IL147639A0 - Process for the preparation of naproxene nitroxyalkylesters - Google Patents

Process for the preparation of naproxene nitroxyalkylesters

Info

Publication number
IL147639A0
IL147639A0 IL14763900A IL14763900A IL147639A0 IL 147639 A0 IL147639 A0 IL 147639A0 IL 14763900 A IL14763900 A IL 14763900A IL 14763900 A IL14763900 A IL 14763900A IL 147639 A0 IL147639 A0 IL 147639A0
Authority
IL
Israel
Prior art keywords
preparation
nitroxyalkylesters
naproxene
naproxene nitroxyalkylesters
naphthyl
Prior art date
Application number
IL14763900A
Other languages
English (en)
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of IL147639A0 publication Critical patent/IL147639A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL14763900A 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters IL147639A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (1)

Publication Number Publication Date
IL147639A0 true IL147639A0 (en) 2002-08-14

Family

ID=11383500

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14763900A IL147639A0 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Country Status (23)

Country Link
US (2) US6700011B1 (zh)
EP (2) EP1384707B1 (zh)
JP (2) JP4667691B2 (zh)
KR (1) KR100687820B1 (zh)
CN (1) CN1198786C (zh)
AT (2) ATE297372T1 (zh)
AU (1) AU778694B2 (zh)
BR (1) BRPI0012915B1 (zh)
CA (1) CA2380116C (zh)
DE (2) DE60020753T2 (zh)
DK (2) DK1200386T3 (zh)
ES (2) ES2243859T3 (zh)
HU (1) HU227109B1 (zh)
IL (1) IL147639A0 (zh)
IT (1) IT1313596B1 (zh)
MX (1) MXPA02001256A (zh)
NO (1) NO327669B1 (zh)
PL (1) PL200165B1 (zh)
PT (2) PT1200386E (zh)
RU (1) RU2248348C2 (zh)
TR (1) TR200200290T2 (zh)
WO (1) WO2001010814A1 (zh)
ZA (2) ZA200200478B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2465697C (en) * 2001-11-27 2010-05-11 Astrazeneca Ab Process for the preparation of (s)-naproxen 4-nitrooxybutyl ester
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
KR20080097989A (ko) * 2006-02-03 2008-11-06 니콕스 에스. 에이. 근위축증 치료를 위한 의약의 니트록시 유도체의 용도
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
US20100137599A1 (en) * 2007-06-28 2010-06-03 Nicox S.A. Process for preparing 1,4-butandiol monitrate
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
WO2021160543A1 (en) 2020-02-10 2021-08-19 Nicox S.A. Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
DE69412109T2 (de) * 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
DK0759899T3 (da) 1994-05-10 1999-12-20 Nicox Sa Nitroforbindelser og sammensætninger deraf med antiinflammatoriske, analgetiske og antitrombotiske aktiviteter
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
AU6835696A (en) * 1995-10-09 1997-04-30 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
EP1200386A1 (en) 2002-05-02
CN1198786C (zh) 2005-04-27
ITMI991753A0 (it) 1999-08-04
CA2380116A1 (en) 2001-02-15
ZA200304525B (en) 2004-04-28
PT1384707E (pt) 2005-08-31
CN1367773A (zh) 2002-09-04
NO327669B1 (no) 2009-09-07
DE60005682D1 (de) 2003-11-06
ES2243859T3 (es) 2005-12-01
DE60020753D1 (de) 2005-07-14
RU2248348C2 (ru) 2005-03-20
EP1384707B1 (en) 2005-06-08
US7238829B2 (en) 2007-07-03
IT1313596B1 (it) 2002-09-09
HUP0202435A3 (en) 2004-03-01
US20050119339A1 (en) 2005-06-02
US6700011B1 (en) 2004-03-02
TR200200290T2 (tr) 2002-05-21
JP2011042690A (ja) 2011-03-03
BR0012915A (pt) 2002-06-04
CA2380116C (en) 2011-07-05
ATE251109T1 (de) 2003-10-15
KR20020013974A (ko) 2002-02-21
EP1200386B1 (en) 2003-10-01
DE60020753T2 (de) 2006-03-16
HUP0202435A2 (hu) 2002-11-28
DE60005682T2 (de) 2004-09-16
BRPI0012915B1 (pt) 2015-09-01
KR100687820B1 (ko) 2007-02-28
EP1384707A1 (en) 2004-01-28
DK1384707T3 (da) 2005-08-15
MXPA02001256A (es) 2005-06-06
ZA200200478B (en) 2003-10-29
ATE297372T1 (de) 2005-06-15
ITMI991753A1 (it) 2001-02-04
HU227109B1 (en) 2010-07-28
NO20020515D0 (no) 2002-02-01
WO2001010814A1 (en) 2001-02-15
DK1200386T3 (da) 2003-12-22
AU778694B2 (en) 2004-12-16
NO20020515L (no) 2002-02-01
PL200165B1 (pl) 2008-12-31
JP2003506425A (ja) 2003-02-18
ES2208390T3 (es) 2004-06-16
PT1200386E (pt) 2004-02-27
AU6438500A (en) 2001-03-05
PL353092A1 (en) 2003-10-06
JP4667691B2 (ja) 2011-04-13

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Legal Events

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