JP2012197282A5 - - Google Patents
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- Publication number
- JP2012197282A5 JP2012197282A5 JP2012115710A JP2012115710A JP2012197282A5 JP 2012197282 A5 JP2012197282 A5 JP 2012197282A5 JP 2012115710 A JP2012115710 A JP 2012115710A JP 2012115710 A JP2012115710 A JP 2012115710A JP 2012197282 A5 JP2012197282 A5 JP 2012197282A5
- Authority
- JP
- Japan
- Prior art keywords
- organic solvent
- formula
- acid
- mixture
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- FIMXSEMBHGTNKT-UHFFFAOYSA-N CN1C(C2)C3OC3C1CC2O Chemical compound CN1C(C2)C3OC3C1CC2O FIMXSEMBHGTNKT-UHFFFAOYSA-N 0.000 description 3
- 0 *C(C(c1ccc[s]1)(c1ccc[s]1)O)=O Chemical compound *C(C(c1ccc[s]1)(c1ccc[s]1)O)=O 0.000 description 1
- TUSYXLWQAHTQFG-UHFFFAOYSA-N CN(C(C1)CC(C2)OC(C(c3ccc[s]3)(c3ccc[s]3)O)=O)C2C1[O-] Chemical compound CN(C(C1)CC(C2)OC(C(c3ccc[s]3)(c3ccc[s]3)O)=O)C2C1[O-] TUSYXLWQAHTQFG-UHFFFAOYSA-N 0.000 description 1
- MEBLMEQTTYOXIT-UHFFFAOYSA-N COC(C(C1SC=CC1)(c1ccc[s]1)O)=O Chemical compound COC(C(C1SC=CC1)(c1ccc[s]1)O)=O MEBLMEQTTYOXIT-UHFFFAOYSA-N 0.000 description 1
- SYHWYWHVEQQDMO-UHFFFAOYSA-N COC(C(c1ccc[s]1)(c1ccc[s]1)O)=O Chemical compound COC(C(c1ccc[s]1)(c1ccc[s]1)O)=O SYHWYWHVEQQDMO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83023106P | 2006-07-10 | 2006-07-10 | |
| US60/830,231 | 2006-07-10 | ||
| US83520006P | 2006-08-03 | 2006-08-03 | |
| US83520106P | 2006-08-03 | 2006-08-03 | |
| US60/835,201 | 2006-08-03 | ||
| US60/835,200 | 2006-08-03 | ||
| US83603706P | 2006-08-07 | 2006-08-07 | |
| US60/836,037 | 2006-08-07 | ||
| US11/643,013 | 2006-12-19 | ||
| US11/643,013 US20070167480A1 (en) | 2005-12-19 | 2006-12-19 | Pure and stable tiotropium bromide |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007181381A Division JP5048408B2 (ja) | 2006-07-10 | 2007-07-10 | 臭化チオトロピウムの調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012197282A JP2012197282A (ja) | 2012-10-18 |
| JP2012197282A5 true JP2012197282A5 (https=) | 2012-11-29 |
| JP5155472B2 JP5155472B2 (ja) | 2013-03-06 |
Family
ID=38814323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007181381A Active JP5048408B2 (ja) | 2006-07-10 | 2007-07-10 | 臭化チオトロピウムの調製方法 |
| JP2012115710A Active JP5155472B2 (ja) | 2006-07-10 | 2012-05-21 | 臭化チオトロピウムの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007181381A Active JP5048408B2 (ja) | 2006-07-10 | 2007-07-10 | 臭化チオトロピウムの調製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070167480A1 (https=) |
| EP (1) | EP2018379B1 (https=) |
| JP (2) | JP5048408B2 (https=) |
| AT (1) | ATE554086T1 (https=) |
| CA (1) | CA2658165A1 (https=) |
| ES (1) | ES2384652T3 (https=) |
| PL (1) | PL2018379T3 (https=) |
| TW (1) | TW200813046A (https=) |
| WO (1) | WO2008008376A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006277968A1 (en) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of severe persistant asthma |
| JP2009525950A (ja) * | 2006-01-04 | 2009-07-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中等症持続型喘息の治療におけるチオトロピウム塩の使用 |
| DK2240477T3 (en) * | 2008-01-10 | 2014-12-08 | Generics Uk Ltd | New process for the preparation of skopinestre |
| WO2010075090A2 (en) * | 2008-12-15 | 2010-07-01 | Auspex Pharmaceuticals, Inc. | Scopine modulators of muscarinic acetylcholine receptor |
| JP5541165B2 (ja) | 2009-01-26 | 2014-07-09 | 旭硝子株式会社 | 電子デバイス用基板の製造方法、電子デバイスの製造方法、電子デバイス用基板、および電子デバイス |
| NZ597920A (en) | 2009-08-07 | 2014-05-30 | Generics Uk Ltd | Anhydrate of tiotropium bromide |
| WO2011015883A1 (en) * | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| WO2011095800A2 (en) * | 2010-02-02 | 2011-08-11 | Generics [Uk] Limited | Analytical methods |
| TR201102068A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal maddeler |
| CZ304368B6 (cs) * | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
| PT106142B (pt) * | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| CZ304808B6 (cs) | 2012-03-16 | 2014-11-05 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma |
| CZ305012B6 (cs) | 2012-03-30 | 2015-03-25 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu |
| CN106188012B (zh) * | 2014-06-20 | 2018-11-30 | 深圳信立泰药业股份有限公司 | 一种阿利沙坦酯结晶及其制备方法及含有该结晶的药物组合物 |
| WO2019129801A1 (en) * | 2017-12-28 | 2019-07-04 | Linnea S.A. | Process for the purification of methyl-2,2-dithienylglycolate |
| WO2021133280A1 (en) * | 2019-12-27 | 2021-07-01 | Deva Holding | An improved process for preparation of scopine hydrobromide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1469781A (en) * | 1974-06-10 | 1977-04-06 | Boehringer Sohn Ingelheim | Production of scopine |
| DE3211185A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung |
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| US6908928B2 (en) * | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| ATE275391T1 (de) * | 2000-10-12 | 2004-09-15 | Boehringer Ingelheim Pharma | Neue tiotropium-haltige inhalationspulver |
| DE10050995A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE10064816A1 (de) * | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
| US6608055B2 (en) * | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| DE602004021921D1 (de) * | 2003-05-28 | 2009-08-20 | Theravance Inc | Azabicycloalkanverbindungen als muscarinrezeptor antagonisten |
| AU2004285685B2 (en) * | 2003-11-03 | 2011-03-24 | Boehringer Ingelheim International Gmbh | Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
| JP2008540367A (ja) * | 2005-05-02 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
-
2006
- 2006-12-19 US US11/643,013 patent/US20070167480A1/en not_active Abandoned
-
2007
- 2007-07-10 ES ES07810332T patent/ES2384652T3/es active Active
- 2007-07-10 TW TW096125102A patent/TW200813046A/zh unknown
- 2007-07-10 JP JP2007181381A patent/JP5048408B2/ja active Active
- 2007-07-10 AT AT07810332T patent/ATE554086T1/de active
- 2007-07-10 PL PL07810332T patent/PL2018379T3/pl unknown
- 2007-07-10 CA CA002658165A patent/CA2658165A1/en not_active Abandoned
- 2007-07-10 EP EP07810332A patent/EP2018379B1/en active Active
- 2007-07-10 WO PCT/US2007/015787 patent/WO2008008376A2/en not_active Ceased
-
2012
- 2012-05-21 JP JP2012115710A patent/JP5155472B2/ja active Active
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