JP2002539181A5 - - Google Patents
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- Publication number
- JP2002539181A5 JP2002539181A5 JP2000605540A JP2000605540A JP2002539181A5 JP 2002539181 A5 JP2002539181 A5 JP 2002539181A5 JP 2000605540 A JP2000605540 A JP 2000605540A JP 2000605540 A JP2000605540 A JP 2000605540A JP 2002539181 A5 JP2002539181 A5 JP 2002539181A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- linear
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 84
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 29
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 229930184725 Lipoxin Natural products 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- -1 lipoxin compound Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12520999P | 1999-03-18 | 1999-03-18 | |
| US60/125,209 | 1999-03-18 | ||
| PCT/US2000/006583 WO2000055109A1 (en) | 1999-03-18 | 2000-03-14 | Lipoxin compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002539181A JP2002539181A (ja) | 2002-11-19 |
| JP2002539181A5 true JP2002539181A5 (https=) | 2005-05-19 |
Family
ID=22418667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000605540A Pending JP2002539181A (ja) | 1999-03-18 | 2000-03-14 | リポキシン化合物およびこれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US6433202B1 (https=) |
| EP (1) | EP1163204B1 (https=) |
| JP (1) | JP2002539181A (https=) |
| AT (1) | ATE303355T1 (https=) |
| AU (2) | AU776271B2 (https=) |
| CA (2) | CA2675416A1 (https=) |
| DE (1) | DE60022327T2 (https=) |
| DK (1) | DK1163204T3 (https=) |
| ES (1) | ES2246230T3 (https=) |
| HK (1) | HK1043357B (https=) |
| PT (1) | PT1163204E (https=) |
| WO (1) | WO2000055109A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| JP4932116B2 (ja) | 2000-02-16 | 2012-05-16 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | アスピリン誘発脂質メディエータ |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| US6409541B1 (en) * | 2000-11-02 | 2002-06-25 | Autonetworks Technologies, Ltd. | Waterproof structure in cable insertion section, method of manufacturing the same, and die for waterproof molding |
| WO2002065303A1 (en) * | 2001-02-13 | 2002-08-22 | Fujitsu Limited | Network terminal having power saving mode |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| PT1406698E (pt) * | 2001-03-02 | 2009-01-12 | Brigham & Womens Hospital | Análogos de lipoxina como novos inibidores da angiogénese |
| GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
| JP4652685B2 (ja) * | 2001-11-06 | 2011-03-16 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| JP2005529945A (ja) | 2002-06-17 | 2005-10-06 | リソルヴィックス ファーマシューティカルズ | オメガ−３ｐｕｆａ由来の脂質メディエーターの類似体及び使用方法 |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| PE20120395A1 (es) | 2006-12-04 | 2012-05-23 | Bayer Ip Gmbh | Sal de potasio cristalina de analogos de lipoxina a4 |
| ES2641751T3 (es) | 2008-11-04 | 2017-11-13 | Index Pharmaceuticals Ab | Compuestos y métodos para reducir el reclutamiento y/o la migración de células polimorfonucleares |
| WO2018144316A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| US20220040136A1 (en) | 2018-10-09 | 2022-02-10 | University Of Rochester | Treatment of vulvovaginal disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US309533A (en) * | 1884-12-23 | Saw-tooth-swaging device | ||
| US54761A (en) * | 1866-05-15 | Improved egg-beater | ||
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| AU780114B2 (en) | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| JP4652685B2 (ja) | 2001-11-06 | 2011-03-16 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
-
2000
- 2000-03-14 CA CA002675416A patent/CA2675416A1/en not_active Abandoned
- 2000-03-14 CA CA002365204A patent/CA2365204C/en not_active Expired - Fee Related
- 2000-03-14 JP JP2000605540A patent/JP2002539181A/ja active Pending
- 2000-03-14 PT PT00916308T patent/PT1163204E/pt unknown
- 2000-03-14 HK HK02104449.7A patent/HK1043357B/en not_active IP Right Cessation
- 2000-03-14 US US09/525,742 patent/US6433202B1/en not_active Expired - Fee Related
- 2000-03-14 WO PCT/US2000/006583 patent/WO2000055109A1/en not_active Ceased
- 2000-03-14 AU AU37431/00A patent/AU776271B2/en not_active Ceased
- 2000-03-14 AT AT00916308T patent/ATE303355T1/de active
- 2000-03-14 EP EP00916308A patent/EP1163204B1/en not_active Expired - Lifetime
- 2000-03-14 DK DK00916308T patent/DK1163204T3/da active
- 2000-03-14 ES ES00916308T patent/ES2246230T3/es not_active Expired - Lifetime
- 2000-03-14 DE DE60022327T patent/DE60022327T2/de not_active Expired - Lifetime
-
2002
- 2002-06-20 US US10/176,744 patent/US6720354B2/en not_active Expired - Fee Related
- 2002-06-20 US US10/176,892 patent/US6659282B2/en not_active Expired - Fee Related
-
2003
- 2003-02-13 US US10/366,194 patent/US6960674B2/en not_active Expired - Fee Related
-
2005
- 2005-04-13 US US11/106,066 patent/US7227031B2/en not_active Expired - Fee Related
-
2007
- 2007-05-01 US US11/742,893 patent/US7615576B2/en not_active Expired - Fee Related
- 2007-08-13 US US11/838,012 patent/US7579494B2/en not_active Expired - Fee Related
-
2008
- 2008-08-28 AU AU2008207590A patent/AU2008207590B2/en not_active Ceased
-
2009
- 2009-08-24 US US12/546,242 patent/US8022105B2/en not_active Expired - Fee Related
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