NO306117B1 - Androstenon-derivater, anvendelse derav samt farmasöytisk formulering, mellomprodukt og fremgangsmÕte anvendt in vitro for inhibering av 5<alfa>-testosteronreduktase-enzym - Google Patents

Androstenon-derivater, anvendelse derav samt farmasöytisk formulering, mellomprodukt og fremgangsmÕte anvendt in vitro for inhibering av 5<alfa>-testosteronreduktase-enzym

Info

Publication number
NO306117B1
NO306117B1 NO961080A NO961080A NO306117B1 NO 306117 B1 NO306117 B1 NO 306117B1 NO 961080 A NO961080 A NO 961080A NO 961080 A NO961080 A NO 961080A NO 306117 B1 NO306117 B1 NO 306117B1
Authority
NO
Norway
Prior art keywords
5alpha
vitro
inhibition
method used
pharmaceutical formulation
Prior art date
Application number
NO961080A
Other languages
English (en)
Other versions
NO961080L (no
NO961080D0 (no
Inventor
Kenneth William Batchelor
Stephen Veronon Frye
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22407744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO306117(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of NO961080L publication Critical patent/NO961080L/no
Publication of NO961080D0 publication Critical patent/NO961080D0/no
Publication of NO306117B1 publication Critical patent/NO306117B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO961080A 1993-09-17 1996-03-15 Androstenon-derivater, anvendelse derav samt farmasöytisk formulering, mellomprodukt og fremgangsmÕte anvendt in vitro for inhibering av 5<alfa>-testosteronreduktase-enzym NO306117B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12328093A 1993-09-17 1993-09-17
PCT/US1994/010530 WO1995007927A1 (en) 1993-09-17 1994-09-16 Androstenone derivative

Publications (3)

Publication Number Publication Date
NO961080L NO961080L (no) 1996-03-15
NO961080D0 NO961080D0 (no) 1996-03-15
NO306117B1 true NO306117B1 (no) 1999-09-20

Family

ID=22407744

Family Applications (2)

Application Number Title Priority Date Filing Date
NO961080A NO306117B1 (no) 1993-09-17 1996-03-15 Androstenon-derivater, anvendelse derav samt farmasöytisk formulering, mellomprodukt og fremgangsmÕte anvendt in vitro for inhibering av 5<alfa>-testosteronreduktase-enzym
NO2003003C NO2003003I2 (no) 1993-09-17 2003-03-07 Dutasteride

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2003003C NO2003003I2 (no) 1993-09-17 2003-03-07 Dutasteride

Country Status (41)

Country Link
US (2) US5565467A (no)
EP (1) EP0719278B1 (no)
JP (1) JP2904310B2 (no)
KR (1) KR100364953B1 (no)
CN (1) CN1057771C (no)
AP (1) AP494A (no)
AT (1) ATE162199T1 (no)
AU (1) AU690925B2 (no)
BG (1) BG62363B1 (no)
BR (1) BR1100329A (no)
CA (2) CA2462061A1 (no)
CY (2) CY2219B1 (no)
CZ (1) CZ286069B6 (no)
DE (2) DE69407978T2 (no)
DK (1) DK0719278T3 (no)
EE (1) EE03241B1 (no)
ES (1) ES2113127T3 (no)
FI (1) FI115216B (no)
GR (1) GR3026144T3 (no)
HK (1) HK1004334A1 (no)
HR (1) HRP940563B1 (no)
HU (1) HU220060B (no)
IL (1) IL110978A (no)
IS (1) IS1713B (no)
LU (1) LU91027I2 (no)
MY (1) MY119778A (no)
NL (1) NL300122I2 (no)
NO (2) NO306117B1 (no)
NZ (1) NZ274642A (no)
OA (1) OA10575A (no)
PE (1) PE15095A1 (no)
PL (1) PL180002B1 (no)
RO (1) RO117455B1 (no)
RU (1) RU2140926C1 (no)
SA (1) SA94150231B1 (no)
SG (1) SG52650A1 (no)
SI (1) SI0719278T1 (no)
SK (1) SK281869B6 (no)
TW (1) TW369521B (no)
WO (1) WO1995007927A1 (no)
ZA (2) ZA947119B (no)

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KR102503428B1 (ko) 2015-12-22 2023-02-24 한미약품 주식회사 두타스테라이드를 포함하는 경구용 연질 캡슐 제형용 포장재
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KR101716878B1 (ko) 2016-05-12 2017-03-15 주식회사 유유제약 글리세롤 지방산에스테르유도체 또는 프로필렌글리콜 지방산에스테르유도체를 함유한 두타스테리드와 타다라필의 복합 캡슐제제 조성물 및 이의 제조방법
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CN118480009A (zh) 2017-02-06 2024-08-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
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KR101996597B1 (ko) 2017-10-13 2019-07-31 주식회사 유유제약 두타스테리드와 타다라필을 용해시킨 경구용 캡슐 제형의 복합제제
WO2019225924A1 (ko) * 2018-05-21 2019-11-28 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
KR102281252B1 (ko) 2018-05-21 2021-07-23 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
CA3120858A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
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