TR200002921T2 - Yarı-Sentetik ekteinasidinler - Google Patents

Yarı-Sentetik ekteinasidinler

Info

Publication number
TR200002921T2
TR200002921T2 TR2000/02921T TR200002921T TR200002921T2 TR 200002921 T2 TR200002921 T2 TR 200002921T2 TR 2000/02921 T TR2000/02921 T TR 2000/02921T TR 200002921 T TR200002921 T TR 200002921T TR 200002921 T2 TR200002921 T2 TR 200002921T2
Authority
TR
Turkey
Prior art keywords
synthetic
semi
ekteinacids
acidacid
boc
Prior art date
Application number
TR2000/02921T
Other languages
English (en)
Turkish (tr)
Inventor
Lloyd Rinehart Kenneth
J Morales Jose
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of TR200002921T2 publication Critical patent/TR200002921T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hydrogenated Pyridines (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
TR2000/02921T 1998-04-06 1999-04-05 Yarı-Sentetik ekteinasidinler TR200002921T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06

Publications (1)

Publication Number Publication Date
TR200002921T2 true TR200002921T2 (tr) 2001-02-21

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02921T TR200002921T2 (tr) 1998-04-06 1999-04-05 Yarı-Sentetik ekteinasidinler

Country Status (27)

Country Link
US (1) US6124293A (https=)
EP (2) EP1876180A3 (https=)
JP (1) JP4443043B2 (https=)
KR (1) KR100603219B1 (https=)
CN (1) CN1157189C (https=)
AT (1) ATE370148T1 (https=)
AU (1) AU758100B2 (https=)
BG (1) BG65088B1 (https=)
BR (1) BR9909488B1 (https=)
CA (1) CA2327468C (https=)
CY (1) CY1106988T1 (https=)
CZ (1) CZ301083B6 (https=)
DE (1) DE69936845T2 (https=)
DK (1) DK1067933T3 (https=)
ES (1) ES2292237T3 (https=)
HU (1) HUP0104273A3 (https=)
IL (2) IL138856A0 (https=)
MX (1) MXPA00009840A (https=)
NO (1) NO328147B1 (https=)
NZ (1) NZ507350A (https=)
PL (1) PL196809B1 (https=)
PT (1) PT1067933E (https=)
RU (1) RU2217432C2 (https=)
SK (1) SK285669B6 (https=)
TR (1) TR200002921T2 (https=)
UA (1) UA59439C2 (https=)
WO (1) WO1999051238A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CA2331593C (en) * 1998-05-11 2008-08-05 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
CA2397597A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2447553A1 (en) * 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
BR0115162A (pt) * 2000-11-06 2003-10-21 Pharma Mar Sa Tratamentos antitumorais eficazes
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
HRP20080598T3 (en) * 2003-11-13 2009-01-31 Pharma Mar Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
WO2006005602A2 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
EP1827500B1 (en) * 2004-10-26 2009-05-06 Pharma Mar S.A., Sociedad Unipersonal Pegylated liposomal doxorubicin in combination with ecteinescidin 743
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
RS54648B1 (sr) 2010-11-12 2016-08-31 Pharma Mar S.A. Kombinovana terapija sa antitumorskim alkaloidom
CA3011527A1 (en) * 2016-02-04 2017-08-10 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
PE20252386A1 (es) 2019-11-21 2025-10-10 Pharma Mar Sa Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
TW221441B (https=) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
UA59439C2 (uk) 2003-09-15
SK285669B6 (sk) 2007-06-07
BG65088B1 (bg) 2007-02-28
KR100603219B1 (ko) 2006-07-20
NZ507350A (en) 2003-03-28
ATE370148T1 (de) 2007-09-15
DE69936845D1 (de) 2007-09-27
IL138856A0 (en) 2001-10-31
PT1067933E (pt) 2007-11-15
AU3471399A (en) 1999-10-25
EP1876180A2 (en) 2008-01-09
CY1106988T1 (el) 2012-09-26
BR9909488B1 (pt) 2011-02-08
WO1999051238A9 (en) 2000-01-27
RU2217432C2 (ru) 2003-11-27
DK1067933T3 (da) 2007-12-27
ES2292237T3 (es) 2008-03-01
BG104902A (en) 2001-07-31
CA2327468C (en) 2008-05-06
NO328147B1 (no) 2009-12-21
CN1304309A (zh) 2001-07-18
HUP0104273A3 (en) 2003-12-29
KR20010074474A (ko) 2001-08-04
HUP0104273A2 (hu) 2002-03-28
AU758100B2 (en) 2003-03-13
US6124293A (en) 2000-09-26
DE69936845T2 (de) 2008-05-08
HK1033651A1 (en) 2001-09-14
NO20004978L (no) 2000-12-05
JP2002510633A (ja) 2002-04-09
SK15012000A3 (sk) 2001-08-06
PL343439A1 (en) 2001-08-13
MXPA00009840A (es) 2002-04-24
EP1067933A4 (en) 2002-12-18
RU2000128058A (ru) 2004-02-20
CZ301083B6 (cs) 2009-11-04
JP4443043B2 (ja) 2010-03-31
EP1067933B1 (en) 2007-08-15
PL196809B1 (pl) 2008-02-29
IL138856A (en) 2007-07-24
CN1157189C (zh) 2004-07-14
BR9909488A (pt) 2000-12-26
WO1999051238A1 (en) 1999-10-14
NO20004978D0 (no) 2000-10-03
CZ20003650A3 (en) 2001-06-13
CA2327468A1 (en) 1999-10-14
EP1067933A1 (en) 2001-01-17
EP1876180A3 (en) 2009-12-16

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