JP2023171659A5 - - Google Patents
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- JP2023171659A5 JP2023171659A5 JP2023177565A JP2023177565A JP2023171659A5 JP 2023171659 A5 JP2023171659 A5 JP 2023171659A5 JP 2023177565 A JP2023177565 A JP 2023177565A JP 2023177565 A JP2023177565 A JP 2023177565A JP 2023171659 A5 JP2023171659 A5 JP 2023171659A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- group
- hydrogen
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2020-0037875 | 2020-03-27 | ||
| KR20200037875 | 2020-03-27 | ||
| JP2021578216A JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
| PCT/KR2021/003807 WO2021194318A1 (en) | 2020-03-27 | 2021-03-27 | Plk1 selective degradation inducing compound |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Division JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023171659A JP2023171659A (ja) | 2023-12-01 |
| JP2023171659A5 true JP2023171659A5 (https=) | 2024-04-10 |
Family
ID=77892014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Active JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
| JP2023177565A Pending JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Active JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US12403198B2 (https=) |
| EP (1) | EP3911654A4 (https=) |
| JP (2) | JP7440940B2 (https=) |
| KR (8) | KR20210122163A (https=) |
| CN (1) | CN113784969A (https=) |
| WO (4) | WO2021194321A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12551563B2 (en) | 2019-09-27 | 2026-02-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
| KR20210122163A (ko) * | 2020-03-27 | 2021-10-08 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 피라졸로퀴나졸린 유도체 화합물 |
| CA3226162A1 (en) | 2021-07-09 | 2023-01-12 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
| PE20240894A1 (es) * | 2021-08-10 | 2024-04-24 | Uppthera Inc | Compuesto inductor de la degradacion de plk1 novedoso |
| TW202321219A (zh) | 2021-08-11 | 2023-06-01 | 大陸商四川海思科製藥有限公司 | 雜環衍生物及其組合物和藥學上的應用 |
| CN114380682A (zh) * | 2021-10-27 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种2,3-二氟-4-甲氧基苯乙酸合成方法 |
| WO2023104195A1 (zh) * | 2021-12-10 | 2023-06-15 | 正大天晴药业集团股份有限公司 | 一种异噻唑并[5,4-d]嘧啶类IRAK4抑制剂的制备方法 |
| CN118382626A (zh) * | 2021-12-10 | 2024-07-23 | 山东绿叶制药有限公司 | 蛋白激酶抑制剂及其制备方法和应用 |
| CN116924929A (zh) * | 2022-07-08 | 2023-10-24 | 重庆圣华曦药业股份有限公司 | 一种碘比醇异构体的合成方法 |
| CN115490675B (zh) * | 2022-09-19 | 2024-11-12 | 安阳师范学院 | 季酮酸衍生物及其制备方法与应用 |
| EP4626889A4 (en) * | 2022-11-29 | 2026-03-18 | Uppthera Inc | COMPOUNDS INDUCING THE DEGRADATION OF PLK1 WITH INCREASED STIFFNESS |
| EP4653443A1 (en) * | 2023-01-17 | 2025-11-26 | Phil Rivers Technology Co., Ltd | Stereoisomer and deuterated derivative of pyrazoloquinazoline compound and use |
| CN119790057A (zh) * | 2023-02-02 | 2025-04-08 | 厄普特拉株式会社 | 新型plk1降解诱导化合物 |
| CN116554044A (zh) * | 2023-05-16 | 2023-08-08 | 上海师范大学 | 一种无氨基保护的2,6-二异丙基-4-羧基苯胺及其合成方法 |
| KR20250058831A (ko) | 2023-10-23 | 2025-05-02 | 주식회사 펩토이드 | Ｐｌｋ－１의 폴로박스 도메인에 결합하는 저분자 화합물을 함유하는 항암제 |
| WO2025239662A1 (ko) * | 2024-05-13 | 2025-11-20 | (주) 업테라 | 분해 약물-항체 접합체용 plk1 분해 유도 화합물 |
| CN119707950A (zh) * | 2024-12-24 | 2025-03-28 | 无锡市南京大学锡山应用生物技术研究所 | 一种用于免疫蛋白靶向降解的嵌合体及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA014111B1 (ru) | 2005-09-06 | 2010-10-29 | Смитклайн Бичем Корпорейшн | Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk) |
| MX2009006613A (es) * | 2006-12-21 | 2009-07-02 | Nerviano Medical Sciences Srl | Derivados de pirazolo-quinazolina sustituidos, proceso para su preparacion y su uso como inhibidores de cinasa. |
| AU2008228303B2 (en) * | 2007-03-22 | 2012-04-19 | Takeda Pharmaceutical Company Limited | Substituted pyrimidodiazepines useful as PLK1 inhibitors |
| EP2205241B1 (en) * | 2007-09-25 | 2014-05-21 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| EP2303889A1 (en) | 2008-06-18 | 2011-04-06 | F. Hoffmann-La Roche AG | Halo-substituted pyrimidodiazepines as plkl inhibitors |
| AR076784A1 (es) | 2009-05-26 | 2011-07-06 | Nerviano Medical Sciences Srl | Combinacion terapeutica que comprende un inhibidor de plk1 y un agente antineoplasico |
| KR102668696B1 (ko) * | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| RU2738833C9 (ru) | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| EP3270917A4 (en) | 2015-03-18 | 2018-08-08 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| WO2016197114A1 (en) * | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| BR112018008918A8 (pt) | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| CN106543185B (zh) | 2016-11-10 | 2017-12-15 | 吉林大学 | 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| IL312367A (en) * | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| CN106977584B (zh) * | 2017-04-19 | 2019-12-06 | 吉林大学 | 靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| CA3085645C (en) | 2017-12-13 | 2024-01-16 | Shanghaitech University | Alk protein degraders and their use in cancer therapy |
| KR102127289B1 (ko) * | 2018-09-18 | 2020-06-26 | 고려대학교 산학협력단 | 암 세포를 표적화하기 위한 plk 선택적 형광 프로브 화합물 및 이를 포함하는 plk 검출용 형광 센서 |
| CN111018857B (zh) * | 2018-10-09 | 2023-06-02 | 嘉兴优博生物技术有限公司 | 靶向蛋白酶降解平台(ted) |
| CN109879877B (zh) | 2019-03-04 | 2021-08-10 | 吉林大学 | 一种可降解plk1和brd4蛋白的化合物及其应用 |
| KR20210122163A (ko) * | 2020-03-27 | 2021-10-08 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 피라졸로퀴나졸린 유도체 화합물 |
| PE20240894A1 (es) * | 2021-08-10 | 2024-04-24 | Uppthera Inc | Compuesto inductor de la degradacion de plk1 novedoso |
-
2021
- 2021-03-27 KR KR1020210040036D patent/KR20210122163A/ko active Granted
- 2021-03-27 KR KR1020210040038D patent/KR20210122165A/ko active Granted
- 2021-03-27 KR KR1020210040036A patent/KR102313752B1/ko active Active
- 2021-03-27 KR KR1020210040037D patent/KR20210122164A/ko active Granted
- 2021-03-27 KR KR1020210040035A patent/KR102337029B1/ko active Active
- 2021-03-27 WO PCT/KR2021/003810 patent/WO2021194321A1/en not_active Ceased
- 2021-03-27 KR KR1020210040038A patent/KR102313753B1/ko active Active
- 2021-03-27 WO PCT/KR2021/003809 patent/WO2021194320A1/en not_active Ceased
- 2021-03-27 JP JP2021578216A patent/JP7440940B2/ja active Active
- 2021-03-27 US US17/914,565 patent/US12403198B2/en active Active
- 2021-03-27 KR KR1020210040037A patent/KR102319264B1/ko active Active
- 2021-03-27 WO PCT/KR2021/003807 patent/WO2021194318A1/en not_active Ceased
- 2021-03-27 WO PCT/KR2021/003808 patent/WO2021194319A1/en not_active Ceased
- 2021-03-27 US US17/914,574 patent/US20230203006A1/en active Pending
- 2021-03-27 US US17/428,467 patent/US11833208B2/en active Active
- 2021-03-27 US US17/914,545 patent/US20230158158A1/en active Pending
- 2021-03-27 CN CN202180002576.XA patent/CN113784969A/zh active Pending
- 2021-03-27 EP EP21749059.8A patent/EP3911654A4/en active Pending
- 2021-12-02 KR KR1020210171223A patent/KR102529222B1/ko active Active
-
2023
- 2023-08-02 US US18/229,353 patent/US20230372498A1/en not_active Abandoned
- 2023-10-13 JP JP2023177565A patent/JP2023171659A/ja active Pending
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