MX9606665A - Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion. - Google Patents

Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.

Info

Publication number
MX9606665A
MX9606665A MX9606665A MX9606665A MX9606665A MX 9606665 A MX9606665 A MX 9606665A MX 9606665 A MX9606665 A MX 9606665A MX 9606665 A MX9606665 A MX 9606665A MX 9606665 A MX9606665 A MX 9606665A
Authority
MX
Mexico
Prior art keywords
substituted
unsubstituted
preparation
compounds
amino
Prior art date
Application number
MX9606665A
Other languages
English (en)
Other versions
MXPA96006665A (es
Inventor
Walter Kunz
Beat Jau
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA96006665A publication Critical patent/MXPA96006665A/es
Publication of MX9606665A publication Critical patent/MX9606665A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/20Esters of monothiocarboxylic acids
    • C07C327/26Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Los compuestos de la formula I: y los disulfuros de los mismos, y las sales de los mismos, son producto intermediarios importantes para la preparacion de los compuestos que tienen una accion microbicida e inmunizante de plantas, de la formula III: En los compuestos de las formulas I y III; X es halogeno, n es 0, 1, 2, o 3; Z es CN, CO-A o CS-A, A es hidrogeno, OR1, SR2 y N(R3)R4; R1 a R4 son hidrogeno, un radical de hidrocarburo saturado o insaturado, de cadena abierta, sustituido o insustituido, que contiene no más de 8 átomos de carbono, un radical de hidrocarburo saturado o insaturado, cíclico, sustituido o insustituido, que contiene no más de 10 átomos de carbono, bencilo o fenetilo sustituidos o insustituidos, un grupo alcanoílo sustituido o insustituido que contiene no más de 8 átomos de carbono, un grupo benzoílo o insustituido, o un radical de heterociclilo sustituido o insustituido; o R3 y R4, junto con el átomo de nitrogeno con el que están enlazados, son un radical heterocíclico sustituido o insustituido de 5 o 6 miembros, que tiene de 1 a 3 heteroátomos O, S, y/o N.
MX9606665A 1995-12-21 1996-12-19 Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion. MX9606665A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH363795 1995-12-21
CH3637/95 1995-12-21
US08/770,353 US5770758A (en) 1995-12-21 1996-12-20 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation

Publications (2)

Publication Number Publication Date
MXPA96006665A MXPA96006665A (es) 1997-06-01
MX9606665A true MX9606665A (es) 1997-06-28

Family

ID=25693502

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA02000515A MXPA02000515A (es) 1995-12-21 1996-12-19 Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.
MX9606665A MX9606665A (es) 1995-12-21 1996-12-19 Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA02000515A MXPA02000515A (es) 1995-12-21 1996-12-19 Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.

Country Status (21)

Country Link
US (1) US5770758A (es)
EP (1) EP0780372B3 (es)
JP (1) JP4217924B2 (es)
KR (1) KR100470887B1 (es)
CN (2) CN1163491C (es)
AT (1) ATE208760T1 (es)
AU (1) AU713526B2 (es)
BR (1) BR9606092A (es)
CA (1) CA2193460C (es)
CZ (1) CZ291857B6 (es)
DE (1) DE69616956T3 (es)
DK (1) DK0780372T3 (es)
ES (1) ES2168121T7 (es)
HU (1) HU221600B (es)
IL (3) IL133900A (es)
MX (2) MXPA02000515A (es)
PL (1) PL187885B1 (es)
PT (1) PT780372E (es)
RU (1) RU2176241C2 (es)
SK (1) SK283840B6 (es)
ZA (1) ZA9610774B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002013A (en) * 1995-12-21 1999-12-14 Novartis Corporation 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation
GB9724586D0 (en) * 1997-11-20 1998-01-21 Rhone Poulenc Agriculture New herbicides
KR101129933B1 (ko) 2002-09-25 2012-03-23 메모리 파마슈티칼스 코포레이션 인다졸, 벤조티아졸 및 벤조이소티아졸 및 그의 제조 및용도
DE10313887A1 (de) * 2003-03-27 2004-10-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum selektiven Gewinnen von Gold aus goldhaltigen Materialien
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
JP2007523868A (ja) * 2003-07-10 2007-08-23 アキリオン ファーマシューティカルズ,インコーポレーテッド ウイルス複製の阻害薬として有用な置換アリールチオウレア誘導体類
US20050234095A1 (en) 2004-03-25 2005-10-20 Wenge Xie Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
CA2644520A1 (en) * 2006-03-02 2007-09-13 Mallinckrodt Inc. Thiadiazole compounds and their use in phototherapy
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CN101492429B (zh) * 2008-12-10 2010-12-15 上海泰禾(集团)有限公司 一种苯并-[1,2,3]-噻二唑-7-甲酸三氟乙酯的提纯方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150140A (en) * 1976-12-23 1979-04-17 The Upjohn Company Benzothiazolyl oxanic acids, esters and salts
DE2757924A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von vinylchlorid-polymerisaten
DE3601286A1 (de) * 1986-01-17 1987-07-23 Consiglio Nazionale Ricerche Sammelmittel fuer die selektive flotation von blei- und zinkerzen und verfahren zu deren herstellung
DE19775050I2 (de) * 1987-08-21 2010-12-16 Syngenta Participations Ag Benzothiadiazole und ihre Verwendung in Verfahren und Mitteln gegen Pflanzenkrankheiten.
EP0384889B1 (de) * 1989-02-21 1993-10-13 Ciba-Geigy Ag Mittel zum Schutz von Pflanzen gegen Krankheiten
EP0529600B1 (de) 1991-08-30 1996-11-06 Hoechst Aktiengesellschaft Verfahren zur Herstellung von 2-Aminobenzthiazolen
JPH0690518A (ja) * 1992-09-09 1994-03-29 Toshiba Corp 地絡継電器
JP3310104B2 (ja) * 1994-04-04 2002-07-29 三新化学工業株式会社 2−アミノチオフェノール類の製造方法
US5883283A (en) * 1994-10-17 1999-03-16 Novartis Finance Corporation Process for the preparation of substituted 3-aminobenzonitriles

Also Published As

Publication number Publication date
IL119819A (en) 2004-07-25
RU2176241C2 (ru) 2001-11-27
US5770758A (en) 1998-06-23
HUP9603527A3 (en) 1999-04-28
JP4217924B2 (ja) 2009-02-04
HU9603527D0 (en) 1997-02-28
ZA9610774B (en) 1997-06-30
PT780372E (pt) 2002-04-29
BR9606092A (pt) 1998-09-01
IL133900A0 (en) 2001-04-30
JPH09235279A (ja) 1997-09-09
CA2193460C (en) 2007-03-27
CN1163491C (zh) 2004-08-25
KR100470887B1 (ko) 2005-03-14
DE69616956D1 (de) 2001-12-20
AU7640496A (en) 1997-06-26
AU713526B2 (en) 1999-12-02
CN1392144A (zh) 2003-01-22
ATE208760T1 (de) 2001-11-15
EP0780372B3 (en) 2013-05-22
PL187885B1 (pl) 2004-10-29
CN1078888C (zh) 2002-02-06
SK283840B6 (sk) 2004-03-02
HU221600B (hu) 2002-11-28
DE69616956T3 (de) 2014-01-30
CZ377396A3 (en) 1997-07-16
CN1156722A (zh) 1997-08-13
EP0780372B1 (en) 2001-11-14
HUP9603527A2 (en) 1997-09-29
DK0780372T3 (da) 2002-03-11
DE69616956T2 (de) 2002-06-20
IL133900A (en) 2004-07-25
IL119819A0 (en) 1997-03-18
ES2168121T3 (es) 2002-06-01
PL317601A1 (en) 1997-06-23
MXPA02000515A (es) 2002-09-17
SK163696A3 (en) 1997-10-08
ES2168121T7 (es) 2013-09-24
CA2193460A1 (en) 1997-06-22
EP0780372A3 (en) 1997-09-17
CZ291857B6 (cs) 2003-06-18
AU713526C (en) 1997-06-26
EP0780372A2 (en) 1997-06-25

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