DK1165066T3 - Anvendelse af lipoxin-forbindelser til inhibering af TNF-alfa-initieret neutrofil respons - Google Patents
Anvendelse af lipoxin-forbindelser til inhibering af TNF-alfa-initieret neutrofil responsInfo
- Publication number
- DK1165066T3 DK1165066T3 DK00917903T DK00917903T DK1165066T3 DK 1165066 T3 DK1165066 T3 DK 1165066T3 DK 00917903 T DK00917903 T DK 00917903T DK 00917903 T DK00917903 T DK 00917903T DK 1165066 T3 DK1165066 T3 DK 1165066T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- inhibit tnf
- neutrophil response
- initiated
- lipoxin compounds
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title abstract 3
- 210000000440 neutrophil Anatomy 0.000 title abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 title 1
- 229930184725 Lipoxin Natural products 0.000 title 1
- -1 lipoxin compounds Chemical class 0.000 title 1
- IXAQOQZEOGMIQS-SSQFXEBMSA-M lipoxin A4(1-) Chemical compound CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC([O-])=O IXAQOQZEOGMIQS-SSQFXEBMSA-M 0.000 abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12520599P | 1999-03-18 | 1999-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1165066T3 true DK1165066T3 (da) | 2006-03-06 |
Family
ID=22418647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00917903T DK1165066T3 (da) | 1999-03-18 | 2000-03-14 | Anvendelse af lipoxin-forbindelser til inhibering af TNF-alfa-initieret neutrofil respons |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US6387953B1 (https=) |
| EP (1) | EP1165066B1 (https=) |
| JP (1) | JP4440481B2 (https=) |
| AT (1) | ATE310512T1 (https=) |
| AU (1) | AU775140B2 (https=) |
| CA (3) | CA2367909C (https=) |
| DE (1) | DE60024242T2 (https=) |
| DK (1) | DK1165066T3 (https=) |
| ES (1) | ES2249257T3 (https=) |
| HK (1) | HK1043307B (https=) |
| WO (1) | WO2000054767A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6353026B1 (en) * | 1999-03-18 | 2002-03-05 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP2002539181A (ja) * | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
| CA2367909C (en) * | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| EP1762557B1 (en) | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| GB2362140B (en) * | 2000-05-12 | 2003-03-05 | Autoliv Dev | Improvements in or relating to an apparatus for a method of folding an air-bag |
| WO2002070068A2 (en) * | 2001-03-02 | 2002-09-12 | The Brigham And Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| EP1911448B1 (en) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Lipoxins and Aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US20030166716A1 (en) * | 2001-11-06 | 2003-09-04 | Serhan Charles N. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| CA2467580C (en) | 2001-12-18 | 2012-10-30 | Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1720893B1 (en) * | 2004-02-26 | 2014-08-13 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| PE20081200A1 (es) | 2006-12-04 | 2008-11-06 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
| WO2011050126A1 (en) * | 2009-10-21 | 2011-04-28 | University Of Medicine And Dentistry Of New Jersey | Method for treating sepsis or septic shock |
| WO2018144316A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| WO2020076578A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69435125D1 (de) | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| CA2367909C (en) * | 1999-03-18 | 2008-02-12 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| US6353026B1 (en) * | 1999-03-18 | 2002-03-05 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP2002539181A (ja) * | 1999-03-18 | 2002-11-19 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物およびこれらの使用 |
-
2000
- 2000-03-14 CA CA002367909A patent/CA2367909C/en not_active Expired - Fee Related
- 2000-03-14 EP EP00917903A patent/EP1165066B1/en not_active Expired - Lifetime
- 2000-03-14 DK DK00917903T patent/DK1165066T3/da active
- 2000-03-14 JP JP2000604843A patent/JP4440481B2/ja not_active Expired - Fee Related
- 2000-03-14 AT AT00917903T patent/ATE310512T1/de active
- 2000-03-14 AU AU38806/00A patent/AU775140B2/en not_active Ceased
- 2000-03-14 DE DE60024242T patent/DE60024242T2/de not_active Expired - Lifetime
- 2000-03-14 ES ES00917903T patent/ES2249257T3/es not_active Expired - Lifetime
- 2000-03-14 CA CA2747376A patent/CA2747376A1/en not_active Abandoned
- 2000-03-14 CA CA2615917A patent/CA2615917C/en not_active Expired - Fee Related
- 2000-03-14 US US09/525,291 patent/US6387953B1/en not_active Expired - Fee Related
- 2000-03-14 WO PCT/US2000/006582 patent/WO2000054767A1/en not_active Ceased
- 2000-03-14 HK HK02104452.1A patent/HK1043307B/en not_active IP Right Cessation
-
2002
- 2002-01-11 US US10/044,499 patent/US6703423B2/en not_active Expired - Fee Related
- 2002-01-11 US US10/044,740 patent/US6710084B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 US US10/794,153 patent/US7132451B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 US US11/531,921 patent/US20080312323A1/en not_active Abandoned
-
2007
- 2007-12-03 US US11/837,964 patent/US20080081838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2367909C (en) | 2008-02-12 |
| CA2615917C (en) | 2011-10-04 |
| DE60024242T2 (de) | 2006-12-14 |
| US6710084B2 (en) | 2004-03-23 |
| US20020143069A1 (en) | 2002-10-03 |
| US20080312323A1 (en) | 2008-12-18 |
| JP2002539159A (ja) | 2002-11-19 |
| US20020132847A1 (en) | 2002-09-19 |
| US6703423B2 (en) | 2004-03-09 |
| WO2000054767A1 (en) | 2000-09-21 |
| DE60024242D1 (de) | 2005-12-29 |
| HK1043307B (en) | 2006-02-03 |
| US20040192785A1 (en) | 2004-09-30 |
| EP1165066A1 (en) | 2002-01-02 |
| AU3880600A (en) | 2000-10-04 |
| US6387953B1 (en) | 2002-05-14 |
| HK1043307A1 (en) | 2002-09-13 |
| ES2249257T3 (es) | 2006-04-01 |
| AU775140B2 (en) | 2004-07-22 |
| JP4440481B2 (ja) | 2010-03-24 |
| US7132451B2 (en) | 2006-11-07 |
| ATE310512T1 (de) | 2005-12-15 |
| CA2747376A1 (en) | 2000-09-21 |
| CA2615917A1 (en) | 2000-09-21 |
| US20080081838A1 (en) | 2008-04-03 |
| CA2367909A1 (en) | 2000-09-21 |
| EP1165066B1 (en) | 2005-11-23 |
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