JP2002539156A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002539156A5 JP2002539156A5 JP2000604837A JP2000604837A JP2002539156A5 JP 2002539156 A5 JP2002539156 A5 JP 2002539156A5 JP 2000604837 A JP2000604837 A JP 2000604837A JP 2000604837 A JP2000604837 A JP 2000604837A JP 2002539156 A5 JP2002539156 A5 JP 2002539156A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- linear
- alkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 229930184725 Lipoxin Natural products 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- -1 lipoxin compound Chemical class 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12519499P | 1999-03-18 | 1999-03-18 | |
| US60/125,194 | 1999-03-18 | ||
| PCT/US2000/006669 WO2000054761A2 (en) | 1999-03-18 | 2000-03-14 | Regulation of phospholipase d activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539156A JP2002539156A (ja) | 2002-11-19 |
| JP2002539156A5 true JP2002539156A5 (https=) | 2005-05-19 |
| JP4392473B2 JP4392473B2 (ja) | 2010-01-06 |
Family
ID=22418604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604837A Expired - Fee Related JP4392473B2 (ja) | 1999-03-18 | 2000-03-14 | ホスホリパーゼｄの活性の調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6353026B1 (https=) |
| EP (2) | EP2236140A1 (https=) |
| JP (1) | JP4392473B2 (https=) |
| AT (1) | ATE466582T1 (https=) |
| AU (1) | AU780114B2 (https=) |
| CA (2) | CA2645558C (https=) |
| DE (1) | DE60044335D1 (https=) |
| ES (1) | ES2344138T3 (https=) |
| HK (1) | HK1043306B (https=) |
| WO (1) | WO2000054761A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6745204B1 (en) * | 1999-02-12 | 2004-06-01 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| EP1153355A2 (en) * | 1999-02-12 | 2001-11-14 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| CA2675416A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP4932116B2 (ja) | 2000-02-16 | 2012-05-16 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | アスピリン誘発脂質メディエータ |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
| JP4652685B2 (ja) * | 2001-11-06 | 2011-03-16 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| CN101278053A (zh) | 2005-07-29 | 2008-10-01 | 孟山都技术有限公司 | 利用来自转基因杂交体的分离子来开发新的种质 |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| JP2009545527A (ja) * | 2006-07-19 | 2009-12-24 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 粘膜炎の治療用の組成物及び方法 |
| EP2131833A2 (en) * | 2006-10-26 | 2009-12-16 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| PE20120395A1 (es) | 2006-12-04 | 2012-05-23 | Bayer Ip Gmbh | Sal de potasio cristalina de analogos de lipoxina a4 |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| KR101306199B1 (ko) | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 ｄ 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
| WO2014084866A1 (en) | 2012-12-01 | 2014-06-05 | Halliburton Energy Services, Inc. | Protection of electronic devices used with perforating guns |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| JPH08512023A (ja) * | 1993-06-15 | 1996-12-17 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物 |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
-
2000
- 2000-03-14 AU AU37451/00A patent/AU780114B2/en not_active Ceased
- 2000-03-14 JP JP2000604837A patent/JP4392473B2/ja not_active Expired - Fee Related
- 2000-03-14 AT AT00916331T patent/ATE466582T1/de not_active IP Right Cessation
- 2000-03-14 CA CA2645558A patent/CA2645558C/en not_active Expired - Fee Related
- 2000-03-14 WO PCT/US2000/006669 patent/WO2000054761A2/en not_active Ceased
- 2000-03-14 CA CA002365240A patent/CA2365240C/en not_active Expired - Fee Related
- 2000-03-14 US US09/525,157 patent/US6353026B1/en not_active Expired - Lifetime
- 2000-03-14 HK HK02104450.3A patent/HK1043306B/en not_active IP Right Cessation
- 2000-03-14 EP EP10003005A patent/EP2236140A1/en not_active Withdrawn
- 2000-03-14 EP EP00916331A patent/EP1162976B1/en not_active Expired - Lifetime
- 2000-03-14 ES ES00916331T patent/ES2344138T3/es not_active Expired - Lifetime
- 2000-03-14 DE DE60044335T patent/DE60044335D1/de not_active Expired - Lifetime
-
2001
- 2001-10-19 US US10/004,155 patent/US6864288B2/en not_active Expired - Fee Related
- 2001-10-19 US US10/042,043 patent/US6927238B2/en not_active Expired - Fee Related
-
2005
- 2005-04-13 US US11/105,803 patent/US20050187294A1/en not_active Abandoned
-
2007
- 2007-08-13 US US11/837,903 patent/US20080064751A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002539156A5 (https=) | ||
| JP2002539181A5 (https=) | ||
| JP2005511592A5 (https=) | ||
| JP2002539159A5 (https=) | ||
| JP2005533835A5 (https=) | ||
| JP2002502874A5 (https=) | ||
| JP2002508352A5 (ja) | ４(３)置換−４(３)−アミノメチル−（チオ）ピラン又はピペリジン誘導体（＝ガバペンチン類似体） | |
| JP2010515731A5 (https=) | ||
| JP2001526218A5 (https=) | ||
| RU2000124100A (ru) | Лиганды рецептора h3 гистамина | |
| JP2002533472A5 (https=) | ||
| JP2001512743A5 (https=) | ||
| CA2645558A1 (en) | Regulation of phospholipase d activity | |
| KR910006277A (ko) | N-치환된-4-피리미딘아민 및 피리미딘디아민, 이의 제조방법 및 약제로서의 이의 용도 | |
| JP2004531544A5 (https=) | ||
| JP2007511546A5 (https=) | ||
| RU97110664A (ru) | Производное индола | |
| CA2615917A1 (en) | Use of lipoxin compounds for inhibiting of tnf-(alpha)initiated neutrophil response | |
| JP2004501940A5 (https=) | ||
| JP2002505323A5 (https=) | ||
| KR840007596A (ko) | 유기인 유도체의염의 제조방법 | |
| JP2002511433A5 (https=) | ||
| CA2467580A1 (en) | Use of lipoxin analogs to promote cell defense against gram-negative infections | |
| JP2002520286A5 (https=) | ||
| JP2005539014A5 (https=) |