DE69831223D1 - Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52 - Google Patents

Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52

Info

Publication number
DE69831223D1
DE69831223D1 DE69831223T DE69831223T DE69831223D1 DE 69831223 D1 DE69831223 D1 DE 69831223D1 DE 69831223 T DE69831223 T DE 69831223T DE 69831223 T DE69831223 T DE 69831223T DE 69831223 D1 DE69831223 D1 DE 69831223D1
Authority
DE
Germany
Prior art keywords
morphogous
freeze
human
dried composition
bone protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831223T
Other languages
English (en)
Other versions
DE69831223T9 (de
DE69831223T2 (de
Inventor
Mitsuko Inagaki
Hideki Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Original Assignee
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH filed Critical Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Publication of DE69831223D1 publication Critical patent/DE69831223D1/de
Application granted granted Critical
Publication of DE69831223T2 publication Critical patent/DE69831223T2/de
Publication of DE69831223T9 publication Critical patent/DE69831223T9/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69831223T 1997-01-30 1998-01-29 Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52 Active DE69831223T9 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1634997 1997-01-30
JP1634997 1997-01-30
PCT/JP1998/000371 WO1998033514A1 (fr) 1997-01-30 1998-01-29 Composition lyophilisee de mp52 humaine de proteines morphogenetiques osseuses

Publications (3)

Publication Number Publication Date
DE69831223D1 true DE69831223D1 (de) 2005-09-22
DE69831223T2 DE69831223T2 (de) 2006-02-16
DE69831223T9 DE69831223T9 (de) 2006-12-07

Family

ID=11913900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831223T Active DE69831223T9 (de) 1997-01-30 1998-01-29 Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52

Country Status (22)

Country Link
EP (1) EP0972520B9 (de)
JP (1) JP4209948B2 (de)
KR (1) KR100548107B1 (de)
CN (1) CN1152712C (de)
AP (1) AP983A (de)
AT (1) ATE302021T1 (de)
AU (1) AU737595B2 (de)
BR (1) BR9807537B1 (de)
CA (1) CA2278546C (de)
DE (1) DE69831223T9 (de)
DK (1) DK0972520T3 (de)
EA (1) EA001579B1 (de)
ES (1) ES2244043T3 (de)
HU (1) HU226554B1 (de)
IL (2) IL130967A0 (de)
NO (1) NO322334B1 (de)
NZ (1) NZ336509A (de)
PL (1) PL189381B1 (de)
RS (1) RS49691B (de)
SI (1) SI0972520T1 (de)
TR (1) TR199901832T2 (de)
WO (1) WO1998033514A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239514T1 (de) † 1997-02-07 2003-05-15 Stryker Corp Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
EP1434569A1 (de) * 2001-10-09 2004-07-07 CellFactors plc Therapeutisches biologisches produkt und methode zur bildung von neuem vaskularisiertem knochengewebe
DK1448246T4 (en) 2001-11-19 2015-12-21 Scil Technology Gmbh Homogeneously coated device with osteoinductive and osteoconductive properties
DK1539261T3 (da) 2002-09-10 2006-08-07 Scil Technology Gmbh Metalimplantat belagt under nedsat oxygenkoncentration med osteoinduktiv protein
EP1651272A1 (de) * 2003-08-05 2006-05-03 Fuji Photo Film B.V. Verwendung von rekombinanter oder synthetischer gelatine als stabilisator in vakzinen
AU2004288854B2 (en) * 2003-11-10 2009-10-01 Arriva-Pharmaceuticals, Inc. Dry recombinant human alpha 1-antitrypsin formulation
PL1737734T3 (pl) 2004-03-10 2011-02-28 Scil Tech Gmbh Powlekane implanty, ich wytwarzanie i zastosowanie
US20160344677A1 (en) 2015-05-22 2016-11-24 Microsoft Technology Licensing, Llc Unified messaging platform for providing interactive semantic objects
US10360287B2 (en) 2015-05-22 2019-07-23 Microsoft Technology Licensing, Llc Unified messaging platform and interface for providing user callouts

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3273597D1 (en) * 1981-11-28 1986-11-06 Sunstar Kk Pharmaceutical composition containing interferon in stable state
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
ATE142460T1 (de) * 1991-06-21 1996-09-15 Genetics Inst Osteogene proteine enthaltende arzneimittel
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
NZ249113A (en) * 1992-02-12 1996-07-26 Bioph Biotech Entw Pharm Gmbh Recombinant dna encoding tgf-b, its production and pharmaceutical compositions thereof
CA2093836A1 (en) * 1992-04-24 1993-10-25 Wayne Gombotz Biodegradable tgf-.beta. delivery system for bone regeneration
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
DE69524456T2 (de) * 1995-03-21 2002-08-01 Applied Research Systems Flüssige hcg-formulierungen
PL186518B1 (pl) * 1995-04-19 2004-01-30 Bioph Biotech Entw Pharm Gmbh Białko, kompozycja farmaceutyczna i sposób wytwarzania białka

Also Published As

Publication number Publication date
CA2278546A1 (en) 1998-08-06
JP4209948B2 (ja) 2009-01-14
AU5679198A (en) 1998-08-25
BR9807537B1 (pt) 2009-01-13
EP0972520A1 (de) 2000-01-19
EA199900694A1 (ru) 2000-04-24
EP0972520A4 (de) 2002-11-05
HUP0002386A2 (hu) 2000-11-28
DE69831223T9 (de) 2006-12-07
NZ336509A (en) 2001-03-30
NO993702L (no) 1999-09-29
PL189381B1 (pl) 2005-07-29
EA001579B1 (ru) 2001-06-25
IL130967A (en) 2006-12-10
EP0972520B9 (de) 2006-03-22
WO1998033514A1 (fr) 1998-08-06
YU34999A (sh) 2002-08-12
CN1152712C (zh) 2004-06-09
PL334852A1 (en) 2000-03-27
AP983A (en) 2001-07-16
BR9807537A (pt) 2000-03-21
IL130967A0 (en) 2001-01-28
CN1244127A (zh) 2000-02-09
DK0972520T3 (da) 2005-12-19
AU737595B2 (en) 2001-08-23
ES2244043T3 (es) 2005-12-01
EP0972520B1 (de) 2005-08-17
RS49691B (sr) 2007-12-31
HUP0002386A3 (en) 2002-09-30
ATE302021T1 (de) 2005-09-15
KR100548107B1 (ko) 2006-02-02
DE69831223T2 (de) 2006-02-16
SI0972520T1 (sl) 2006-02-28
HU226554B1 (en) 2009-03-30
AP9901602A0 (en) 1999-09-30
KR20000070586A (ko) 2000-11-25
CA2278546C (en) 2008-04-01
NO993702D0 (no) 1999-07-29
NO322334B1 (no) 2006-09-18
TR199901832T2 (xx) 1999-12-21

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