JO3771B1 - متوسطات لتحضير ساكوبيتريل وتحضيرها - Google Patents

متوسطات لتحضير ساكوبيتريل وتحضيرها

Info

Publication number
JO3771B1
JO3771B1 JOP/2016/0255A JOP20160255A JO3771B1 JO 3771 B1 JO3771 B1 JO 3771B1 JO P20160255 A JOP20160255 A JO P20160255A JO 3771 B1 JO3771 B1 JO 3771B1
Authority
JO
Jordan
Prior art keywords
preparation
intermediates
sacubitril
chemical synthesis
new
Prior art date
Application number
JOP/2016/0255A
Other languages
English (en)
Inventor
Paolo Filipponi
Martin Benjamin
Schlama Thierry
Venturoni Francesco
Penn Gerhard
Ruch Thomas
Allmendinger Thomas
Karl Florian
Wietfeld Bernhard
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3771B1 publication Critical patent/JO3771B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
    • C07C251/64—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids
    • C07C251/66—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids with the esterifying carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/035—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with saturated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بتركيب كيميائي جديد، متوسطات وعوامل حفازة مفيدة لتحضير مثبط النيبريلسين (NEP) ساكوبيتريل. يتعلق أيضاً بمركبات متوسطة جديدة واستخدامها لمسار التركيب الكيميائي الجديد المذكور.
JOP/2016/0255A 2015-12-10 2016-12-08 متوسطات لتحضير ساكوبيتريل وتحضيرها JO3771B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15199378 2015-12-10
EP16198655 2016-11-14

Publications (1)

Publication Number Publication Date
JO3771B1 true JO3771B1 (ar) 2021-01-31

Family

ID=57543110

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0255A JO3771B1 (ar) 2015-12-10 2016-12-08 متوسطات لتحضير ساكوبيتريل وتحضيرها

Country Status (14)

Country Link
US (2) US10377697B2 (ar)
EP (1) EP3386955B1 (ar)
JP (1) JP7001597B2 (ar)
KR (1) KR102763706B1 (ar)
CN (1) CN108602785B (ar)
AU (1) AU2016366795B2 (ar)
CA (1) CA3006254A1 (ar)
ES (1) ES2830266T3 (ar)
HK (1) HK1254367A1 (ar)
IL (1) IL259454B (ar)
JO (1) JO3771B1 (ar)
RU (1) RU2769445C2 (ar)
TW (1) TWI628158B (ar)
WO (1) WO2017098430A1 (ar)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10377697B2 (en) 2015-12-10 2019-08-13 Novartis Ag Process and intermediates
EP3424899B1 (en) 2016-02-29 2022-05-11 Sunshine Lake Pharma Co., Ltd. Sacubitril intermediate and preparation method thereof
CN107602399B (zh) * 2016-07-11 2020-09-25 江西东邦药业有限公司 一种脑啡肽酶抑制剂中间体的制备方法
CA3064574A1 (en) * 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
WO2020092693A1 (en) * 2018-10-31 2020-05-07 Polycore Therapeutics Llc Method for synthesizing d3 dopamine receptor agonists
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN110878039A (zh) * 2019-12-18 2020-03-13 株洲千金药业股份有限公司 一种沙库巴曲缬沙坦钠杂质的制备方法
CN119798080B (zh) * 2023-10-11 2025-10-03 杭州科巢生物科技有限公司 一种(r)-5-([1,1′-联苯基]-4-基)-2-甲基-4-氧代戊酸钙盐的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644281B2 (en) * 1991-04-24 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Novel thiazole derivatives
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
US6924290B2 (en) 2002-01-23 2005-08-02 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
WO2008036420A2 (en) 2006-09-21 2008-03-27 Achillion Pharmaceuticals, Inc. 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
RU2530900C2 (ru) * 2007-01-12 2014-10-20 Новартис Аг Способ получения 5-бифенил-4-амино-2-метилпентановой кислоты
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
CN101684077B (zh) * 2008-09-24 2013-01-02 浙江九洲药业股份有限公司 N-酰基联苯丙氨酸的制备方法
ES2840000T3 (es) 2009-01-08 2021-07-06 Codexis Inc Polipéptidos de transaminasa
CN101774941A (zh) 2009-01-13 2010-07-14 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的制备及拆分方法
CA2772681C (en) 2009-09-23 2017-01-03 Zhejiang Jiuzhou Pharmaceutical Co., Ltd. Process for manufacture of n-acylbphenyl alanine
SI2526088T1 (sl) 2010-01-22 2015-12-31 Novartis Ag Intermediati nevtralnih endopeptidaznih inhibitorjev in metoda za njihovo pripravo
BR112013004164A2 (pt) 2010-08-23 2016-05-10 Novartis Ag processo para a preparação de intermediários para a produção de inibidores da nep
ES2608780T3 (es) 2010-08-23 2017-04-17 Novartis Ag Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP
AR092278A1 (es) 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
CA2956075C (en) * 2014-08-01 2020-03-10 Massachusetts Institute Of Technology Modified alginates for anti-fibrotic materials and applications
CN104557600B (zh) 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
WO2016135751A1 (en) 2015-02-25 2016-09-01 Mylan Laboratories Limited Novel process for the preparation of sacubitril and its intermediates
CN105152980B (zh) 2015-09-11 2017-03-29 浙江永宁药业股份有限公司 N‑叔丁氧羰基‑（4s）‑（对苯基苯基甲基）‑4‑氨基‑（2r）‑甲基丁酸的手性制备方法
CN105330569A (zh) 2015-09-11 2016-02-17 天台宜生生化科技有限公司 一种(r)-2-(n-叔丁氧羰基氨基)联苯丙醇的制备方法
US10377697B2 (en) 2015-12-10 2019-08-13 Novartis Ag Process and intermediates
CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
CN105601524B (zh) 2016-03-17 2017-09-29 海门慧聚药业有限公司 Lcz696关键中间体的制备
CN105884656B (zh) 2016-04-20 2017-09-19 沧州那瑞化学科技有限公司 一种lcz696中间体的制备方法
CN105753741A (zh) 2016-04-26 2016-07-13 常州制药厂有限公司 一种抗心衰药物Sacubitril中间体的制备方法
CN105924355B (zh) * 2016-05-11 2018-08-17 浙江宏元药业有限公司 沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
CN107602399B (zh) * 2016-07-11 2020-09-25 江西东邦药业有限公司 一种脑啡肽酶抑制剂中间体的制备方法

Also Published As

Publication number Publication date
RU2018123321A (ru) 2020-01-10
IL259454A (en) 2018-07-31
CN108602785B (zh) 2023-08-11
CA3006254A1 (en) 2017-06-15
US20180354889A1 (en) 2018-12-13
TWI628158B (zh) 2018-07-01
RU2769445C2 (ru) 2022-03-31
KR20180093984A (ko) 2018-08-22
HK1254367A1 (zh) 2019-07-19
TW201725191A (zh) 2017-07-16
US11434192B2 (en) 2022-09-06
JP2018538295A (ja) 2018-12-27
JP7001597B2 (ja) 2022-01-19
WO2017098430A1 (en) 2017-06-15
KR102763706B1 (ko) 2025-02-07
EP3386955A1 (en) 2018-10-17
AU2016366795B2 (en) 2019-06-13
ES2830266T3 (es) 2021-06-03
CN108602785A (zh) 2018-09-28
RU2018123321A3 (ar) 2020-03-06
US20190308927A1 (en) 2019-10-10
EP3386955B1 (en) 2020-08-05
IL259454B (en) 2021-01-31
US10377697B2 (en) 2019-08-13
AU2016366795A1 (en) 2018-06-07

Similar Documents

Publication Publication Date Title
HK1254367A1 (zh) 新的工艺和中间体
PH12018501096A1 (en) Modulators of chemokine receptors
PH12018500034A1 (en) Bicyclic lactams and methods of use thereof
CU20180001A7 (es) Derivados de oxopiridina sustituidos y procesos para su preparación
CR20140229A (es) Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona
EA201691799A1 (ru) Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
BR112016029333A2 (pt) síntese de compostos de carbamoilpiridona policíclico
PH12018500409A1 (en) New bicyclic compounds as dual atx/ca inhibitors
CY1121602T1 (el) Συνθεση της κοπανλισιμπης και του διυδροχλωρικου αλατος της
MY176465A (en) Synthetic route to 2?-deoxy-2?,2?-difluorotetrahydrouridines
EA201790982A1 (ru) Синтез копанлисиба и его дигидрохлорида
MX384794B (es) Proceso para la preparacion de 5-fluoro-1h-pirazoles a partir de hexafluoropropeno.
SI3325453T1 (sl) Postopki kemijske sinteze substituiranih 10H-fenotiazin-3,7-diaminskih spojin
BR112017019176A2 (pt) processos para a preparação de fluorocetolídeos
MX2016015298A (es) Inhibidores de nampt y metodos.
MX2016007186A (es) Nuevo procedimiento de sintesis de la agomelatina.
MX2019008375A (es) Tiobenzoimidazol como fungicidas.
PH12017500499A1 (en) Synthesis of ent-progesterone and intermediates thereof
EA201491913A1 (ru) Синтез калебина-а и его биологически активных аналогов
CU20130092A7 (es) Nuevo procedimiento para la síntesis de la agomelatina
BR112016028941A2 (pt) uso de antiespumantes como aditivos antideriva".
GB201510544D0 (en) New synthesis of tapentadol-hci intermediates
BR112018007282A2 (pt) métodos para síntese total de resolvina e1
MX375880B (es) Proceso para preparar 5-bromo-1,2,3-triclorobenceno.
IN2014MU00197A (ar)