AU2018297305B2 - Synthesis of halichondrins - Google Patents

Synthesis of halichondrins Download PDF

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Publication number
AU2018297305B2
AU2018297305B2 AU2018297305A AU2018297305A AU2018297305B2 AU 2018297305 B2 AU2018297305 B2 AU 2018297305B2 AU 2018297305 A AU2018297305 A AU 2018297305A AU 2018297305 A AU2018297305 A AU 2018297305A AU 2018297305 B2 AU2018297305 B2 AU 2018297305B2
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AU
Australia
Prior art keywords
optionally substituted
compound
formula
certain embodiments
salt
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AU2018297305A
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English (en)
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AU2018297305A1 (en
Inventor
Yanran AI
Takashi Fukuyama
Kentaro Iso
Yoshito Kishi
Jihoon Lee
Santhosh Reddy NAINI
Isao Ohashi
Qiaoyi WANG
Kenzo YAHATA
Shuji Yamashita
Ning Ye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Harvard University
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Eisai R&D Management Co Ltd
Harvard University
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Publication of AU2018297305A1 publication Critical patent/AU2018297305A1/en
Application granted granted Critical
Publication of AU2018297305B2 publication Critical patent/AU2018297305B2/en
Priority to AU2023203013A priority Critical patent/AU2023203013B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2018297305A 2017-07-06 2018-07-06 Synthesis of halichondrins Active AU2018297305B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023203013A AU2023203013B2 (en) 2017-07-06 2023-05-15 Synthesis of halichondrins

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762529333P 2017-07-06 2017-07-06
US201762529310P 2017-07-06 2017-07-06
US62/529,333 2017-07-06
US62/529,310 2017-07-06
PCT/US2018/041005 WO2019010363A1 (en) 2017-07-06 2018-07-06 HALICHONDRINES SYNTHESIS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023203013A Division AU2023203013B2 (en) 2017-07-06 2023-05-15 Synthesis of halichondrins

Publications (2)

Publication Number Publication Date
AU2018297305A1 AU2018297305A1 (en) 2020-01-16
AU2018297305B2 true AU2018297305B2 (en) 2023-02-16

Family

ID=63036376

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018297305A Active AU2018297305B2 (en) 2017-07-06 2018-07-06 Synthesis of halichondrins
AU2023203013A Active AU2023203013B2 (en) 2017-07-06 2023-05-15 Synthesis of halichondrins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2023203013A Active AU2023203013B2 (en) 2017-07-06 2023-05-15 Synthesis of halichondrins

Country Status (14)

Country Link
US (2) US11548898B2 (https=)
EP (2) EP3649135B1 (https=)
JP (2) JP7370313B2 (https=)
KR (2) KR102438417B1 (https=)
CN (2) CN118515685A (https=)
AU (2) AU2018297305B2 (https=)
BR (1) BR112020000141A2 (https=)
CA (2) CA3211559A1 (https=)
ES (1) ES2940688T3 (https=)
HU (1) HUE061306T2 (https=)
IL (3) IL295588B2 (https=)
MX (1) MX2020000142A (https=)
SG (1) SG11201912342QA (https=)
WO (1) WO2019010363A1 (https=)

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Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
ES2931533T3 (es) 2017-04-05 2022-12-30 Harvard College Compuesto macrocíclico y usos del mismo
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
CN111484393A (zh) * 2019-01-28 2020-08-04 上海茂晟康慧科技有限公司 一种顺,顺-3,5-二甲基-1-环己醇的制备方法
CN117820275A (zh) * 2023-12-29 2024-04-05 上海科技大学 一种列净类药物及其中间体的催化合成方法

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US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
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US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

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Also Published As

Publication number Publication date
JP7370313B2 (ja) 2023-10-27
KR20220124279A (ko) 2022-09-13
AU2018297305A1 (en) 2020-01-16
CN118515685A (zh) 2024-08-20
KR102438417B1 (ko) 2022-09-01
IL307273B2 (en) 2025-03-01
EP4169924A3 (en) 2023-07-05
CN111433211A (zh) 2020-07-17
CA3211559A1 (en) 2019-01-10
US11548898B2 (en) 2023-01-10
ES2940688T3 (es) 2023-05-10
AU2023203013A1 (en) 2023-06-01
HUE061306T2 (hu) 2023-06-28
KR20200042464A (ko) 2020-04-23
IL271660A (en) 2020-02-27
EP4169924A2 (en) 2023-04-26
EP3649135A1 (en) 2020-05-13
WO2019010363A8 (en) 2019-06-06
IL307273A (en) 2023-11-01
JP7764432B2 (ja) 2025-11-05
CA3069160C (en) 2023-10-17
AU2023203013B2 (en) 2025-06-05
IL307273B1 (en) 2024-11-01
IL295588A (en) 2022-10-01
BR112020000141A2 (pt) 2020-07-14
CA3069160A1 (en) 2019-01-10
EP3649135B1 (en) 2022-12-28
IL295588B2 (en) 2024-03-01
CN111433211B (zh) 2024-05-07
JP2020536046A (ja) 2020-12-10
WO2019010363A1 (en) 2019-01-10
JP2023166381A (ja) 2023-11-21
MX2020000142A (es) 2020-07-22
RU2020104842A (ru) 2021-08-06
US20230128195A1 (en) 2023-04-27
SG11201912342QA (en) 2020-01-30
IL271660B (en) 2022-09-01
US20210230177A1 (en) 2021-07-29
IL295588B1 (en) 2023-11-01

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