JO1850B1 - مشتقات اريثرومايسين جديدة وطرق تحضيرها واستعمالاتها كدواء - Google Patents

مشتقات اريثرومايسين جديدة وطرق تحضيرها واستعمالاتها كدواء

Info

Publication number
JO1850B1
JO1850B1 JO19951850A JOP19951850A JO1850B1 JO 1850 B1 JO1850 B1 JO 1850B1 JO 19951850 A JO19951850 A JO 19951850A JO P19951850 A JOP19951850 A JO P19951850A JO 1850 B1 JO1850 B1 JO 1850B1
Authority
JO
Jordan
Prior art keywords
optionally
compounds
carbon atoms
hydrogen atom
medicament
Prior art date
Application number
JO19951850A
Other languages
English (en)
Inventor
اغوريداس كونستانتين
بينيديت ياتيك
شانتوت جان-فرانسوا
دينس اليكسس
لو مارتريت أوديل
Original Assignee
أفانتيس فارما إس إيه
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by أفانتيس فارما إس إيه filed Critical أفانتيس فارما إس إيه
Application granted granted Critical
Publication of JO1850B1 publication Critical patent/JO1850B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

موضوع الاختراع هو مكونات المعادلة العامة ( ‏I‏):‏ التي فيها:‏ اما ‏R1‎‏ و ‏R2‎‏ ( متشابهة او مختلفة) تمثل ذرة هيدروجين او عنصر هيدروجين كاربنون تحتوي على ما ‏يعادل 24 ذرة كاربون ( مشبعه او غير مشبعه) يقاطعها( بصورة اختيارية) احدى او اكثر من الذرات ‏المختلفة وتحمل( بصورة اختيارية) احدى او اكثر من المجموعات العاملة.‏ او ‏R1‎‏ و ‏R2‎‏ تمثل مع ذرة النتيروجين ( التي مرتبطة معها) دوائر غير متشابهة تحتوي بصورة اختيارية ‏واحد او اكثر من الذرات الغير متشابهة المختارة من النتروجين، الاوكسجين، والكبريت ‏ او ‏R1‎‏ و ‏R2‎‏ معا يكونان عنصرا، التي فيها ‏R’1‎‏ و ‏R’2‎‏ (( متشابهة او مختلفة) تمثل ذرة هيدوجين او عنصر هيدروكاربون تحتوي على ما ‏يعادل 23 ذرة كاربون (مشبعه او غير مشبعه) يقاطعها( بصورة اختيارية) واحد او اكثر من الذرات المختلفة ‏والتي تحمل بصورة اختيارية على واحد او اكثر من المجموعات العاملة و ‏Z‏ تمثل ذرة هيدروجين او بقايا ‏حامض الكربوكسيلي تحتوي على ما يعادل 18 ذرة كاربون بالاضافة الى الاملاح المضافة مع حوامض ‏مكونات المعادلة رقم (1).‏ مكونات المعادلة رقم (1) تمتلك خواص مضاد حيوي مفيدة.‏
JO19951850A 1994-04-08 1995-03-19 مشتقات اريثرومايسين جديدة وطرق تحضيرها واستعمالاتها كدواء JO1850B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number Publication Date
JO1850B1 true JO1850B1 (ar) 1995-12-27

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
JO19951850A JO1850B1 (ar) 1994-04-08 1995-03-19 مشتقات اريثرومايسين جديدة وطرق تحضيرها واستعمالاتها كدواء

Country Status (49)

Country Link
US (2) US5656607A (ar)
EP (1) EP0676409B1 (ar)
JP (1) JP3000023B2 (ar)
KR (1) KR100317148B1 (ar)
CN (1) CN1059445C (ar)
AP (1) AP587A (ar)
AT (1) ATE234853T1 (ar)
AU (1) AU684939B2 (ar)
BG (1) BG61916B1 (ar)
BR (1) BR9506147A (ar)
CA (1) CA2164638C (ar)
CO (1) CO4370097A1 (ar)
CZ (1) CZ296005B6 (ar)
DE (1) DE69529934T2 (ar)
DK (1) DK0676409T3 (ar)
DZ (1) DZ1869A1 (ar)
EE (1) EE04498B1 (ar)
ES (1) ES2189820T3 (ar)
FI (1) FI111264B (ar)
FR (1) FR2718450B1 (ar)
GB (1) GB2288174A (ar)
GE (1) GEP19991836B (ar)
HR (1) HRP950217B1 (ar)
HU (1) HU215396B (ar)
IL (1) IL112954A (ar)
IS (1) IS1865B (ar)
JO (1) JO1850B1 (ar)
LV (1) LV11182B (ar)
MA (1) MA23501A1 (ar)
MD (1) MD663G2 (ar)
MY (1) MY114672A (ar)
NO (1) NO308361B1 (ar)
NZ (1) NZ284498A (ar)
OA (1) OA10200A (ar)
PE (1) PE2896A1 (ar)
PL (1) PL180837B1 (ar)
PT (1) PT676409E (ar)
RO (1) RO115634B1 (ar)
RU (1) RU2141965C1 (ar)
SA (1) SA97170757A (ar)
SI (1) SI0676409T1 (ar)
SK (1) SK284079B6 (ar)
SV (1) SV1995000018A (ar)
TN (1) TNSN95026A1 (ar)
TW (1) TW316908B (ar)
UA (1) UA44705C2 (ar)
WO (1) WO1995027720A1 (ar)
YU (1) YU49221B (ar)
ZA (1) ZA952059B (ar)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
PT922050E (pt) * 1996-05-07 2003-12-31 Abbott Lab Derivados de 3-descladinose-2,3-anidroeritromicina
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE296831T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-0-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
EP0988308A1 (en) * 1997-06-11 2000-03-29 Pfizer Products Inc. 9-oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU775637B2 (en) * 1999-04-16 2004-08-12 Kosan Biosciences, Inc. Macrolide antiinfective agents
TR200103395T2 (tr) * 1999-05-24 2002-04-22 Pfizer Products Inc. 13-metil eritromisin türevleri.
JP4509553B2 (ja) 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
KR101035043B1 (ko) 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
DK2358379T3 (en) * 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
BR112015023670A2 (pt) 2013-03-15 2017-07-18 Cempra Pharmaceuticals Inc processo para preparar um composto
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
HK1242920A1 (zh) * 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
EE04498B1 (et) 2005-06-15
JP3000023B2 (ja) 2000-01-17
IL112954A (en) 2000-07-16
WO1995027720A1 (fr) 1995-10-19
FR2718450A1 (fr) 1995-10-13
RU2141965C1 (ru) 1999-11-27
DZ1869A1 (fr) 2002-02-17
DE69529934T2 (de) 2003-09-04
ZA952059B (en) 1996-03-13
UA44705C2 (uk) 2002-03-15
HU9503505D0 (en) 1996-02-28
SA97170757A (ar) 2005-12-03
ES2189820T3 (es) 2003-07-16
MA23501A1 (fr) 1995-12-31
SK154695A3 (en) 1996-10-02
CN1059445C (zh) 2000-12-13
CA2164638C (fr) 2003-12-30
NO954942L (no) 1996-02-07
PT676409E (pt) 2003-08-29
PL180837B1 (pl) 2001-04-30
BR9506147A (pt) 1996-04-16
CN1126997A (zh) 1996-07-17
AP587A (en) 1997-04-29
US5656607A (en) 1997-08-12
FR2718450B1 (fr) 1997-01-10
GEP19991836B (en) 1999-11-05
FI955913A7 (fi) 1995-12-08
DE69529934D1 (de) 2003-04-24
BG100150A (bg) 1996-06-28
HUT73772A (en) 1996-09-30
GB9506856D0 (en) 1995-05-24
SK284079B6 (sk) 2004-09-08
IS1865B (is) 2003-05-02
FI955913A0 (fi) 1995-12-08
CO4370097A1 (es) 1996-10-07
NO308361B1 (no) 2000-09-04
SI0676409T1 (en) 2003-06-30
RO115634B1 (ro) 2000-04-28
IL112954A0 (en) 1995-06-29
HRP950217A2 (en) 1997-08-31
YU49221B (sh) 2004-11-25
FI111264B (fi) 2003-06-30
CZ322395A3 (en) 1996-08-14
MD663F1 (ro) 1997-01-31
EE9500080A (et) 1996-12-16
TNSN95026A1 (fr) 1996-02-06
NO954942D0 (no) 1995-12-06
HRP950217B1 (en) 2004-06-30
AU684939B2 (en) 1998-01-08
AU2310795A (en) 1995-10-30
EP0676409B1 (fr) 2003-03-19
PE2896A1 (es) 1996-02-12
MY114672A (en) 2002-12-31
LV11182A (lv) 1996-04-20
AP9500743A0 (en) 1995-07-31
ATE234853T1 (de) 2003-04-15
CA2164638A1 (fr) 1995-10-19
CZ296005B6 (cs) 2005-12-14
GB2288174A (en) 1995-10-11
BG61916B1 (bg) 1998-09-30
IS4309A (is) 1995-11-17
DK0676409T3 (da) 2003-06-23
KR100317148B1 (ko) 2002-06-22
MD663G2 (ro) 1997-07-31
YU21695A (sh) 1997-12-05
LV11182B (en) 1997-04-20
OA10200A (fr) 1996-12-18
NZ284498A (en) 1997-07-27
EP0676409A1 (fr) 1995-10-11
TW316908B (ar) 1997-10-01
JPH07278177A (ja) 1995-10-24
PL311871A1 (en) 1996-03-18
US5760233A (en) 1998-06-02
HU215396B (hu) 1998-12-28
SV1995000018A (es) 1997-10-24

Similar Documents

Publication Publication Date Title
JO1850B1 (ar) مشتقات اريثرومايسين جديدة وطرق تحضيرها واستعمالاتها كدواء
NZ227251A (en) Macrolide derivatives and pharmaceutical compositions
ATE107875T1 (de) Wässrige polyurethan dispersionen.
MX9606665A (es) Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
MXPA03000547A (es) Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
HU9300677D0 (en) Method for producing anti-microbal carbapeneme derivatives and medical preparatives therewith
GR3030234T3 (en) 4-Phenylcarbamoyl-3-isoxazolecarboxylic acid derivatives with antiinflammatory activity
AU625886B2 (en) New oxazolopyridine derivatives, process for preparing them and pharmaceutical compositions containing them
PH24762A (en) 1,6-naphthyridine derivatives, pharmaceutical compositions and method of use
DE3787844D1 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
IT1230595B (it) Perossiacidi immido derivati
JO1889B1 (ar) مشتقات اكسيم جديدة من اريثروميسين وتحضيرها واستعمالها كأدوية وتراكيب صيدلية تحتويها
ES8602775A1 (es) Procedimiento para fotoestabilizar molsidomina
AU539348B2 (en) 5,6,8,9-tetrahydro-7h-dibenz(d,f)azonine derivatives
AP9901566A0 (en) Novel erythromycin derivatives, method of preparation and application as medicines.
HUT38346A (en) Process for producing azabicyclo-heptane derivatives pharmaceutical compositions containing them
HUT37935A (en) Process for production of 3-alkoxi-2-n-pirrolidin-n-piridil-n-furil /or n-tienil/-methil-prophil amins
HUT53638A (en) Process for producing 15-amino-substituted 20,21-dinoreburnamenie derivatives and pharmaceutical compositions containing them
ATE115132T1 (de) Derivate des 1,2,5,6-tetrahydropyridin-3- caboxaldehydoxims, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
TH13804A (th) กรรมวิธีที่ดีขึ้นสำหรับเตรียมซับสทิทิวเทด สเทอรอยดอล เบนโซ เอสเทอร์ และซับสทิทิวเทด สเทอรอยดอล เบนโซแอซิด