CA3211559A1 - Synthesis of halichondrins - Google Patents

Synthesis of halichondrins

Info

Publication number
CA3211559A1
CA3211559A1 CA3211559A CA3211559A CA3211559A1 CA 3211559 A1 CA3211559 A1 CA 3211559A1 CA 3211559 A CA3211559 A CA 3211559A CA 3211559 A CA3211559 A CA 3211559A CA 3211559 A1 CA3211559 A1 CA 3211559A1
Authority
CA
Canada
Prior art keywords
optionally substituted
certain embodiments
compound
hydrogen
substituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3211559A
Other languages
English (en)
French (fr)
Inventor
Yoshito Kishi
Yanran Al
Ning Ye
Qiaoyi WANG
Kenzo YAHATA
Kentaro Iso
Santhosh Reddy NAINI
Shuji Yamashita
Jihoon Lee
Isao Ohashi
Takashi Fukuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Harvard University
Original Assignee
Eisai R&D Management Co Ltd
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Harvard University filed Critical Eisai R&D Management Co Ltd
Publication of CA3211559A1 publication Critical patent/CA3211559A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA3211559A 2017-07-06 2018-07-06 Synthesis of halichondrins Pending CA3211559A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762529333P 2017-07-06 2017-07-06
US201762529310P 2017-07-06 2017-07-06
US62/529,333 2017-07-06
US62/529,310 2017-07-06
CA3069160A CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3069160A Division CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Publications (1)

Publication Number Publication Date
CA3211559A1 true CA3211559A1 (en) 2019-01-10

Family

ID=63036376

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3211559A Pending CA3211559A1 (en) 2017-07-06 2018-07-06 Synthesis of halichondrins
CA3069160A Active CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3069160A Active CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Country Status (14)

Country Link
US (2) US11548898B2 (https=)
EP (2) EP3649135B1 (https=)
JP (2) JP7370313B2 (https=)
KR (2) KR102438417B1 (https=)
CN (2) CN118515685A (https=)
AU (2) AU2018297305B2 (https=)
BR (1) BR112020000141A2 (https=)
CA (2) CA3211559A1 (https=)
ES (1) ES2940688T3 (https=)
HU (1) HUE061306T2 (https=)
IL (3) IL295588B2 (https=)
MX (1) MX2020000142A (https=)
SG (1) SG11201912342QA (https=)
WO (1) WO2019010363A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
ES2931533T3 (es) 2017-04-05 2022-12-30 Harvard College Compuesto macrocíclico y usos del mismo
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
CN111484393A (zh) * 2019-01-28 2020-08-04 上海茂晟康慧科技有限公司 一种顺,顺-3,5-二甲基-1-环己醇的制备方法
CN117820275A (zh) * 2023-12-29 2024-04-05 上海科技大学 一种列净类药物及其中间体的催化合成方法

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CN104080793B (zh) 2011-12-29 2017-09-19 阿方拉研究股份有限公司 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
WO2013142999A1 (en) 2012-03-30 2013-10-03 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
AR096238A1 (es) 2013-05-15 2015-12-16 Alphora Res Inc Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo
CA2916537C (en) 2013-07-03 2021-07-27 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
EP3689881B1 (en) 2013-11-04 2022-01-12 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
MX384292B (es) 2013-12-06 2025-03-14 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
JP2020508315A (ja) 2017-02-20 2020-03-19 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ がんを治療するための薬剤組合せ
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
ES2931533T3 (es) 2017-04-05 2022-12-30 Harvard College Compuesto macrocíclico y usos del mismo
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

Also Published As

Publication number Publication date
JP7370313B2 (ja) 2023-10-27
KR20220124279A (ko) 2022-09-13
AU2018297305A1 (en) 2020-01-16
CN118515685A (zh) 2024-08-20
KR102438417B1 (ko) 2022-09-01
IL307273B2 (en) 2025-03-01
EP4169924A3 (en) 2023-07-05
CN111433211A (zh) 2020-07-17
US11548898B2 (en) 2023-01-10
ES2940688T3 (es) 2023-05-10
AU2023203013A1 (en) 2023-06-01
HUE061306T2 (hu) 2023-06-28
KR20200042464A (ko) 2020-04-23
IL271660A (en) 2020-02-27
EP4169924A2 (en) 2023-04-26
EP3649135A1 (en) 2020-05-13
WO2019010363A8 (en) 2019-06-06
IL307273A (en) 2023-11-01
JP7764432B2 (ja) 2025-11-05
CA3069160C (en) 2023-10-17
AU2023203013B2 (en) 2025-06-05
IL307273B1 (en) 2024-11-01
IL295588A (en) 2022-10-01
BR112020000141A2 (pt) 2020-07-14
CA3069160A1 (en) 2019-01-10
EP3649135B1 (en) 2022-12-28
IL295588B2 (en) 2024-03-01
CN111433211B (zh) 2024-05-07
JP2020536046A (ja) 2020-12-10
WO2019010363A1 (en) 2019-01-10
JP2023166381A (ja) 2023-11-21
MX2020000142A (es) 2020-07-22
AU2018297305B2 (en) 2023-02-16
RU2020104842A (ru) 2021-08-06
US20230128195A1 (en) 2023-04-27
SG11201912342QA (en) 2020-01-30
IL271660B (en) 2022-09-01
US20210230177A1 (en) 2021-07-29
IL295588B1 (en) 2023-11-01

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