DE3777590D1 - 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene-pgi2-derivate. - Google Patents

2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene-pgi2-derivate.

Info

Publication number
DE3777590D1
DE3777590D1 DE8787118053T DE3777590T DE3777590D1 DE 3777590 D1 DE3777590 D1 DE 3777590D1 DE 8787118053 T DE8787118053 T DE 8787118053T DE 3777590 T DE3777590 T DE 3777590T DE 3777590 D1 DE3777590 D1 DE 3777590D1
Authority
DE
Germany
Prior art keywords
derivatives
pgi2
tetradehydro
tetranor
phenylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787118053T
Other languages
English (en)
Inventor
Kiyotaka Ohno
Toshiya Takahashi
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE3777590D1 publication Critical patent/DE3777590D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE8787118053T 1986-12-11 1987-12-07 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene-pgi2-derivate. Expired - Fee Related DE3777590D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29536786 1986-12-11

Publications (1)

Publication Number Publication Date
DE3777590D1 true DE3777590D1 (de) 1992-04-23

Family

ID=17819706

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787118053T Expired - Fee Related DE3777590D1 (de) 1986-12-11 1987-12-07 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene-pgi2-derivate.

Country Status (10)

Country Link
US (1) US4880939A (de)
EP (1) EP0274064B1 (de)
JP (1) JPS63264475A (de)
KR (1) KR930003853B1 (de)
AT (1) ATE73768T1 (de)
AU (1) AU600054B2 (de)
CA (1) CA1291131C (de)
DE (1) DE3777590D1 (de)
ES (1) ES2032427T3 (de)
ZA (1) ZA879186B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3886936T2 (de) * 1987-10-16 1994-04-28 Toray Industries 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLEN 2-PGI-DERIVATE, VERFAHREN ZUR HERSTELLUNG UND DEREN VERWENDUNG.
ES2053180T3 (es) * 1989-02-27 1994-07-16 Toray Industries Preparacion de derivados pgi 2 de 5,6,7-trinor-4,8-inter-m-fenileno pgi 2.
EP0389162B1 (de) * 1989-03-14 1993-12-08 Toray Industries, Inc. 2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
EP0925788A4 (de) * 1997-03-13 1999-12-01 Toray Industries Arzneimittel zur behandlung von diabetischen vaskulären verletzungen
CA2271475A1 (en) * 1997-09-17 1999-03-25 Masami Moriyama Cervical ripening agent
CN105315247B (zh) 2011-06-16 2019-07-26 琅歌生物技术股份有限公司 贝前列素的生产方法
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
JP6440896B2 (ja) 2015-08-12 2018-12-19 ユナイテッド セラピューティクス コーポレイション ベラプロストを作製するための方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
DE3041601A1 (de) * 1980-10-31 1982-06-16 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3147714A1 (de) * 1981-11-27 1983-06-01 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacycline und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Also Published As

Publication number Publication date
CA1291131C (en) 1991-10-22
JPH0571592B2 (de) 1993-10-07
JPS63264475A (ja) 1988-11-01
US4880939A (en) 1989-11-14
EP0274064B1 (de) 1992-03-18
EP0274064A3 (en) 1988-07-27
ES2032427T3 (es) 1993-02-16
ZA879186B (en) 1988-06-06
ATE73768T1 (de) 1992-04-15
AU600054B2 (en) 1990-08-02
KR880007453A (ko) 1988-08-27
KR930003853B1 (ko) 1993-05-14
AU8242087A (en) 1988-06-16
EP0274064A2 (de) 1988-07-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee