JP2023166381A5 - - Google Patents

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Publication number
JP2023166381A5
JP2023166381A5 JP2023128422A JP2023128422A JP2023166381A5 JP 2023166381 A5 JP2023166381 A5 JP 2023166381A5 JP 2023128422 A JP2023128422 A JP 2023128422A JP 2023128422 A JP2023128422 A JP 2023128422A JP 2023166381 A5 JP2023166381 A5 JP 2023166381A5
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JP
Japan
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optionally substituted
substituted alkyl
hydrogen
independently hydrogen
protecting group
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JP2023128422A
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English (en)
Japanese (ja)
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JP2023166381A (ja
JP7764432B2 (ja
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Priority claimed from JP2020500097A external-priority patent/JP7370313B2/ja
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Publication of JP2023166381A5 publication Critical patent/JP2023166381A5/ja
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JP2023128422A 2017-07-06 2023-08-07 ハリコンドリンの合成 Active JP7764432B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762529333P 2017-07-06 2017-07-06
US201762529310P 2017-07-06 2017-07-06
US62/529,310 2017-07-06
US62/529,333 2017-07-06
JP2020500097A JP7370313B2 (ja) 2017-07-06 2018-07-06 ハリコンドリンの合成
PCT/US2018/041005 WO2019010363A1 (en) 2017-07-06 2018-07-06 HALICHONDRINES SYNTHESIS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020500097A Division JP7370313B2 (ja) 2017-07-06 2018-07-06 ハリコンドリンの合成

Publications (3)

Publication Number Publication Date
JP2023166381A JP2023166381A (ja) 2023-11-21
JP2023166381A5 true JP2023166381A5 (https=) 2024-05-09
JP7764432B2 JP7764432B2 (ja) 2025-11-05

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ID=63036376

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JP2020500097A Active JP7370313B2 (ja) 2017-07-06 2018-07-06 ハリコンドリンの合成
JP2023128422A Active JP7764432B2 (ja) 2017-07-06 2023-08-07 ハリコンドリンの合成

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2020500097A Active JP7370313B2 (ja) 2017-07-06 2018-07-06 ハリコンドリンの合成

Country Status (14)

Country Link
US (2) US11548898B2 (https=)
EP (2) EP4169924A3 (https=)
JP (2) JP7370313B2 (https=)
KR (2) KR102438417B1 (https=)
CN (2) CN118515685A (https=)
AU (2) AU2018297305B2 (https=)
BR (1) BR112020000141A2 (https=)
CA (2) CA3211559A1 (https=)
ES (1) ES2940688T3 (https=)
HU (1) HUE061306T2 (https=)
IL (3) IL271660B (https=)
MX (1) MX2020000142A (https=)
SG (1) SG11201912342QA (https=)
WO (1) WO2019010363A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
SMT202200455T1 (it) 2017-04-05 2023-01-13 Harvard College Composto macrociclico e relativi usi
WO2019010363A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College HALICHONDRINES SYNTHESIS
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
WO2019099646A1 (en) * 2017-11-15 2019-05-23 President And Fellows Of Harvard College Macrocyclic compounds and uses thereof
CN111484393A (zh) * 2019-01-28 2020-08-04 上海茂晟康慧科技有限公司 一种顺,顺-3,5-二甲基-1-环己醇的制备方法
CN117820275A (zh) * 2023-12-29 2024-04-05 上海科技大学 一种列净类药物及其中间体的催化合成方法

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US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
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US5426194A (en) 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
US5352804A (en) 1993-01-19 1994-10-04 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 2
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US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10208058B2 (en) 2014-09-09 2019-02-19 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX392296B (es) 2015-05-07 2025-03-24 Eisai R&D Man Co Ltd Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
PE20231050A1 (es) 2016-03-02 2023-07-11 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
EP3582804A1 (en) 2017-02-20 2019-12-25 Polyphor Ag Pharmaceutical combinations for treating cancer
SMT202200455T1 (it) * 2017-04-05 2023-01-13 Harvard College Composto macrociclico e relativi usi
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
WO2019010363A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College HALICHONDRINES SYNTHESIS
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
WO2019099646A1 (en) 2017-11-15 2019-05-23 President And Fellows Of Harvard College Macrocyclic compounds and uses thereof

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