2012-09-26
JP2002510633A (ja) 2002-04-09
BR9909488A (pt) 2000-12-26
EP1067933A1 (de) 2001-01-17
BG104902A (en) 2001-07-31
UA59439C2 (uk) 2003-09-15
EP1876180A3 (de) 2009-12-16
HUP0104273A2 (hu) 2002-03-28
ES2292237T3 (es) 2008-03-01
AU3471399A (en) 1999-10-25
NO20004978L (no) 2000-12-05
CA2327468C (en) 2008-05-06
WO1999051238A1 (en) 1999-10-14
BR9909488B1 (pt) 2011-02-08
EP1876180A2 (de) 2008-01-09
US6124293A (en) 2000-09-26
BG65088B1 (bg) 2007-02-28
MXPA00009840A (es) 2002-04-24

Similar Documents

Publication Publication Date Title
DE69936845D1 (de) Halbsynthetische ectein-ascidine
EA199900598A1 (ru) Производные 1-арил- и пиридилпиразола с пестицидными свойствами
DE69130614D1 (de) Herbizide, substituierte aryl-haloalkylpyrazole
DE69903988D1 (de) Fungizide Trifluorophenyltriazolopyrimidine
DE59709414D1 (de) Oxyiminopregnancarbolactone
ES2179822T3 (es) Nuevas 4-arilpiperazinas y 4-arilpiperidinas.
NO902394D0 (no) Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
ES2093037T3 (es) Derivados de beta-lactama y su preparacion.
ATE73768T1 (de) 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8inter-m-phenylene-pgi2-derivate.
FI903779A0 (fi) S-substituerade betatioacrylamider och deras anvaendning som mikrobicider.
FI930092A0 (fi) Indanopyrrolidinkarbamater
EA200200026A1 (ru) ПРОИЗВОДНЫЕ 4'-ДЕМИКАРОЗИЛ-8а-АЗА-8а-ГОМОТИЛОЗИНА
SE8700566L (sv) Tetracykliska kinazolinoner
DE69019610D1 (de) Cyclische Derivate des Amidinylthiocarbapenems.
DE69915688D1 (de) Benzonaphtyridin-1,8 derivate
ATE206700T1 (de) Arylthio, -sulfinyl und -sulfonyl-pyrrol mit insektizider wirkung
ES2106858T3 (es) Nuevos derivados de la citarabina, su procedimiento de preparacion y su uso contra enfermedades cancerosas.
SU1774617A1 (ru) Производные 3-хлор-1,4-нафтохинона, обладающие бактерицидными и фунгицидными свойствами
SU1690242A1 (ru) Антифидант
SU1626617A1 (ru) Производные хлораля, обладающие фунгицидными свойствами

Legal Events

Date Code Title Description
8364 No opposition during term of opposition