|
US6608060B1
(en)
|
1996-12-18 |
2003-08-19 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
CA2294057A1
(en)
|
1997-06-13 |
1998-12-17 |
Smithkline Beecham Corporation |
Novel pyrazole and pyrazoline substituted compounds
|
|
US6281231B1
(en)
|
1997-09-10 |
2001-08-28 |
Dainippon Ink And Chemical, Inc. |
2,6-dichloro-4-pyridinemethanol derivatives and agricultural chemicals
|
|
US6858617B2
(en)
|
1998-05-26 |
2005-02-22 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
|
WO2000025791A1
(en)
|
1998-11-04 |
2000-05-11 |
Smithkline Beecham Corporation |
Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
|
|
US6469018B1
(en)
|
1999-01-08 |
2002-10-22 |
Smithkline Beecham Corporation |
Compounds
|
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
ATE538794T1
(de)
|
1999-01-13 |
2012-01-15 |
Bayer Healthcare Llc |
Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
|
|
PL215901B1
(pl)
|
1999-04-15 |
2014-02-28 |
Bristol Myers Squibb Co |
Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek
|
|
US7125875B2
(en)
|
1999-04-15 |
2006-10-24 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
|
WO2000075118A1
(en)
*
|
1999-06-03 |
2000-12-14 |
Vertex Pharmaceuticals Incorporated |
INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK)
|
|
AU1781601A
(en)
|
1999-11-23 |
2001-06-04 |
Smithkline Beecham Corporation |
3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
|
|
EP1233951B1
(en)
|
1999-11-23 |
2005-06-01 |
SmithKline Beecham Corporation |
3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
|
|
ATE305787T1
(de)
|
1999-11-23 |
2005-10-15 |
Smithkline Beecham Corp |
3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
|
|
US6537996B2
(en)
|
2000-02-23 |
2003-03-25 |
Iconix Pharmaceuticals, Inc. |
Modulators of p38 MAP kinase
|
|
US7235551B2
(en)
|
2000-03-02 |
2007-06-26 |
Smithkline Beecham Corporation |
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
|
|
CA2403828A1
(en)
*
|
2000-03-22 |
2001-09-27 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
JP4993838B2
(ja)
|
2000-08-11 |
2012-08-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
P38のインヒビターとしてのピリジン誘導体
|
|
US6645990B2
(en)
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
WO2002092087A1
(en)
*
|
2001-05-11 |
2002-11-21 |
Vertex Pharmaceuticals Incorporated |
2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2, 4-triazine derivatives for use as p38 inhibitors
|
|
ATE415162T1
(de)
|
2001-06-11 |
2008-12-15 |
Vertex Pharma |
Isochinolin-inhibitoren von p38
|
|
US20030139435A1
(en)
*
|
2001-06-26 |
2003-07-24 |
Gulzar Ahmed |
N-heterocyclic inhibitors of TNF-alpha expression
|
|
MXPA04007832A
(es)
|
2002-02-11 |
2005-09-08 |
Bayer Pharmaceuticals Corp |
Aril-ureas con actividad inhibitoria de angiogenesis.
|
|
EP2258687B1
(en)
*
|
2002-02-12 |
2012-12-26 |
Glaxosmithkline LLC |
Nicotinamide derivates useful as P38 inhibitors
|
|
GB0214268D0
(en)
*
|
2002-06-20 |
2002-07-31 |
Celltech R&D Ltd |
Chemical compounds
|
|
DE60310730T2
(de)
|
2002-07-09 |
2007-05-16 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
|
|
CN101723891A
(zh)
|
2003-02-10 |
2010-06-09 |
沃泰克斯药物股份有限公司 |
通过使n-芳基氨基甲酸酯与卤代杂芳基反应制备n-杂芳基-n-芳基胺的方法和类似方法
|
|
WO2004113274A2
(en)
|
2003-05-20 |
2004-12-29 |
Bayer Pharmaceuticals Corporation |
Diaryl ureas with kinase inhibiting activity
|
|
EA010485B1
(ru)
|
2003-07-23 |
2008-10-30 |
Байер Фамэсьютиклс Копэрейшн |
Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
|
|
EP1742936A2
(en)
|
2004-04-13 |
2007-01-17 |
Icagen, Inc. |
Polycyclic pyridines as potassium ion channel modulators
|
|
KR100575344B1
(ko)
*
|
2004-07-14 |
2006-05-03 |
주식회사 이큐스팜 |
C형 간염 예방 및 치료용 약학적 조성물
|
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
|
WO2006021848A1
(en)
*
|
2004-08-27 |
2006-03-02 |
Ranbaxy Laboratories Limited |
Anti-inflammatory agents
|
|
US8017395B2
(en)
|
2004-12-17 |
2011-09-13 |
Lifescan, Inc. |
Seeding cells on porous supports
|
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
|
AU2006202209B2
(en)
|
2005-05-27 |
2011-04-14 |
Lifescan, Inc. |
Amniotic fluid derived cells
|
|
BRPI0502016B8
(pt)
*
|
2005-06-03 |
2021-05-25 |
Univ Federal Do Rio De Janeiro Ufrj |
composto ureídicos, composições farmacêuticas contendo os mesmos e seu uso no tratamento de doenças inflamatórias
|
|
CA2613889A1
(en)
*
|
2005-06-08 |
2006-12-14 |
Centocor, Inc. |
A cellular therapy for ocular degeneration
|
|
US20070122448A1
(en)
*
|
2005-11-28 |
2007-05-31 |
Alireza Rezania |
Compositions and methods to create a vascularized environment for cellular transplantation
|
|
CA2650812C
(en)
|
2006-04-28 |
2017-12-12 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
CN103627671A
(zh)
*
|
2007-01-30 |
2014-03-12 |
佐治亚大学研究基金会 |
产生中内胚层细胞及多能游走细胞的方法与细胞群及用途
|
|
CA2681420A1
(en)
*
|
2007-03-20 |
2008-09-25 |
Cadila Pharmaceuticals Limited |
P38 inhibitors
|
|
EP1992344A1
(en)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
WO2009012428A2
(en)
|
2007-07-18 |
2009-01-22 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells
|
|
CA3114827C
(en)
|
2007-07-31 |
2023-09-05 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells to pancreatic endocrine
|
|
EP2229434B1
(en)
|
2007-11-27 |
2011-09-07 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells
|
|
KR101731474B1
(ko)
|
2008-02-21 |
2017-05-11 |
얀센 바이오테크 인코포레이티드 |
세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
PL2310492T3
(pl)
*
|
2008-06-30 |
2015-12-31 |
Janssen Biotech Inc |
Różnocowanie pluripotencjalnych komórek macierzystych
|
|
EP2318520B1
(en)
|
2008-07-25 |
2017-10-11 |
The University Of Georgia Research Foundation, Inc. |
Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use
|
|
US20110305672A1
(en)
|
2008-07-25 |
2011-12-15 |
University Of Georgia Research Foundation, Inc. |
COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME
|
|
US20100028307A1
(en)
*
|
2008-07-31 |
2010-02-04 |
O'neil John J |
Pluripotent stem cell differentiation
|
|
WO2010038428A1
(ja)
*
|
2008-09-30 |
2010-04-08 |
武田薬品工業株式会社 |
タキサン系抗がん剤の置き換え薬
|
|
PL2346988T3
(pl)
*
|
2008-10-31 |
2017-10-31 |
Janssen Biotech Inc |
Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki
|
|
MX349178B
(es)
|
2008-10-31 |
2017-07-17 |
Centocor Ortho Biotech Inc |
Diferenciación de células madre embrionarias humanas al linaje endocrino pancreático.
|
|
ES2642070T3
(es)
|
2008-11-20 |
2017-11-15 |
Janssen Biotech, Inc. |
Cultivo de células madre pluripotentes en microportadores
|
|
ES2584053T3
(es)
*
|
2008-11-20 |
2016-09-23 |
Janssen Biotech, Inc. |
Métodos y composiciones para la unión de células y cultivo en sustratos planos
|
|
WO2010067987A2
(ko)
*
|
2008-12-10 |
2010-06-17 |
동화약품주식회사 |
신규한 2, 6-위치에 치환된 3-니트로피리딘 유도체, 그의 제조방법 및 이를 포함하는 약학 조성물
|
|
BRPI0922572A2
(pt)
|
2008-12-17 |
2019-09-24 |
Scripps Research Inst |
método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero.
|
|
EP2396302A2
(en)
*
|
2009-02-13 |
2011-12-21 |
Vertex Pharmceuticals Incorporated |
Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides)
|
|
GB0908317D0
(en)
*
|
2009-05-14 |
2009-06-24 |
Argenta Discovery Ltd |
Pharmaceutical compounds and compositions
|
|
KR102058901B1
(ko)
|
2009-07-20 |
2019-12-24 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 분화
|
|
EP2456859A4
(en)
*
|
2009-07-20 |
2015-03-18 |
Janssen Biotech Inc |
DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
|
|
SG177483A1
(en)
*
|
2009-07-20 |
2012-02-28 |
Janssen Biotech Inc |
Differentiation of human embryonic stem cells
|
|
ES2665006T3
(es)
|
2009-10-29 |
2018-04-24 |
Janssen Biotech, Inc. |
Células madre pluripotentes
|
|
SG181687A1
(en)
|
2009-12-23 |
2012-07-30 |
Centocor Ortho Biotech Inc |
Differentiation of human embryonic stem cells
|
|
CA2784425A1
(en)
*
|
2009-12-23 |
2011-06-30 |
Centocor Ortho Biotech Inc. |
Differentiation of human embryonic stem cells
|
|
EP2542667A4
(en)
|
2010-03-01 |
2013-07-31 |
Janssen Biotech Inc |
PROCESS FOR CLEANING CELLS OBTAINED FROM PLURIPOTENTIAL STEM CELLS
|
|
RU2663339C1
(ru)
|
2010-05-12 |
2018-08-03 |
Янссен Байотек, Инк. |
Дифференцирование эмбриональных стволовых клеток человека
|
|
US20120039955A1
(en)
|
2010-08-12 |
2012-02-16 |
Janssen Biotech, Inc. |
Treatment of Diabetes with Pancreatic Endocrine Precursor Cells
|
|
EP2611907B1
(en)
|
2010-08-31 |
2016-05-04 |
Janssen Biotech, Inc. |
Differentiation of pluripotent stem cells
|
|
CN103221536B
(zh)
|
2010-08-31 |
2016-08-31 |
詹森生物科技公司 |
人胚胎干细胞的分化
|
|
ES2658146T3
(es)
|
2010-08-31 |
2018-03-08 |
Janssen Biotech, Inc. |
Diferenciación de células madre embrionarias humanas
|
|
EP2646543A4
(en)
|
2010-12-02 |
2014-09-03 |
Technion Res & Dev Foundation |
METHOD OF GENERATING CORNEAL CELLS AND CELL POPULATIONS THEREWITH
|
|
JP5922147B2
(ja)
|
2010-12-15 |
2016-05-24 |
カディマステム リミテッド |
多能性幹細胞に由来するインスリン産生細胞
|
|
KR102203056B1
(ko)
|
2011-12-22 |
2021-01-14 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
|
|
HK1206058A1
(en)
|
2012-03-07 |
2015-12-31 |
Janssen Biotech, Inc. |
Defined media for expansion and maintenance of pluripotent stem cells
|
|
EP2843049B1
(en)
|
2012-04-27 |
2018-04-11 |
Keio University |
Neuronal differentiation promoter
|
|
AU2013271581B2
(en)
|
2012-06-08 |
2018-08-09 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells into pancreatic endocrine cells
|
|
JP6557147B2
(ja)
|
2012-12-31 |
2019-08-07 |
ヤンセン バイオテツク,インコーポレーテツド |
Hb9調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化
|
|
RU2687379C2
(ru)
|
2012-12-31 |
2019-05-13 |
Янссен Байотек, Инк. |
Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
BR112015015770A2
(pt)
|
2012-12-31 |
2017-07-11 |
Janssen Biotech Inc |
cultivo de células-tronco embrionárias humanas na interface ar-líquido para diferenciação em células pancreáticas endócrinas
|
|
US12558316B2
(en)
|
2013-03-13 |
2026-02-24 |
University Of Miami |
Methods and compositions for the treatment of epidermolysis bullosa
|
|
CN105209881B
(zh)
|
2013-03-13 |
2021-01-22 |
迈阿密大学 |
从细胞培养上清液和生物流体分离并纯化微泡的方法
|
|
US10006006B2
(en)
|
2014-05-16 |
2018-06-26 |
Janssen Biotech, Inc. |
Use of small molecules to enhance MAFA expression in pancreatic endocrine cells
|
|
WO2017075274A1
(en)
|
2015-10-27 |
2017-05-04 |
Children's Hospital Medical Center |
Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation
|
|
BR112018010946A2
(en)
|
2015-11-30 |
2018-12-04 |
Kadimastem Ltd |
pancreatic endocrine cell enrichment method, pancreatic endocrine cell enriched population, diabetes treatment method and insulin production beta cell preparation method
|
|
DK3443073T3
(da)
|
2016-04-14 |
2024-09-02 |
Janssen Biotech Inc |
Differentiering af pluripotente stamceller til intestinale mellemtarmendodermceller
|
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|
|
WO2019071147A1
(en)
|
2017-10-05 |
2019-04-11 |
Fulcrum Therapeutics, Inc. |
INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
|
|
KR20200121800A
(ko)
|
2018-01-05 |
2020-10-26 |
싸이브렉사 1, 인크. |
산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법
|
|
EP3773579A4
(en)
|
2018-03-26 |
2022-03-09 |
Clear Creek Bio, Inc. |
COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
|
|
TW202116356A
(zh)
|
2019-07-10 |
2021-05-01 |
美商斯布雷克薩三號公司 |
作為治療劑之微管靶向藥劑之肽結合物
|
|
CN114341162B
(zh)
|
2019-07-10 |
2025-10-17 |
赛博克萨2公司 |
作为治疗剂的细胞毒素的肽缀合物
|
|
US20210300873A1
(en)
|
2020-03-20 |
2021-09-30 |
Clear Creek Bio, Inc. |
Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof
|
|
KR20230074475A
(ko)
|
2020-08-21 |
2023-05-30 |
더 유니버시티 오브 마이애미 |
골수-유래 중간엽 줄기 세포로부터의 미세소포를 사용한 치료의 조성물 및 방법
|
|
EP4511045A1
(en)
|
2022-04-19 |
2025-02-26 |
University of Miami |
Compositions comprising microvesicles for use in the prevention and treatment of graft versus host disease
|