JP2023171659A5 - - Google Patents
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- JP2023171659A5 JP2023171659A5 JP2023177565A JP2023177565A JP2023171659A5 JP 2023171659 A5 JP2023171659 A5 JP 2023171659A5 JP 2023177565 A JP2023177565 A JP 2023177565A JP 2023177565 A JP2023177565 A JP 2023177565A JP 2023171659 A5 JP2023171659 A5 JP 2023171659A5
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- JP
- Japan
- Prior art keywords
- formula
- alkyl
- group
- hydrogen
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2020-0037875 | 2020-03-27 | ||
| KR20200037875 | 2020-03-27 | ||
| PCT/KR2021/003807 WO2021194318A1 (en) | 2020-03-27 | 2021-03-27 | Plk1 selective degradation inducing compound |
| JP2021578216A JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Division JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023171659A JP2023171659A (ja) | 2023-12-01 |
| JP2023171659A5 true JP2023171659A5 (https=) | 2024-04-10 |
Family
ID=77892014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Active JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
| JP2023177565A Pending JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Active JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20230158158A1 (https=) |
| EP (1) | EP3911654A4 (https=) |
| JP (2) | JP7440940B2 (https=) |
| KR (8) | KR20210122165A (https=) |
| CN (1) | CN113784969A (https=) |
| WO (4) | WO2021194318A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020356484A1 (en) * | 2019-09-27 | 2022-03-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
| KR20240035820A (ko) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Ikzf2를 조절하는 아릴 화합물 및 약학 조성물 |
| EP4157849A4 (en) * | 2021-08-10 | 2024-12-11 | Uppthera, Inc. | NOVEL PLK1 DEGRADATION-INDUCING COMPOUND |
| US20250171417A1 (en) | 2021-08-11 | 2025-05-29 | Xizang Haisco Pharmaceutical Co., Ltd. | Heterocyclic derivative, and composition and pharmaceutical use thereof |
| CN114380682A (zh) * | 2021-10-27 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种2,3-二氟-4-甲氧基苯乙酸合成方法 |
| CN118339161B (zh) * | 2021-12-10 | 2025-12-09 | 正大天晴药业集团股份有限公司 | 一种异噻唑并[5,4-d]嘧啶类IRAK4抑制剂的制备方法 |
| CN118382626A (zh) * | 2021-12-10 | 2024-07-23 | 山东绿叶制药有限公司 | 蛋白激酶抑制剂及其制备方法和应用 |
| CN116924929A (zh) * | 2022-07-08 | 2023-10-24 | 重庆圣华曦药业股份有限公司 | 一种碘比醇异构体的合成方法 |
| CN115490675B (zh) * | 2022-09-19 | 2024-11-12 | 安阳师范学院 | 季酮酸衍生物及其制备方法与应用 |
| CN120603831A (zh) * | 2022-11-29 | 2025-09-05 | 厄普特拉株式会社 | 具有增加的刚性的plk1降解诱导化合物 |
| CN120530121A (zh) * | 2023-01-17 | 2025-08-22 | 北京哲源科技有限责任公司 | 吡唑并喹唑啉类化合物的立体异构体和氘代衍生物及应用 |
| KR20250037591A (ko) * | 2023-02-02 | 2025-03-17 | (주) 업테라 | 신규 plk1 분해 유도 화합물 |
| CN116554044A (zh) * | 2023-05-16 | 2023-08-08 | 上海师范大学 | 一种无氨基保护的2,6-二异丙基-4-羧基苯胺及其合成方法 |
| KR20250058831A (ko) | 2023-10-23 | 2025-05-02 | 주식회사 펩토이드 | Ｐｌｋ－１의 폴로박스 도메인에 결합하는 저분자 화합물을 함유하는 항암제 |
| WO2025239662A1 (ko) * | 2024-05-13 | 2025-11-20 | (주) 업테라 | 분해 약물-항체 접합체용 plk1 분해 유도 화합물 |
| CN119707950A (zh) * | 2024-12-24 | 2025-03-28 | 无锡市南京大学锡山应用生物技术研究所 | 一种用于免疫蛋白靶向降解的嵌合体及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1937671E (pt) * | 2005-09-06 | 2010-03-12 | Smithkline Beecham Corp | Compostos de benzimidazole tiofeno como inibidores de plk |
| PT2125822E (pt) * | 2006-12-21 | 2015-01-30 | Nerviano Medical Sciences Srl | Derivados de pirazol-quinazolina substituídos, processo para sua preparação e seu uso como inibidores da quinase |
| WO2008113711A1 (en) * | 2007-03-22 | 2008-09-25 | F. Hoffmann-La Roche Ag | Substituted pyrimidodiazepines useful as plk1 inhibitors |
| WO2009042711A1 (en) * | 2007-09-25 | 2009-04-02 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| JP2011527667A (ja) | 2008-06-18 | 2011-11-04 | 武田薬品工業株式会社 | ハロ置換ピリミドジアゼピン |
| AR076784A1 (es) * | 2009-05-26 | 2011-07-06 | Nerviano Medical Sciences Srl | Combinacion terapeutica que comprende un inhibidor de plk1 y un agente antineoplasico |
| CA2861066C (en) * | 2012-01-12 | 2024-01-02 | Yale University | Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase |
| AU2015247817C1 (en) | 2014-04-14 | 2022-02-10 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| US10730870B2 (en) | 2015-03-18 | 2020-08-04 | Arvinas Operations, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| AU2016349781A1 (en) * | 2015-11-02 | 2018-05-10 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| CN106543185B (zh) | 2016-11-10 | 2017-12-15 | 吉林大学 | 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| BR112019015484A2 (pt) * | 2017-01-31 | 2020-04-28 | Arvinas Operations Inc | ligantes de cereblon e compostos bifuncionais compreendendo os mesmos |
| CN106977584B (zh) * | 2017-04-19 | 2019-12-06 | 吉林大学 | 靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| CN109912655B (zh) | 2017-12-13 | 2021-12-10 | 上海科技大学 | Alk蛋白降解剂及其抗肿瘤应用 |
| KR102127289B1 (ko) * | 2018-09-18 | 2020-06-26 | 고려대학교 산학협력단 | 암 세포를 표적화하기 위한 plk 선택적 형광 프로브 화합물 및 이를 포함하는 plk 검출용 형광 센서 |
| CN111018857B (zh) * | 2018-10-09 | 2023-06-02 | 嘉兴优博生物技术有限公司 | 靶向蛋白酶降解平台(ted) |
| CN109879877B (zh) | 2019-03-04 | 2021-08-10 | 吉林大学 | 一种可降解plk1和brd4蛋白的化合物及其应用 |
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
| EP4157849A4 (en) * | 2021-08-10 | 2024-12-11 | Uppthera, Inc. | NOVEL PLK1 DEGRADATION-INDUCING COMPOUND |
-
2021
- 2021-03-27 US US17/914,545 patent/US20230158158A1/en active Pending
- 2021-03-27 WO PCT/KR2021/003807 patent/WO2021194318A1/en not_active Ceased
- 2021-03-27 WO PCT/KR2021/003810 patent/WO2021194321A1/en not_active Ceased
- 2021-03-27 CN CN202180002576.XA patent/CN113784969A/zh active Pending
- 2021-03-27 JP JP2021578216A patent/JP7440940B2/ja active Active
- 2021-03-27 EP EP21749059.8A patent/EP3911654A4/en active Pending
- 2021-03-27 KR KR1020210040038D patent/KR20210122165A/ko active Granted
- 2021-03-27 KR KR1020210040036D patent/KR20210122163A/ko active Granted
- 2021-03-27 US US17/428,467 patent/US11833208B2/en active Active
- 2021-03-27 KR KR1020210040037A patent/KR102319264B1/ko active Active
- 2021-03-27 KR KR1020210040038A patent/KR102313753B1/ko active Active
- 2021-03-27 KR KR1020210040035A patent/KR102337029B1/ko active Active
- 2021-03-27 KR KR1020210040037D patent/KR20210122164A/ko active Granted
- 2021-03-27 KR KR1020210040036A patent/KR102313752B1/ko active Active
- 2021-03-27 WO PCT/KR2021/003809 patent/WO2021194320A1/en not_active Ceased
- 2021-03-27 US US17/914,565 patent/US12403198B2/en active Active
- 2021-03-27 US US17/914,574 patent/US20230203006A1/en active Pending
- 2021-03-27 WO PCT/KR2021/003808 patent/WO2021194319A1/en not_active Ceased
- 2021-12-02 KR KR1020210171223A patent/KR102529222B1/ko active Active
-
2023
- 2023-08-02 US US18/229,353 patent/US20230372498A1/en not_active Abandoned
- 2023-10-13 JP JP2023177565A patent/JP2023171659A/ja active Pending
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