|
GB1419788A
(en)
|
1972-08-02 |
1975-12-31 |
Pfizer |
Herbicidal method using 2-trifuluromethyl-4-quinolinols
|
|
WO1992000075A1
(en)
|
1990-06-29 |
1992-01-09 |
Pfizer Inc. |
Pyridopyrazine derivatives for treating substance abuse and addiction
|
|
NO179904C
(no)
|
1992-09-04 |
1997-01-08 |
Takeda Chemical Industries Ltd |
Kondenserte heterocykliske forbindelser og deres anvendelse
|
|
EP0683234B2
(en)
|
1993-01-25 |
2007-06-06 |
Takeda Chemical Industries, Ltd. |
Antibody against beta-amyloid or their derivative and use thereof
|
|
ES2194937T3
(es)
|
1995-03-24 |
2003-12-01 |
Takeda Chemical Industries Ltd |
Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina.
|
|
DE19709877A1
(de)
|
1997-03-11 |
1998-09-17 |
Bayer Ag |
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
|
|
DK0994728T3
(da)
|
1997-04-09 |
2008-12-01 |
Intellect Neurosciences Inc |
Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf
|
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US6743427B1
(en)
|
1997-12-02 |
2004-06-01 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
JP3537394B2
(ja)
|
1998-03-03 |
2004-06-14 |
ピーピージー インダストリーズ オハイオ， インコーポレイテッド |
含浸ガラス繊維ストランドおよびそれを含む製品
|
|
US20020132817A1
(en)
|
1998-03-19 |
2002-09-19 |
Hideaki Natsugari |
Heterocyclic compounds, their production and use
|
|
AU1409100A
(en)
|
1998-11-27 |
2000-06-19 |
Takeda Chemical Industries Ltd. |
Drugs
|
|
EP1257584B2
(en)
|
2000-02-24 |
2013-03-06 |
Washington University St. Louis |
Humanized antibodies that sequester amyloid beta peptide
|
|
DE10045112A1
(de)
|
2000-09-11 |
2002-03-21 |
Merck Patent Gmbh |
Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
|
|
NZ544691A
(en)
|
2000-11-03 |
2007-12-21 |
Proteotech Inc |
Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
|
|
CA2451998A1
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
Anti-a.beta. antibodies
|
|
US20030195205A1
(en)
|
2001-11-02 |
2003-10-16 |
Pfizer Inc. |
PDE9 inhibitors for treating cardiovascular disorders
|
|
DE10238724A1
(de)
|
2002-08-23 |
2004-03-04 |
Bayer Ag |
Alkyl-substituierte Pyrazolpyrimidine
|
|
DE10238723A1
(de)
|
2002-08-23 |
2004-03-11 |
Bayer Ag |
Phenyl-substituierte Pyrazolyprimidine
|
|
CA2498111A1
(en)
|
2002-09-11 |
2004-03-25 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
|
|
KR20050071564A
(ko)
|
2002-10-09 |
2005-07-07 |
리나트 뉴로사이언스 코퍼레이션 |
아밀로이드 베타 펩티드에 대한 항체를 사용하여알츠하이머병을 치료하는 방법 및 그의 조성물
|
|
WO2004033434A1
(en)
|
2002-10-09 |
2004-04-22 |
Pfizer Products Inc. |
Pyrazole compounds for treatment of neurodegenerative disorders
|
|
AU2003301439A1
(en)
|
2002-10-16 |
2004-05-04 |
Gilead Sciences, Inc. |
Pre-organized tricyclic integrase inhibitor compounds
|
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
JP2006527756A
(ja)
|
2003-06-19 |
2006-12-07 |
ファイザー・プロダクツ・インク |
Ｎｋ１拮抗薬
|
|
CA2534532A1
(en)
|
2003-08-21 |
2005-03-10 |
Pfizer Products, Inc. |
Compounds for the treatment of neurodegenerative disorders
|
|
EP1666061A1
(en)
|
2003-09-09 |
2006-06-07 |
Takeda Pharmaceutical Company Limited |
Use of antibody
|
|
GB0327319D0
(en)
|
2003-11-24 |
2003-12-24 |
Pfizer Ltd |
Novel pharmaceuticals
|
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
JP2007519734A
(ja)
|
2004-01-28 |
2007-07-19 |
メルク エンド カムパニー インコーポレーテッド |
アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
|
|
EP1720847A1
(en)
|
2004-02-02 |
2006-11-15 |
Pfizer Products Incorporated |
Histamine-3 receptor modulators
|
|
JP2007528394A
(ja)
|
2004-03-09 |
2007-10-11 |
メルク エンド カムパニー インコーポレーテッド |
Ｈｉｖインテグラーゼ阻害薬
|
|
CA2560580C
(en)
|
2004-03-23 |
2008-12-23 |
Pfizer Products Inc. |
Imidazole compounds for inhibition of a.beta.-peptide production and for modulation of the notch signaling pathway
|
|
SI1742642T1
(sl)
|
2004-04-14 |
2009-04-30 |
Gilead Sciences Inc |
Fosfonatni analogi inhibitorskih spojin HIV integraze
|
|
US7456164B2
(en)
|
2004-05-07 |
2008-11-25 |
Pfizer, Inc |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
|
|
EP1595881A1
(en)
|
2004-05-12 |
2005-11-16 |
Pfizer Limited |
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
|
|
EA016357B1
(ru)
|
2004-07-30 |
2012-04-30 |
Ринат Ньюросайенс Корп. |
Антитела, направленные против бета-амилоидного пептида, и способы их применения
|
|
FR2877015B1
(fr)
|
2004-10-21 |
2007-10-26 |
Commissariat Energie Atomique |
Revetement nanostructure et procede de revetement.
|
|
GB0423356D0
(en)
|
2004-10-21 |
2004-11-24 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US20090074775A1
(en)
|
2004-12-22 |
2009-03-19 |
David Michael Holtzman |
Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
|
|
UY29504A1
(es)
|
2005-04-29 |
2006-10-31 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
|
|
WO2006121831A2
(en)
|
2005-05-10 |
2006-11-16 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
BRPI0609225A2
(pt)
|
2005-05-12 |
2010-03-09 |
Pfizer |
formas cristalinas anidras de n-[1-(2-etoxietil)-5-(n-etil-n-metilamino)-7-(4-metilpiridi n-2-il-amino)-1h-pirazolo[4,3-d]pirimidina-3-carbonil] metanossulfonamida, composição farmacêutica compreendendo as mesmas e uso das mesmas
|
|
WO2006126081A2
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
|
|
CA2608672A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
|
|
WO2006126083A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
|
|
ES2354569T3
(es)
|
2005-06-22 |
2011-03-16 |
Pfizer Products Inc. |
Antagonistas del receptor de histamina-3.
|
|
US20070060534A1
(en)
|
2005-06-30 |
2007-03-15 |
Threshold Pharmaceuticals, Inc. |
Anthracycline analogs
|
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
|
CA2624625A1
(en)
|
2005-11-04 |
2007-05-10 |
Pfizer Limited |
Tetrahydronaphthyridine derivative
|
|
JP2009516703A
(ja)
|
2005-11-18 |
2009-04-23 |
グラクソ グループ リミテッド |
新規中間体およびその使用
|
|
JP2009515997A
(ja)
|
2005-11-18 |
2009-04-16 |
タケダ サン ディエゴ インコーポレイテッド |
グルコキナーゼ活性剤
|
|
TWI386207B
(zh)
|
2005-11-24 |
2013-02-21 |
Eisai R&D Man Co Ltd |
味啉類型之肉桂醯胺化合物
|
|
US20070117839A1
(en)
|
2005-11-24 |
2007-05-24 |
Eisai R&D Management Co., Ltd. |
Two cyclic cinnamide compound
|
|
WO2007063385A2
(en)
|
2005-12-01 |
2007-06-07 |
Pfizer Products Inc. |
Spirocyclic amine histamine-3 receptor antagonists
|
|
WO2007069053A1
(en)
|
2005-12-14 |
2007-06-21 |
Pfizer Products Inc. |
Benzimidazole antagonists of the h-3 receptor
|
|
EP1976843B1
(en)
*
|
2006-01-20 |
2013-09-04 |
Merck Sharp & Dohme Corp. |
Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
|
|
WO2007088462A1
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Spirochromane antagonists of the h-3 receptor
|
|
WO2007088450A2
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Chromane antagonist of the h-3 receptor
|
|
WO2007099423A1
(en)
|
2006-03-02 |
2007-09-07 |
Pfizer Products Inc. |
1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
|
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
|
JP2009539762A
(ja)
|
2006-03-13 |
2009-11-19 |
ファイザー・プロダクツ・インク |
Ｈ３受容体のテトラリン拮抗薬
|
|
ES2366239T3
(es)
|
2006-04-21 |
2011-10-18 |
Pfizer Products Inc. |
Piridin[3,4-b]pirazinonas.
|
|
ATE552245T1
(de)
|
2006-05-15 |
2012-04-15 |
Merck Sharp & Dohme |
Antidiabetische bicyclische verbindungen
|
|
NZ572367A
(en)
|
2006-05-16 |
2011-09-30 |
Gilead Sciences Inc |
Fused cyclic compounds as integrase inhibitors
|
|
JPWO2007135969A1
(ja)
|
2006-05-19 |
2009-10-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ウレア系−シンナミド誘導体
|
|
WO2007138431A2
(en)
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Azabicyclic ether histamine-3 antagonists
|
|
WO2008090429A1
(en)
|
2007-01-22 |
2008-07-31 |
Pfizer Products Inc. |
Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
|
|
JP2010518064A
(ja)
|
2007-02-12 |
2010-05-27 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Ａｄおよび関連状態の治療のためのピペラジン誘導体
|
|
JP2010518083A
(ja)
|
2007-02-12 |
2010-05-27 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピペリジン誘導体
|
|
PE20081791A1
(es)
|
2007-02-28 |
2009-02-07 |
Eisai Randd Man Co Ltd |
Dos derivados ciclicos de oxomorfolina
|
|
WO2008137102A2
(en)
|
2007-05-04 |
2008-11-13 |
Torreypines Therapeutics, Inc. |
Methods of modulating amyloid beta and compounds useful therefor
|
|
AU2008248129B8
(en)
|
2007-05-07 |
2013-05-30 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
BRPI0811993A2
(pt)
|
2007-05-11 |
2014-11-18 |
Hoffmann La Roche |
" hetarilanilinas como moduladores para beta-amiloide ".
|
|
TW200908968A
(en)
|
2007-05-29 |
2009-03-01 |
Sgx Pharmaceuticals Inc |
Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
|
|
US8580956B2
(en)
|
2007-06-01 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
CA2689948A1
(en)
|
2007-06-01 |
2008-12-18 |
Schering Corporation |
Gamma secretase modulators
|
|
WO2008156580A1
(en)
|
2007-06-13 |
2008-12-24 |
Merck & Co., Inc. |
Triazole derivatives for treating alzheimer's disease and related conditions
|
|
US20110053918A1
(en)
|
2007-06-29 |
2011-03-03 |
Zhaoning Zhu |
Gamma secretase modulators
|
|
US20110009392A1
(en)
|
2007-08-06 |
2011-01-13 |
Schering Corporation |
Gamma secretase modulators
|
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
|
CA2694401C
(en)
|
2007-08-31 |
2012-12-04 |
Eisai R&D Management Co., Ltd. |
Polycyclic compound
|
|
MX2010002674A
(es)
|
2007-09-06 |
2010-03-25 |
Schering Corp |
Moduladores de gamma secretasa.
|
|
US20100298381A1
(en)
|
2007-09-28 |
2010-11-25 |
Schering Corporation |
Gamma secretase modulators
|
|
GB0720444D0
(en)
|
2007-10-18 |
2007-11-28 |
Glaxo Group Ltd |
Novel compounds
|
|
MX2010005028A
(es)
|
2007-11-05 |
2010-05-27 |
Schering Corp |
Moduladores de gamma secretasa.
|
|
EP2229375A1
(en)
|
2007-12-06 |
2010-09-22 |
Schering Corporation |
Gamma secretase modulators
|
|
US20100298372A1
(en)
|
2007-12-11 |
2010-11-25 |
Schering Corporation |
Gamma secretase modulators
|
|
WO2009076352A1
(en)
|
2007-12-11 |
2009-06-18 |
Schering Corporation |
Gamma secretase modulators
|
|
MX2010006046A
(es)
|
2007-12-13 |
2010-06-23 |
Amgen Inc |
Moduladores de gamma secretasa.
|
|
RU2010132728A
(ru)
|
2008-01-11 |
2012-02-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Модуляторы бета-амилоида
|
|
CA2713716A1
(en)
|
2008-02-22 |
2009-08-27 |
F. Hoffmann-La Roche Ag |
Modulators for amyloid beta
|
|
US20100137320A1
(en)
|
2008-02-29 |
2010-06-03 |
Schering Corporation |
Gamma secretase modulators
|
|
CA2716747A1
(en)
|
2008-02-29 |
2009-09-03 |
Schering Corporation |
Gamma secretase modulators for the treatment of alzheimer's disease
|
|
AU2009244504A1
(en)
|
2008-05-05 |
2009-11-12 |
Amgen Inc. |
Urea compounds as gamma secretase modulators
|
|
FR2933700B1
(fr)
*
|
2008-07-08 |
2010-07-30 |
Sanofi Aventis |
Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
|
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
|
WO2010019392A1
(en)
|
2008-08-13 |
2010-02-18 |
Merck Sharp & Dohme Corp. |
Purine derivatives for treatment of alzheimer's disease
|
|
WO2010019393A1
(en)
|
2008-08-13 |
2010-02-18 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives for treatment of alzheimer's disease
|
|
CA2733606A1
(en)
|
2008-08-27 |
2010-03-04 |
Eisai R&D Management Co., Ltd. |
Process for preparing certain cinnamide compounds
|
|
MX2011003246A
(es)
|
2008-10-09 |
2011-04-21 |
Hoffmann La Roche |
Moduladores de beta amiloide.
|
|
EP2367826A4
(en)
|
2008-11-06 |
2012-07-04 |
Astrazeneca Ab |
MODULATORS OF THE PROTEIN -AMYLOID
|
|
CA2742602A1
(en)
|
2008-11-06 |
2010-05-14 |
Schering Corporation |
Gamma secretase modulators
|
|
US20110263529A1
(en)
|
2008-11-06 |
2011-10-27 |
Ruo Xu |
Gamma secretase modulators
|
|
JP5378532B2
(ja)
|
2008-11-10 |
2013-12-25 |
エフ．ホフマン−ラ ロシュ アーゲー |
複素環γ−セクレターゼモジュレーター
|
|
WO2010077582A1
(en)
|
2008-12-16 |
2010-07-08 |
Merck Sharp & Dohme Corp. |
Triazole derivatives for treatment of alzheimer's disease
|
|
EP2378879A4
(en)
|
2008-12-16 |
2012-06-06 |
Merck Sharp & Dohme |
TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
|
|
PA8854101A1
(es)
|
2008-12-18 |
2010-07-27 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
|
|
WO2010070032A1
(en)
|
2008-12-19 |
2010-06-24 |
Boehringer Ingelheim International Gmbh |
Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
|
|
AU2009330233A1
(en)
|
2008-12-22 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
AU2009330234A1
(en)
|
2008-12-22 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
TW201030002A
(en)
|
2009-01-16 |
2010-08-16 |
Bristol Myers Squibb Co |
Bicyclic compounds for the reduction of beta-amyloid production
|
|
CN102325765B
(zh)
|
2009-02-06 |
2014-12-24 |
杨森制药公司 |
作为γ-分泌酶调节剂的取代的双环杂环化合物
|
|
TWI461425B
(zh)
|
2009-02-19 |
2014-11-21 |
Janssen Pharmaceuticals Inc |
作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
|
|
JP2012121809A
(ja)
|
2009-02-26 |
2012-06-28 |
Eisai R & D Management Co Ltd |
多環式化合物の製造法およびその中間体
|
|
JP2012051805A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
テトラヒドロトリアゾロピリジン誘導体の製造方法
|
|
MX2011006782A
(es)
|
2009-02-26 |
2011-07-20 |
Eisai R&D Man Co Ltd |
Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma.
|
|
JP2012051807A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
アリールイミダゾール化合物
|
|
JP2012051806A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
イミダゾリルピラジン誘導体
|
|
US20120053165A1
(en)
|
2009-03-03 |
2012-03-01 |
Pfizer Inc. |
Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
|
|
UA108208C2
(xx)
|
2009-08-07 |
2015-04-10 |
|
Пестицидні композиції
|
|
WO2011048525A1
(en)
*
|
2009-10-20 |
2011-04-28 |
Pfizer Inc. |
Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
|
|
US20120040950A1
(en)
*
|
2009-12-22 |
2012-02-16 |
Vertex Pharmaceuticals Incorporated |
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
ES2602794T3
(es)
|
2011-03-31 |
2017-02-22 |
Pfizer Inc |
Piridinonas bicíclicas novedosas
|
|
NZ702611A
(en)
*
|
2012-05-16 |
2016-10-28 |
Cellzome Ltd |
Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer’s disease
|
|
UA110688C2
(uk)
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
TWI614238B
(zh)
|
2012-09-21 |
2018-02-11 |
必治妥美雅史谷比公司 |
雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
|
|
JP6275161B2
(ja)
|
2012-12-20 |
2018-02-07 |
ヤンセン ファーマシューティカ エヌ．ベー． |
γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
|
|
HK1212346A1
(en)
|
2013-01-17 |
2016-06-10 |
Janssen Pharmaceutica Nv |
Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
|
|
JP6425717B2
(ja)
|
2013-10-04 |
2018-11-21 |
ファイザー・インク |
ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
|
|
WO2015140614A1
(en)
|
2014-03-21 |
2015-09-24 |
Align Technology, Inc. |
Segmented orthodontic appliance with elastics
|
|
DK3126361T3
(da)
|
2014-04-01 |
2020-01-02 |
Pfizer |
Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer
|