JP2017536369A5 - - Google Patents
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- JP2017536369A5 JP2017536369A5 JP2017527260A JP2017527260A JP2017536369A5 JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5 JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017527260 A JP2017527260 A JP 2017527260A JP 2017536369 A5 JP2017536369 A5 JP 2017536369A5
- Authority
- JP
- Japan
- Prior art keywords
- nrc
- compound according
- sulfur
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462082231P | 2014-11-20 | 2014-11-20 | |
| US62/082,231 | 2014-11-20 | ||
| PCT/US2015/061463 WO2016081679A1 (en) | 2014-11-20 | 2015-11-19 | Heteroaryl compounds as irak inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536369A JP2017536369A (ja) | 2017-12-07 |
| JP2017536369A5 true JP2017536369A5 (https=) | 2018-12-20 |
| JP6787892B2 JP6787892B2 (ja) | 2020-11-18 |
Family
ID=54705914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527260A Active JP6787892B2 (ja) | 2014-11-20 | 2015-11-19 | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9790221B2 (https=) |
| EP (1) | EP3221306B1 (https=) |
| JP (1) | JP6787892B2 (https=) |
| KR (2) | KR20170086057A (https=) |
| CN (1) | CN107108561B (https=) |
| AR (1) | AR103138A1 (https=) |
| AU (1) | AU2015349899B9 (https=) |
| CA (1) | CA2964982C (https=) |
| DK (1) | DK3221306T3 (https=) |
| ES (1) | ES2772133T3 (https=) |
| HR (1) | HRP20200179T1 (https=) |
| HU (1) | HUE047586T2 (https=) |
| IL (1) | IL252346B (https=) |
| LT (1) | LT3221306T (https=) |
| MX (1) | MX375625B (https=) |
| NZ (1) | NZ730728A (https=) |
| PL (1) | PL3221306T3 (https=) |
| PT (1) | PT3221306T (https=) |
| RS (1) | RS59974B1 (https=) |
| RU (1) | RU2743718C2 (https=) |
| SG (1) | SG11201702741SA (https=) |
| SI (1) | SI3221306T1 (https=) |
| WO (1) | WO2016081679A1 (https=) |
| ZA (1) | ZA201702402B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA039043B1 (ru) | 2015-04-22 | 2021-11-25 | Райджел Фармасьютикалз, Инк. | Пиразольные соединения и способ получения и применения данных соединений |
| KR20180132629A (ko) * | 2016-02-25 | 2018-12-12 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10414753B2 (en) | 2016-10-26 | 2019-09-17 | Rigel Pharmaceuticals, Inc. | Amide compounds and method for making and using |
| CN110099899B (zh) | 2016-10-26 | 2024-01-02 | 里格尔药品股份有限公司 | 用作irak抑制剂的噁唑衍生物及其制备方法 |
| CA3042731A1 (en) | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
| TW201837027A (zh) * | 2017-02-01 | 2018-10-16 | 以色列商以色列耶路撒冷希伯來大學伊索研究發展有限公司 | 吡唑衍生物及其用途 |
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| EP3620457A4 (en) * | 2017-05-02 | 2021-01-06 | Korea Research Institute of Chemical Technology | PYRIMIDE-DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICAL SALT THEREOF AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF TYRO-3 RELATED DISEASES THEREOF AS ACTIVE SUBSTANCE |
| BR112020000122A2 (pt) * | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | derivados da n-(3-(2-(4-clorofenóxi)acetamido)biciclo[1.1.1] pentan-1-il)-2-ciclobutano-1-carboxamida e compostos relacionados como inibidores do atf4 para tratamento contra o câncer e outras doenças |
| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| TWI727392B (zh) | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| BR112021026517A2 (pt) | 2019-06-28 | 2022-05-10 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN121159524A (zh) | 2019-08-30 | 2025-12-19 | 里格尔药品股份有限公司 | 吡唑化合物，其配制品以及使用所述化合物和/或配制品的方法 |
| US12551564B2 (en) | 2019-12-10 | 2026-02-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021127190A1 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| PH12023500015A1 (en) | 2020-12-30 | 2024-03-11 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| WO2022187303A1 (en) | 2021-03-03 | 2022-09-09 | Rigel Pharmaceuticals, Inc. | A method for treating a disease or condition using a pyrazole compound or formulation thereof |
| EP4320103A1 (en) * | 2021-04-09 | 2024-02-14 | Quanta Therapeutics, Inc. | Pyrimidine based ras modulators and uses thereof |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| US12187744B2 (en) | 2021-10-29 | 2025-01-07 | Kymera Therapeutics, Inc. | IRAK4 degraders and synthesis thereof |
| CN116514769B (zh) * | 2022-01-21 | 2024-02-27 | 中国药科大学 | 4-羟基嘧啶-5-甲酰腙衍生物、制备方法、药物组合物和应用 |
| EP4472967A4 (en) | 2022-01-31 | 2026-04-15 | Kymera Therapeutics Inc | Iraqi Degradation Agents and Their Uses |
| AU2023218370B2 (en) | 2022-02-09 | 2024-11-28 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| JP2025513716A (ja) | 2022-03-23 | 2025-04-30 | ライジェル・ファーマシューティカルズ・インコーポレイテッド | Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物 |
| IL317601A (en) | 2022-05-25 | 2025-02-01 | Quanta Therapeutics Inc | Pyrimidine-based modulators and their uses |
| WO2024192424A1 (en) | 2023-03-15 | 2024-09-19 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| CN117924102A (zh) * | 2024-01-23 | 2024-04-26 | 成都伊诺达博医药科技有限公司 | 一种微管亲和力调节激酶抑制剂中间体的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090058276A1 (en) * | 2007-08-20 | 2009-03-05 | Holliday Bradley J | METAL-CONTAINING POLYMERS and uses thereof |
| WO2009054253A1 (ja) * | 2007-10-26 | 2009-04-30 | Konica Minolta Holdings, Inc. | 有機エレクトロルミネッセンス素子、表示装置及び照明装置 |
| UA107183C2 (uk) | 2008-08-04 | 2014-12-10 | Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань | |
| EP2414337B1 (en) * | 2009-04-03 | 2013-05-01 | Cellzome GmbH | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| JP2011098948A (ja) * | 2009-06-25 | 2011-05-19 | Yamagata Promotional Organization For Industrial Technology | ビピリジン誘導体及びそれを含む有機エレクトロルミネッセンス素子 |
| JP2013514973A (ja) * | 2009-12-21 | 2013-05-02 | メルク・シャープ・エンド・ドーム・コーポレイション | チロシンキナーゼ阻害剤 |
| JP5985473B2 (ja) * | 2010-07-13 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＩＲＡＫ４モジュレーターとしてのピラゾロ［１，５ａ］ピリミジン及びチエノ［３，２ｂ］ピリミジン誘導体 |
| US20130261077A1 (en) * | 2012-03-07 | 2013-10-03 | Vertex Pharmaceuticals Incorporated | Mannose derivatives for treating bacterial infections |
| US20150041789A1 (en) * | 2012-03-22 | 2015-02-12 | Konica Minolta, Inc. | Transparent electrode, electronic device, and organic electroluminescent element |
| SG11201500005SA (en) * | 2012-07-10 | 2015-01-29 | Ares Trading Sa | Pyrimidine pyrazolyl derivatives |
| US10314841B2 (en) * | 2014-01-09 | 2019-06-11 | Merck Patent Gmbh | Substituted pyrazoles as IRAK inhibitors |
-
2015
- 2015-11-19 CA CA2964982A patent/CA2964982C/en active Active
- 2015-11-19 LT LTEP15801650.1T patent/LT3221306T/lt unknown
- 2015-11-19 HR HRP20200179TT patent/HRP20200179T1/hr unknown
- 2015-11-19 SG SG11201702741SA patent/SG11201702741SA/en unknown
- 2015-11-19 JP JP2017527260A patent/JP6787892B2/ja active Active
- 2015-11-19 PT PT158016501T patent/PT3221306T/pt unknown
- 2015-11-19 MX MX2017006266A patent/MX375625B/es active IP Right Grant
- 2015-11-19 RS RS20200153A patent/RS59974B1/sr unknown
- 2015-11-19 KR KR1020177015188A patent/KR20170086057A/ko not_active Ceased
- 2015-11-19 SI SI201531094T patent/SI3221306T1/sl unknown
- 2015-11-19 ES ES15801650T patent/ES2772133T3/es active Active
- 2015-11-19 KR KR1020237038922A patent/KR102683518B1/ko active Active
- 2015-11-19 DK DK15801650.1T patent/DK3221306T3/da active
- 2015-11-19 NZ NZ730728A patent/NZ730728A/en not_active IP Right Cessation
- 2015-11-19 CN CN201580073060.9A patent/CN107108561B/zh not_active Expired - Fee Related
- 2015-11-19 AU AU2015349899A patent/AU2015349899B9/en active Active
- 2015-11-19 EP EP15801650.1A patent/EP3221306B1/en active Active
- 2015-11-19 WO PCT/US2015/061463 patent/WO2016081679A1/en not_active Ceased
- 2015-11-19 PL PL15801650T patent/PL3221306T3/pl unknown
- 2015-11-19 RU RU2017120274A patent/RU2743718C2/ru active
- 2015-11-19 US US14/945,610 patent/US9790221B2/en active Active
- 2015-11-19 HU HUE15801650A patent/HUE047586T2/hu unknown
- 2015-11-20 AR ARP150103793A patent/AR103138A1/es unknown
-
2017
- 2017-04-05 ZA ZA2017/02402A patent/ZA201702402B/en unknown
- 2017-05-17 IL IL252346A patent/IL252346B/en active IP Right Grant
- 2017-09-12 US US15/701,842 patent/US10030013B2/en active Active
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