MX2020000142A - Sintesis de halicondrinas. - Google Patents
Sintesis de halicondrinas.Info
- Publication number
- MX2020000142A MX2020000142A MX2020000142A MX2020000142A MX2020000142A MX 2020000142 A MX2020000142 A MX 2020000142A MX 2020000142 A MX2020000142 A MX 2020000142A MX 2020000142 A MX2020000142 A MX 2020000142A MX 2020000142 A MX2020000142 A MX 2020000142A
- Authority
- MX
- Mexico
- Prior art keywords
- synthesis
- halichondrins
- analogs
- present
- useful
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 6
- 238000003786 synthesis reaction Methods 0.000 title abstract 6
- 229930195695 Halichondrin Natural products 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- GIEQUQHFFCIXFP-GVEGDGMYSA-N halichondrin a Chemical compound O([C@@H]1[C@@H](C)[C@@H]2O[C@@H]3C[C@@]4(O[C@H]5[C@@H](C)C[C@@]6(C[C@@H]([C@@H]7O[C@@H](C[C@@H]7O6)[C@@H](O)C[C@@H](O)CO)C)O[C@H]5C4)O[C@@H]3C[C@@H]2O[C@H]1C[C@@H]1C(=C)[C@H](C)C[C@@H](O1)CC[C@H]1C(=C)C[C@@H](O1)CC1)C(=O)C[C@H](O2)CC[C@H](O[C@@H]34)[C@H]2[C@H](O2)[C@@H]4O[C@@]4(O)[C@@H]3O[C@@]12[C@@H]4O GIEQUQHFFCIXFP-GVEGDGMYSA-N 0.000 abstract 1
- 229930194670 homohalichondrin Natural products 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Carbon And Carbon Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
- Catalysts (AREA)
Abstract
La presente invencion proporciona metodos durante la sintesis de cetonas que involucra una reaccion de acoplamiento mediado por Ni/Zr; las reacciones de cetolizacion mediadas por Ni/Zr se pueden usar en la sintesis de halicondrinas (por ejemplo, halicondrina A, B, C; homohalicondrina A, B, C; norhalicondrina A, B, C) y analogos de las mismas; por lo tanto, la presente invencion tambien proporciona metodos sinteticos utiles para la sintesis de halicondrinas y sus analogos; tambien se proporcionan en el presente documento compuestos (es decir, intermedios) utiles en la sintesis de halicondrinas y analogos de los mismos; en particular, la presente invencion proporciona metodos y compuestos utiles en la sintesis del compuesto de formula (H3-A): (ver formula).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529333P | 2017-07-06 | 2017-07-06 | |
| US201762529310P | 2017-07-06 | 2017-07-06 | |
| PCT/US2018/041005 WO2019010363A1 (en) | 2017-07-06 | 2018-07-06 | HALICHONDRINES SYNTHESIS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020000142A true MX2020000142A (es) | 2020-07-22 |
Family
ID=63036376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020000142A MX2020000142A (es) | 2017-07-06 | 2018-07-06 | Sintesis de halicondrinas. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11548898B2 (es) |
| EP (2) | EP3649135B1 (es) |
| JP (2) | JP7370313B2 (es) |
| KR (2) | KR102438417B1 (es) |
| CN (2) | CN118515685A (es) |
| AU (2) | AU2018297305B2 (es) |
| BR (1) | BR112020000141A2 (es) |
| CA (2) | CA3211559A1 (es) |
| ES (1) | ES2940688T3 (es) |
| HU (1) | HUE061306T2 (es) |
| IL (3) | IL295588B2 (es) |
| MX (1) | MX2020000142A (es) |
| SG (1) | SG11201912342QA (es) |
| WO (1) | WO2019010363A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| HUE060466T2 (hu) | 2017-04-05 | 2023-03-28 | Harvard College | Makrociklusos vegyület és alkalmazása |
| IL295588B2 (en) | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of the Lichondrins |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| JP7353281B2 (ja) | 2017-11-15 | 2023-09-29 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびそれらの使用 |
| CN111484393A (zh) * | 2019-01-28 | 2020-08-04 | 上海茂晟康慧科技有限公司 | 一种顺,顺-3,5-二甲基-1-环己醇的制备方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61191687A (ja) | 1985-02-20 | 1986-08-26 | Fujisawa Pharmaceut Co Ltd | ハリコンドリンｂ |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| US5426194A (en) | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| US5352804A (en) | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| JP2818381B2 (ja) | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| JP2001305734A (ja) | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| EP1771431A1 (en) | 2004-06-03 | 2007-04-11 | Eisai Co., Ltd. | Intermediates for the preparation of halichondrin b |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| KR101440201B1 (ko) | 2007-03-07 | 2014-09-15 | 인터디지탈 테크날러지 코포레이션 | ＭＡＣ-ｅｈｓ 프로토콜 데이터 유닛을 생성하고 프로세싱하기 위한 방법 및 장치 |
| EP2069795A4 (en) | 2007-06-18 | 2010-10-06 | Medimmune Llc | SYNERGISTIC TREATMENT OF EPHA2 AND ERBB2 EXPRESSIVE CELLS |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| MX2010005340A (es) | 2007-11-16 | 2010-12-21 | Eisai R&D Man Co Ltd | Novedoso intermediario para la sintesis del analogo b de halicondrina y novedosa reaccion de desulfonilacion usada para el intermediario. |
| EP2274309B1 (en) | 2008-04-04 | 2015-07-29 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| EP2528914B1 (en) | 2010-01-26 | 2014-06-11 | Eisai R&D Management Co., Ltd. | Furo[3,2-b]pyrane derivatives useful in the synthesis of halichondrin b analogs |
| WO2012096926A2 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| AU2012350420A1 (en) | 2011-12-16 | 2014-07-10 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| JP6300030B2 (ja) | 2011-12-29 | 2018-03-28 | サンド アクツィエンゲゼルシャフト | ２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| US9650397B2 (en) | 2013-05-15 | 2017-05-16 | Alphora Research Inc. | 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| CA2916537C (en) | 2013-07-03 | 2021-07-27 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| HUE043088T2 (hu) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Halikondrin B analógok szintézisében alkalmazható eljárások |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| WO2016038624A1 (en) | 2014-09-09 | 2016-03-17 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| EP3292130B1 (en) * | 2015-05-07 | 2020-09-30 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MD3423105T2 (ro) | 2016-03-02 | 2021-10-31 | Eisai R&D Man Co Ltd | Conjugați anticorp-medicament pe bază de eribulină și metode de utilizare |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| KR20190138633A (ko) | 2017-02-20 | 2019-12-13 | 폴리포 리미티드 | 암 치료용 약제학적 조합물 |
| HUE060466T2 (hu) * | 2017-04-05 | 2023-03-28 | Harvard College | Makrociklusos vegyület és alkalmazása |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019009956A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | SUMMARY OF MEDIUM MEDIATED KETONE |
| IL295588B2 (en) | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of the Lichondrins |
| JP7353281B2 (ja) | 2017-11-15 | 2023-09-29 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびそれらの使用 |
-
2018
- 2018-07-06 IL IL295588A patent/IL295588B2/en unknown
- 2018-07-06 ES ES18746401T patent/ES2940688T3/es active Active
- 2018-07-06 CN CN202410481438.XA patent/CN118515685A/zh active Pending
- 2018-07-06 MX MX2020000142A patent/MX2020000142A/es unknown
- 2018-07-06 JP JP2020500097A patent/JP7370313B2/ja active Active
- 2018-07-06 IL IL307273A patent/IL307273A/en unknown
- 2018-07-06 CN CN201880058283.1A patent/CN111433211B/zh active Active
- 2018-07-06 SG SG11201912342QA patent/SG11201912342QA/en unknown
- 2018-07-06 KR KR1020207003432A patent/KR102438417B1/ko active IP Right Grant
- 2018-07-06 WO PCT/US2018/041005 patent/WO2019010363A1/en active Application Filing
- 2018-07-06 CA CA3211559A patent/CA3211559A1/en active Pending
- 2018-07-06 EP EP18746401.1A patent/EP3649135B1/en active Active
- 2018-07-06 EP EP22214189.7A patent/EP4169924A3/en active Pending
- 2018-07-06 US US16/628,504 patent/US11548898B2/en active Active
- 2018-07-06 HU HUE18746401A patent/HUE061306T2/hu unknown
- 2018-07-06 KR KR1020227029591A patent/KR20220124279A/ko not_active Application Discontinuation
- 2018-07-06 IL IL271660A patent/IL271660B/en unknown
- 2018-07-06 BR BR112020000141-4A patent/BR112020000141A2/pt active Search and Examination
- 2018-07-06 AU AU2018297305A patent/AU2018297305B2/en active Active
- 2018-07-06 CA CA3069160A patent/CA3069160C/en active Active
-
2022
- 2022-11-23 US US18/058,441 patent/US20230128195A1/en active Pending
-
2023
- 2023-05-15 AU AU2023203013A patent/AU2023203013A1/en active Pending
- 2023-08-07 JP JP2023128422A patent/JP2023166381A/ja active Pending
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