JP2002539156A5 - - Google Patents
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- Publication number
- JP2002539156A5 JP2002539156A5 JP2000604837A JP2000604837A JP2002539156A5 JP 2002539156 A5 JP2002539156 A5 JP 2002539156A5 JP 2000604837 A JP2000604837 A JP 2000604837A JP 2000604837 A JP2000604837 A JP 2000604837A JP 2002539156 A5 JP2002539156 A5 JP 2002539156A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- linear
- alkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 229930184725 Lipoxin Natural products 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- -1 lipoxin compound Chemical class 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12519499P | 1999-03-18 | 1999-03-18 | |
| US60/125,194 | 1999-03-18 | ||
| PCT/US2000/006669 WO2000054761A2 (en) | 1999-03-18 | 2000-03-14 | Regulation of phospholipase d activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539156A JP2002539156A (ja) | 2002-11-19 |
| JP2002539156A5 true JP2002539156A5 (https=) | 2005-05-19 |
| JP4392473B2 JP4392473B2 (ja) | 2010-01-06 |
Family
ID=22418604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604837A Expired - Fee Related JP4392473B2 (ja) | 1999-03-18 | 2000-03-14 | ホスホリパーゼｄの活性の調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6353026B1 (https=) |
| EP (2) | EP2236140A1 (https=) |
| JP (1) | JP4392473B2 (https=) |
| AT (1) | ATE466582T1 (https=) |
| AU (1) | AU780114B2 (https=) |
| CA (2) | CA2645558C (https=) |
| DE (1) | DE60044335D1 (https=) |
| ES (1) | ES2344138T3 (https=) |
| HK (1) | HK1043306B (https=) |
| WO (1) | WO2000054761A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| EP1153355A2 (en) * | 1999-02-12 | 2001-11-14 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| US6745204B1 (en) * | 1999-02-12 | 2004-06-01 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| JP2002539181A (ja) | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
| US6353026B1 (en) * | 1999-03-18 | 2002-03-05 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| CA2367909C (en) * | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
| EP1762557B1 (en) | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
| US20030166716A1 (en) * | 2001-11-06 | 2003-09-04 | Serhan Charles N. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| CA2467580C (en) * | 2001-12-18 | 2012-10-30 | Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| CA2616535A1 (en) | 2005-07-29 | 2007-02-08 | Monsanto Technology Llc | Development of novel germplasm using segregates from transgenic crosses |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| MX2009000657A (es) * | 2006-07-19 | 2009-05-28 | Resolvyx Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de mucositis. |
| WO2008057283A2 (en) * | 2006-10-26 | 2008-05-15 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| PE20081200A1 (es) | 2006-12-04 | 2008-11-06 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| KR101306199B1 (ko) | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 ｄ 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
| US9926777B2 (en) | 2012-12-01 | 2018-03-27 | Halliburton Energy Services, Inc. | Protection of electronic devices used with perforating guns |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| DE69435125D1 (de) | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
| CA2367909C (en) * | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| US6353026B1 (en) * | 1999-03-18 | 2002-03-05 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP2002539181A (ja) * | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
-
2000
- 2000-03-14 US US09/525,157 patent/US6353026B1/en not_active Expired - Lifetime
- 2000-03-14 AU AU37451/00A patent/AU780114B2/en not_active Ceased
- 2000-03-14 JP JP2000604837A patent/JP4392473B2/ja not_active Expired - Fee Related
- 2000-03-14 CA CA2645558A patent/CA2645558C/en not_active Expired - Fee Related
- 2000-03-14 DE DE60044335T patent/DE60044335D1/de not_active Expired - Lifetime
- 2000-03-14 EP EP10003005A patent/EP2236140A1/en not_active Withdrawn
- 2000-03-14 WO PCT/US2000/006669 patent/WO2000054761A2/en not_active Ceased
- 2000-03-14 AT AT00916331T patent/ATE466582T1/de not_active IP Right Cessation
- 2000-03-14 ES ES00916331T patent/ES2344138T3/es not_active Expired - Lifetime
- 2000-03-14 EP EP00916331A patent/EP1162976B1/en not_active Expired - Lifetime
- 2000-03-14 CA CA002365240A patent/CA2365240C/en not_active Expired - Fee Related
- 2000-03-14 HK HK02104450.3A patent/HK1043306B/en not_active IP Right Cessation
-
2001
- 2001-10-19 US US10/042,043 patent/US6927238B2/en not_active Expired - Fee Related
- 2001-10-19 US US10/004,155 patent/US6864288B2/en not_active Expired - Fee Related
-
2005
- 2005-04-13 US US11/105,803 patent/US20050187294A1/en not_active Abandoned
-
2007
- 2007-08-13 US US11/837,903 patent/US20080064751A1/en not_active Abandoned
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