CA3211559A1 - Synthesis of halichondrins - Google Patents

Synthesis of halichondrins

Info

Publication number
CA3211559A1
CA3211559A1 CA3211559A CA3211559A CA3211559A1 CA 3211559 A1 CA3211559 A1 CA 3211559A1 CA 3211559 A CA3211559 A CA 3211559A CA 3211559 A CA3211559 A CA 3211559A CA 3211559 A1 CA3211559 A1 CA 3211559A1
Authority
CA
Canada
Prior art keywords
optionally substituted
certain embodiments
compound
hydrogen
substituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3211559A
Other languages
English (en)
French (fr)
Inventor
Yoshito Kishi
Yanran Al
Ning Ye
Qiaoyi WANG
Kenzo YAHATA
Kentaro Iso
Santhosh Reddy NAINI
Shuji Yamashita
Jihoon Lee
Isao Ohashi
Takashi Fukuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Harvard University
Original Assignee
Eisai R&D Management Co Ltd
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Harvard University filed Critical Eisai R&D Management Co Ltd
Publication of CA3211559A1 publication Critical patent/CA3211559A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA3211559A 2017-07-06 2018-07-06 Synthesis of halichondrins Pending CA3211559A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762529333P 2017-07-06 2017-07-06
US201762529310P 2017-07-06 2017-07-06
US62/529,310 2017-07-06
US62/529,333 2017-07-06
CA3069160A CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3069160A Division CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Publications (1)

Publication Number Publication Date
CA3211559A1 true CA3211559A1 (en) 2019-01-10

Family

ID=63036376

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3211559A Pending CA3211559A1 (en) 2017-07-06 2018-07-06 Synthesis of halichondrins
CA3069160A Active CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3069160A Active CA3069160C (en) 2017-07-06 2018-07-06 Synthesis of halichondrins

Country Status (14)

Country Link
US (2) US11548898B2 (https=)
EP (2) EP4169924A3 (https=)
JP (2) JP7370313B2 (https=)
KR (2) KR102438417B1 (https=)
CN (2) CN118515685A (https=)
AU (2) AU2018297305B2 (https=)
BR (1) BR112020000141A2 (https=)
CA (2) CA3211559A1 (https=)
ES (1) ES2940688T3 (https=)
HU (1) HUE061306T2 (https=)
IL (3) IL271660B (https=)
MX (1) MX2020000142A (https=)
SG (1) SG11201912342QA (https=)
WO (1) WO2019010363A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
SMT202200455T1 (it) 2017-04-05 2023-01-13 Harvard College Composto macrociclico e relativi usi
WO2019010363A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College HALICHONDRINES SYNTHESIS
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
WO2019099646A1 (en) * 2017-11-15 2019-05-23 President And Fellows Of Harvard College Macrocyclic compounds and uses thereof
CN111484393A (zh) * 2019-01-28 2020-08-04 上海茂晟康慧科技有限公司 一种顺,顺-3,5-二甲基-1-环己醇的制备方法
CN117820275A (zh) * 2023-12-29 2024-04-05 上海科技大学 一种列净类药物及其中间体的催化合成方法

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JP2015501818A (ja) 2011-12-16 2015-01-19 アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法
CA2860446C (en) 2011-12-29 2017-01-10 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
US9278979B2 (en) 2012-03-30 2016-03-08 Alphora Research Inc. Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
CA2909209A1 (en) 2013-05-15 2014-11-20 Alphora Research Inc. 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
EP3016957A4 (en) 2013-07-03 2016-11-30 Alphora Res Inc SYNTHETIC METHOD FOR THE PRODUCTION OF CYCLIC C1-KETO ANALOGUE OF HALICHONDRIN B AND USEFUL INTERMEDIATE PRODUCTS, INCLUDING INTERMEDIATE PRODUCTS WITH -SO2- (P-TOLYL) GROUPS
BR112016009452B1 (pt) 2013-11-04 2022-06-07 Eisai R&D Management Co., Ltd Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários
EP3077399B1 (en) 2013-12-06 2019-02-20 Eisai R&D Management Co., Ltd. Methods useful in the synthesis of halichondrin b analogs
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10208058B2 (en) 2014-09-09 2019-02-19 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX392296B (es) 2015-05-07 2025-03-24 Eisai R&D Man Co Ltd Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
PE20231050A1 (es) 2016-03-02 2023-07-11 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
EP3582804A1 (en) 2017-02-20 2019-12-25 Polyphor Ag Pharmaceutical combinations for treating cancer
SMT202200455T1 (it) * 2017-04-05 2023-01-13 Harvard College Composto macrociclico e relativi usi
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
WO2019010363A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College HALICHONDRINES SYNTHESIS
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
WO2019099646A1 (en) 2017-11-15 2019-05-23 President And Fellows Of Harvard College Macrocyclic compounds and uses thereof

Also Published As

Publication number Publication date
EP3649135B1 (en) 2022-12-28
KR102438417B1 (ko) 2022-09-01
BR112020000141A2 (pt) 2020-07-14
KR20220124279A (ko) 2022-09-13
JP7370313B2 (ja) 2023-10-27
CN111433211B (zh) 2024-05-07
CA3069160A1 (en) 2019-01-10
HUE061306T2 (hu) 2023-06-28
US20230128195A1 (en) 2023-04-27
US20210230177A1 (en) 2021-07-29
CN111433211A (zh) 2020-07-17
IL307273B2 (en) 2025-03-01
ES2940688T3 (es) 2023-05-10
IL271660A (en) 2020-02-27
EP4169924A2 (en) 2023-04-26
IL295588B1 (en) 2023-11-01
AU2018297305B2 (en) 2023-02-16
JP2023166381A (ja) 2023-11-21
WO2019010363A1 (en) 2019-01-10
AU2018297305A1 (en) 2020-01-16
CN118515685A (zh) 2024-08-20
US11548898B2 (en) 2023-01-10
MX2020000142A (es) 2020-07-22
SG11201912342QA (en) 2020-01-30
IL307273A (en) 2023-11-01
RU2020104842A (ru) 2021-08-06
WO2019010363A8 (en) 2019-06-06
AU2023203013A1 (en) 2023-06-01
CA3069160C (en) 2023-10-17
IL295588B2 (en) 2024-03-01
KR20200042464A (ko) 2020-04-23
IL307273B1 (en) 2024-11-01
IL295588A (en) 2022-10-01
JP7764432B2 (ja) 2025-11-05
JP2020536046A (ja) 2020-12-10
AU2023203013B2 (en) 2025-06-05
EP4169924A3 (en) 2023-07-05
IL271660B (en) 2022-09-01
EP3649135A1 (en) 2020-05-13

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