IS1713B - Hliðstæð aðferð til framleiðslu á andróstenón afleiðu og milliefni til notkunar með aðferðinni - Google Patents
Hliðstæð aðferð til framleiðslu á andróstenón afleiðu og milliefni til notkunar með aðferðinniInfo
- Publication number
- IS1713B IS1713B IS4205A IS4205A IS1713B IS 1713 B IS1713 B IS 1713B IS 4205 A IS4205 A IS 4205A IS 4205 A IS4205 A IS 4205A IS 1713 B IS1713 B IS 1713B
- Authority
- IS
- Iceland
- Prior art keywords
- intermediates
- production
- analogous
- androstenone
- derivative
- Prior art date
Links
- HFVMLYAGWXSTQI-QYXZOKGRSA-N 5alpha-androst-16-en-3-one Chemical class C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CC[C@H]21 HFVMLYAGWXSTQI-QYXZOKGRSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12328093A | 1993-09-17 | 1993-09-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS4205A IS4205A (is) | 1995-03-18 |
| IS1713B true IS1713B (is) | 1998-12-30 |
Family
ID=22407744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS4205A IS1713B (is) | 1993-09-17 | 1994-09-13 | Hliðstæð aðferð til framleiðslu á andróstenón afleiðu og milliefni til notkunar með aðferðinni |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US5565467A (is) |
| EP (1) | EP0719278B1 (is) |
| JP (1) | JP2904310B2 (is) |
| KR (1) | KR100364953B1 (is) |
| CN (1) | CN1057771C (is) |
| AP (1) | AP494A (is) |
| AT (1) | ATE162199T1 (is) |
| AU (1) | AU690925B2 (is) |
| BG (1) | BG62363B1 (is) |
| BR (1) | BR1100329A (is) |
| CA (2) | CA2170047C (is) |
| CY (2) | CY2219B1 (is) |
| CZ (1) | CZ286069B6 (is) |
| DE (2) | DE69407978T2 (is) |
| DK (1) | DK0719278T3 (is) |
| EE (1) | EE03241B1 (is) |
| ES (1) | ES2113127T3 (is) |
| FI (1) | FI115216B (is) |
| GR (1) | GR3026144T3 (is) |
| HR (1) | HRP940563B1 (is) |
| HU (1) | HU220060B (is) |
| IL (1) | IL110978A (is) |
| IS (1) | IS1713B (is) |
| LU (1) | LU91027I2 (is) |
| MY (1) | MY119778A (is) |
| NL (1) | NL300122I2 (is) |
| NO (2) | NO306117B1 (is) |
| NZ (1) | NZ274642A (is) |
| OA (1) | OA10575A (is) |
| PE (1) | PE15095A1 (is) |
| PL (1) | PL180002B1 (is) |
| RO (1) | RO117455B1 (is) |
| RU (1) | RU2140926C1 (is) |
| SA (1) | SA94150231B1 (is) |
| SG (1) | SG52650A1 (is) |
| SI (1) | SI0719278T1 (is) |
| SK (1) | SK281869B6 (is) |
| TW (1) | TW369521B (is) |
| WO (1) | WO1995007927A1 (is) |
| ZA (2) | ZA947119B (is) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023051A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors |
| AU5323694A (en) * | 1992-10-06 | 1994-04-26 | Merck & Co., Inc. | 17beta -carboxanilides of 4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors |
| TW408127B (en) * | 1993-09-17 | 2000-10-11 | Glaxo Inc | Androstenones |
| TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
| US5547957A (en) * | 1993-10-15 | 1996-08-20 | Merck & Co., Inc. | Method of treating androgenic alopecia with 5-α reductase inhibitors |
| BR9407866A (pt) * | 1993-10-21 | 1996-10-29 | Merck & Co Inc | Composto processos para inibiçao de 5 -redufase ou isoenzimas da mesma paratratamento de condiçoes de acne vulgar alopécia androgènica hirsutismo feminino hiperplasia prostática benigna prostatite e para o tratamento e/ou prevençao do cancer da próstata para interrupçao e reversao de alopécia androgènica e promoçao do crescimento de cabelo em um mamifero e para inibiçao de conversao biossintética da testosterona para di-hidro- testosterona em um mamifero e composiçao farmacèutica |
| US5817818A (en) * | 1994-09-16 | 1998-10-06 | Glaxo Wellcome Inc. | Androstenones |
| USRE39056E1 (en) * | 1995-09-15 | 2006-04-04 | Merck & Co, Inc. | 4-Azasteroids for treatment of hyperandrogenic conditions |
| US5872126A (en) * | 1996-09-06 | 1999-02-16 | Merck & Co., Inc. | Methods and compositions for treating preterm labor |
| US5935968A (en) * | 1997-03-17 | 1999-08-10 | Merck & Co., Inc. | Methods for treating polycystic ovary syndrome |
| GB9717428D0 (en) * | 1997-08-19 | 1997-10-22 | Glaxo Group Ltd | Pharmaceutical composition |
| JP2001521000A (ja) * | 1997-10-28 | 2001-11-06 | メルク エンド カムパニー インコーポレーテッド | 誘発性急性閉尿の予防 |
| EP1321146A3 (en) * | 1998-03-11 | 2004-06-02 | Endorecherche Inc. | Inhibitors of type 5 and 3 17beta-hydroxysteroid dehydrogenase and methods for their use |
| US6541463B1 (en) * | 1998-03-11 | 2003-04-01 | Endorecherche, Inc. | Inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase and methods for their use |
| US5998427A (en) * | 1998-05-14 | 1999-12-07 | Glaxo Wellcome Inc. | Androstenones |
| WO1999066915A2 (en) * | 1998-06-23 | 1999-12-29 | Southern Illinois University At Carbondale | Therapeutic applications of estrogenic carboxylic acids |
| WO2000045806A1 (en) * | 1999-02-03 | 2000-08-10 | Eli Lilly And Company | α1-ADRENERGIC RECEPTOR ANTAGONISTS |
| MXPA01011227A (es) | 1999-05-04 | 2002-07-02 | Strakan Ltd | Glicosidas androgenas y su actividad androgenica. |
| US6645974B2 (en) | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| JP4490689B2 (ja) * | 2001-10-03 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類 |
| DK1468983T3 (da) * | 2002-01-25 | 2008-01-07 | Asahi Glass Co Ltd | Fremgangsmåde til fremstilling af 2,5-bis(trifluormethyl)nitrobenzen |
| ES2287474T3 (es) * | 2002-04-24 | 2007-12-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Combinacion farmaceutica para el tratamiento de la hiperplasia prostatica benigna o para la prevencion a la largo plazo de la retencion urinaria aguda. |
| WO2003092588A2 (en) * | 2002-04-30 | 2003-11-13 | Merck & Co., Inc. | 4-azasteroid derivatives as androgen receptor modulators |
| US7326717B2 (en) * | 2003-05-06 | 2008-02-05 | L'oreal | Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof |
| US7022854B2 (en) * | 2003-07-17 | 2006-04-04 | Dr. Reddy's Laboratories, Limited | Forms of dutasteride and methods for preparation thereof |
| US20050059692A1 (en) * | 2003-09-09 | 2005-03-17 | Dr. Reddy's Laboratories Limited | Process for the preparation of 17beta-N-[2,5-bis(trifluoromethyl)phenyl] carbamoyl-4-aza-5-alpha-androst-1-en-3-one |
| EP1746998A1 (en) * | 2004-03-22 | 2007-01-31 | Ranbaxy Laboratories, Ltd. | Combination therapy for lower urinary tract symptoms |
| EP1734963A4 (en) * | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| CN101005841A (zh) * | 2004-08-25 | 2007-07-25 | 默克公司 | 雄激素受体调节剂 |
| WO2006058781A2 (en) * | 2004-12-03 | 2006-06-08 | Proteosys Ag | Finasteride, dutasteride and related compounds for preventing/treating neurologically-associated disorders |
| US20060193804A1 (en) * | 2005-02-24 | 2006-08-31 | L'oreal | Haircare use of cyclic amine derivatives |
| EP2371367A1 (en) | 2005-03-25 | 2011-10-05 | Merck Sharp & Dohme (I.A.) Corp. | Method of treating men with testosterone supplement and 5alpha reductase inhibitor |
| WO2007120263A2 (en) * | 2005-11-10 | 2007-10-25 | Dr. Reddy's Laboratories Ltd. | Preparation of dutasteride |
| EP1897533A1 (en) * | 2006-09-08 | 2008-03-12 | Revotar Biopharmaceuticals AG | Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions |
| EP1946756A1 (en) * | 2007-01-17 | 2008-07-23 | Revotar Biopharmaceuticals AG | Use of entacapone in cosmetic, dermatological and pharmaceutical compositions |
| FR2920309B1 (fr) | 2007-08-28 | 2010-05-28 | Galderma Res & Dev | Utilisation de travoprost pour traiter la chute des cheveux |
| US20090076057A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched dutasteride |
| EP2050436A1 (en) | 2007-12-21 | 2009-04-22 | Siegfried Generics International AG | Pharmaceutical composition containing dutasteride |
| AR070313A1 (es) | 2008-01-03 | 2010-03-31 | Gador Sa | Un procedimiento para preparar una forma solida y cristalina de dutasteride, una forma polimorfica del compuesto (forma iii) y una composicion farmaceutica que incluye dicha forma |
| FR2929117B1 (fr) | 2008-03-28 | 2010-05-07 | Oreal | Utilisation de l'association du 2,4-diaminopyrimidine 3-n-oxyde et du madecassosside et/ou du terminoloside pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute |
| FR2929118B1 (fr) | 2008-03-28 | 2010-05-07 | Oreal | Utilisation de l'association de madecassoside et/ou de terminoloside et d'une arginine pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute |
| JP2011527986A (ja) | 2008-04-03 | 2011-11-10 | ハーバー バイオサイエンシーズ，インコーポレイテッド | 医薬の固体状態形態 |
| US20100048598A1 (en) * | 2008-08-21 | 2010-02-25 | Sateesh Kandavilli | Topical compositions comprising 5-alpha reductase inhibitors |
| CN101759762B (zh) * | 2008-11-06 | 2013-03-20 | 天津金耀集团有限公司 | 4ad在制备度他雄胺中的应用 |
| WO2011004242A2 (en) * | 2009-07-09 | 2011-01-13 | Aurobindo Pharma Limited | An improved process for the preparation of dutasteride |
| FR2949052B1 (fr) | 2009-08-13 | 2015-03-27 | Oreal | Procede de traitement cosmetique du cuir chevelu. |
| EP2468262A1 (en) | 2010-12-06 | 2012-06-27 | Krka Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical composition comprising dutasteride |
| BRPI1103204A2 (pt) * | 2011-06-03 | 2014-02-25 | Eurofarma Lab S A | Composição farmacêutica para o tratamento de hiperplasia prostática benigna |
| HU230730B1 (hu) | 2011-06-30 | 2017-12-28 | Richter Gedeon Nyrt | Eljárás (5alfa,17béta)-N-[2,5-bisz-(trifluormetil)-fenil]-3-oxo-4-aza-5-androszt-1-én-17-karbonsavamid előállítására |
| CN103059098B (zh) * | 2011-10-24 | 2015-04-01 | 成都国为医药科技有限公司 | 一种度他雄胺的制备方法 |
| US9622981B2 (en) | 2011-11-17 | 2017-04-18 | Mylan Inc. | Liquid-filled hard gel capsule pharmaceutical formulations |
| CN102382165B (zh) * | 2011-12-02 | 2014-05-07 | 华润赛科药业有限责任公司 | 一种度他雄胺的制备方法 |
| CN103554210A (zh) * | 2012-01-05 | 2014-02-05 | 中国药科大学 | 甾体类5α-还原酶抑制剂、其制备方法及其医药用途 |
| CN102532236B (zh) * | 2012-01-05 | 2014-04-16 | 中国药科大学 | 甾体类5α-还原酶抑制剂、其制备方法及其医药用途 |
| KR101976137B1 (ko) | 2012-01-25 | 2019-05-09 | 한미약품 주식회사 | 두타스테라이드 함유 자가 유화 약물전달 시스템용 조성물 및 이의 제조 방법 |
| CA2870666A1 (en) | 2012-04-16 | 2013-10-24 | Case Western Reserve University | Compositions and methods of modulating 15-pgdh activity |
| WO2015065716A1 (en) | 2013-10-15 | 2015-05-07 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| WO2014002015A1 (en) | 2012-06-25 | 2014-01-03 | Ranbaxy Laboratories Limited | Pharmaceutical composition comprising dutasteride |
| AU2014241816B9 (en) * | 2013-03-14 | 2019-02-14 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
| CN103254268A (zh) * | 2013-05-16 | 2013-08-21 | 寿光市富康化学工业有限公司 | 一种制备度他雄胺的工艺 |
| BR102013020508B1 (pt) | 2013-08-12 | 2021-01-12 | Ems S/A. | Forma de dosagem que compreende um inibidor de esteroide 5-alfa-redutase e um bloqueador alfa, processo para a preparaçãode uma forma de dosagem e uso da forma de dosagem |
| ES2555485T1 (es) | 2014-05-26 | 2016-01-04 | Galenicum Health S.L. | Composiciones farmacéuticas que contienen un agente activo |
| CA2969857A1 (en) | 2014-12-05 | 2016-06-09 | Case Western Reserve University | Compositions and methods of modulating s-nitrosylation |
| KR101590072B1 (ko) | 2014-12-23 | 2016-01-29 | 한미약품 주식회사 | 두타스테라이드를 포함하는 자가유화 약물전달 시스템용 조성물 |
| US10376869B2 (en) * | 2015-03-13 | 2019-08-13 | Dow Global Technologies Llc | Process for oligomerization |
| KR102503428B1 (ko) | 2015-12-22 | 2023-02-24 | 한미약품 주식회사 | 두타스테라이드를 포함하는 경구용 연질 캡슐 제형용 포장재 |
| WO2017160106A2 (ko) | 2016-03-16 | 2017-09-21 | 한미약품 주식회사 | 두타스테라이드 및 탐수로신 함유 경질 캡슐 복합제 및 그 제조방법 |
| KR101716878B1 (ko) | 2016-05-12 | 2017-03-15 | 주식회사 유유제약 | 글리세롤 지방산에스테르유도체 또는 프로필렌글리콜 지방산에스테르유도체를 함유한 두타스테리드와 타다라필의 복합 캡슐제제 조성물 및 이의 제조방법 |
| JP7595413B2 (ja) | 2016-11-30 | 2024-12-06 | ケース ウエスタン リザーブ ユニバーシティ | １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 |
| CA3052466A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| WO2019045501A1 (ko) | 2017-09-01 | 2019-03-07 | 제이더블유중외제약 주식회사 | 두타스테라이드를 포함하는 고형 제제 및 이의 제조방법 |
| KR101996597B1 (ko) | 2017-10-13 | 2019-07-31 | 주식회사 유유제약 | 두타스테리드와 타다라필을 용해시킨 경구용 캡슐 제형의 복합제제 |
| KR102281252B1 (ko) | 2018-05-21 | 2021-07-23 | (주)인벤티지랩 | 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법 |
| WO2019225924A1 (ko) * | 2018-05-21 | 2019-11-28 | (주)인벤티지랩 | 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법 |
| US12336982B2 (en) | 2018-11-21 | 2025-06-24 | Rodeo Therapeutics Corporation | Compositions and methods of modulating short-chain dehydrogenase activity |
| KR20200074759A (ko) | 2018-12-17 | 2020-06-25 | 동국제약 주식회사 | 두타스테라이드를 함유하는 고형제제 |
| AU2021275122A1 (en) | 2020-05-20 | 2022-12-15 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| WO2024144084A1 (ko) * | 2022-12-26 | 2024-07-04 | 주식회사 유영제약 | 주 1회 투여를 위한 정제 형태의 고함량 두타스테리드 약제학적 조성물 및 이의 제조방법 |
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| US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
| US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
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-
1994
- 1994-09-03 TW TW083108127A patent/TW369521B/zh active
- 1994-09-13 IS IS4205A patent/IS1713B/is unknown
- 1994-09-14 MY MYPI94002449A patent/MY119778A/en unknown
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- 1994-09-15 PE PE1994250737A patent/PE15095A1/es not_active Application Discontinuation
- 1994-09-15 AP APAP/P/1994/000669A patent/AP494A/en active
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- 1994-09-16 IL IL11097894A patent/IL110978A/en active Protection Beyond IP Right Term
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- 1994-09-16 CN CN94193410A patent/CN1057771C/zh not_active Expired - Lifetime
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- 1994-09-16 JP JP7509391A patent/JP2904310B2/ja not_active Expired - Lifetime
- 1994-09-16 CA CA002462061A patent/CA2462061A1/en not_active Abandoned
- 1994-09-16 DK DK94929828T patent/DK0719278T3/da active
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- 1994-09-16 WO PCT/US1994/010530 patent/WO1995007927A1/en active IP Right Grant
- 1994-09-16 RU RU96108410A patent/RU2140926C1/ru active
- 1994-09-16 AU AU78751/94A patent/AU690925B2/en not_active Expired
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