ATE67503T1 - 17-beta-substituierte-4-aza-5-alpha-androstenon und ihre anwendung als 5-alpha-reduktaseinhibitoren. - Google Patents
17-beta-substituierte-4-aza-5-alpha-androstenon und ihre anwendung als 5-alpha-reduktaseinhibitoren.Info
- Publication number
- ATE67503T1 ATE67503T1 AT88119105T AT88119105T ATE67503T1 AT E67503 T1 ATE67503 T1 AT E67503T1 AT 88119105 T AT88119105 T AT 88119105T AT 88119105 T AT88119105 T AT 88119105T AT E67503 T1 ATE67503 T1 AT E67503T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- methyl
- beta
- hydrogen
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58406184A | 1984-02-27 | 1984-02-27 | |
US58406284A | 1984-02-27 | 1984-02-27 | |
EP88119105A EP0314199B1 (de) | 1984-02-27 | 1985-02-20 | 17-Beta-substituierte-4-aza-5-alpha-Androstenone und ihre Anwendung als 5-Alpha-Reduktase-Inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE67503T1 true ATE67503T1 (de) | 1991-10-15 |
Family
ID=27231354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88119105T ATE67503T1 (de) | 1984-02-27 | 1985-02-20 | 17-beta-substituierte-4-aza-5-alpha-androstenon und ihre anwendung als 5-alpha-reduktaseinhibitoren. |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0314199B1 (de) |
AT (1) | ATE67503T1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120742A (en) * | 1984-02-27 | 1992-06-09 | Merck & Co., Inc. | 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors |
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5151429A (en) * | 1984-02-27 | 1992-09-29 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
CA2023157A1 (en) * | 1989-08-21 | 1991-02-22 | Gary H. Rasmusson | 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
EP0462664A3 (en) * | 1990-06-20 | 1992-11-25 | Merck & Co. Inc. | Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
ES2118222T3 (es) * | 1991-12-20 | 1998-09-16 | Glaxo Wellcome Inc | Inhibidores de 5-alfa-testosterona reductasa. |
WO1993023039A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors |
EP0649431B1 (de) * | 1992-05-20 | 1999-08-11 | Merck & Co. Inc. | 17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren |
WO1993023420A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS |
WO1993023419A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | NEW 7β-SUBSTITUTED-4-AZA-5α-CHOLESTAN-ONES AS 5α-REDUCTASE INHIBITORS |
WO1993023048A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | 4-azasteroid 5-alpha-reductase inhibitors |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
CA2135173A1 (en) * | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | Ester derivatives of 4-aza-steroids |
DE69329240D1 (de) * | 1992-05-20 | 2000-09-21 | Merck & Co Inc | 17-ether und thioether von 4-aza-steroiden |
AU4258493A (en) * | 1992-05-21 | 1993-12-13 | Endorecherche Inc. | Inhibitors of testosterone 5alpha-reductase activity |
US5302589A (en) * | 1992-08-07 | 1994-04-12 | Glaxo, Inc. | Heterocyclic inhibitors of 5-α-testosterone reductase |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
US5621104A (en) * | 1993-03-24 | 1997-04-15 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors |
EP0711164B1 (de) * | 1993-06-28 | 1997-09-17 | Merck & Co. Inc. | 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren |
US5438061A (en) * | 1993-07-16 | 1995-08-01 | Merck & Co., Inc. | 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US5595996A (en) * | 1994-10-25 | 1997-01-21 | Merck & Co., Inc. | 7-substituted 4-aza cholanic acid derivatives and their use |
CN102089486A (zh) | 2008-07-09 | 2011-06-08 | 天空燃料有限公司 | 空间框架连接件 |
WO2010006056A1 (en) | 2008-07-09 | 2010-01-14 | Skyfuel, Inc. | Solar collectors having slidably removable reflective panels for use in solar thermal applications |
US8904774B2 (en) | 2008-08-22 | 2014-12-09 | Skyfuel, Inc. | Hydraulic-based rotational system for solar concentrators that resists high wind loads without a mechanical lock |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU527030B2 (en) * | 1978-04-13 | 1983-02-10 | Merck & Co., Inc. | 4-aza-17-substituted-5a-androstan-3-ones |
-
1985
- 1985-02-20 EP EP88119105A patent/EP0314199B1/de not_active Expired - Lifetime
- 1985-02-20 AT AT88119105T patent/ATE67503T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0314199B1 (de) | 1991-09-18 |
EP0314199A1 (de) | 1989-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |