JP2015518903A5 - - Google Patents
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- Publication number
- JP2015518903A5 JP2015518903A5 JP2015516256A JP2015516256A JP2015518903A5 JP 2015518903 A5 JP2015518903 A5 JP 2015518903A5 JP 2015516256 A JP2015516256 A JP 2015516256A JP 2015516256 A JP2015516256 A JP 2015516256A JP 2015518903 A5 JP2015518903 A5 JP 2015518903A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acceptable salt
- pharmaceutically acceptable
- optionally substituted
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *C(C(CCN(C1)c(ncnc2N)c2F)C1N(CCCC1NC2CCCC=CCCC2)C1=O)O Chemical compound *C(C(CCN(C1)c(ncnc2N)c2F)C1N(CCCC1NC2CCCC=CCCC2)C1=O)O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657360P | 2012-06-08 | 2012-06-08 | |
| US61/657,360 | 2012-06-08 | ||
| PCT/US2013/044800 WO2013185084A1 (en) | 2012-06-08 | 2013-06-07 | Pyrimidinyl tyrosine kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017150480A Division JP2017193583A (ja) | 2012-06-08 | 2017-08-03 | ピリミジニルチロシンキナーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518903A JP2015518903A (ja) | 2015-07-06 |
| JP2015518903A5 true JP2015518903A5 (https=) | 2016-07-28 |
| JP6214643B2 JP6214643B2 (ja) | 2017-10-18 |
Family
ID=49712704
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516256A Expired - Fee Related JP6214643B2 (ja) | 2012-06-08 | 2013-06-07 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2017150480A Withdrawn JP2017193583A (ja) | 2012-06-08 | 2017-08-03 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2019017850A Withdrawn JP2019077728A (ja) | 2012-06-08 | 2019-02-04 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2021018127A Pending JP2021073298A (ja) | 2012-06-08 | 2021-02-08 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2021018128A Pending JP2021073299A (ja) | 2012-06-08 | 2021-02-08 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2023004462A Pending JP2023052415A (ja) | 2012-06-08 | 2023-01-16 | ピリミジニルチロシンキナーゼ阻害剤 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017150480A Withdrawn JP2017193583A (ja) | 2012-06-08 | 2017-08-03 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2019017850A Withdrawn JP2019077728A (ja) | 2012-06-08 | 2019-02-04 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2021018127A Pending JP2021073298A (ja) | 2012-06-08 | 2021-02-08 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2021018128A Pending JP2021073299A (ja) | 2012-06-08 | 2021-02-08 | ピリミジニルチロシンキナーゼ阻害剤 |
| JP2023004462A Pending JP2023052415A (ja) | 2012-06-08 | 2023-01-16 | ピリミジニルチロシンキナーゼ阻害剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US9394277B2 (https=) |
| EP (3) | EP3753934A1 (https=) |
| JP (6) | JP6214643B2 (https=) |
| KR (4) | KR20220154850A (https=) |
| CN (3) | CN104540385B (https=) |
| AR (1) | AR091273A1 (https=) |
| AU (5) | AU2013271407B2 (https=) |
| BR (2) | BR112014030655B1 (https=) |
| CA (2) | CA3108186A1 (https=) |
| CY (1) | CY1120638T1 (https=) |
| DK (1) | DK2858499T3 (https=) |
| EA (2) | EA027823B1 (https=) |
| ES (2) | ES2684268T3 (https=) |
| HR (1) | HRP20181294T1 (https=) |
| HU (1) | HUE039897T2 (https=) |
| IL (2) | IL235938B (https=) |
| IN (1) | IN2014DN10576A (https=) |
| LT (1) | LT2858499T (https=) |
| MX (2) | MX363672B (https=) |
| NZ (1) | NZ702715A (https=) |
| PH (2) | PH12018501463B1 (https=) |
| PL (1) | PL2858499T3 (https=) |
| PT (1) | PT2858499T (https=) |
| RS (1) | RS57978B1 (https=) |
| SG (2) | SG11201408173WA (https=) |
| SI (1) | SI2858499T1 (https=) |
| SM (1) | SMT201800442T1 (https=) |
| TW (3) | TWI719209B (https=) |
| WO (1) | WO2013185084A1 (https=) |
| ZA (1) | ZA201409255B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ598985A (en) * | 2009-09-04 | 2013-07-26 | Biogen Idec Inc | Bruton's tyrosine kinase inhibitors |
| WO2012058645A1 (en) | 2010-10-29 | 2012-05-03 | Biogen Idec Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| US9353087B2 (en) | 2012-06-08 | 2016-05-31 | Biogen Ma Inc. | Inhibitors of Bruton's tyrosine kinase |
| AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
| AU2014362231B2 (en) * | 2013-12-11 | 2019-04-04 | Biogen Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| WO2015151006A1 (en) | 2014-03-29 | 2015-10-08 | Lupin Limited | Substituted purine compounds as btk inhibitors |
| WO2015170266A1 (en) | 2014-05-07 | 2015-11-12 | Lupin Limited | Substituted pyrimidine compounds as btk inhibitors |
| PE20190710A1 (es) * | 2014-10-24 | 2019-05-17 | Bristol Myers Squibb Co | Compuestos de indol carboxamida utiles como inhibidores de cinasas |
| JP7214632B2 (ja) * | 2016-07-21 | 2023-01-30 | バイオジェン エムエー インク． | ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物 |
| WO2019208805A1 (ja) | 2018-04-27 | 2019-10-31 | 小野薬品工業株式会社 | Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤 |
| CN117285467A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| EP4313023A1 (en) | 2021-04-02 | 2024-02-07 | Biogen MA Inc. | Combination treatment methods of multiple sclerosis |
| WO2023081709A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Vecabrutinib for the treatment of graft-versus-host disease |
| US20260083848A1 (en) | 2021-11-03 | 2026-03-26 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| KR20240157639A (ko) | 2021-12-14 | 2024-11-01 | 크로스파이어 온콜로지 홀딩 비.브이. | 거대고리 btk 억제제 |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
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| EP2485589A4 (en) | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | HETEROARYL-BTK INHIBITORS |
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| WO2012058645A1 (en) | 2010-10-29 | 2012-05-03 | Biogen Idec Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| US9353087B2 (en) | 2012-06-08 | 2016-05-31 | Biogen Ma Inc. | Inhibitors of Bruton's tyrosine kinase |
| AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
| EP3444251B1 (en) | 2013-12-11 | 2023-06-07 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| AU2014362231B2 (en) | 2013-12-11 | 2019-04-04 | Biogen Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
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| JP7214632B2 (ja) * | 2016-07-21 | 2023-01-30 | バイオジェン エムエー インク． | ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物 |
-
2013
- 2013-06-05 AR ARP130101980 patent/AR091273A1/es not_active Application Discontinuation
- 2013-06-07 EP EP20186539.1A patent/EP3753934A1/en not_active Withdrawn
- 2013-06-07 KR KR1020227039393A patent/KR20220154850A/ko not_active Ceased
- 2013-06-07 BR BR112014030655-9A patent/BR112014030655B1/pt not_active IP Right Cessation
- 2013-06-07 ES ES13800042.7T patent/ES2684268T3/es active Active
- 2013-06-07 EP EP13800042.7A patent/EP2858499B1/en active Active
- 2013-06-07 MX MX2014015044A patent/MX363672B/es unknown
- 2013-06-07 WO PCT/US2013/044800 patent/WO2013185084A1/en not_active Ceased
- 2013-06-07 JP JP2015516256A patent/JP6214643B2/ja not_active Expired - Fee Related
- 2013-06-07 CA CA3108186A patent/CA3108186A1/en not_active Abandoned
- 2013-06-07 CN CN201380036869.5A patent/CN104540385B/zh not_active Expired - Fee Related
- 2013-06-07 RS RS20180950A patent/RS57978B1/sr unknown
- 2013-06-07 NZ NZ702715A patent/NZ702715A/en not_active IP Right Cessation
- 2013-06-07 CN CN201810384098.3A patent/CN109305959B/zh active Active
- 2013-06-07 MX MX2019003618A patent/MX385593B/es unknown
- 2013-06-07 ES ES18171833T patent/ES2834333T3/es active Active
- 2013-06-07 BR BR122021002178-3A patent/BR122021002178B1/pt active IP Right Grant
- 2013-06-07 LT LTEP13800042.7T patent/LT2858499T/lt unknown
- 2013-06-07 CA CA2875799A patent/CA2875799C/en active Active
- 2013-06-07 SG SG11201408173WA patent/SG11201408173WA/en unknown
- 2013-06-07 CN CN202110783143.4A patent/CN113549055A/zh active Pending
- 2013-06-07 AU AU2013271407A patent/AU2013271407B2/en not_active Ceased
- 2013-06-07 HR HRP20181294TT patent/HRP20181294T1/hr unknown
- 2013-06-07 TW TW106116775A patent/TWI719209B/zh not_active IP Right Cessation
- 2013-06-07 TW TW110102365A patent/TWI792158B/zh not_active IP Right Cessation
- 2013-06-07 PT PT13800042T patent/PT2858499T/pt unknown
- 2013-06-07 US US14/406,315 patent/US9394277B2/en active Active
- 2013-06-07 SG SG10201708535UA patent/SG10201708535UA/en unknown
- 2013-06-07 EP EP18171833.9A patent/EP3385263B1/en not_active Not-in-force
- 2013-06-07 SI SI201331130T patent/SI2858499T1/sl unknown
- 2013-06-07 PH PH1/2018/501463A patent/PH12018501463B1/en unknown
- 2013-06-07 EA EA201492056A patent/EA027823B1/ru unknown
- 2013-06-07 KR KR1020207010675A patent/KR20200043497A/ko not_active Ceased
- 2013-06-07 KR KR1020157000393A patent/KR102102587B1/ko not_active Expired - Fee Related
- 2013-06-07 IN IN10576DEN2014 patent/IN2014DN10576A/en unknown
- 2013-06-07 HU HUE13800042A patent/HUE039897T2/hu unknown
- 2013-06-07 DK DK13800042.7T patent/DK2858499T3/en active
- 2013-06-07 EA EA201790418A patent/EA201790418A1/ru unknown
- 2013-06-07 PL PL13800042T patent/PL2858499T3/pl unknown
- 2013-06-07 KR KR1020217017552A patent/KR102468430B1/ko active Active
- 2013-06-07 TW TW102120447A patent/TWI592406B/zh not_active IP Right Cessation
- 2013-06-08 SM SM20180442T patent/SMT201800442T1/it unknown
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2014
- 2014-11-27 IL IL235938A patent/IL235938B/en active IP Right Grant
- 2014-12-03 PH PH12014502699A patent/PH12014502699A1/en unknown
- 2014-12-15 ZA ZA2014/09255A patent/ZA201409255B/en unknown
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2016
- 2016-06-29 US US15/196,389 patent/US9944622B2/en active Active
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2017
- 2017-03-07 AU AU2017201536A patent/AU2017201536B2/en not_active Ceased
- 2017-08-03 JP JP2017150480A patent/JP2017193583A/ja not_active Withdrawn
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2018
- 2018-03-05 US US15/911,546 patent/US10618887B2/en active Active
- 2018-08-16 CY CY181100861T patent/CY1120638T1/el unknown
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2019
- 2019-02-04 JP JP2019017850A patent/JP2019077728A/ja not_active Withdrawn
- 2019-05-17 AU AU2019203476A patent/AU2019203476B2/en not_active Ceased
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2020
- 2020-02-27 US US16/802,959 patent/US20210017155A1/en not_active Abandoned
- 2020-10-11 IL IL277951A patent/IL277951A/en unknown
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2021
- 2021-02-08 JP JP2021018127A patent/JP2021073298A/ja active Pending
- 2021-02-08 JP JP2021018128A patent/JP2021073299A/ja active Pending
- 2021-04-21 AU AU2021202412A patent/AU2021202412A1/en not_active Abandoned
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2022
- 2022-08-08 US US17/883,202 patent/US20230174511A1/en not_active Abandoned
- 2022-11-25 AU AU2022275504A patent/AU2022275504A1/en not_active Abandoned
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2023
- 2023-01-16 JP JP2023004462A patent/JP2023052415A/ja active Pending
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2024
- 2024-08-23 US US18/813,750 patent/US20240417389A1/en active Pending
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