JP2002539159A5 - - Google Patents
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- Publication number
- JP2002539159A5 JP2002539159A5 JP2000604843A JP2000604843A JP2002539159A5 JP 2002539159 A5 JP2002539159 A5 JP 2002539159A5 JP 2000604843 A JP2000604843 A JP 2000604843A JP 2000604843 A JP2000604843 A JP 2000604843A JP 2002539159 A5 JP2002539159 A5 JP 2002539159A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- straight
- alkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 120
- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
- 229930184725 Lipoxin Natural products 0.000 claims description 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
- 150000002639 lipoxins Chemical class 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 229910052717 sulfur Inorganic materials 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 208000001840 Dandruff Diseases 0.000 claims description 8
- 201000004624 Dermatitis Diseases 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 238000002372 labelling Methods 0.000 claims description 8
- -1 lipoxin compound Chemical class 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 239000002453 shampoo Substances 0.000 claims description 8
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 7
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 7
- 206010061218 Inflammation Diseases 0.000 claims description 5
- 230000004054 inflammatory process Effects 0.000 claims description 5
- 210000003622 mature neutrocyte Anatomy 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12520599P | 1999-03-18 | 1999-03-18 | |
| US60/125,205 | 1999-03-18 | ||
| PCT/US2000/006582 WO2000054767A1 (en) | 1999-03-18 | 2000-03-14 | Use of lipoxin compounds for inhibiting of tnf-(alfa) initiated neutrophil response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539159A JP2002539159A (ja) | 2002-11-19 |
| JP2002539159A5 true JP2002539159A5 (https=) | 2006-05-18 |
| JP4440481B2 JP4440481B2 (ja) | 2010-03-24 |
Family
ID=22418647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604843A Expired - Fee Related JP4440481B2 (ja) | 1999-03-18 | 2000-03-14 | ＴＮＦ−αにより開始される好中球応答を阻害するためのリポキシン化合物の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US6387953B1 (https=) |
| EP (1) | EP1165066B1 (https=) |
| JP (1) | JP4440481B2 (https=) |
| AT (1) | ATE310512T1 (https=) |
| AU (1) | AU775140B2 (https=) |
| CA (3) | CA2615917C (https=) |
| DE (1) | DE60024242T2 (https=) |
| DK (1) | DK1165066T3 (https=) |
| ES (1) | ES2249257T3 (https=) |
| HK (1) | HK1043307B (https=) |
| WO (1) | WO2000054767A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| AU780114B2 (en) | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP4932116B2 (ja) | 2000-02-16 | 2012-05-16 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | アスピリン誘発脂質メディエータ |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| GB2362140B (en) * | 2000-05-12 | 2003-03-05 | Autoliv Dev | Improvements in or relating to an apparatus for a method of folding an air-bag |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| PT1406698E (pt) * | 2001-03-02 | 2009-01-12 | Brigham & Womens Hospital | Análogos de lipoxina como novos inibidores da angiogénese |
| EP1911448B1 (en) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Lipoxins and Aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| JP4652685B2 (ja) * | 2001-11-06 | 2011-03-16 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| AU2005216298B2 (en) | 2004-02-26 | 2010-09-02 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
| US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| PE20120395A1 (es) | 2006-12-04 | 2012-05-23 | Bayer Ip Gmbh | Sal de potasio cristalina de analogos de lipoxina a4 |
| WO2011050126A1 (en) * | 2009-10-21 | 2011-04-28 | University Of Medicine And Dentistry Of New Jersey | Method for treating sepsis or septic shock |
| WO2018144316A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| US20220040136A1 (en) | 2018-10-09 | 2022-02-10 | University Of Rochester | Treatment of vulvovaginal disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08512023A (ja) * | 1993-06-15 | 1996-12-17 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物 |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
-
2000
- 2000-03-14 ES ES00917903T patent/ES2249257T3/es not_active Expired - Lifetime
- 2000-03-14 WO PCT/US2000/006582 patent/WO2000054767A1/en not_active Ceased
- 2000-03-14 HK HK02104452.1A patent/HK1043307B/en not_active IP Right Cessation
- 2000-03-14 CA CA2615917A patent/CA2615917C/en not_active Expired - Fee Related
- 2000-03-14 AT AT00917903T patent/ATE310512T1/de active
- 2000-03-14 JP JP2000604843A patent/JP4440481B2/ja not_active Expired - Fee Related
- 2000-03-14 EP EP00917903A patent/EP1165066B1/en not_active Expired - Lifetime
- 2000-03-14 US US09/525,291 patent/US6387953B1/en not_active Expired - Fee Related
- 2000-03-14 AU AU38806/00A patent/AU775140B2/en not_active Ceased
- 2000-03-14 DK DK00917903T patent/DK1165066T3/da active
- 2000-03-14 CA CA002367909A patent/CA2367909C/en not_active Expired - Fee Related
- 2000-03-14 DE DE60024242T patent/DE60024242T2/de not_active Expired - Lifetime
- 2000-03-14 CA CA2747376A patent/CA2747376A1/en not_active Abandoned
-
2002
- 2002-01-11 US US10/044,499 patent/US6703423B2/en not_active Expired - Fee Related
- 2002-01-11 US US10/044,740 patent/US6710084B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 US US10/794,153 patent/US7132451B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 US US11/531,921 patent/US20080312323A1/en not_active Abandoned
-
2007
- 2007-12-03 US US11/837,964 patent/US20080081838A1/en not_active Abandoned
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