BRPI0812170A8 - Moduladores de gama secretase - Google Patents
Moduladores de gama secretaseInfo
- Publication number
- BRPI0812170A8 BRPI0812170A8 BRPI0812170A BRPI0812170A BRPI0812170A8 BR PI0812170 A8 BRPI0812170 A8 BR PI0812170A8 BR PI0812170 A BRPI0812170 A BR PI0812170A BR PI0812170 A BRPI0812170 A BR PI0812170A BR PI0812170 A8 BRPI0812170 A8 BR PI0812170A8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- secretase
- methods
- modulators
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MODULADORES DE GAMA SECRETASE. Em suas muitas modalidades, a presente invenção fornece uma nova classe de compostos heterocíclicos da formula: Fórmula I como moduladores de gama secretase, métodos de preparação de tais compostos, composições farmacêuticas contendo um ou mais de tais compostos, métodos de preparação de formulações farmacêuticas compreendendo um ou mais de tais compostos, e métodos de tratamento, prevenção, inibição, ou melhora de uma ou mais doenças associadas com um sistema nervoso central usando tais compostos ou composições farmacêuticas não entram na inicial.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94140507P | 2007-06-01 | 2007-06-01 | |
US98448407P | 2007-11-01 | 2007-11-01 | |
PCT/US2008/006734 WO2008153793A2 (en) | 2007-06-01 | 2008-05-28 | Gamma secretase modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0812170A2 BRPI0812170A2 (pt) | 2014-12-02 |
BRPI0812170A8 true BRPI0812170A8 (pt) | 2016-02-10 |
Family
ID=40084164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0812170A BRPI0812170A8 (pt) | 2007-06-01 | 2008-05-28 | Moduladores de gama secretase |
Country Status (18)
Country | Link |
---|---|
US (1) | US8426403B2 (pt) |
EP (1) | EP2152695A2 (pt) |
JP (1) | JP5495331B2 (pt) |
KR (1) | KR20100037053A (pt) |
CN (1) | CN101809016A (pt) |
AR (1) | AR066152A1 (pt) |
AU (1) | AU2008263207B2 (pt) |
BR (1) | BRPI0812170A8 (pt) |
CA (1) | CA2689948A1 (pt) |
CL (1) | CL2008001560A1 (pt) |
CO (1) | CO6241123A2 (pt) |
EC (1) | ECSP099776A (pt) |
IL (1) | IL202315A0 (pt) |
MX (1) | MX2009013131A (pt) |
PE (1) | PE20090363A1 (pt) |
RU (1) | RU2009148866A (pt) |
TW (1) | TW200914459A (pt) |
WO (1) | WO2008153793A2 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2117311A4 (en) * | 2007-02-08 | 2011-05-11 | Merck Sharp & Dohme | THERAPEUTICS |
AU2009313538A1 (en) * | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
CA2742472A1 (en) * | 2008-11-13 | 2010-05-20 | Schering Corporation | Gamma secretase modulators |
MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
WO2010075204A2 (en) * | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
WO2010147975A1 (en) * | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
US20120238546A1 (en) * | 2009-06-16 | 2012-09-20 | Zhaoning Zhu | Gamma secretase modulators |
US20120232108A1 (en) * | 2009-06-16 | 2012-09-13 | Xianhai Huang | Gamma secretase modulators |
JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
JP5767393B2 (ja) | 2011-03-31 | 2015-08-19 | ファイザー・インク | 新規二環式ピリジノン |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US9598437B2 (en) | 2013-12-04 | 2017-03-21 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
DK3253755T3 (da) | 2015-02-03 | 2020-09-28 | Pfizer | Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner |
US20230137562A1 (en) | 2017-06-07 | 2023-05-04 | Adrx, Inc. | Tau aggregation inhibitors |
CA3073062A1 (en) | 2017-08-18 | 2019-02-21 | Adrx, Inc. | Tau aggregation peptide inhibitors |
EP3760619B1 (en) | 2018-02-28 | 2023-10-25 | Japan Tobacco Inc. | Saturated ring-condensed dihydropyrimidinone or dihydrotriazinone compound, and pharmaceutical use thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1065324A (en) | 1974-05-13 | 1979-10-30 | E.R. Squibb And Sons | 2-aminoalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(phenylmethylene)-2h-indazoles and related cyclohepta (c) pyrazoles and cyclopentapyrazoles |
CH594667A5 (en) | 1974-05-31 | 1978-01-13 | Squibb & Sons Inc | Hexahydro-2H-pyrazolo(4,3-C) pyridine derivs |
US3979381A (en) | 1975-08-11 | 1976-09-07 | E. R. Squibb & Sons, Inc. | Thiopyrano[4,3-c] pyrazoles |
US4003890A (en) * | 1976-05-27 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Benzylidene pyrano[4,3-c]pyrazoles |
US4065617A (en) * | 1977-02-04 | 1977-12-27 | E. R. Squibb & Sons, Inc. | 2-(2,2,2,-Trifluoroethyl)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridines |
AU757290B2 (en) * | 1998-03-25 | 2003-02-13 | Bristol-Myers Squibb Company | Imidazolone anorectic agents: II. phenyl derivatives |
ES2220753T3 (es) * | 2000-03-20 | 2004-12-16 | N-Gene Research Laboratories Inc. | Derivados de amidoxina del acido propencarboxilico, procedimiento para su preparacion, y composiciones farmaceuticas que los contienen. |
EP1603548A4 (en) | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS |
JP4847868B2 (ja) | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
WO2006001877A2 (en) | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
JP2007538024A (ja) | 2004-05-19 | 2007-12-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミロイドベータペプチドのレベル変化に関連する疾患及び状態の治療方法及び新規エノールカルボキサミド化合物 |
MXPA06013534A (es) * | 2004-05-26 | 2007-05-10 | Eisai R&D Man Co Ltd | Compuesto de cinamida. |
EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
BRPI0618814A2 (pt) * | 2005-11-24 | 2014-04-29 | Eisai R&D Man Co Ltd | Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico |
KR101464651B1 (ko) * | 2006-03-09 | 2014-11-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 다환식 신나미드 유도체 |
KR20100017573A (ko) | 2007-05-07 | 2010-02-16 | 쉐링 코포레이션 | 감마 세크레타제 조정인자 |
KR20100021633A (ko) | 2007-06-01 | 2010-02-25 | 쉐링 코포레이션 | 감마 세크레타제 조절인자 |
MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
-
2008
- 2008-05-28 RU RU2009148866/04A patent/RU2009148866A/ru not_active Application Discontinuation
- 2008-05-28 JP JP2010510316A patent/JP5495331B2/ja not_active Expired - Fee Related
- 2008-05-28 CN CN200880100987A patent/CN101809016A/zh active Pending
- 2008-05-28 KR KR1020097027345A patent/KR20100037053A/ko not_active Application Discontinuation
- 2008-05-28 US US12/601,322 patent/US8426403B2/en active Active
- 2008-05-28 CA CA2689948A patent/CA2689948A1/en not_active Abandoned
- 2008-05-28 BR BRPI0812170A patent/BRPI0812170A8/pt not_active IP Right Cessation
- 2008-05-28 WO PCT/US2008/006734 patent/WO2008153793A2/en active Application Filing
- 2008-05-28 MX MX2009013131A patent/MX2009013131A/es not_active Application Discontinuation
- 2008-05-28 AU AU2008263207A patent/AU2008263207B2/en not_active Ceased
- 2008-05-28 EP EP08767902A patent/EP2152695A2/en not_active Withdrawn
- 2008-05-29 PE PE2008000920A patent/PE20090363A1/es not_active Application Discontinuation
- 2008-05-29 CL CL2008001560A patent/CL2008001560A1/es unknown
- 2008-05-29 TW TW097119930A patent/TW200914459A/zh unknown
- 2008-05-29 AR ARP080102261A patent/AR066152A1/es not_active Application Discontinuation
-
2009
- 2009-11-24 IL IL202315A patent/IL202315A0/en unknown
- 2009-12-01 CO CO09137086A patent/CO6241123A2/es not_active Application Discontinuation
- 2009-12-01 EC EC2009009776A patent/ECSP099776A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2689948A1 (en) | 2008-12-18 |
KR20100037053A (ko) | 2010-04-08 |
RU2009148866A (ru) | 2011-07-20 |
US8426403B2 (en) | 2013-04-23 |
US20100256128A1 (en) | 2010-10-07 |
CN101809016A (zh) | 2010-08-18 |
EP2152695A2 (en) | 2010-02-17 |
WO2008153793A2 (en) | 2008-12-18 |
AU2008263207A1 (en) | 2008-12-18 |
CO6241123A2 (es) | 2011-01-20 |
MX2009013131A (es) | 2010-01-15 |
JP5495331B2 (ja) | 2014-05-21 |
AU2008263207A2 (en) | 2010-01-28 |
ECSP099776A (es) | 2010-01-29 |
BRPI0812170A2 (pt) | 2014-12-02 |
TW200914459A (en) | 2009-04-01 |
JP2010529015A (ja) | 2010-08-26 |
WO2008153793A3 (en) | 2009-03-19 |
AU2008263207B2 (en) | 2013-10-03 |
CL2008001560A1 (es) | 2009-05-22 |
AR066152A1 (es) | 2009-07-29 |
PE20090363A1 (es) | 2009-04-01 |
IL202315A0 (en) | 2010-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B25D | Requested change of name of applicant approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
B25G | Requested change of headquarter approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |