JP4392473B2 - ホスホリパーゼｄの活性の調節 - Google Patents
ホスホリパーゼｄの活性の調節 Download PDFInfo
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- JP4392473B2 JP4392473B2 JP2000604837A JP2000604837A JP4392473B2 JP 4392473 B2 JP4392473 B2 JP 4392473B2 JP 2000604837 A JP2000604837 A JP 2000604837A JP 2000604837 A JP2000604837 A JP 2000604837A JP 4392473 B2 JP4392473 B2 JP 4392473B2
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- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A61K31/02—Halogenated hydrocarbons
- A61K31/035—Halogenated hydrocarbons having aliphatic unsaturation
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- A—HUMAN NECESSITIES
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
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- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US60/125,194 | 1999-03-18 | ||
| PCT/US2000/006669 WO2000054761A2 (en) | 1999-03-18 | 2000-03-14 | Regulation of phospholipase d activity |
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| JP2002539156A JP2002539156A (ja) | 2002-11-19 |
| JP2002539156A5 JP2002539156A5 (https=) | 2005-05-19 |
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| ES (1) | ES2344138T3 (https=) |
| HK (1) | HK1043306B (https=) |
| WO (1) | WO2000054761A2 (https=) |
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| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6745204B1 (en) * | 1999-02-12 | 2004-06-01 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| EP1153355A2 (en) * | 1999-02-12 | 2001-11-14 | Mount Sinai Hospital | System for electronically managing, finding, and/or displaying biomolecular interactions |
| CA2675416A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| JP4932116B2 (ja) | 2000-02-16 | 2012-05-16 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | アスピリン誘発脂質メディエータ |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
| JP4652685B2 (ja) * | 2001-11-06 | 2011-03-16 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| WO2003051350A1 (en) * | 2001-12-18 | 2003-06-26 | The Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| CN101278053A (zh) | 2005-07-29 | 2008-10-01 | 孟山都技术有限公司 | 利用来自转基因杂交体的分离子来开发新的种质 |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| JP2009545527A (ja) * | 2006-07-19 | 2009-12-24 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 粘膜炎の治療用の組成物及び方法 |
| EP2131833A2 (en) * | 2006-10-26 | 2009-12-16 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| PE20120395A1 (es) | 2006-12-04 | 2012-05-23 | Bayer Ip Gmbh | Sal de potasio cristalina de analogos de lipoxina a4 |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| KR101306199B1 (ko) | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 ｄ 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
| WO2014084866A1 (en) | 2012-12-01 | 2014-06-05 | Halliburton Energy Services, Inc. | Protection of electronic devices used with perforating guns |
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| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| JPH08512023A (ja) * | 1993-06-15 | 1996-12-17 | ブリガム・アンド・ウイメンズ・ホスピタル | リポキシン化合物 |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
| CA2675416A1 (en) * | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| AU780114B2 (en) * | 1999-03-18 | 2005-03-03 | Brigham And Women's Hospital | Regulation of phospholipase D activity |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
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| US20020120013A1 (en) | 2002-08-29 |
| JP2002539156A (ja) | 2002-11-19 |
| ATE466582T1 (de) | 2010-05-15 |
| WO2000054761A9 (en) | 2001-10-25 |
| US6353026B1 (en) | 2002-03-05 |
| EP2236140A1 (en) | 2010-10-06 |
| HK1043306B (en) | 2010-09-17 |
| US20020107289A1 (en) | 2002-08-08 |
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| WO2000054761A3 (en) | 2001-03-29 |
| CA2645558C (en) | 2012-05-15 |
| DE60044335D1 (de) | 2010-06-17 |
| US20050187294A1 (en) | 2005-08-25 |
| AU780114B2 (en) | 2005-03-03 |
| AU3745100A (en) | 2000-10-04 |
| US6927238B2 (en) | 2005-08-09 |
| CA2645558A1 (en) | 2000-09-21 |
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