|
JPS61191687A
(ja)
|
1985-02-20 |
1986-08-26 |
Fujisawa Pharmaceut Co Ltd |
ハリコンドリンｂ
|
|
US5338865A
(en)
|
1992-03-12 |
1994-08-16 |
President And Fellows Of Harvard College |
Synthesis of halichondrin B and norhalichondrin B
|
|
US5436238A
(en)
|
1992-03-12 |
1995-07-25 |
President And Fellows Of Harvard College |
Halichondrins and related compounds
|
|
GB9206244D0
(en)
|
1992-03-23 |
1992-05-06 |
Pharma Mar Sa |
Cytotoxic compound from a marine sponge
|
|
US5426194A
(en)
|
1993-01-19 |
1995-06-20 |
Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University |
Isolation and structure of Halistatin 1
|
|
US5352804A
(en)
|
1993-01-19 |
1994-10-04 |
Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University |
Isolation and structure of Halistatin 2
|
|
JP2818381B2
(ja)
|
1994-01-18 |
1998-10-30 |
帝人株式会社 |
７−チアプロスタグランジン類およびその製造法
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
US6653341B1
(en)
|
1998-06-17 |
2003-11-25 |
Eisai Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
US6214865B1
(en)
|
1998-06-17 |
2001-04-10 |
Eisai Co., Ltd. |
Macrocyclic analogs and methods of their use and preparation
|
|
JP2001305734A
(ja)
|
2000-04-20 |
2001-11-02 |
Fuji Photo Film Co Ltd |
光重合性組成物
|
|
JP2003261447A
(ja)
|
2002-03-07 |
2003-09-16 |
Kyosei Seiyaku Kk |
抗腫瘍剤
|
|
EP2522663B1
(en)
|
2004-06-03 |
2015-04-01 |
Eisai R&D Management Co., Ltd. |
Intermediates for the preparation of halichondrin B
|
|
EP1831697A4
(en)
|
2004-12-09 |
2011-01-26 |
Eisai R&D Man Co Ltd |
SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG
|
|
JP2009184924A
(ja)
|
2006-05-31 |
2009-08-20 |
Eisai R & D Management Co Ltd |
生物学的試薬用化合物
|
|
MY153742A
(en)
|
2007-03-07 |
2015-03-13 |
Interdigital Tech Corp |
Method and apparatus for generating and processing a mac-ehs protocol data unit
|
|
US20100254996A1
(en)
|
2007-06-18 |
2010-10-07 |
Medimmune, Llc |
Synergistic treatment of cells that express epha2 and erbb2
|
|
RU2489437C2
(ru)
*
|
2007-10-03 |
2013-08-10 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Промежуточные соединения и способы синтеза аналогов галихондрина в
|
|
RU2010118063A
(ru)
|
2007-11-16 |
2011-12-27 |
ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) |
Новое промежуточное соединение для синтеза аналога галихондрина в и новая реакция десульфонилирования, применяемая для получения промежуточного соединения
|
|
CN105801599A
(zh)
|
2008-04-04 |
2016-07-27 |
卫材R&D管理有限公司 |
软海绵素b类似物
|
|
WO2011094339A1
(en)
|
2010-01-26 |
2011-08-04 |
Eisai R&D Management Co., Ltd. |
Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
|
|
WO2012096926A2
(en)
|
2011-01-10 |
2012-07-19 |
President And Fellows Of Harvard College |
Method for delivering agents into cells using bacterial toxins
|
|
WO2012147900A1
(en)
|
2011-04-28 |
2012-11-01 |
Eisai R&D Management Co., Ltd. |
Microreactor process for halichondrin b analog synthesis
|
|
CN104024237B
(zh)
|
2011-12-16 |
2016-02-24 |
阿方拉研究股份有限公司 |
用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
|
|
CN104080793B
(zh)
|
2011-12-29 |
2017-09-19 |
阿方拉研究股份有限公司 |
2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
|
|
WO2013142999A1
(en)
|
2012-03-30 |
2013-10-03 |
Alphora Research Inc. |
Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
|
|
AR096238A1
(es)
|
2013-05-15 |
2015-12-16 |
Alphora Res Inc |
Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo
|
|
CA2916537C
(en)
|
2013-07-03 |
2021-07-27 |
Alphora Research Inc. |
Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
|
|
EP3689881B1
(en)
|
2013-11-04 |
2022-01-12 |
Eisai R&D Management Co., Ltd. |
Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
|
|
MX384292B
(es)
|
2013-12-06 |
2025-03-14 |
Eisai R&D Man Co Ltd |
Metodos utiles en la sintesis de analogos de halicondrina b.
|
|
US10556910B2
(en)
|
2014-06-30 |
2020-02-11 |
President And Fellows Of Harvard College |
Synthesis of halichondrin analogs and uses thereof
|
|
WO2016038624A1
(en)
|
2014-09-09 |
2016-03-17 |
Cipla Limited |
"process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
|
|
US10344038B2
(en)
|
2015-04-30 |
2019-07-09 |
President And Fellows Of Harvard College |
Chromium-mediated coupling and application to the synthesis of halichondrins
|
|
KR102743950B1
(ko)
|
2015-05-07 |
2024-12-18 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
|
|
EP3423105B1
(en)
|
2016-03-02 |
2021-05-05 |
Eisai R&D Management Co., Ltd. |
Eribulin-based antibody-drug conjugates and methods of use
|
|
JP6978758B2
(ja)
|
2016-11-11 |
2021-12-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
パラジウム媒介ケトール化
|
|
JP2020508315A
(ja)
|
2017-02-20 |
2020-03-19 |
ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ |
がんを治療するための薬剤組合せ
|
|
US9938288B1
(en)
|
2017-04-05 |
2018-04-10 |
President And Fellows Of Harvard College |
Macrocyclic compound and uses thereof
|
|
ES2931533T3
(es)
|
2017-04-05 |
2022-12-30 |
Harvard College |
Compuesto macrocíclico y usos del mismo
|
|
WO2019009956A1
(en)
|
2017-07-06 |
2019-01-10 |
President And Fellows Of Harvard College |
SUMMARY OF MEDIUM MEDIATED KETONE
|
|
US11498892B2
(en)
|
2017-07-06 |
2022-11-15 |
President And Fellows Of Harvard College |
Fe/Cu-mediated ketone synthesis
|
|
HUE061306T2
(hu)
|
2017-07-06 |
2023-06-28 |
Harvard College |
Halikondrinok szintézise
|
|
CN111566113B
(zh)
|
2017-11-15 |
2024-01-09 |
哈佛大学的校长及成员们 |
大环化合物及其用途
|