IN2015DN01119A - - Google Patents

Info

Publication number
IN2015DN01119A
IN2015DN01119A IN1119DEN2015A IN2015DN01119A IN 2015DN01119 A IN2015DN01119 A IN 2015DN01119A IN 1119DEN2015 A IN1119DEN2015 A IN 1119DEN2015A IN 2015DN01119 A IN2015DN01119 A IN 2015DN01119A
Authority
IN
India
Prior art keywords
compounds
disclosed
methods
intermediates
synthesis
Prior art date
Application number
Other languages
English (en)
Inventor
Ende Christopher William Am
Michael Eric Green
Douglas Scott Johnson
Gregory Wayne Kauffman
Christopher John Odonnell
Nandini Chaturbhai Patel
Martin Youngjin Pettersson
Antonia Friederike Stepan
Cory Michael Stiff
Chakrapani Subramanyam
Tuan Phong Tran
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN2015DN01119A publication Critical patent/IN2015DN01119A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
IN1119DEN2015 2012-09-21 2013-09-06 IN2015DN01119A (OSRAM)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21
PCT/IB2013/058347 WO2014045156A1 (en) 2012-09-21 2013-09-06 Novel bicyclic pyridinones

Publications (1)

Publication Number Publication Date
IN2015DN01119A true IN2015DN01119A (OSRAM) 2015-06-26

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1119DEN2015 IN2015DN01119A (OSRAM) 2012-09-21 2013-09-06

Country Status (46)

Country Link
US (3) US8916564B2 (OSRAM)
EP (1) EP2897956B1 (OSRAM)
JP (1) JP5844018B2 (OSRAM)
KR (1) KR101725696B1 (OSRAM)
CN (1) CN104662021B (OSRAM)
AP (1) AP2015008277A0 (OSRAM)
AR (1) AR092628A1 (OSRAM)
AU (1) AU2013319845B2 (OSRAM)
BR (1) BR112015006436A2 (OSRAM)
CA (1) CA2882386C (OSRAM)
CL (1) CL2015000717A1 (OSRAM)
CR (1) CR20150053A (OSRAM)
CU (1) CU20150021A7 (OSRAM)
CY (1) CY1118662T1 (OSRAM)
DK (1) DK2897956T3 (OSRAM)
DO (1) DOP2015000069A (OSRAM)
EA (1) EA026668B1 (OSRAM)
EC (1) ECSP15015594A (OSRAM)
ES (1) ES2609987T3 (OSRAM)
GE (1) GEP201706659B (OSRAM)
GT (1) GT201500069A (OSRAM)
HR (1) HRP20161558T1 (OSRAM)
HU (1) HUE031248T2 (OSRAM)
IL (1) IL237163A (OSRAM)
IN (1) IN2015DN01119A (OSRAM)
LT (1) LT2897956T (OSRAM)
MA (1) MA37886B1 (OSRAM)
MD (1) MD4583B1 (OSRAM)
ME (1) ME02571B (OSRAM)
MX (1) MX360599B (OSRAM)
MY (1) MY181891A (OSRAM)
NI (1) NI201500038A (OSRAM)
NZ (1) NZ704863A (OSRAM)
PE (1) PE20150686A1 (OSRAM)
PH (1) PH12015500376A1 (OSRAM)
PL (1) PL2897956T3 (OSRAM)
PT (1) PT2897956T (OSRAM)
RS (1) RS55426B1 (OSRAM)
SG (1) SG11201501074WA (OSRAM)
SI (1) SI2897956T1 (OSRAM)
TN (1) TN2015000084A1 (OSRAM)
TW (1) TWI500616B (OSRAM)
UA (1) UA110688C2 (OSRAM)
UY (1) UY35039A (OSRAM)
WO (1) WO2014045156A1 (OSRAM)
ZA (1) ZA201501195B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CA2889249C (en) 2012-12-20 2021-02-16 Francois Paul Bischoff Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
WO2014111457A1 (en) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
EP3052495B1 (en) * 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CR20160454A (es) * 2014-04-01 2016-12-06 Pfizer CROMENO Y 1,1 a,2,7b—TETRAHIDROCICLOPROPA[C]CROMENO PIRIDOPIRAZINADIONAS NOVEDOSAS
KR102000382B1 (ko) * 2015-02-03 2019-07-15 화이자 인코포레이티드 신규 시클로프로파벤조푸라닐 피리도피라진디온
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof
WO2017216279A1 (en) 2016-06-16 2017-12-21 F. Hoffmann-La Roche Ag Heteroaryl estrogen receptor modulators and uses thereof
RU2757276C2 (ru) * 2016-12-16 2021-10-12 Пайплайн Терапьютикс, Инк. Способы лечения кохлеарной синаптопатии
CN113164381A (zh) 2018-10-02 2021-07-23 频率医疗公司 有关耳用治疗剂的药物组合物及方法
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
BR112021020141A2 (pt) 2019-04-08 2021-12-21 Frequency Therapeutics Inc Combinação de chir99021 e ácido valpróico para tratamento de perda auditiva
UA130303C2 (uk) 2019-12-06 2026-01-14 Вертекс Фармасьютикалз Інкорпорейтед Заміщені тетрагідрофурани як модулятори натрієвих каналів
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮的制备方法
PE20241335A1 (es) 2021-06-04 2024-07-03 Vertex Pharma N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio
CN114034792B (zh) * 2021-11-09 2024-06-25 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
WO1992000075A1 (en) 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
NO179904C (no) 1992-09-04 1997-01-08 Takeda Chemical Industries Ltd Kondenserte heterocykliske forbindelser og deres anvendelse
EP1308461A3 (en) 1993-01-25 2004-02-11 Takeda Chemical Industries, Ltd. Antibodies to beta-amyloids or their derivatives and use thereof
TW394773B (en) 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
DE69839808D1 (de) 1997-04-09 2008-09-11 Intellect Neurosciences Inc Für die termini des beta-amyloids spezifische, rekombinante antikörper, dafür kodierende dna und verfahren zu ihrer verwendung
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
JP3537394B2 (ja) 1998-03-03 2004-06-14 ピーピージー インダストリーズ オハイオ, インコーポレイテッド 含浸ガラス繊維ストランドおよびそれを含む製品
US20020132817A1 (en) 1998-03-19 2002-09-19 Hideaki Natsugari Heterocyclic compounds, their production and use
CA2352612A1 (en) 1998-11-27 2000-06-08 Hideo Fukui Pharmaceuticals
MXPA02008145A (es) 2000-02-24 2004-04-05 Univ Washington Anticuerpos humanizados que secuestran al peptido beta amiloide.
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
WO2002042429A2 (en) 2000-11-03 2002-05-30 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
JP2005503789A (ja) 2001-08-17 2005-02-10 イーライ・リリー・アンド・カンパニー 抗Aβ抗体
US20030195205A1 (en) 2001-11-02 2003-10-16 Pfizer Inc. PDE9 inhibitors for treating cardiovascular disorders
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
WO2004024078A2 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
BR0315158A (pt) 2002-10-09 2005-08-16 Pfizer Prod Inc Compostos de pirazol para o tratamento de distúrbios neurodegenarativos
PL377769A1 (pl) 2002-10-09 2006-02-20 Rinat Neuroscience Corp. Sposób leczenia choroby Alzheimera z zastosowaniem przeciwciał skierowanych przeciw peptydowi beta amyloidu i ich kompozycje
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
BRPI0410630A (pt) 2003-06-19 2006-06-13 Pfizer Prod Inc antagonista de nk1
EP1658072A4 (en) 2003-08-21 2009-03-25 Pfizer Prod Inc Compounds for the Treatment of Neurodegenerative Diseases
EP1666061A1 (en) 2003-09-09 2006-06-07 Takeda Pharmaceutical Company Limited Use of antibody
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
EP1718152A4 (en) 2004-01-28 2009-09-16 Merck & Co Inc AMINOCYCLOPENTYLPYRIDOPYRAZINONE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
BRPI0507374A (pt) 2004-02-02 2007-07-10 Pfizer Prod Inc moduladores do receptor de histamina-3
AU2005227258A1 (en) 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
AU2005225635B2 (en) 2004-03-23 2010-06-24 Pfizer Products Inc. Imidazole compounds for the treatment of neurodegenerative disorders
PL1742642T3 (pl) 2004-04-14 2009-06-30 Gilead Sciences Inc Analogi fosfonianowe związków inhibitorów integrazy HIV
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
US7807165B2 (en) 2004-07-30 2010-10-05 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
GB0423356D0 (en) 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
FR2877015B1 (fr) 2004-10-21 2007-10-26 Commissariat Energie Atomique Revetement nanostructure et procede de revetement.
WO2006069081A2 (en) 2004-12-22 2006-06-29 Washington University In St. Louis USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
UY29504A1 (es) 2005-04-29 2006-10-31 Rinat Neuroscience Corp Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
CA2607151C (en) 2005-05-10 2012-06-19 Merck & Co., Inc. Hiv integrase inhibitors
PT1881985E (pt) 2005-05-12 2011-02-01 Pfizer Formas cristalinas anidras de n-[1-(2-etoxietil)-5-(n- -etil-n-metilamino)-7-(4-metilpiridin-2-il-amino)-1h- -pirazolo[4,3-d]pirimidino-3-carbonil]metanossulfonamida
WO2006126082A2 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
CA2603830A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Co Llc PYRIDINE [2,3-B] PYRAZINONES
WO2006126083A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
JP2008543923A (ja) 2005-06-22 2008-12-04 ファイザー・プロダクツ・インク ヒスタミン−3受容体アンタゴニスト
US20070060534A1 (en) 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
WO2007052124A1 (en) 2005-11-04 2007-05-10 Pfizer Limited Tetrahydronaphthyridine derivative
EP1957465A4 (en) 2005-11-18 2009-04-08 Glaxo Group Ltd NEW INTERMEDIATE PRODUCTS AND THEIR USE
WO2007061923A2 (en) 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
JP5221144B2 (ja) 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
WO2007063385A2 (en) 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
WO2007069053A1 (en) 2005-12-14 2007-06-21 Pfizer Products Inc. Benzimidazole antagonists of the h-3 receptor
PE20071321A1 (es) 2006-01-20 2007-12-29 Schering Corp Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
WO2007088462A1 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Spirochromane antagonists of the h-3 receptor
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US20090163482A1 (en) 2006-03-13 2009-06-25 Mchardy Stanton Furst Tetralines antagonists of the h-3 receptor
WO2007122466A1 (en) 2006-04-21 2007-11-01 Pfizer Products Inc. Pyridine[3,4-b]pyrazinones
JP5271895B2 (ja) 2006-05-15 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション 抗糖尿病性の二環式化合物
EP2066670A2 (en) 2006-05-16 2009-06-10 Gilead Sciences, Inc. Integrase inhibitors
JPWO2007135969A1 (ja) 2006-05-19 2009-10-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア系−シンナミド誘導体
WO2007138431A2 (en) 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
ES2395744T3 (es) 2007-01-22 2013-02-14 Pfizer Products Inc. Sal de tosilato de un compuesto terapéutico y sus composiciones farmacéuticas
EP2120573A4 (en) 2007-02-12 2011-05-25 Merck Sharp & Dohme piperidine
EP2121633A2 (en) 2007-02-12 2009-11-25 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
PE20081791A1 (es) 2007-02-28 2009-02-07 Eisai Randd Man Co Ltd Dos derivados ciclicos de oxomorfolina
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
EP2155737A1 (en) 2007-05-07 2010-02-24 Schering Corporation Gamma secretase modulators
JP5264890B2 (ja) 2007-05-11 2013-08-14 エフ.ホフマン−ラ ロシュ アーゲー アミロイドベータの調節剤としてのヘタリールアニリン
TW200908968A (en) 2007-05-29 2009-03-01 Sgx Pharmaceuticals Inc Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
BRPI0812491A2 (pt) 2007-06-01 2014-12-02 Schering Corp Moduladores de gama secretase
CA2689948A1 (en) 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
US8242150B2 (en) 2007-06-13 2012-08-14 Merck Sharp & Dohme Corp. Triazole derivatives for treating alzheimer'S disease and related conditions
EP2178857A1 (en) 2007-06-29 2010-04-28 Schering Corporation Gamma secretase modulators
CA2695543A1 (en) 2007-08-06 2009-02-12 Schering Corporation Gamma secretase modulators
KR20100055456A (ko) 2007-08-31 2010-05-26 에자이 알앤드디 매니지먼트 가부시키가이샤 다환식 화합물
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
CA2698341A1 (en) 2007-09-06 2009-03-12 Schering Corporation Gamma secretase modulators
EP2205567A1 (en) 2007-09-28 2010-07-14 Schering Corporation Gamma secretase modulators
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
JP2011503002A (ja) 2007-11-05 2011-01-27 シェーリング コーポレイション γセクレターゼ調節剤
CN101939312A (zh) 2007-12-06 2011-01-05 先灵公司 γ分泌酶调节剂
EP2268636A1 (en) 2007-12-11 2011-01-05 Schering Corporation Gamma secretase modulators
MX2010006378A (es) 2007-12-11 2010-09-07 Schering Corp Moduladores de gamma secretasa.
MX2010006046A (es) 2007-12-13 2010-06-23 Amgen Inc Moduladores de gamma secretasa.
WO2009087127A1 (en) 2008-01-11 2009-07-16 F. Hoffmann-La Roche Ag Modulators for amyloid beta
JP5328816B2 (ja) 2008-02-22 2013-10-30 エフ.ホフマン−ラ ロシュ アーゲー アミロイドβの調節薬
US20110027264A1 (en) 2008-02-29 2011-02-03 Xianhai Huang Gamma secretase modulators for the treatment of alzheimer's disease
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
JP2011520809A (ja) 2008-05-05 2011-07-21 アムジエン・インコーポレーテツド γセクレターゼモジュレーターとしての尿素化合物
FR2933700B1 (fr) * 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
WO2010019392A1 (en) 2008-08-13 2010-02-18 Merck Sharp & Dohme Corp. Purine derivatives for treatment of alzheimer's disease
WO2010019393A1 (en) 2008-08-13 2010-02-18 Merck Sharp & Dohme Corp. Pyrimidine derivatives for treatment of alzheimer's disease
RU2011111534A (ru) 2008-08-27 2012-10-10 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Способ получения определенных цинниамидных соединений
MX2011003246A (es) 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
CA2742602A1 (en) 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
EP2356124A1 (en) 2008-11-06 2011-08-17 Schering Corporation Gamma secretase modulators
CN102272133A (zh) 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 淀粉样β的调节剂
WO2010052199A1 (en) 2008-11-10 2010-05-14 F. Hoffmann-La Roche Ag Heterocyclic gamma secretase modulators
EP2379075A4 (en) 2008-12-16 2012-05-30 Merck Sharp & Dohme TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
WO2010071741A1 (en) 2008-12-16 2010-06-24 Merck Sharp & Dohme Corp. Triazole derivatives for treatment of alzheimer's disease
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
EP2379525B1 (en) 2008-12-19 2015-07-29 Boehringer Ingelheim International GmbH Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
US20120135980A1 (en) 2008-12-22 2012-05-31 Theodros Asberom Gamma secretase modulators
WO2010075203A1 (en) 2008-12-22 2010-07-01 Schering Corporation Gamma secretase modulators
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
KR20110113197A (ko) 2009-02-06 2011-10-14 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012121809A (ja) 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
KR20110118626A (ko) 2009-02-26 2011-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 테트라하이드로트리아졸로피리딘 유도체의 염과 이의 결정
CA2751534A1 (en) 2009-03-03 2010-09-10 Pfizer Inc. Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
AP3534A (en) 2009-08-07 2016-01-13 Dow Agrosciences Llc Pesticidal compositions
US20120202787A1 (en) * 2009-10-20 2012-08-09 Pfizer Inc. Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
US20120040950A1 (en) * 2009-12-22 2012-02-16 Vertex Pharmaceuticals Incorporated Isoindolinone inhibitors of phosphatidylinositol 3-kinase
EP2691393B1 (en) * 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
KR102096625B1 (ko) * 2012-05-16 2020-04-03 얀센 파마슈티칼즈, 인코포레이티드 (무엇보다도) 알츠하이머병의 치료에 유용한 치환 3,4-디하이드로-2h-피리도[1,2-a]피라진-1,6-디온 유도체
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
CA2889249C (en) 2012-12-20 2021-02-16 Francois Paul Bischoff Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
WO2014111457A1 (en) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
EP3052495B1 (en) 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
US11497586B2 (en) 2014-03-21 2022-11-15 Align Technology, Inc. Segmented orthodontic appliance with elastics
CR20160454A (es) 2014-04-01 2016-12-06 Pfizer CROMENO Y 1,1 a,2,7b—TETRAHIDROCICLOPROPA[C]CROMENO PIRIDOPIRAZINADIONAS NOVEDOSAS

Also Published As

Publication number Publication date
TWI500616B (zh) 2015-09-21
IL237163A0 (en) 2015-04-30
HK1206013A1 (zh) 2015-12-31
GEP201706659B (en) 2017-04-25
MA37886B1 (fr) 2016-09-30
US20150072990A1 (en) 2015-03-12
PH12015500376B1 (en) 2015-04-20
EA201590319A1 (ru) 2015-09-30
RS55426B1 (sr) 2017-04-28
ECSP15015594A (es) 2017-08-31
MX2015003637A (es) 2015-06-05
AU2013319845A1 (en) 2015-02-26
TW201425311A (zh) 2014-07-01
UY35039A (es) 2014-04-30
EP2897956B1 (en) 2016-11-09
NZ704863A (en) 2017-03-31
CU20150021A7 (es) 2015-08-27
US9751877B2 (en) 2017-09-05
EA026668B1 (ru) 2017-05-31
PT2897956T (pt) 2017-01-13
TN2015000084A1 (fr) 2016-06-29
EP2897956A1 (en) 2015-07-29
MD20150023A2 (ro) 2015-07-31
AR092628A1 (es) 2015-04-29
US20140088111A1 (en) 2014-03-27
CA2882386A1 (en) 2014-03-27
ES2609987T3 (es) 2017-04-25
JP5844018B2 (ja) 2016-01-13
JP2015529238A (ja) 2015-10-05
GT201500069A (es) 2016-03-01
CN104662021B (zh) 2016-08-24
US9193726B2 (en) 2015-11-24
MA37886A1 (fr) 2016-02-29
SG11201501074WA (en) 2015-05-28
PH12015500376A1 (en) 2015-04-20
ME02571B (me) 2017-06-20
US8916564B2 (en) 2014-12-23
CA2882386C (en) 2017-11-28
WO2014045156A1 (en) 2014-03-27
KR101725696B1 (ko) 2017-04-10
DOP2015000069A (es) 2015-05-15
PE20150686A1 (es) 2015-05-23
CR20150053A (es) 2015-03-25
MX360599B (es) 2018-11-08
US20160024088A1 (en) 2016-01-28
NI201500038A (es) 2015-06-05
IL237163A (en) 2016-12-29
CN104662021A (zh) 2015-05-27
UA110688C2 (uk) 2016-01-25
BR112015006436A2 (pt) 2017-07-04
KR20150044948A (ko) 2015-04-27
HUE031248T2 (en) 2017-06-28
CY1118662T1 (el) 2017-07-12
MD4583B1 (ro) 2018-07-31
LT2897956T (lt) 2017-01-10
CL2015000717A1 (es) 2015-06-19
AU2013319845B2 (en) 2017-09-14
PL2897956T3 (pl) 2017-05-31
DK2897956T3 (en) 2017-01-16
AP2015008277A0 (en) 2015-02-28
HRP20161558T1 (hr) 2016-12-30
SI2897956T1 (sl) 2017-02-28
ZA201501195B (en) 2016-01-27
MY181891A (en) 2021-01-12

Similar Documents

Publication Publication Date Title
IN2015DN01119A (OSRAM)
IN2014MN02598A (OSRAM)
IN2012DN03182A (OSRAM)
UA113541C2 (xx) Заміщені піролідин-2-карбоксаміди
PH12014501514A1 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
IN2014DN09434A (OSRAM)
IN2014DN09352A (OSRAM)
IN2015DN01156A (OSRAM)
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
IN2014DN09348A (OSRAM)
EA201390381A1 (ru) Триазиноксадиазолы
PH12013501600A1 (en) Novel heterocyclic derivatives
IN2014CN04530A (OSRAM)
EA201500298A1 (ru) Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы
PH12013500007A1 (en) Piperidine derivatives and their use for the treatment of metabolic disorders
WO2014045162A8 (en) ALKYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-d] [1,3]THIAZIN-2-AMINE COMPOUNDS
MX2012013274A (es) Novedosos derivados de la pirimidina.
IN2015DN01151A (OSRAM)
GB201209587D0 (en) Therapeutic compounds
MX340574B (es) Imidazo pirazinas.
IN2014DN09347A (OSRAM)
WO2012135615A3 (en) Enopeptins, uses thereof, and methods of synthesis thereto
MX2013008340A (es) Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer.
IN2013DN02555A (OSRAM)
PH12015500399A1 (en) Azaindolines