CN1157189C - 半合成海鞘素 - Google Patents

半合成海鞘素 Download PDF

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Publication number
CN1157189C
CN1157189C CNB998070769A CN99807076A CN1157189C CN 1157189 C CN1157189 C CN 1157189C CN B998070769 A CNB998070769 A CN B998070769A CN 99807076 A CN99807076 A CN 99807076A CN 1157189 C CN1157189 C CN 1157189C
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CN
China
Prior art keywords
compd
ascidin
excipient
semi
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998070769A
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English (en)
Chinese (zh)
Other versions
CN1304309A (zh
Inventor
Kl
K·L·莱恩哈特
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J·J·莫拉莱斯
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University of Illinois System
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University of Illinois System
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Publication date
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Publication of CN1304309A publication Critical patent/CN1304309A/zh
Application granted granted Critical
Publication of CN1157189C publication Critical patent/CN1157189C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Dental Preparations (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
CNB998070769A 1998-04-06 1999-04-05 半合成海鞘素 Expired - Fee Related CN1157189C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
US60/080,802 1998-04-06

Publications (2)

Publication Number Publication Date
CN1304309A CN1304309A (zh) 2001-07-18
CN1157189C true CN1157189C (zh) 2004-07-14

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998070769A Expired - Fee Related CN1157189C (zh) 1998-04-06 1999-04-05 半合成海鞘素

Country Status (27)

Country Link
US (1) US6124293A (https=)
EP (2) EP1067933B1 (https=)
JP (1) JP4443043B2 (https=)
KR (1) KR100603219B1 (https=)
CN (1) CN1157189C (https=)
AT (1) ATE370148T1 (https=)
AU (1) AU758100B2 (https=)
BG (1) BG65088B1 (https=)
BR (1) BR9909488B1 (https=)
CA (1) CA2327468C (https=)
CY (1) CY1106988T1 (https=)
CZ (1) CZ301083B6 (https=)
DE (1) DE69936845T2 (https=)
DK (1) DK1067933T3 (https=)
ES (1) ES2292237T3 (https=)
HU (1) HUP0104273A3 (https=)
IL (2) IL138856A0 (https=)
MX (1) MXPA00009840A (https=)
NO (1) NO328147B1 (https=)
NZ (1) NZ507350A (https=)
PL (1) PL196809B1 (https=)
PT (1) PT1067933E (https=)
RU (1) RU2217432C2 (https=)
SK (1) SK285669B6 (https=)
TR (1) TR200002921T2 (https=)
UA (1) UA59439C2 (https=)
WO (1) WO1999051238A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1339713A2 (en) 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EP1365808B1 (en) * 2000-11-06 2011-01-19 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
MX2007000360A (es) * 2004-07-09 2007-06-12 Pharma Mar Sa Marcadores moleculares de pronostico.
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
DK1827500T3 (da) * 2004-10-26 2009-08-31 Pharma Mar Sa Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
ME02395B (me) 2010-11-12 2016-09-20 Pharma Mar Sa Kombinovana terapija sa antitumorskim alkaloidima
CN107427512B (zh) * 2016-02-04 2021-10-08 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi
JP2023503318A (ja) 2019-11-21 2023-01-27 ファルマ、マール、ソシエダード、アノニマ ルルビネクテジン製剤で小細胞肺がんを処置する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
TW221441B (https=) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
RU2217432C2 (ru) 2003-11-27
JP4443043B2 (ja) 2010-03-31
EP1067933B1 (en) 2007-08-15
HUP0104273A3 (en) 2003-12-29
PL196809B1 (pl) 2008-02-29
TR200002921T2 (tr) 2001-02-21
ES2292237T3 (es) 2008-03-01
EP1067933A1 (en) 2001-01-17
WO1999051238A9 (en) 2000-01-27
BR9909488B1 (pt) 2011-02-08
PL343439A1 (en) 2001-08-13
BG65088B1 (bg) 2007-02-28
HUP0104273A2 (hu) 2002-03-28
BR9909488A (pt) 2000-12-26
CA2327468A1 (en) 1999-10-14
IL138856A0 (en) 2001-10-31
JP2002510633A (ja) 2002-04-09
DE69936845D1 (de) 2007-09-27
CN1304309A (zh) 2001-07-18
DK1067933T3 (da) 2007-12-27
AU758100B2 (en) 2003-03-13
AU3471399A (en) 1999-10-25
SK285669B6 (sk) 2007-06-07
NO20004978L (no) 2000-12-05
KR20010074474A (ko) 2001-08-04
KR100603219B1 (ko) 2006-07-20
CZ20003650A3 (en) 2001-06-13
HK1033651A1 (en) 2001-09-14
DE69936845T2 (de) 2008-05-08
MXPA00009840A (es) 2002-04-24
WO1999051238A1 (en) 1999-10-14
ATE370148T1 (de) 2007-09-15
US6124293A (en) 2000-09-26
EP1876180A3 (en) 2009-12-16
RU2000128058A (ru) 2004-02-20
EP1067933A4 (en) 2002-12-18
CY1106988T1 (el) 2012-09-26
BG104902A (en) 2001-07-31
CA2327468C (en) 2008-05-06
NO20004978D0 (no) 2000-10-03
CZ301083B6 (cs) 2009-11-04
PT1067933E (pt) 2007-11-15
UA59439C2 (uk) 2003-09-15
NZ507350A (en) 2003-03-28
EP1876180A2 (en) 2008-01-09
NO328147B1 (no) 2009-12-21
IL138856A (en) 2007-07-24
SK15012000A3 (sk) 2001-08-06

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Granted publication date: 20040714

Termination date: 20110405