IL129103A0 - Human telomerase catalytic subunit and pharmaceutical compositions containing same - Google Patents
Human telomerase catalytic subunit and pharmaceutical compositions containing sameInfo
- Publication number
- IL129103A0 IL129103A0 IL12910397A IL12910397A IL129103A0 IL 129103 A0 IL129103 A0 IL 129103A0 IL 12910397 A IL12910397 A IL 12910397A IL 12910397 A IL12910397 A IL 12910397A IL 129103 A0 IL129103 A0 IL 129103A0
- Authority
- IL
- Israel
- Prior art keywords
- human telomerase
- pharmaceutical compositions
- compositions containing
- catalytic subunit
- containing same
- Prior art date
Links
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011282 treatment Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000002067 Protein Subunits Human genes 0.000 abstract 1
- 108010001267 Protein Subunits Proteins 0.000 abstract 1
- 108010017842 Telomerase Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72464396A | 1996-10-01 | 1996-10-01 | |
US84441997A | 1997-04-18 | 1997-04-18 | |
US84601797A | 1997-04-25 | 1997-04-25 | |
US08/851,843 US6093809A (en) | 1996-10-01 | 1997-05-06 | Telomerase |
US08/854,050 US6261836B1 (en) | 1996-10-01 | 1997-05-09 | Telomerase |
US91550397A | 1997-08-14 | 1997-08-14 | |
US91131297A | 1997-08-14 | 1997-08-14 | |
US08/912,951 US6475789B1 (en) | 1996-10-01 | 1997-08-14 | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
PCT/US1997/017885 WO1998014593A2 (en) | 1996-10-01 | 1997-10-01 | Human telomerase catalytic subunit |
Publications (1)
Publication Number | Publication Date |
---|---|
IL129103A0 true IL129103A0 (en) | 2000-02-17 |
Family
ID=27575511
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12910397A IL129103A0 (en) | 1996-10-01 | 1997-10-01 | Human telomerase catalytic subunit and pharmaceutical compositions containing same |
IL12922297A IL129222A0 (en) | 1996-10-01 | 1997-10-01 | Telomerase reverse transcriptase |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12922297A IL129222A0 (en) | 1996-10-01 | 1997-10-01 | Telomerase reverse transcriptase |
Country Status (21)
Country | Link |
---|---|
US (4) | US6166178A (de) |
EP (6) | EP1783139B8 (de) |
JP (7) | JP2001510985A (de) |
KR (2) | KR100530483B1 (de) |
CN (3) | CN1254376A (de) |
AT (3) | ATE245194T1 (de) |
AU (2) | AU734089B2 (de) |
BR (3) | BR9711844A (de) |
CA (3) | CA2266752A1 (de) |
DE (5) | DE69723531T3 (de) |
EA (2) | EA199900355A1 (de) |
ES (1) | ES2205132T5 (de) |
FI (1) | FI990655A0 (de) |
FR (1) | FR2757177A1 (de) |
GB (2) | GB2321642B8 (de) |
HK (1) | HK1156967A1 (de) |
IL (2) | IL129103A0 (de) |
NO (2) | NO319982B1 (de) |
NZ (1) | NZ334709A (de) |
SG (1) | SG94355A1 (de) |
WO (2) | WO1998014592A2 (de) |
Families Citing this family (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
US6517834B1 (en) | 1995-08-04 | 2003-02-11 | Geron Corporation | Purified telomerase |
US6545133B1 (en) | 1995-08-04 | 2003-04-08 | Geron Corporation | Methods for purifying telomerase |
DE19681033D2 (de) | 1995-11-16 | 1999-03-18 | Michael W Dahm | Verfahren zur Quantifizierung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits |
US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
US6607898B1 (en) | 1996-03-26 | 2003-08-19 | Oncomedx, Inc. | Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum |
US6093809A (en) | 1996-10-01 | 2000-07-25 | University Technology Corporation | Telomerase |
US6475789B1 (en) | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
EP1783139B8 (de) | 1996-10-01 | 2009-09-23 | Geron Corporation | Menschlische Telomerase katalytische Untereinheit |
US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
US7585622B1 (en) | 1996-10-01 | 2009-09-08 | Geron Corporation | Increasing the proliferative capacity of cells using telomerase reverse transcriptase |
US6777203B1 (en) | 1997-11-19 | 2004-08-17 | Geron Corporation | Telomerase promoter driving expression of therapeutic gene sequences |
US6808880B2 (en) | 1996-10-01 | 2004-10-26 | Geron Corporation | Method for detecting polynucleotides encoding telomerase |
US6444650B1 (en) * | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
US7390891B1 (en) | 1996-11-15 | 2008-06-24 | Amgen Inc. | Polynucleotides encoding a telomerase component TP2 |
JP2001507570A (ja) * | 1996-11-26 | 2001-06-12 | バイラー・カレッジ・オブ・メディスン | 染色体末端へのテロメラーゼのアクセスを阻害する阻害剤の同定 |
WO1998037181A2 (en) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Telomerase catalytic subunit gene and encoded protein |
US7413864B2 (en) | 1997-04-18 | 2008-08-19 | Geron Corporation | Treating cancer using a telomerase vaccine |
US7622549B2 (en) | 1997-04-18 | 2009-11-24 | Geron Corporation | Human telomerase reverse transcriptase polypeptides |
US20050013825A1 (en) * | 1997-04-18 | 2005-01-20 | Geron Corporation | Vaccine containing the catalytic subunit of telomerase for treating cancer |
WO1998059040A2 (de) * | 1997-06-20 | 1998-12-30 | Bayer Aktiengesellschaft | Humane katalytische telomerase-untereinheit und deren diagnostische und therapeutische verwendung |
CN1270634A (zh) | 1997-07-01 | 2000-10-18 | 卡姆比亚生物系统有限责任公司 | 脊椎动物端粒酶基因和蛋白质及其用途 |
EP1571215A3 (de) * | 1997-07-01 | 2007-10-31 | Cambia Biosystems LLC | Gene und Proteine von vertebraten Telomerasen, und deren Verwendungen |
US7378244B2 (en) | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
WO1999027113A1 (en) * | 1997-11-26 | 1999-06-03 | Geron Corporation | Mouse telomerase reverse transcriptase |
DE19757984A1 (de) * | 1997-12-24 | 1999-07-01 | Bayer Ag | Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung |
DE19804372A1 (de) * | 1998-02-04 | 1999-08-05 | Michael W Dr Dr Dahm | Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits |
US6639057B1 (en) * | 1998-03-26 | 2003-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Monoclonal antibody against human telomerase catalytic subunit |
US6337200B1 (en) * | 1998-03-31 | 2002-01-08 | Geron Corporation | Human telomerase catalytic subunit variants |
JP2002509716A (ja) | 1998-03-31 | 2002-04-02 | ユニバーシティ テクノロジー コーポレイション | テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物 |
US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
US20030105315A1 (en) * | 1998-04-09 | 2003-06-05 | Metagen Pharmaceuticals Gmbh | Human nucleic acid sequences from ovarian tumor tissue |
US7030211B1 (en) * | 1998-07-08 | 2006-04-18 | Gemvax As | Antigenic peptides derived from telomerase |
US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
AU1331100A (en) | 1998-10-29 | 2000-05-22 | Dana-Farber Cancer Institute | Cancer immunotheraphy and diagnosis using universal tumor associated antigens, including htert |
GB9900298D0 (en) * | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
WO2000043501A2 (de) * | 1999-01-22 | 2000-07-27 | Humboldt-Universität Zu Berlin Universitätsklinikum Charite | GEGEN DIE KATALYTISCHE UNTEREINHEIT DER HUMANEN TELOMERASE (hTERT) GERICHTETE RIBOZYME |
DK1147181T3 (da) * | 1999-02-04 | 2004-09-20 | Geron Corp | Telomerase revers transkriptase transskriptionelle regulatoriske sekvenser |
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
CA2370000A1 (en) | 1999-04-08 | 2000-10-19 | Uab Research Foundation | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
AU781376B2 (en) * | 1999-04-09 | 2005-05-19 | Biomira Inc. | Telomerase-specific cancer vaccine |
US6358739B1 (en) * | 1999-04-12 | 2002-03-19 | Modex Therapeutiques, S.A. | Transiently immortalized cells |
DE19916929A1 (de) * | 1999-04-15 | 2000-10-19 | Bayer Ag | Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden |
US6995145B1 (en) | 1999-06-04 | 2006-02-07 | Au Jessie L-S | Methods and compositions for modulating drug activity through telomere damage |
US20050255596A1 (en) * | 1999-09-07 | 2005-11-17 | West Michael D | Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer |
KR100858465B1 (ko) | 1999-09-10 | 2008-09-16 | 제론 코포레이션 | 올리고뉴클레오티드 엔3'→피5' 티오포스포라미데이트,이의 합성 및 용도 |
FR2798673B1 (fr) * | 1999-09-16 | 2004-05-28 | Exonhit Therapeutics Sa | Methodes et compositions pour la detection d'evenements pathologiques |
US6399384B1 (en) | 1999-09-17 | 2002-06-04 | Reneuron Limited | Conditional immortalization of cells |
AU1309101A (en) * | 1999-11-16 | 2001-05-30 | Kyowa Hakko Kogyo Co. Ltd. | Method of searching for substance inhibiting binding between telomerase subunits |
GB9927353D0 (en) * | 1999-11-19 | 2000-01-19 | Cantab Pharma Res | Virus preparation and use |
US6664046B1 (en) * | 1999-12-16 | 2003-12-16 | Roche Molecular Systems, Inc. | Quantitation of hTERT mRNA expression |
KR20010096991A (ko) * | 2000-04-19 | 2001-11-08 | 임정빈 | 텔로머레이즈의 프로모터에 특정하게 결합하는더블유티이1 절편, 그 유전자, 발현벡터 및 그것을 이용한세포성장 억제 방법 |
US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
IT1318504B1 (it) * | 2000-05-08 | 2003-08-27 | Talent Srl | Metodo e apparecchiatura per la diagnosi precoce di tumori vescicalisu campioni di urina. |
US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
US6492171B2 (en) * | 2000-05-16 | 2002-12-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of TERT expression |
US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
EP1158055A1 (de) | 2000-05-26 | 2001-11-28 | Xu Qi University of Teaxs Laboratoire de Leucémie Chen | Verfahren zur Diagnose von Krebs |
US7078491B1 (en) | 2000-09-21 | 2006-07-18 | Amgen Inc. | Selective binding agents of telomerase |
US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
AU2002235141A1 (en) | 2000-11-27 | 2002-06-03 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
WO2002048319A1 (en) * | 2000-12-14 | 2002-06-20 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Telomerase immortalized human liver cell lines |
US6906237B2 (en) * | 2001-02-27 | 2005-06-14 | G. Scott Herron | Vivo assay for anti angiogenic compounds |
US20040063922A1 (en) * | 2001-04-17 | 2004-04-01 | Conrad Charles A. | Methods and compositions for catalytic DNA exchange in a sequence specific manner |
WO2002091999A2 (en) * | 2001-05-09 | 2002-11-21 | Geron Corporation | Treatment for wounds |
GB0112342D0 (en) * | 2001-05-21 | 2001-07-11 | Norsk Hydro As | Polypeptides |
WO2003008577A1 (fr) * | 2001-07-16 | 2003-01-30 | Fuyuki Ishikawa | Nouvelles cellules transformees, methode de criblage d'agent anti-vieillissement et agents anti-vieillissement |
US7150989B2 (en) * | 2001-08-10 | 2006-12-19 | Cornell Research Foundation, Inc. | Telomerase immortalized neural progenitor cells |
AUPR769701A0 (en) * | 2001-09-14 | 2001-10-11 | Li, He | Telomerase inhibitory peptides and uses thereof |
WO2003035884A2 (de) * | 2001-10-18 | 2003-05-01 | Heart Biosystems Gmbh | Transiente immortalisierung von zellen durch onkogenproteine oder telomerproteine |
CA2466732A1 (en) * | 2001-10-22 | 2003-05-01 | University Of Rochester | Telomerase interference |
JPWO2003038076A1 (ja) * | 2001-10-31 | 2005-02-24 | 株式会社レノメディクス研究所 | 不死化間葉系細胞及びその利用 |
CN102008503B (zh) | 2001-12-07 | 2018-10-09 | 阿斯特利亚斯生物治疗股份公司 | 人胚胎干细胞衍生的造血细胞 |
GB2415432B (en) | 2001-12-07 | 2006-09-06 | Geron Corp | Islet cells from human embryonic stem cells |
DE10163130B4 (de) * | 2001-12-20 | 2009-05-14 | Cyto Tools Gmbh | Apoptotisch wirksame Peptide und diese umfassende pharmazeutische Zusammensetzungen |
WO2003054545A1 (fr) * | 2001-12-21 | 2003-07-03 | Mitsubishi Kagaku Iatron, Inc. | Procede permettant de detecter un anticorps anti-telomerase |
GB0200929D0 (en) * | 2002-01-16 | 2002-03-06 | Univ Glasgow | Tissue rejection |
EP1474522B1 (de) * | 2002-01-18 | 2012-03-07 | Morphotek, Inc. | Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse |
US20030175961A1 (en) * | 2002-02-26 | 2003-09-18 | Herron G. Scott | Immortal micorvascular endothelial cells and uses thereof |
US20050106729A1 (en) * | 2002-05-03 | 2005-05-19 | Mark Irvin Rosenblatt | Gene transfer methods and compositions |
AU2003239901A1 (en) * | 2002-05-28 | 2003-12-12 | Kathy M. Ensrud | Crisp polypeptides as contraceptives and inhibitors of sperm capacitation |
US7294708B2 (en) * | 2002-05-31 | 2007-11-13 | Beijing Institute Of Biotechnology | Telomerase reverse transcriptase fragments and uses thereof |
US7262025B2 (en) * | 2002-06-18 | 2007-08-28 | Zymogenetics, Inc. | Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter |
US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
AU2003290689A1 (en) | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
US8771982B2 (en) * | 2003-04-30 | 2014-07-08 | Duke University | Chimeric molecule and nucleic acid encoding same |
BRPI0411856A (pt) | 2003-06-23 | 2006-08-29 | Geron Corp | composições e métodos para o aumento da atividade de telomerase |
AU2004272340B2 (en) * | 2003-09-12 | 2008-01-03 | Dana Farber Cancer Institute | Immortalisation of mammalian cells and therapeutic applications of said cells |
EP1522858A1 (de) * | 2003-10-10 | 2005-04-13 | Jean-Christophe Roegel | Methoden für Selektion von Verbindungen unter Verwendung von Antikörpern mit Aktivität als Agonist, Antagonist oder allosterischen Modulatoren |
US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
US7420099B2 (en) | 2004-04-22 | 2008-09-02 | Kirin Holdings Kabushiki Kaisha | Transgenic animals and uses thereof |
EP1745144B1 (de) | 2004-05-11 | 2010-12-01 | Axiogenesis Ag | Methoden zur medikamentenaufspürung auf der basis von in vitro differenzierten zellen |
AU2005285483A1 (en) * | 2004-08-05 | 2006-03-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for cell activation |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
JP2006242618A (ja) * | 2005-03-01 | 2006-09-14 | Univ Of Tokyo | 組織fish法によるテロメア量を指標とした癌の診断 |
JP4635196B2 (ja) * | 2005-03-04 | 2011-02-16 | 国立大学法人広島大学 | 遺伝子導入細胞、及びそれを用いたテロメラーゼ誘導物質の検出方法 |
RU2007137122A (ru) * | 2005-03-09 | 2009-04-20 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем (Us) | НОВЫЙ ПРОМОТОР hTMC И ВЕКТОРЫ ДЛЯ ОПУХОЛЕСЕЛЕКТИВНОЙ И ВЫСОКОЭФФЕКТИВНОЙ ЭКСПРЕССИИ ТЕРАПЕВТИЧЕСКИХ ПРОТИВОРАКОВЫХ ГЕНОВ |
US20090305236A1 (en) * | 2005-05-11 | 2009-12-10 | Genetic Technologies Limited | Methods of enriching fetal cells |
EP1748067A1 (de) * | 2005-07-29 | 2007-01-31 | Institut Pasteur | Polynukleotide, die für MHC Klasse I-beschränkte Epitope der hTERT, Analoge und Polyepitope kodieren |
DK2281875T3 (en) | 2005-12-21 | 2018-06-06 | Univ Catholique Louvain | Isolated liver stem cells |
US8415153B2 (en) | 2006-06-19 | 2013-04-09 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
US20080131442A1 (en) * | 2006-06-26 | 2008-06-05 | Science Applications International Corporation | IgY antibodies to human telomerase reverse transcriptase |
WO2008002285A1 (en) * | 2006-06-26 | 2008-01-03 | Science Applications International Corporation | Igy antibodies to human telomerase reverse transcriptase |
AU2013203229C1 (en) * | 2006-07-28 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
CN105132439A (zh) | 2006-07-28 | 2015-12-09 | 宾夕法尼亚大学托管会 | 改进的疫苗及其使用方法 |
BRPI0719865A2 (pt) | 2006-10-12 | 2016-03-15 | Angeletti P Ist Richerche Bio | molécula de ácido nucleico, proteína de fusão purificada, vetor, célula hospedeira, processo para expressar uma proteína de fusão, e, método para tratar um paciente sofrendo de ou predisposto a um câncer |
EP3255061B1 (de) | 2006-11-03 | 2021-06-16 | The Board of Trustees of the Leland Stanford Junior University | Selektive immundepletion einer endogenen stammzellennische zur transplantation |
EP1994942A1 (de) * | 2007-05-25 | 2008-11-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmazeutische Zusammensetzungen mit Telomerase sowie deren Verwendungen |
ES2751997T3 (es) | 2008-01-14 | 2020-04-02 | Conventus Orthopaedics Inc | Aparato de reparación de fracturas |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
WO2010121294A1 (en) | 2009-04-21 | 2010-10-28 | Genetic Technologies Limited | Methods for obtaining fetal genetic material |
MX338100B (es) * | 2009-07-09 | 2016-04-01 | Janssen Biotech Inc | Celulas derivadas de tejido cardiaco. |
EP2523614A4 (de) | 2010-01-15 | 2017-02-15 | Conventus Orthopaedics, Inc. | Drehbare und starre orthopädische stange |
WO2011091052A1 (en) | 2010-01-20 | 2011-07-28 | Kyle Taylor | Apparatus and methods for bone access and cavity preparation |
SI2536830T1 (sl) | 2010-02-16 | 2019-12-31 | Ultimovacs As | Polipeptidi |
US9249452B2 (en) * | 2010-02-26 | 2016-02-02 | Zhu Zhen Pirot | Method of detecting and assaying telomerase activity of telomerase bound by anti-telomerase antibodies |
JP2013521880A (ja) | 2010-03-08 | 2013-06-13 | コンベンタス オーソピディックス, インコーポレイテッド | 骨インプラントを固定するための装置および方法 |
AU2011236653B2 (en) | 2010-04-08 | 2016-10-27 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
WO2012026309A1 (ja) * | 2010-08-23 | 2012-03-01 | 公立大学法人横浜市立大学 | 抗pad4抗体医薬の創成 |
CN102093980B (zh) * | 2010-12-10 | 2013-04-17 | 梁伟国 | 永生化人椎间盘髓核细胞体系的制备方法 |
US8420617B2 (en) * | 2011-03-11 | 2013-04-16 | Biocell Laboratories | Multiantivirus compound, composition and method for treatment of virus diseases |
CN102676518B (zh) * | 2012-02-27 | 2013-09-18 | 华侨大学 | 一种新型抗肿瘤amiRNA序列及其应用 |
EP2639299A1 (de) | 2012-03-16 | 2013-09-18 | Invectys | Aus Telomerase abgeleitete, universelle Krebspeptide |
WO2013169077A1 (ko) * | 2012-05-11 | 2013-11-14 | 주식회사 카엘젬백스 | 악액질 예방 또는 치료용 조성물 |
KR102578891B1 (ko) * | 2012-05-11 | 2023-09-15 | 주식회사 젬백스앤카엘 | 항염증 활성을 갖는 펩티드 및 이를 포함하는 조성물 |
BR112014032677A2 (pt) * | 2012-06-27 | 2019-01-15 | Univ Rutgers | ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxo |
US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
KR102038487B1 (ko) | 2012-09-19 | 2019-10-30 | 주식회사 젬백스앤카엘 | 텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물 |
WO2014046481A1 (ko) * | 2012-09-19 | 2014-03-27 | 주식회사 카엘젬백스 | 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 |
ES2802253T3 (es) * | 2012-09-19 | 2021-01-18 | Gemvax & Kael Co Ltd | Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado |
KR102166542B1 (ko) | 2012-09-28 | 2020-10-16 | 주식회사 젬백스앤카엘 | 줄기세포 검출을 위한 텔로머라제 유래 펩티드 및 조영물질의 컨쥬게이트 및 이를 포함하는 조영제 |
KR102093093B1 (ko) | 2012-12-13 | 2020-03-25 | 주식회사 젬백스앤카엘 | 피부 노화 개선용 조성물 |
KR102106756B1 (ko) | 2012-12-13 | 2020-05-06 | 주식회사 젬백스앤카엘 | 자외선에 의한 피부 손상 예방 또는 치료용 조성물 |
EP3988112A1 (de) | 2013-02-22 | 2022-04-27 | The Board of Trustees of the Leland Stanford Junior University | Verfahren bezüglich telomerverlängerung |
US10138488B2 (en) | 2013-03-28 | 2018-11-27 | Invectys | Cancer vaccine for dogs |
AU2014242915B2 (en) | 2013-03-28 | 2018-08-09 | Invectys | A cancer vaccine for cats |
MX2015017103A (es) | 2013-06-11 | 2016-11-07 | Harvard College | Celulas beta derivadas de células madre ( sc-beta ) y composiciones y métodos para generarlas. |
JP6601915B2 (ja) | 2013-10-28 | 2019-11-06 | アンヴェクティ | 皮膚細胞への電気的遺伝子導入 |
PL3062824T3 (pl) | 2013-10-28 | 2020-06-15 | Invectys | Szczepionka zawierająca dna kodujący telomerazę |
EP2871235A1 (de) | 2013-11-07 | 2015-05-13 | Centre National de la Recherche Scientifique (CNRS) | Neues Verfahren zur Herstellung von aktiver hTERT |
US10022132B2 (en) | 2013-12-12 | 2018-07-17 | Conventus Orthopaedics, Inc. | Tissue displacement tools and methods |
KR102166549B1 (ko) | 2014-01-10 | 2020-10-16 | 주식회사 젬백스앤카엘 | 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트 |
EP3822364B1 (de) | 2014-08-26 | 2023-05-10 | The Board of Trustees of the Leland Stanford Junior University | Transplantation von stammzellen mit einer kombination aus einem auf stammzellen abzielenden wirkstoff und modulation von immunregulatorischer signalisierung |
EP3370764A4 (de) | 2015-11-05 | 2019-07-17 | The Regents of The University of California | Mit lipidkonjugaten markierte zellen und verfahren zur verwendung davon |
JP6820935B2 (ja) | 2016-01-19 | 2021-01-27 | ファイザー・インク | がんワクチン |
IL267912B2 (en) | 2017-01-30 | 2023-09-01 | Univ Leland Stanford Junior | A genotoxic matching regimen for stem cell transplantation |
US10631881B2 (en) | 2017-03-09 | 2020-04-28 | Flower Orthopedics Corporation | Plating depth gauge and countersink instrument |
US11351246B2 (en) | 2017-05-09 | 2022-06-07 | Invectys SAS | Recombinant measles vaccine expressing hTERT |
US10918426B2 (en) | 2017-07-04 | 2021-02-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for treatment of a bone |
WO2019070740A2 (en) | 2017-10-02 | 2019-04-11 | Fred Hutchinson Cancer Research Center | LUTENING HORMONE RECEPTOR BINDING AGENTS AND LUTINISING HORMONE AGONISTS FOR IDENTIFICATION, MULTIPLICATION, REMOVAL AND MODIFICATION OF PRIMITIVE STEM CELL POPULATIONS |
CN108715863B (zh) * | 2018-05-30 | 2020-09-11 | 吉林大学 | 一种肿瘤靶向性载体pcTERT及其构建方法及其应用 |
CN110827920B (zh) * | 2018-08-14 | 2022-11-22 | 武汉华大医学检验所有限公司 | 测序数据分析方法和设备及高通量测序方法 |
SG11202102255VA (en) * | 2018-09-05 | 2021-04-29 | Readcoor Llc | Methods and systems for therapeutic agent analysis |
KR20210057024A (ko) * | 2018-09-06 | 2021-05-20 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 텔로머라제 완전효소 복합체 및 이의 사용 방법 |
WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
CN109545039A (zh) * | 2019-01-15 | 2019-03-29 | 苏州大学 | 一种核孔复合体结构模型教具及其使用方法 |
AU2020311877B2 (en) | 2019-07-05 | 2024-01-04 | Case Western Reserve University | Priming media and methods for stem cell culture and therapy |
JP2021151979A (ja) * | 2020-03-24 | 2021-09-30 | 均 石井 | 再生医療薬 |
CN116870195A (zh) * | 2020-09-22 | 2023-10-13 | 浙江愈方生物科技有限公司 | 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用 |
JP2022119144A (ja) * | 2021-02-03 | 2022-08-16 | 均 石井 | パーキンソン病治療薬 |
JP2022151412A (ja) * | 2021-03-23 | 2022-10-07 | 均 石井 | 脳卒中治療薬 |
CN113355303B (zh) * | 2021-06-07 | 2023-06-16 | 中元汇吉生物技术股份有限公司 | 一种m-mlv逆转录酶突变体及其应用 |
WO2023141534A1 (en) * | 2022-01-19 | 2023-07-27 | Northwestern University | Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy |
CN114920802B (zh) * | 2022-05-16 | 2023-05-23 | 中国地质大学(武汉) | 调节端粒酶限速蛋白运动的多肽探针及其复合物和方法 |
CN116364195B (zh) * | 2023-05-10 | 2023-10-13 | 浙大城市学院 | 一种基于预训练模型的微生物遗传序列表型预测方法 |
Family Cites Families (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US912629A (en) | 1908-08-29 | 1909-02-16 | Conrad L Stueber | Foundation-top for pipe-carriers. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4254082A (en) | 1978-06-12 | 1981-03-03 | Miles Laboratories, Inc. | Specific binding-adsorbent assay test means |
US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
JPS57502090A (de) | 1980-07-18 | 1982-11-25 | ||
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
US5055556A (en) | 1981-10-06 | 1991-10-08 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Fluorescent conjugates for analysis of molecules and cells |
JPS58215453A (ja) | 1982-06-09 | 1983-12-14 | Toray Silicone Co Ltd | 室温硬化後塗装可能なオルガノポリシロキサン組成物 |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
FR2542494B1 (fr) | 1983-03-08 | 1985-08-16 | Sevylor International | Combinaison protectrice, utilisable notamment en atmosphere irradiee |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
GB8612087D0 (en) | 1986-05-19 | 1986-06-25 | Ici Plc | Hybridisation probes |
US5001225A (en) | 1986-12-08 | 1991-03-19 | Georgetown University | Monoclonal antibodies to a pan-malarial antigen |
US4889806A (en) | 1987-04-15 | 1989-12-26 | Washington University | Large DNA cloning system based on yeast artificial chromosomes |
US5017478A (en) | 1987-07-16 | 1991-05-21 | Berlex Laboratories, Inc. | Transfected cells containing plasmids having genes oriented in opposing directions and methods of using |
US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5093245A (en) | 1988-01-26 | 1992-03-03 | Applied Biosystems | Labeling by simultaneous ligation and restriction |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5075227A (en) * | 1989-03-07 | 1991-12-24 | Zymogenetics, Inc. | Directional cloning |
JPH02307059A (ja) | 1989-05-23 | 1990-12-20 | Seiko Instr Inc | 反応容器 |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
EP0502976B1 (de) | 1989-12-01 | 1996-07-03 | Pharming B.V. | Herstellung rekombinanter polypeptide durch rinder und transgene methoden |
AU647741B2 (en) | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
ES2151463T5 (es) | 1989-12-22 | 2012-10-29 | Merck Serono Sa | Constructos de ADN para la activación y la modificación de la expresión de genes endógenos |
EP0466874A1 (de) | 1990-02-09 | 1992-01-22 | Asulab S.A. | Elektrostatischer mikromotor mit radialem feld, mittels photolithographischem mikrofertigungsverfahren hergestellt und herstellungsverfahren eines solchen mikromotors |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
SE468913B (sv) | 1990-05-16 | 1993-04-05 | Igesto Ab | Saekerhetskrok |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
KR100198659B1 (ko) | 1996-05-16 | 1999-06-15 | 구본준 | 메모리 셀, 메모리 장치 및 그의 제조 방법 |
DE69216385T2 (de) | 1991-10-11 | 1997-06-12 | Promega Corp | Gekoppelte transkription und translation in zellfreien eukaryoten-extrakten |
US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
AU687736B2 (en) | 1992-05-11 | 1998-03-05 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
US5645986A (en) | 1992-05-13 | 1997-07-08 | Board Of Reagents, The University Of Texas System | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5639613A (en) | 1992-05-13 | 1997-06-17 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
US5648215A (en) | 1992-05-13 | 1997-07-15 | Board Of Regents, The University Of Texas System | Telomerase diagnostic methods |
US5489508A (en) * | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5629154A (en) | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
AU4769893A (en) | 1992-07-17 | 1994-02-14 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
US6107062A (en) | 1992-07-30 | 2000-08-22 | Inpax, Inc. | Antisense viruses and antisense-ribozyme viruses |
GB2273932A (en) | 1992-11-24 | 1994-07-06 | Stiefel Laboratories | Stable oligonucleotides |
US5674703A (en) | 1992-12-02 | 1997-10-07 | Woo; Savio L. C. | Episomal vector systems and related methods |
TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
WO1994012649A2 (en) | 1992-12-03 | 1994-06-09 | Genzyme Corporation | Gene therapy for cystic fibrosis |
EP0686200A4 (de) | 1993-01-27 | 1997-07-02 | Oncor Inc | Amplifikation von nukleinsäuresequenzen |
US6120764A (en) | 1993-06-24 | 2000-09-19 | Advec, Inc. | Adenoviruses for control of gene expression |
US6140087A (en) | 1993-06-24 | 2000-10-31 | Advec, Inc. | Adenovirus vectors for gene therapy |
US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
WO1995013382A1 (en) * | 1993-11-12 | 1995-05-18 | Geron Corporation | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
RO117328B1 (ro) * | 1994-07-07 | 2002-01-30 | Geron Corp | Componenta rna a telomerazei de mamifere, plasmida recombinanta, de exprimare a acesteia, si metoda pentru detectarea prezentei unei stari neoplazice |
US5597697A (en) | 1994-09-30 | 1997-01-28 | Diamond; Paul | Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases |
US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
WO1996019580A2 (en) * | 1994-12-19 | 1996-06-27 | Cold Spring Harbor Laboratory | Telomerase protein component |
CA2221602A1 (en) | 1995-06-07 | 1996-12-19 | Cold Spring Harbor Laboratory | Essential oligonucleotides of vertebrate telomerase |
WO1997015687A1 (en) | 1995-06-07 | 1997-05-01 | Geron Corporation | Telomerase activity assays |
US5722998A (en) | 1995-06-07 | 1998-03-03 | Intermedics, Inc. | Apparatus and method for the control of an implantable medical device |
US5741677A (en) | 1995-06-07 | 1998-04-21 | Geron Corporation | Methods for measuring telomere length |
US6545133B1 (en) | 1995-08-04 | 2003-04-08 | Geron Corporation | Methods for purifying telomerase |
US5968506A (en) | 1995-08-04 | 1999-10-19 | Geron Corporation | Purified telomerase |
WO1997006012A1 (en) | 1995-08-04 | 1997-02-20 | International Business Machines Corporation | Stamp for a lithographic process |
US6517834B1 (en) | 1995-08-04 | 2003-02-11 | Geron Corporation | Purified telomerase |
JPH09154575A (ja) | 1995-10-04 | 1997-06-17 | Soosei:Kk | テロメラーゼ |
JPH09164575A (ja) | 1995-12-13 | 1997-06-24 | Japan Steel Works Ltd:The | 流れ模様を有する樹脂板の製造方法およびその装置 |
US6015710A (en) | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
US5770422A (en) * | 1996-07-08 | 1998-06-23 | The Regents Of The University Of California | Human telomerase |
US5747317A (en) | 1996-07-08 | 1998-05-05 | Tularik Inc. | Human telomerase RNA interacting protein gene |
US5724021A (en) | 1996-07-09 | 1998-03-03 | Stephen C. Perrone | Self-contained, programmable, time interval alarm reminder device for eyedrop medication administration and a means for affixing such to eyedrop/medication container |
WO1998007838A1 (fr) | 1996-08-21 | 1998-02-26 | Mitsubishi Chemical Corporation | Proteine de telomerase d'animaux superieurs et gene codant pour elle |
AU4030697A (en) | 1996-08-28 | 1998-03-19 | Shonen Yoshida | Proteins having telomerase activity |
DE19638482A1 (de) | 1996-09-20 | 1998-04-02 | Bosch Gmbh Robert | Verfahren zur Auswahl einer Sendefrequenz |
US6093809A (en) | 1996-10-01 | 2000-07-25 | University Technology Corporation | Telomerase |
US6475789B1 (en) | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
US6777203B1 (en) | 1997-11-19 | 2004-08-17 | Geron Corporation | Telomerase promoter driving expression of therapeutic gene sequences |
EP1783139B8 (de) | 1996-10-01 | 2009-09-23 | Geron Corporation | Menschlische Telomerase katalytische Untereinheit |
US6767719B1 (en) | 1997-11-26 | 2004-07-27 | Geron Corporation | Mouse telomerase reverse transcriptase |
US6444650B1 (en) | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
US7585622B1 (en) | 1996-10-01 | 2009-09-08 | Geron Corporation | Increasing the proliferative capacity of cells using telomerase reverse transcriptase |
US6808880B2 (en) | 1996-10-01 | 2004-10-26 | Geron Corporation | Method for detecting polynucleotides encoding telomerase |
US5890326A (en) | 1996-11-06 | 1999-04-06 | Hill-Rom, Inc. | Head wall for a hospital room |
US5919656A (en) | 1996-11-15 | 1999-07-06 | Amgen Canada Inc. | Genes encoding telomerase protein 1 |
US7390891B1 (en) * | 1996-11-15 | 2008-06-24 | Amgen Inc. | Polynucleotides encoding a telomerase component TP2 |
JP2001507570A (ja) | 1996-11-26 | 2001-06-12 | バイラー・カレッジ・オブ・メディスン | 染色体末端へのテロメラーゼのアクセスを阻害する阻害剤の同定 |
WO1998037181A2 (en) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Telomerase catalytic subunit gene and encoded protein |
US6617119B2 (en) | 1997-02-21 | 2003-09-09 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
DE69725018T2 (de) * | 1997-04-04 | 2004-06-09 | Geron Corp., Menlo Park | Gereinigte telomerase |
US6485789B1 (en) | 1997-04-14 | 2002-11-26 | 3M Innovative Properties Company | Fluorochemical composition containing a condensation product of a fluorochemical polyether and a poly-isocyanate to impart stain release properties to a substrate |
US7622549B2 (en) | 1997-04-18 | 2009-11-24 | Geron Corporation | Human telomerase reverse transcriptase polypeptides |
US7413864B2 (en) | 1997-04-18 | 2008-08-19 | Geron Corporation | Treating cancer using a telomerase vaccine |
US20050013825A1 (en) | 1997-04-18 | 2005-01-20 | Geron Corporation | Vaccine containing the catalytic subunit of telomerase for treating cancer |
US6201830B1 (en) | 1997-06-11 | 2001-03-13 | Texas Instruments Incorporated | Low computation idle transmission method for DSL modems |
WO1998059040A2 (de) * | 1997-06-20 | 1998-12-30 | Bayer Aktiengesellschaft | Humane katalytische telomerase-untereinheit und deren diagnostische und therapeutische verwendung |
CN1270634A (zh) | 1997-07-01 | 2000-10-18 | 卡姆比亚生物系统有限责任公司 | 脊椎动物端粒酶基因和蛋白质及其用途 |
US7378244B2 (en) | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
WO1999027113A1 (en) | 1997-11-26 | 1999-06-03 | Geron Corporation | Mouse telomerase reverse transcriptase |
DE19757984A1 (de) | 1997-12-24 | 1999-07-01 | Bayer Ag | Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung |
AU1785099A (en) | 1998-01-08 | 1999-07-26 | Chugai Seiyaku Kabushiki Kaisha | Novel gene having reverse transcriptase motif |
GB9801902D0 (en) | 1998-01-29 | 1998-03-25 | Cancer Res Campaign Tech | A gene promoter |
JP2002509716A (ja) | 1998-03-31 | 2002-04-02 | ユニバーシティ テクノロジー コーポレイション | テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物 |
US6337200B1 (en) * | 1998-03-31 | 2002-01-08 | Geron Corporation | Human telomerase catalytic subunit variants |
US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
EP1085892A4 (de) | 1998-06-12 | 2002-07-17 | Sloan Kettering Inst Cancer | Impfstrategie zur vorbeugung und behandlung von krebs |
US7030211B1 (en) | 1998-07-08 | 2006-04-18 | Gemvax As | Antigenic peptides derived from telomerase |
DK1147181T3 (da) | 1999-02-04 | 2004-09-20 | Geron Corp | Telomerase revers transkriptase transskriptionelle regulatoriske sekvenser |
AU781376B2 (en) | 1999-04-09 | 2005-05-19 | Biomira Inc. | Telomerase-specific cancer vaccine |
WO2000073420A2 (en) | 1999-06-02 | 2000-12-07 | Whitehead Institute For Biomedical Research | Creation of human tumorigenic cells and uses therefor |
US6354941B2 (en) | 1999-11-03 | 2002-03-12 | 516 Holdings | Electronic system for a game of chance |
AU2001241533A1 (en) | 2000-02-15 | 2001-08-27 | The Regents Of The University Of California | A universal vaccine and method for treating cancer employing telomerase reverse transcriptase |
WO2002091999A2 (en) | 2001-05-09 | 2002-11-21 | Geron Corporation | Treatment for wounds |
JP2002348474A (ja) | 2001-05-23 | 2002-12-04 | Dow Corning Toray Silicone Co Ltd | ポリオルガノシロキサンマイクロエマルジョン組成物および化粧料原料 |
US20030143228A1 (en) | 2001-10-29 | 2003-07-31 | Baylor College Of Medicine | Human telomerase reverse transcriptase as a class-II restricted tumor-associated antigen |
US7294708B2 (en) | 2002-05-31 | 2007-11-13 | Beijing Institute Of Biotechnology | Telomerase reverse transcriptase fragments and uses thereof |
KR100705868B1 (ko) | 2003-05-06 | 2007-04-10 | 후지 덴키 디바이스 테크놀로지 가부시키가이샤 | 반도체 장치 및 그 제조 방법 |
-
1997
- 1997-10-01 EP EP06117664A patent/EP1783139B8/de not_active Expired - Lifetime
- 1997-10-01 JP JP51690998A patent/JP2001510985A/ja active Pending
- 1997-10-01 EP EP97910785A patent/EP0954585B1/de not_active Expired - Lifetime
- 1997-10-01 EA EA199900355A patent/EA199900355A1/ru unknown
- 1997-10-01 CN CN97199534A patent/CN1254376A/zh active Pending
- 1997-10-01 AU AU48073/97A patent/AU734089B2/en not_active Expired
- 1997-10-01 CA CA002266752A patent/CA2266752A1/en not_active Abandoned
- 1997-10-01 BR BR9711844-3A patent/BR9711844A/pt unknown
- 1997-10-01 BR BRPI9712254A patent/BRPI9712254B1/pt unknown
- 1997-10-01 DE DE69723531T patent/DE69723531T3/de not_active Expired - Lifetime
- 1997-10-01 FR FR9712217A patent/FR2757177A1/fr active Pending
- 1997-10-01 CA CA2645721A patent/CA2645721C/en not_active Expired - Lifetime
- 1997-10-01 CN CN201010150493.9A patent/CN102021153B/zh not_active Expired - Lifetime
- 1997-10-01 DE DE69739497T patent/DE69739497D1/de not_active Expired - Lifetime
- 1997-10-01 DE DE69739675T patent/DE69739675D1/de not_active Expired - Lifetime
- 1997-10-01 JP JP51680298A patent/JP2001523947A/ja active Pending
- 1997-10-01 GB GB9804859A patent/GB2321642B8/en not_active Expired - Lifetime
- 1997-10-01 IL IL12910397A patent/IL129103A0/xx not_active IP Right Cessation
- 1997-10-01 BR BR9712254-8A patent/BR9712254A/pt not_active IP Right Cessation
- 1997-10-01 EP EP20090176870 patent/EP2213740A1/de not_active Withdrawn
- 1997-10-01 AT AT97307757T patent/ATE245194T1/de active
- 1997-10-01 EA EA199900349A patent/EA199900349A1/ru unknown
- 1997-10-01 KR KR1019997002838A patent/KR100530483B1/ko not_active IP Right Cessation
- 1997-10-01 JP JP28618297A patent/JP3869092B2/ja not_active Expired - Lifetime
- 1997-10-01 ES ES97307757T patent/ES2205132T5/es not_active Expired - Lifetime
- 1997-10-01 CN CN971802564A patent/CN1291231B/zh not_active Expired - Lifetime
- 1997-10-01 EP EP97307757A patent/EP0841396B2/de not_active Expired - Lifetime
- 1997-10-01 IL IL12922297A patent/IL129222A0/xx unknown
- 1997-10-01 NZ NZ334709A patent/NZ334709A/en not_active IP Right Cessation
- 1997-10-01 EP EP97910737A patent/EP0932686A2/de not_active Withdrawn
- 1997-10-01 DE DE0841396T patent/DE841396T1/de active Pending
- 1997-10-01 EP EP03075454A patent/EP1333094B1/de not_active Expired - Lifetime
- 1997-10-01 AT AT97910785T patent/ATE449851T1/de not_active IP Right Cessation
- 1997-10-01 AT AT03075454T patent/ATE552341T1/de active
- 1997-10-01 SG SG200101834A patent/SG94355A1/en unknown
- 1997-10-01 KR KR1019990702815A patent/KR20000048820A/ko not_active Application Discontinuation
- 1997-10-01 CA CA2267664A patent/CA2267664C/en not_active Expired - Lifetime
- 1997-10-01 DE DE19743497A patent/DE19743497A1/de not_active Withdrawn
- 1997-10-01 AU AU48036/97A patent/AU4803697A/en not_active Abandoned
- 1997-10-01 WO PCT/US1997/017618 patent/WO1998014592A2/en not_active Application Discontinuation
- 1997-10-01 WO PCT/US1997/017885 patent/WO1998014593A2/en not_active Application Discontinuation
- 1997-10-01 GB GB9720890.4A patent/GB2317891C/en not_active Expired - Lifetime
- 1997-11-19 US US08/974,549 patent/US6166178A/en not_active Expired - Lifetime
-
1998
- 1998-10-15 JP JP32016998A patent/JP4070331B2/ja not_active Expired - Lifetime
-
1999
- 1999-02-19 JP JP11042410A patent/JPH11313689A/ja active Pending
- 1999-03-24 FI FI990655A patent/FI990655A0/fi unknown
- 1999-03-31 NO NO19991588A patent/NO319982B1/no not_active IP Right Cessation
-
2000
- 2000-07-27 JP JP2000227474A patent/JP2001081042A/ja not_active Withdrawn
- 2000-11-22 US US09/721,456 patent/US6617110B1/en not_active Expired - Lifetime
- 2000-11-22 US US09/721,477 patent/US7517971B1/en not_active Expired - Fee Related
-
2005
- 2005-06-24 NO NO20053120A patent/NO332085B1/no unknown
-
2007
- 2007-08-20 US US11/894,600 patent/US8222392B2/en not_active Expired - Fee Related
-
2008
- 2008-07-28 JP JP2008194208A patent/JP4852576B2/ja not_active Expired - Lifetime
-
2011
- 2011-10-18 HK HK11111117.2A patent/HK1156967A1/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL129103A0 (en) | Human telomerase catalytic subunit and pharmaceutical compositions containing same | |
WO1999033869A3 (en) | Compounds for immunotherapy and diagnosis of breast cancer and methods for their use | |
DE60136099D1 (de) | Zusammensetzungen zur behandlung und diagnose von eierstockkrebs | |
TR199901971T2 (xx) | Bir resept�re ba�lanan peptidler ve bile�ikler. | |
MXPA02011656A (es) | Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos. | |
NZ512247A (en) | Compositions and methods for therapy and diagnosis of ovarian cancer | |
IL138330A0 (en) | Polynucleotides, polypeptides and pharmaceutical compositions for treating lung cancer | |
WO2001018046A3 (en) | Ovarian tumor sequences and methods of use therefor | |
BR0009608A (pt) | Compostos para imunoterapia e diagnóstico de câncer de mama e métodos para sua utilização | |
NZ500216A (en) | Beta-amyloid peptide-binding proteins and pharmaceutical use | |
ATE310828T1 (de) | Implantat und vektor zur behandlung von erworbenen krankheiten | |
DE69831223D1 (de) | Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52 | |
PL336897A1 (en) | Novel salts of bpc peptides, pharmaceutic compositions conatining them and method of obtaining such salts | |
NZ333515A (en) | Polynucleotide encoding a human chemokine beta-15 use in treatment of thymus related diseases | |
ATE288959T1 (de) | Men1, mit typ 1 multipler endokriner neoplasie assoziiertes gen, meninpolypeptide und deren verwendungen | |
IT1270614B (it) | Proteine ad attivita' antitumorale da organi di mammiferi |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |