HUP0104273A3 - Semi-synthetic ecteinascidins and pharmaceutical compositions containing them - Google Patents
Semi-synthetic ecteinascidins and pharmaceutical compositions containing themInfo
- Publication number
- HUP0104273A3 HUP0104273A3 HU0104273A HUP0104273A HUP0104273A3 HU P0104273 A3 HUP0104273 A3 HU P0104273A3 HU 0104273 A HU0104273 A HU 0104273A HU P0104273 A HUP0104273 A HU P0104273A HU P0104273 A3 HUP0104273 A3 HU P0104273A3
- Authority
- HU
- Hungary
- Prior art keywords
- semi
- pharmaceutical compositions
- compositions containing
- ecteinascidins
- synthetic
- Prior art date
Links
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Dental Preparations (AREA)
- Hydrogenated Pyridines (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8080298P | 1998-04-06 | 1998-04-06 | |
| PCT/US1999/007471 WO1999051238A1 (en) | 1998-04-06 | 1999-04-05 | Semi-synthetic ecteinascidins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104273A2 HUP0104273A2 (hu) | 2002-03-28 |
| HUP0104273A3 true HUP0104273A3 (en) | 2003-12-29 |
Family
ID=22159716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104273A HUP0104273A3 (en) | 1998-04-06 | 1999-04-05 | Semi-synthetic ecteinascidins and pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6124293A (hu) |
| EP (2) | EP1876180A3 (hu) |
| JP (1) | JP4443043B2 (hu) |
| KR (1) | KR100603219B1 (hu) |
| CN (1) | CN1157189C (hu) |
| AT (1) | ATE370148T1 (hu) |
| AU (1) | AU758100B2 (hu) |
| BG (1) | BG65088B1 (hu) |
| BR (1) | BR9909488B1 (hu) |
| CA (1) | CA2327468C (hu) |
| CY (1) | CY1106988T1 (hu) |
| CZ (1) | CZ301083B6 (hu) |
| DE (1) | DE69936845T2 (hu) |
| DK (1) | DK1067933T3 (hu) |
| ES (1) | ES2292237T3 (hu) |
| HK (1) | HK1033651A1 (hu) |
| HU (1) | HUP0104273A3 (hu) |
| IL (2) | IL138856A0 (hu) |
| MX (1) | MXPA00009840A (hu) |
| NO (1) | NO328147B1 (hu) |
| NZ (1) | NZ507350A (hu) |
| PL (1) | PL196809B1 (hu) |
| PT (1) | PT1067933E (hu) |
| RU (1) | RU2217432C2 (hu) |
| SK (1) | SK285669B6 (hu) |
| TR (1) | TR200002921T2 (hu) |
| UA (1) | UA59439C2 (hu) |
| WO (1) | WO1999051238A1 (hu) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| WO1999058125A1 (en) * | 1998-05-11 | 1999-11-18 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| US6686470B2 (en) | 2000-01-19 | 2004-02-03 | The Trustees Of Columbia University In The City Of New York | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
| US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| CA2447553A1 (en) * | 2000-11-03 | 2002-05-23 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| AU1249902A (en) * | 2000-11-06 | 2002-05-15 | Pharma Mar Sa | Effective antitumour treatments |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| EP1689404B9 (en) | 2003-11-13 | 2009-04-22 | Pharma Mar, S.A.U. | Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| EP1691809A1 (en) * | 2003-11-14 | 2006-08-23 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| JP2008505862A (ja) * | 2004-07-09 | 2008-02-28 | ファルマ、マール、ソシエダード、アノニマ | 予後分子マーカー |
| US20080242670A2 (en) * | 2004-09-29 | 2008-10-02 | Pharma Mar S.A., Sociedad Unipersonal | Anti-Inflammatory Agents |
| RS50822B (sr) * | 2004-10-26 | 2010-08-31 | Pharma Mar S.A., Sociedad Unipersonal | Pegilovani lipozomalni doksorubicin u kombinaciji sa ekteinescidinom 743 |
| RU2382647C2 (ru) | 2004-10-29 | 2010-02-27 | Фарма Мар С.А., Сосьедад Униперсональ | Композиции, содержащие эктинэсайдин и дисахарид |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| CN100355775C (zh) * | 2006-01-20 | 2007-12-19 | 南方医科大学 | 一种海鞘多肽及其制备方法 |
| JP2011500046A (ja) * | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Ｅｔ−７４３治療のための予後分子マーカー |
| HUE049389T2 (hu) | 2010-11-12 | 2020-09-28 | Pharma Mar Sa | Kombinált terápia topoizomeráz inhibitorral |
| JP2019504061A (ja) * | 2016-02-04 | 2019-02-14 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | トラベクテジンの注射可能な胃腸外用医薬組成物及びその製造方法 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5440055A (en) * | 1993-03-12 | 1995-08-08 | Aphios Corporation | Method and apparatus for extracting taxol from source materials |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
-
1999
- 1999-04-05 SK SK1501-2000A patent/SK285669B6/sk not_active IP Right Cessation
- 1999-04-05 WO PCT/US1999/007471 patent/WO1999051238A1/en active IP Right Grant
- 1999-04-05 AT AT99916379T patent/ATE370148T1/de not_active IP Right Cessation
- 1999-04-05 AU AU34713/99A patent/AU758100B2/en not_active Ceased
- 1999-04-05 CN CNB998070769A patent/CN1157189C/zh not_active Expired - Fee Related
- 1999-04-05 DE DE69936845T patent/DE69936845T2/de not_active Expired - Lifetime
- 1999-04-05 HU HU0104273A patent/HUP0104273A3/hu unknown
- 1999-04-05 CZ CZ20003650A patent/CZ301083B6/cs not_active IP Right Cessation
- 1999-04-05 JP JP2000542009A patent/JP4443043B2/ja not_active Expired - Fee Related
- 1999-04-05 EP EP07011035A patent/EP1876180A3/en not_active Withdrawn
- 1999-04-05 RU RU2000128058/04A patent/RU2217432C2/ru not_active IP Right Cessation
- 1999-04-05 TR TR2000/02921T patent/TR200002921T2/xx unknown
- 1999-04-05 PT PT99916379T patent/PT1067933E/pt unknown
- 1999-04-05 DK DK99916379T patent/DK1067933T3/da active
- 1999-04-05 CA CA002327468A patent/CA2327468C/en not_active Expired - Fee Related
- 1999-04-05 MX MXPA00009840A patent/MXPA00009840A/es active IP Right Grant
- 1999-04-05 ES ES99916379T patent/ES2292237T3/es not_active Expired - Lifetime
- 1999-04-05 US US09/286,242 patent/US6124293A/en not_active Expired - Fee Related
- 1999-04-05 BR BRPI9909488-6A patent/BR9909488B1/pt not_active IP Right Cessation
- 1999-04-05 IL IL13885699A patent/IL138856A0/xx active IP Right Grant
- 1999-04-05 NZ NZ507350A patent/NZ507350A/xx unknown
- 1999-04-05 EP EP99916379A patent/EP1067933B1/en not_active Expired - Lifetime
- 1999-04-05 KR KR1020007011112A patent/KR100603219B1/ko not_active IP Right Cessation
- 1999-04-05 PL PL343439A patent/PL196809B1/pl not_active IP Right Cessation
- 1999-05-04 UA UA2000105674A patent/UA59439C2/uk unknown
-
2000
- 2000-10-03 NO NO20004978A patent/NO328147B1/no not_active IP Right Cessation
- 2000-10-04 IL IL138856A patent/IL138856A/en not_active IP Right Cessation
- 2000-11-02 BG BG104902A patent/BG65088B1/bg unknown
-
2001
- 2001-06-19 HK HK01104227A patent/HK1033651A1/xx not_active IP Right Cessation
-
2007
- 2007-11-08 CY CY20071101439T patent/CY1106988T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |