IL295588B2 - Synthesis of halichondrins - Google Patents
Synthesis of halichondrinsInfo
- Publication number
- IL295588B2 IL295588B2 IL295588A IL29558822A IL295588B2 IL 295588 B2 IL295588 B2 IL 295588B2 IL 295588 A IL295588 A IL 295588A IL 29558822 A IL29558822 A IL 29558822A IL 295588 B2 IL295588 B2 IL 295588B2
- Authority
- IL
- Israel
- Prior art keywords
- optionally substituted
- compound
- salt
- hydrogen
- substituted alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529333P | 2017-07-06 | 2017-07-06 | |
| US201762529310P | 2017-07-06 | 2017-07-06 | |
| PCT/US2018/041005 WO2019010363A1 (en) | 2017-07-06 | 2018-07-06 | HALICHONDRINES SYNTHESIS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL295588A IL295588A (en) | 2022-10-01 |
| IL295588B1 IL295588B1 (en) | 2023-11-01 |
| IL295588B2 true IL295588B2 (en) | 2024-03-01 |
Family
ID=63036376
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL295588A IL295588B2 (en) | 2017-07-06 | 2018-07-06 | Synthesis of halichondrins |
| IL307273A IL307273B2 (en) | 2017-07-06 | 2018-07-06 | Synthesis of halichondrins |
| IL271660A IL271660B (en) | 2017-07-06 | 2018-07-06 | Synthesis of the Lichondrins |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL307273A IL307273B2 (en) | 2017-07-06 | 2018-07-06 | Synthesis of halichondrins |
| IL271660A IL271660B (en) | 2017-07-06 | 2018-07-06 | Synthesis of the Lichondrins |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11548898B2 (https=) |
| EP (2) | EP3649135B1 (https=) |
| JP (2) | JP7370313B2 (https=) |
| KR (2) | KR102438417B1 (https=) |
| CN (2) | CN118515685A (https=) |
| AU (2) | AU2018297305B2 (https=) |
| BR (1) | BR112020000141A2 (https=) |
| CA (2) | CA3211559A1 (https=) |
| ES (1) | ES2940688T3 (https=) |
| HU (1) | HUE061306T2 (https=) |
| IL (3) | IL295588B2 (https=) |
| MX (1) | MX2020000142A (https=) |
| SG (1) | SG11201912342QA (https=) |
| WO (1) | WO2019010363A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| ES2931533T3 (es) | 2017-04-05 | 2022-12-30 | Harvard College | Compuesto macrocíclico y usos del mismo |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| HUE061306T2 (hu) | 2017-07-06 | 2023-06-28 | Harvard College | Halikondrinok szintézise |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN111566113B (zh) * | 2017-11-15 | 2024-01-09 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
| CN111484393A (zh) * | 2019-01-28 | 2020-08-04 | 上海茂晟康慧科技有限公司 | 一种顺,顺-3,5-二甲基-1-环己醇的制备方法 |
| CN117820275A (zh) * | 2023-12-29 | 2024-04-05 | 上海科技大学 | 一种列净类药物及其中间体的催化合成方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61191687A (ja) | 1985-02-20 | 1986-08-26 | Fujisawa Pharmaceut Co Ltd | ハリコンドリンｂ |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| US5426194A (en) | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| US5352804A (en) | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| JP2818381B2 (ja) | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| US6214865B1 (en) | 1998-06-17 | 2001-04-10 | Eisai Co., Ltd. | Macrocyclic analogs and methods of their use and preparation |
| JP2001305734A (ja) | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| EP2522663B1 (en) | 2004-06-03 | 2015-04-01 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of halichondrin B |
| EP1831697A4 (en) | 2004-12-09 | 2011-01-26 | Eisai R&D Man Co Ltd | SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| MY153742A (en) | 2007-03-07 | 2015-03-13 | Interdigital Tech Corp | Method and apparatus for generating and processing a mac-ehs protocol data unit |
| US20100254996A1 (en) | 2007-06-18 | 2010-10-07 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| RU2489437C2 (ru) * | 2007-10-03 | 2013-08-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Промежуточные соединения и способы синтеза аналогов галихондрина в |
| RU2010118063A (ru) | 2007-11-16 | 2011-12-27 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Новое промежуточное соединение для синтеза аналога галихондрина в и новая реакция десульфонилирования, применяемая для получения промежуточного соединения |
| CN105801599A (zh) | 2008-04-04 | 2016-07-27 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| WO2011094339A1 (en) | 2010-01-26 | 2011-08-04 | Eisai R&D Management Co., Ltd. | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| WO2012096926A2 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| CN104024237B (zh) | 2011-12-16 | 2016-02-24 | 阿方拉研究股份有限公司 | 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体 |
| CN104080793B (zh) | 2011-12-29 | 2017-09-19 | 阿方拉研究股份有限公司 | 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法 |
| WO2013142999A1 (en) | 2012-03-30 | 2013-10-03 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein |
| AR096238A1 (es) | 2013-05-15 | 2015-12-16 | Alphora Res Inc | Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo |
| CA2916537C (en) | 2013-07-03 | 2021-07-27 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups |
| EP3689881B1 (en) | 2013-11-04 | 2022-01-12 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| MX384292B (es) | 2013-12-06 | 2025-03-14 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| WO2016038624A1 (en) | 2014-09-09 | 2016-03-17 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| KR102743950B1 (ko) | 2015-05-07 | 2024-12-18 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편 |
| EP3423105B1 (en) | 2016-03-02 | 2021-05-05 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| JP2020508315A (ja) | 2017-02-20 | 2020-03-19 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | がんを治療するための薬剤組合せ |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| ES2931533T3 (es) | 2017-04-05 | 2022-12-30 | Harvard College | Compuesto macrocíclico y usos del mismo |
| WO2019009956A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | SUMMARY OF MEDIUM MEDIATED KETONE |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| HUE061306T2 (hu) | 2017-07-06 | 2023-06-28 | Harvard College | Halikondrinok szintézise |
| CN111566113B (zh) | 2017-11-15 | 2024-01-09 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
-
2018
- 2018-07-06 HU HUE18746401A patent/HUE061306T2/hu unknown
- 2018-07-06 EP EP18746401.1A patent/EP3649135B1/en active Active
- 2018-07-06 IL IL295588A patent/IL295588B2/en unknown
- 2018-07-06 KR KR1020207003432A patent/KR102438417B1/ko active Active
- 2018-07-06 IL IL307273A patent/IL307273B2/en unknown
- 2018-07-06 EP EP22214189.7A patent/EP4169924A3/en active Pending
- 2018-07-06 MX MX2020000142A patent/MX2020000142A/es unknown
- 2018-07-06 WO PCT/US2018/041005 patent/WO2019010363A1/en not_active Ceased
- 2018-07-06 KR KR1020227029591A patent/KR20220124279A/ko not_active Ceased
- 2018-07-06 JP JP2020500097A patent/JP7370313B2/ja active Active
- 2018-07-06 ES ES18746401T patent/ES2940688T3/es active Active
- 2018-07-06 CA CA3211559A patent/CA3211559A1/en active Pending
- 2018-07-06 IL IL271660A patent/IL271660B/en unknown
- 2018-07-06 CA CA3069160A patent/CA3069160C/en active Active
- 2018-07-06 BR BR112020000141-4A patent/BR112020000141A2/pt active Search and Examination
- 2018-07-06 SG SG11201912342QA patent/SG11201912342QA/en unknown
- 2018-07-06 US US16/628,504 patent/US11548898B2/en active Active
- 2018-07-06 CN CN202410481438.XA patent/CN118515685A/zh active Pending
- 2018-07-06 CN CN201880058283.1A patent/CN111433211B/zh active Active
- 2018-07-06 AU AU2018297305A patent/AU2018297305B2/en active Active
-
2022
- 2022-11-23 US US18/058,441 patent/US20230128195A1/en active Pending
-
2023
- 2023-05-15 AU AU2023203013A patent/AU2023203013B2/en active Active
- 2023-08-07 JP JP2023128422A patent/JP7764432B2/ja active Active
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