TR200002921T2 - Yarı-Sentetik ekteinasidinler - Google Patents

Yarı-Sentetik ekteinasidinler

Info

Publication number
TR200002921T2
TR200002921T2 TR2000/02921T TR200002921T TR200002921T2 TR 200002921 T2 TR200002921 T2 TR 200002921T2 TR 2000/02921 T TR2000/02921 T TR 2000/02921T TR 200002921 T TR200002921 T TR 200002921T TR 200002921 T2 TR200002921 T2 TR 200002921T2
Authority
TR
Turkey
Prior art keywords
synthetic
semi
ekteinacids
acidacid
boc
Prior art date
Application number
TR2000/02921T
Other languages
English (en)
Turkish (tr)
Inventor
Lloyd Rinehart Kenneth
J Morales Jose
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of TR200002921T2 publication Critical patent/TR200002921T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Dental Preparations (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
TR2000/02921T 1998-04-06 1999-04-05 Yarı-Sentetik ekteinasidinler TR200002921T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06

Publications (1)

Publication Number Publication Date
TR200002921T2 true TR200002921T2 (tr) 2001-02-21

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02921T TR200002921T2 (tr) 1998-04-06 1999-04-05 Yarı-Sentetik ekteinasidinler

Country Status (27)

Country Link
US (1) US6124293A (https=)
EP (2) EP1067933B1 (https=)
JP (1) JP4443043B2 (https=)
KR (1) KR100603219B1 (https=)
CN (1) CN1157189C (https=)
AT (1) ATE370148T1 (https=)
AU (1) AU758100B2 (https=)
BG (1) BG65088B1 (https=)
BR (1) BR9909488B1 (https=)
CA (1) CA2327468C (https=)
CY (1) CY1106988T1 (https=)
CZ (1) CZ301083B6 (https=)
DE (1) DE69936845T2 (https=)
DK (1) DK1067933T3 (https=)
ES (1) ES2292237T3 (https=)
HU (1) HUP0104273A3 (https=)
IL (2) IL138856A0 (https=)
MX (1) MXPA00009840A (https=)
NO (1) NO328147B1 (https=)
NZ (1) NZ507350A (https=)
PL (1) PL196809B1 (https=)
PT (1) PT1067933E (https=)
RU (1) RU2217432C2 (https=)
SK (1) SK285669B6 (https=)
TR (1) TR200002921T2 (https=)
UA (1) UA59439C2 (https=)
WO (1) WO1999051238A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1339713A2 (en) 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EP1365808B1 (en) * 2000-11-06 2011-01-19 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
MX2007000360A (es) * 2004-07-09 2007-06-12 Pharma Mar Sa Marcadores moleculares de pronostico.
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
DK1827500T3 (da) * 2004-10-26 2009-08-31 Pharma Mar Sa Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
ME02395B (me) 2010-11-12 2016-09-20 Pharma Mar Sa Kombinovana terapija sa antitumorskim alkaloidima
CN107427512B (zh) * 2016-02-04 2021-10-08 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi
JP2023503318A (ja) 2019-11-21 2023-01-27 ファルマ、マール、ソシエダード、アノニマ ルルビネクテジン製剤で小細胞肺がんを処置する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
TW221441B (https=) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
RU2217432C2 (ru) 2003-11-27
JP4443043B2 (ja) 2010-03-31
EP1067933B1 (en) 2007-08-15
HUP0104273A3 (en) 2003-12-29
PL196809B1 (pl) 2008-02-29
ES2292237T3 (es) 2008-03-01
EP1067933A1 (en) 2001-01-17
WO1999051238A9 (en) 2000-01-27
BR9909488B1 (pt) 2011-02-08
PL343439A1 (en) 2001-08-13
BG65088B1 (bg) 2007-02-28
HUP0104273A2 (hu) 2002-03-28
BR9909488A (pt) 2000-12-26
CA2327468A1 (en) 1999-10-14
IL138856A0 (en) 2001-10-31
JP2002510633A (ja) 2002-04-09
DE69936845D1 (de) 2007-09-27
CN1304309A (zh) 2001-07-18
DK1067933T3 (da) 2007-12-27
AU758100B2 (en) 2003-03-13
AU3471399A (en) 1999-10-25
CN1157189C (zh) 2004-07-14
SK285669B6 (sk) 2007-06-07
NO20004978L (no) 2000-12-05
KR20010074474A (ko) 2001-08-04
KR100603219B1 (ko) 2006-07-20
CZ20003650A3 (en) 2001-06-13
HK1033651A1 (en) 2001-09-14
DE69936845T2 (de) 2008-05-08
MXPA00009840A (es) 2002-04-24
WO1999051238A1 (en) 1999-10-14
ATE370148T1 (de) 2007-09-15
US6124293A (en) 2000-09-26
EP1876180A3 (en) 2009-12-16
RU2000128058A (ru) 2004-02-20
EP1067933A4 (en) 2002-12-18
CY1106988T1 (el) 2012-09-26
BG104902A (en) 2001-07-31
CA2327468C (en) 2008-05-06
NO20004978D0 (no) 2000-10-03
CZ301083B6 (cs) 2009-11-04
PT1067933E (pt) 2007-11-15
UA59439C2 (uk) 2003-09-15
NZ507350A (en) 2003-03-28
EP1876180A2 (en) 2008-01-09
NO328147B1 (no) 2009-12-21
IL138856A (en) 2007-07-24
SK15012000A3 (sk) 2001-08-06

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