IL99225A - History of 3-amidopyrazole, their preparation and the pharmaceutical preparations containing them - Google Patents

History of 3-amidopyrazole, their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL99225A
IL99225A IL9922591A IL9922591A IL99225A IL 99225 A IL99225 A IL 99225A IL 9922591 A IL9922591 A IL 9922591A IL 9922591 A IL9922591 A IL 9922591A IL 99225 A IL99225 A IL 99225A
Authority
IL
Israel
Prior art keywords
group
alkyl
substituted
formula
atom
Prior art date
Application number
IL9922591A
Other languages
English (en)
Hebrew (he)
Other versions
IL99225A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL99225A0 publication Critical patent/IL99225A0/xx
Publication of IL99225A publication Critical patent/IL99225A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL9922591A 1990-08-20 1991-08-19 History of 3-amidopyrazole, their preparation and the pharmaceutical preparations containing them IL99225A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9010486A FR2665898B1 (fr) 1990-08-20 1990-08-20 Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
IL99225A0 IL99225A0 (en) 1992-07-15
IL99225A true IL99225A (en) 1995-10-31

Family

ID=9399742

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9922591A IL99225A (en) 1990-08-20 1991-08-19 History of 3-amidopyrazole, their preparation and the pharmaceutical preparations containing them

Country Status (32)

Country Link
US (6) US5420141A (xx)
EP (1) EP0477049B1 (xx)
JP (1) JP2694932B2 (xx)
KR (1) KR100223074B1 (xx)
AR (1) AR248133A1 (xx)
AT (1) ATE187167T1 (xx)
AU (1) AU646683B2 (xx)
BR (1) BR9103550A (xx)
CA (4) CA2166903C (xx)
CZ (1) CZ281864B6 (xx)
DE (1) DE69131813T2 (xx)
DK (1) DK0477049T3 (xx)
ES (1) ES2142798T3 (xx)
FI (1) FI104170B (xx)
FR (1) FR2665898B1 (xx)
GR (1) GR3032732T3 (xx)
HK (1) HK1005136A1 (xx)
HU (2) HU217435B (xx)
IE (1) IE912932A1 (xx)
IL (1) IL99225A (xx)
LT (1) LT3520B (xx)
LV (1) LV10434B (xx)
MX (1) MX9203576A (xx)
MY (1) MY121908A (xx)
NO (1) NO300212B1 (xx)
NZ (1) NZ239476A (xx)
PL (1) PL169085B1 (xx)
PT (1) PT98717B (xx)
RU (1) RU2066317C1 (xx)
SG (1) SG52322A1 (xx)
TW (1) TW366337B (xx)
ZA (1) ZA916583B (xx)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2713224B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
JPH08502973A (ja) * 1992-11-02 1996-04-02 メルク エンド カンパニー インコーポレーテッド ニューロテンシンアンタゴニストとしての置換フタラジノン
FR2711140B1 (fr) * 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
US6492411B1 (en) 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
RU2139281C1 (ru) * 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
US6716991B1 (en) 1993-11-30 2004-04-06 G. D. Searle & Co. Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2722193B1 (fr) * 1994-07-08 1996-10-04 Sanofi Sa Derives n-oxydes de 1-(7-chloro-4-quinoleinyl)pyrazole-3-carboxamides substitues, procede pour leur preparation et les compositions pharmaceitiques les contenant
FR2732967B1 (fr) * 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
US5756529A (en) * 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
FR2741621B1 (fr) * 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
AR009435A1 (es) * 1996-12-16 2000-04-12 Yamanouchi Pharma Co Ltd Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos.
US5760056A (en) * 1997-03-03 1998-06-02 Sanofi Pharmaceuticals, Inc. Pharmaceutical formulation
US6197787B1 (en) 1997-03-03 2001-03-06 Sanofi-Synthelabo Pharmaceutical formulations containing poorly soluble drug substances
US5837714A (en) * 1997-03-03 1998-11-17 Sanofi Solid pharmaceutical dispersions
DE69830997T2 (de) * 1997-03-03 2006-02-09 Sanofi-Aventis Pharmazeutische zusammensetzungen, die schwerlösliche arzneistoffe enthalten
US5776987A (en) * 1997-03-03 1998-07-07 Sanofi Pharmaceuticals, Inc. Pharmaceutical suspension formulation
AU7966198A (en) * 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999032121A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
CA2341370A1 (en) * 1998-08-20 2000-03-02 Smithkline Beecham Corporation Novel substituted triazole compounds
EP1126852B1 (en) 1998-11-04 2004-01-21 SmithKline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
US6191147B1 (en) 1998-12-24 2001-02-20 Ppd Discovery, Inc. Pyrazole compounds and uses thereof
FR2800372B1 (fr) * 1999-11-03 2001-12-07 Sanofi Synthelabo Derives tricycliques d'acide 1-benzylpyrazole-3- carboxylique, leur preparation, les medicaments en contenant
FR2800375B1 (fr) * 1999-11-03 2004-07-23 Sanofi Synthelabo Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
JP2003514900A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
DE60015599T2 (de) 1999-11-23 2005-11-03 Smithkline Beecham Corp. 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
PT1282418E (pt) 2000-05-19 2005-10-31 Applied Research Systems Utilizacao de derivados pirazolo para o tratamento da infertilidade
IL155367A0 (en) 2000-10-23 2003-12-23 Smithkline Beecham Corp NOVEL 2,4,8-TRISUBSTITUTED-8h-PYRIDO[2,3,-d]PYRIMIDIN-7-ONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, PROCESSES FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING CSBP/p38 KINASE MEDIATED DISEASES
MXPA04002683A (es) 2001-09-19 2004-06-18 Pharmacia Corp Compuestos bencenosulfamida pirazolil sustituidos para el tratamiento de la inflamacion.
CA2460942A1 (en) 2001-09-19 2003-03-27 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation
DE10146867A1 (de) * 2001-09-24 2003-04-24 Bayer Ag Tetrahydroisochinoline
ATE372114T1 (de) * 2001-09-27 2007-09-15 Applied Research Systems Verfahren zur erhöhung des testosteronspiegels
AR038967A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina
US6649638B1 (en) * 2002-08-14 2003-11-18 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
WO2004016741A2 (en) * 2002-08-14 2004-02-26 Ppd Discovery, Inc. Prenylation inhibitors containing dimethyl-cyclobutane and methods of their synthesis and use
US7166619B2 (en) * 2002-08-14 2007-01-23 Ppd Discovery , Inc. Prenylation inhibitors and methods of their synthesis and use
EP1556373A1 (en) * 2002-10-18 2005-07-27 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
US7129239B2 (en) * 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
EP1433788A1 (en) * 2002-12-23 2004-06-30 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
JPWO2004069824A1 (ja) * 2003-02-07 2006-05-25 第一製薬株式会社 ピラゾール誘導体
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US20040214856A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US7268133B2 (en) * 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
BRPI0410289A (pt) * 2003-05-07 2006-05-16 Pfizer Prod Inc ligantes do receptor de canabinóides e suas utilizações
US7232823B2 (en) 2003-06-09 2007-06-19 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
US20040259887A1 (en) * 2003-06-18 2004-12-23 Pfizer Inc Cannabinoid receptor ligands and uses thereof
EP1651612B9 (en) 2003-07-22 2012-09-05 Astex Therapeutics Limited 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
US7517900B2 (en) * 2003-10-10 2009-04-14 Bristol-Myers Squibb Company Pyrazole derivatives as cannabinoid receptor modulators
TW200526641A (en) * 2003-12-26 2005-08-16 Daiichi Seiyaku Co Amidopyrazole derivatives
BRPI0507786A (pt) * 2004-02-20 2007-07-17 Astrazeneca Ab composto e sais farmaceuticamente aceitáveis do mesmo, formulação farmacêutica, uso de um composto, método de tratar uma doença, e, processo para a preparação de compostos
ITMI20041032A1 (it) 2004-05-24 2004-08-24 Neuroscienze S C A R L Compositi farmaceutici
MX2007000016A (es) * 2004-07-01 2007-03-27 Daiichi Seiyaku Co Derivados de pirazol.
US20080146614A1 (en) * 2004-12-23 2008-06-19 Leifeng Cheng Therapeutic Agents
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
PE20100737A1 (es) 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
WO2006133926A1 (en) * 2005-06-17 2006-12-21 Carex Sa Pyrazole derivates as cannabinoid receptor modulators
GB0514738D0 (en) * 2005-07-19 2005-08-24 Astrazeneca Ab Therapeutic agents
CN101437398A (zh) * 2006-03-10 2009-05-20 詹里恩探索公司 用于治疗肥胖症的大麻素受体拮抗剂/反向激动剂
EP2049516A2 (en) * 2006-07-14 2009-04-22 Astex Therapeutics Limited Pharmaceutical compounds
GB0619611D0 (en) 2006-10-04 2006-11-15 Ark Therapeutics Ltd Compounds and their use
JP5222855B2 (ja) * 2006-12-18 2013-06-26 ７ティーエム ファーマ エイ／エス Ｃｂ１受容体のモジュレーター
US7977358B2 (en) * 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
US7943653B2 (en) * 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
US8133904B2 (en) * 2007-09-07 2012-03-13 Jenrin Discovery, Inc. Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
US20110009463A1 (en) * 2007-10-17 2011-01-13 Yuri Karl Petersson Geranylgeranyl transferase inhibitors and methods of making and using the same
KR100917037B1 (ko) * 2007-11-01 2009-09-10 한국과학기술연구원 피라졸릴카르복스아미도알킬피페라진 유도체 및 이의제조방법
DE102009036604A1 (de) 2009-07-30 2011-02-03 Aicuris Gmbh & Co. Kg Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung
WO2011156557A2 (en) * 2010-06-11 2011-12-15 Thomas James B Compounds active at the neurotensin receptor
CN102250006B (zh) * 2011-05-12 2014-03-05 范如霖 3-吡唑羧酸酰胺类化合物、其制备方法及其在制备作为cb1受体抑制剂药物中的应用
EP2740726A1 (en) * 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
WO2015148465A1 (en) * 2014-03-25 2015-10-01 Research Triangle Institute Pyrazole compounds selective for neurotensin 2 receptor
CA2949559C (en) * 2014-06-06 2023-08-29 Research Triangle Institute Apelin receptor (apj) agonists and uses thereof
KR20180090852A (ko) 2015-12-09 2018-08-13 리써치 트라이앵글 인스티튜트 개선된 아펠린 수용체(apj) 효능제 및 이의 용도
EP3279197A1 (en) * 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
TWI805699B (zh) 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
SG11202009179TA (en) 2018-04-04 2020-10-29 Japan Tobacco Inc Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
EP4021447A4 (en) * 2019-08-29 2023-10-11 Research Triangle Institute METHODS AND USES FOR APELIN RECEPTOR AGONISTS

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
ES513398A0 (es) * 1981-06-26 1983-03-01 Warner Lambert Co "un procedimiento para preparar derivados de dialcohilpirazol".
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
JPS611651A (ja) * 1984-06-12 1986-01-07 Toyama Chem Co Ltd Ｎ−アシル酸性アミノ酸ジアミド類およびその製造法並びにそれらを含有する抗潰瘍剤
BR8506974A (pt) * 1984-10-29 1986-12-23 Sumitomo Chemical Co Derivado pirazolcarboxamida,processo para o seu preparo e fungicida contendo o mesmo como substancia atuante
JPH0678342B2 (ja) * 1986-01-07 1994-10-05 三共株式会社 新規マクロライド化合物
US4792565A (en) * 1986-04-24 1988-12-20 Mitsui Toatsu Chemicals, Inc. Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds
US4826868A (en) * 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US4916142A (en) * 1987-02-02 1990-04-10 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics
US4954506A (en) * 1987-02-02 1990-09-04 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4912109A (en) * 1987-02-02 1990-03-27 Boc, Inc. N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds
US4791112A (en) * 1987-02-02 1988-12-13 The Boc Group, Inc. N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds
JPS6425763A (en) * 1987-04-24 1989-01-27 Mitsubishi Chem Ind Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient
US4971978A (en) * 1987-09-21 1990-11-20 Nadzan Alex M Derivatives of D-glutamic acid and D-aspartic acid
JPH04500796A (ja) * 1987-11-30 1992-02-13 イー・アイ・デユポン・デ・ニモアス・アンド・カンパニー 複素環族ピラゾリンカルボキシアニリド類
JP2861104B2 (ja) * 1988-10-14 1999-02-24 三菱化学株式会社 ピラゾールアミド類およびこれを有効成分とする殺虫、殺ダニ剤
WO1990014347A1 (en) * 1989-05-24 1990-11-29 Nippon Shinyaku Co., Ltd. Indole derivatives and medicine

Also Published As

Publication number Publication date
CZ281864B6 (cs) 1997-03-12
TW366337B (en) 1999-08-11
LV10434B (en) 1995-10-20
FR2665898A1 (fr) 1992-02-21
HU217435B (hu) 2000-01-28
EP0477049B1 (fr) 1999-12-01
HU211970A9 (en) 1996-01-29
ATE187167T1 (de) 1999-12-15
US5420141A (en) 1995-05-30
IE912932A1 (en) 1992-02-26
FI913917A (fi) 1992-02-21
LTIP656A (en) 1995-01-31
BR9103550A (pt) 1992-04-07
CA2049514A1 (en) 1992-02-21
LV10434A (lv) 1995-02-20
US5616592A (en) 1997-04-01
DE69131813T2 (de) 2000-05-31
NO913234L (no) 1992-02-21
US5744493A (en) 1998-04-28
PL169085B1 (pl) 1996-05-31
ES2142798T3 (es) 2000-05-01
KR920004354A (ko) 1992-03-27
HU912750D0 (en) 1992-01-28
PT98717A (pt) 1992-07-31
CA2166901C (en) 1999-01-26
DK0477049T3 (da) 2000-04-25
NZ239476A (en) 1993-11-25
ZA916583B (en) 1992-05-27
IL99225A0 (en) 1992-07-15
MX9203576A (es) 1992-07-01
GR3032732T3 (en) 2000-06-30
SG52322A1 (en) 1998-09-28
KR100223074B1 (ko) 1999-10-15
CA2166903C (en) 1998-09-01
HK1005136A1 (en) 1998-12-24
FI104170B1 (fi) 1999-11-30
NO913234D0 (no) 1991-08-19
JPH04244065A (ja) 1992-09-01
US5635526A (en) 1997-06-03
MY121908A (en) 2006-03-31
FI913917A0 (fi) 1991-08-19
LT3520B (en) 1995-11-27
CA2166901A1 (en) 1992-02-21
FR2665898B1 (fr) 1994-03-11
US5744491A (en) 1998-04-28
HUT59106A (en) 1992-04-28
EP0477049A1 (fr) 1992-03-25
US5607958A (en) 1997-03-04
PT98717B (pt) 1999-01-29
CA2166902C (en) 1999-01-19
CA2166903A1 (en) 1992-02-21
NO300212B1 (no) 1997-04-28
FI104170B (fi) 1999-11-30
CA2049514C (en) 1997-02-25
JP2694932B2 (ja) 1997-12-24
DE69131813D1 (de) 2000-01-05
AU646683B2 (en) 1994-03-03
PL291463A1 (en) 1992-07-13
RU2066317C1 (ru) 1996-09-10
AU8259691A (en) 1992-02-27
CA2166902A1 (en) 1992-02-21
CS257491A3 (en) 1992-06-17
AR248133A1 (es) 1995-06-30

Similar Documents

Publication Publication Date Title
IL99225A (en) History of 3-amidopyrazole, their preparation and the pharmaceutical preparations containing them
CA2274594C (en) Aminopyrazole derivatives
US6043246A (en) Urea derivatives
EP0945438B1 (en) Pyrazole derivatives
JP2001518504A (ja) ５ｈｔ４作動薬および拮抗薬
HU222724B1 (hu) Eljárás 3-amino-2-fenil-piperidin elżállítására
NO338263B1 (no) Imidazolforbindelser, farmasøytiske sammensetninger inneholdende slike, og anvendelse derav for behandling av en sykdom eller tilstand assosiert med modulering av Notch signaliseringsreaksjonsveien
WO2006068591A1 (en) Novel pyrazole derivatives and their use as modulators of nicotinic acetylcholine receptors
US6166038A (en) Aminopyrazole derivatives
IL203956A (en) Indole-2-on-2 derivatives are positioned in position 3, their preparation and use for drug preparation
IL96384A (en) History of pyridazine, their preparation and pharmaceutical preparations containing them
TW200934497A (en) Heterocyclic derivatives
KR20060009899A (ko) 니코틴성 아세틸콜린 수용체의 양성 조절제
JP2018510131A (ja) Ｒｏｒｃ２のスルホンアミド置換インドールモジュレーターおよびその使用方法
JP5536227B2 (ja) α４β２ニコチン性アセチルコリン受容体リガンドとしての二環式化合物
MX2011008578A (es) Derivados de 3-benzofuranilindol-2-ona sustituidos en posicion 3, su preparacion y su uso en terapeutica.
CA2805219A1 (en) Pyrazole compound
Vraničar et al. Synthesis and transformations of a pyrazole containing α, β-didehydro-α-amino acid derivatives
JPH04234369A (ja) ６−アルキルピリダジン誘導体、調製方法およびそれらを含有する医薬組成物
TW200916442A (en) 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1receptor modulators
CZ176895A3 (cs) Substituované N-oxidované deriváty l-(7-chlorchinolein-4-yl)-pyrazoI-3-karboxamidů, způsob jejich přípravy a farmaceutické přípravky sjejich obsahem

Legal Events

Date Code Title Description
FF Patent granted
HE Change of address of proprietor(s)
KB Patent renewed
KB Patent renewed
HC Change of name of proprietor(s)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees