JP7370313B2 - ハリコンドリンの合成 - Google Patents

ハリコンドリンの合成 Download PDF

Info

Publication number
JP7370313B2
JP7370313B2 JP2020500097A JP2020500097A JP7370313B2 JP 7370313 B2 JP7370313 B2 JP 7370313B2 JP 2020500097 A JP2020500097 A JP 2020500097A JP 2020500097 A JP2020500097 A JP 2020500097A JP 7370313 B2 JP7370313 B2 JP 7370313B2
Authority
JP
Japan
Prior art keywords
optionally substituted
formula
certain embodiments
salt
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020500097A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020536046A5 (https=
JP2020536046A (ja
Inventor
義人 岸
アイ，ヤンラン
エー，ニン
ワン，シャオイー
健三 八幡
健太郎 磯
レッディー ナイニ，サントシュ
修治 山下
リー，ジホン
功 大橋
尚 福山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Harvard University
Original Assignee
Eisai R&D Management Co Ltd
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Harvard University filed Critical Eisai R&D Management Co Ltd
Publication of JP2020536046A publication Critical patent/JP2020536046A/ja
Publication of JP2020536046A5 publication Critical patent/JP2020536046A5/ja
Priority to JP2023128422A priority Critical patent/JP7764432B2/ja
Application granted granted Critical
Publication of JP7370313B2 publication Critical patent/JP7370313B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2020500097A 2017-07-06 2018-07-06 ハリコンドリンの合成 Active JP7370313B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023128422A JP7764432B2 (ja) 2017-07-06 2023-08-07 ハリコンドリンの合成

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762529333P 2017-07-06 2017-07-06
US201762529310P 2017-07-06 2017-07-06
US62/529,333 2017-07-06
US62/529,310 2017-07-06
PCT/US2018/041005 WO2019010363A1 (en) 2017-07-06 2018-07-06 HALICHONDRINES SYNTHESIS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023128422A Division JP7764432B2 (ja) 2017-07-06 2023-08-07 ハリコンドリンの合成

Publications (3)

Publication Number Publication Date
JP2020536046A JP2020536046A (ja) 2020-12-10
JP2020536046A5 JP2020536046A5 (https=) 2021-08-12
JP7370313B2 true JP7370313B2 (ja) 2023-10-27

Family

ID=63036376

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020500097A Active JP7370313B2 (ja) 2017-07-06 2018-07-06 ハリコンドリンの合成
JP2023128422A Active JP7764432B2 (ja) 2017-07-06 2023-08-07 ハリコンドリンの合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023128422A Active JP7764432B2 (ja) 2017-07-06 2023-08-07 ハリコンドリンの合成

Country Status (14)

Country Link
US (2) US11548898B2 (https=)
EP (2) EP3649135B1 (https=)
JP (2) JP7370313B2 (https=)
KR (2) KR102438417B1 (https=)
CN (2) CN118515685A (https=)
AU (2) AU2018297305B2 (https=)
BR (1) BR112020000141A2 (https=)
CA (2) CA3211559A1 (https=)
ES (1) ES2940688T3 (https=)
HU (1) HUE061306T2 (https=)
IL (3) IL295588B2 (https=)
MX (1) MX2020000142A (https=)
SG (1) SG11201912342QA (https=)
WO (1) WO2019010363A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
ES2931533T3 (es) 2017-04-05 2022-12-30 Harvard College Compuesto macrocíclico y usos del mismo
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
CN111484393A (zh) * 2019-01-28 2020-08-04 上海茂晟康慧科技有限公司 一种顺,顺-3,5-二甲基-1-环己醇的制备方法
CN117820275A (zh) * 2023-12-29 2024-04-05 上海科技大学 一种列净类药物及其中间体的催化合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513021A (ja) 2017-04-05 2020-04-30 プレジデント アンド フェローズ オブ ハーバード カレッジ 大環状化合物およびその使用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61191687A (ja) 1985-02-20 1986-08-26 Fujisawa Pharmaceut Co Ltd ハリコンドリンｂ
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
GB9206244D0 (en) 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge
US5426194A (en) 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
US5352804A (en) 1993-01-19 1994-10-04 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 2
JP2818381B2 (ja) 1994-01-18 1998-10-30 帝人株式会社 ７−チアプロスタグランジン類およびその製造法
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
US6214865B1 (en) 1998-06-17 2001-04-10 Eisai Co., Ltd. Macrocyclic analogs and methods of their use and preparation
JP2001305734A (ja) 2000-04-20 2001-11-02 Fuji Photo Film Co Ltd 光重合性組成物
JP2003261447A (ja) 2002-03-07 2003-09-16 Kyosei Seiyaku Kk 抗腫瘍剤
EP2522663B1 (en) 2004-06-03 2015-04-01 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
EP1831697A4 (en) 2004-12-09 2011-01-26 Eisai R&D Man Co Ltd SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
MY153742A (en) 2007-03-07 2015-03-13 Interdigital Tech Corp Method and apparatus for generating and processing a mac-ehs protocol data unit
US20100254996A1 (en) 2007-06-18 2010-10-07 Medimmune, Llc Synergistic treatment of cells that express epha2 and erbb2
RU2489437C2 (ru) * 2007-10-03 2013-08-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Промежуточные соединения и способы синтеза аналогов галихондрина в
RU2010118063A (ru) 2007-11-16 2011-12-27 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Новое промежуточное соединение для синтеза аналога галихондрина в и новая реакция десульфонилирования, применяемая для получения промежуточного соединения
CN105801599A (zh) 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
WO2011094339A1 (en) 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
WO2012096926A2 (en) 2011-01-10 2012-07-19 President And Fellows Of Harvard College Method for delivering agents into cells using bacterial toxins
WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
CN104080793B (zh) 2011-12-29 2017-09-19 阿方拉研究股份有限公司 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
WO2013142999A1 (en) 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
AR096238A1 (es) 2013-05-15 2015-12-16 Alphora Res Inc Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo
CA2916537C (en) 2013-07-03 2021-07-27 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
EP3689881B1 (en) 2013-11-04 2022-01-12 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
MX384292B (es) 2013-12-06 2025-03-14 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
JP2020508315A (ja) 2017-02-20 2020-03-19 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ がんを治療するための薬剤組合せ
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513021A (ja) 2017-04-05 2020-04-30 プレジデント アンド フェローズ オブ ハーバード カレッジ 大環状化合物およびその使用

Also Published As

Publication number Publication date
KR20220124279A (ko) 2022-09-13
AU2018297305A1 (en) 2020-01-16
CN118515685A (zh) 2024-08-20
KR102438417B1 (ko) 2022-09-01
IL307273B2 (en) 2025-03-01
EP4169924A3 (en) 2023-07-05
CN111433211A (zh) 2020-07-17
CA3211559A1 (en) 2019-01-10
US11548898B2 (en) 2023-01-10
ES2940688T3 (es) 2023-05-10
AU2023203013A1 (en) 2023-06-01
HUE061306T2 (hu) 2023-06-28
KR20200042464A (ko) 2020-04-23
IL271660A (en) 2020-02-27
EP4169924A2 (en) 2023-04-26
EP3649135A1 (en) 2020-05-13
WO2019010363A8 (en) 2019-06-06
IL307273A (en) 2023-11-01
JP7764432B2 (ja) 2025-11-05
CA3069160C (en) 2023-10-17
AU2023203013B2 (en) 2025-06-05
IL307273B1 (en) 2024-11-01
IL295588A (en) 2022-10-01
BR112020000141A2 (pt) 2020-07-14
CA3069160A1 (en) 2019-01-10
EP3649135B1 (en) 2022-12-28
IL295588B2 (en) 2024-03-01
CN111433211B (zh) 2024-05-07
JP2020536046A (ja) 2020-12-10
WO2019010363A1 (en) 2019-01-10
JP2023166381A (ja) 2023-11-21
MX2020000142A (es) 2020-07-22
AU2018297305B2 (en) 2023-02-16
RU2020104842A (ru) 2021-08-06
US20230128195A1 (en) 2023-04-27
SG11201912342QA (en) 2020-01-30
IL271660B (en) 2022-09-01
US20210230177A1 (en) 2021-07-29
IL295588B1 (en) 2023-11-01

Similar Documents

Publication Publication Date Title
JP7764432B2 (ja) ハリコンドリンの合成
US11220513B2 (en) Chromium-mediated coupling and application to the synthesis of halichondrins
EP2550285B1 (en) Trioxacarcins and uses thereof
US10844073B2 (en) Palladium-mediated ketolization
US11498892B2 (en) Fe/Cu-mediated ketone synthesis
EP3664799A1 (en) Lincosamide antibiotics and uses thereof
RU2794176C2 (ru) Синтез галихондринов
Feltenberger et al. Development of an Intramolecular Gassman's [2+ 2] Cycloaddition
Wong Synthetic Studies Towards the 13-Desmethyl Spirolide C Bis-Spiroketal Fragment
WO2026025019A1 (en) Synthesis of macrobicyclic thiolincosamines
Roushanbakhti Synthesis of the EFG-ring system of pectenotoxin-4
Tornos Synthetic Studies Towards the Marine Natural Product Phorboxazole A.
Mahapatra Part I: Total Synthesis of Marine Macrolide Amphidinolide F and Synthetic Studies Toward Amphidinolide C; Part II: Computational Study on Proline Sulfonamide-catalyzed Aldol Reaction
Clark Synthetic studies towards discodermolide and a total synthesis of didehydrodiscodermolide
Martin Progress toward the total synthesis of the marine natural product amphidinol 3
Williams Stereoselective Synthesis of Quaternary Carbons via the Dianionic Ireland-Claisen Rearrangement: An Approach to the Synthesis of Briarane Diterpenes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201029

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210630

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210630

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220616

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221005

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221205

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230807

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20230808

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20230831

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230929

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20231017

R150 Certificate of patent or registration of utility model

Ref document number: 7370313

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150