IL119590A - 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates - Google Patents
7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediatesInfo
- Publication number
- IL119590A IL119590A IL11959092A IL11959092A IL119590A IL 119590 A IL119590 A IL 119590A IL 11959092 A IL11959092 A IL 11959092A IL 11959092 A IL11959092 A IL 11959092A IL 119590 A IL119590 A IL 119590A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- demethyl
- intermediates
- deoxytetracycline
- substituted amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77157691A | 1991-10-04 | 1991-10-04 | |
IL10332092A IL103320A (en) | 1991-10-04 | 1992-10-01 | 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines |
Publications (1)
Publication Number | Publication Date |
---|---|
IL119590A true IL119590A (en) | 1999-03-12 |
Family
ID=25092264
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11959092A IL119590A (en) | 1991-10-04 | 1992-10-01 | 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates |
IL10332092A IL103320A (en) | 1991-10-04 | 1992-10-01 | 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines |
IL11959096A IL119590A0 (en) | 1991-10-04 | 1996-11-10 | Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10332092A IL103320A (en) | 1991-10-04 | 1992-10-01 | 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines |
IL11959096A IL119590A0 (en) | 1991-10-04 | 1996-11-10 | Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0536515B1 (ko) |
JP (1) | JP3186863B2 (ko) |
KR (1) | KR100269072B1 (ko) |
CN (1) | CN1048240C (ko) |
AT (1) | ATE211128T1 (ko) |
AU (1) | AU654049B2 (ko) |
BR (1) | BR1100853A (ko) |
CA (1) | CA2079692C (ko) |
CL (1) | CL2004001623A1 (ko) |
CZ (2) | CZ284159B6 (ko) |
DE (4) | DE69232302D1 (ko) |
DK (1) | DK0536515T3 (ko) |
ES (1) | ES2168254T3 (ko) |
FI (1) | FI114911B (ko) |
HK (1) | HK1011348A1 (ko) |
HU (2) | HU219973B (ko) |
IL (3) | IL119590A (ko) |
LU (1) | LU91279I2 (ko) |
MX (1) | MX9205532A (ko) |
NL (1) | NL300244I2 (ko) |
NO (3) | NO301472B1 (ko) |
NZ (1) | NZ244585A (ko) |
PL (4) | PL172282B1 (ko) |
PT (1) | PT536515E (ko) |
SG (1) | SG52361A1 (ko) |
SK (2) | SK280837B6 (ko) |
TW (1) | TW275616B (ko) |
ZA (1) | ZA927607B (ko) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
JP2784847B2 (ja) * | 1994-02-17 | 1998-08-06 | ファイザー インク. | 9−(置換アミノ)−アルファ−6−デオキシ−5−オキシテトラサイクリン誘導体、それらの製造及び、抗生物質としてのそれらの使用 |
EP2327686A3 (en) | 1999-09-14 | 2012-08-22 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US8106225B2 (en) | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
JP2004505012A (ja) | 2000-03-31 | 2004-02-19 | トラスティーズ・オブ・タフツ・カレッジ | 7−および9−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物 |
EP1286954B1 (en) * | 2000-05-15 | 2004-04-14 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
MXPA03000055A (es) * | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
JP2005506291A (ja) | 2001-03-13 | 2005-03-03 | パラテック ファーマシューティカルズ, インク. | 7,9−置換テトラサイクリン化合物 |
US20040092490A1 (en) * | 2001-04-24 | 2004-05-13 | Michael Draper | Substituted tetracycline compounds for the treatment of malaria |
EP2332550A1 (en) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of neurodegenerative diseases |
WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2311799A1 (en) | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
IL163931A0 (en) * | 2002-03-08 | 2005-12-18 | Paratek Pharm Innc | Amino-methyl substituted tetracyline compounds |
AU2004259659B2 (en) | 2003-07-09 | 2011-11-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
UA83266C2 (en) * | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
PA8652001A1 (es) | 2004-11-05 | 2006-10-13 | Wyeth Corp | Metabolitos glucuronidos de tigeciclina y epimeros de los mismos |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
WO2007027599A1 (en) * | 2005-08-31 | 2007-03-08 | Wyeth | 9-aminocarbonylsubstituted derivatives of glycylcyclines |
EP2537934A3 (en) | 2006-05-15 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
RU2483072C2 (ru) | 2007-11-29 | 2013-05-27 | Актелион Фармасьютиклз Лтд | Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12 |
PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
ITMI20080807A1 (it) | 2008-05-05 | 2009-11-06 | Antibioticos Spa | Procedimento per la preparazione di tigeciclina in forma amorfa |
TWI680117B (zh) | 2008-05-23 | 2019-12-21 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
MX2011001367A (es) * | 2008-08-08 | 2011-06-28 | Tetraphase Pharmaceuticals Inc | Compuestos de tetraciclina sustituidos con fluor en c7. |
US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
DK2470500T3 (en) | 2009-08-28 | 2018-01-08 | Tetraphase Pharmaceuticals Inc | tetracycline |
KR101799304B1 (ko) | 2010-05-12 | 2017-11-20 | 렘펙스 파머수티클스 인코퍼레이티드 | 테트라사이클린 조성물 |
WO2013013504A1 (zh) * | 2011-07-26 | 2013-01-31 | 山东亨利医药科技有限责任公司 | 替加环素衍生物 |
EP3461809A1 (en) | 2012-08-31 | 2019-04-03 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
EP3068370A2 (en) | 2013-11-12 | 2016-09-21 | Galenicum Health S.L. | Stable pharmaceutical compositions |
CN117903083A (zh) | 2016-10-19 | 2024-04-19 | 四相制药公司 | 艾若威四环素的结晶形式 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
-
1992
- 1992-08-21 PT PT92114281T patent/PT536515E/pt unknown
- 1992-08-21 AT AT92114281T patent/ATE211128T1/de active
- 1992-08-21 SG SG1996003437A patent/SG52361A1/en unknown
- 1992-08-21 EP EP92114281A patent/EP0536515B1/en not_active Expired - Lifetime
- 1992-08-21 DE DE69232302A patent/DE69232302D1/de not_active Expired - Lifetime
- 1992-08-21 ES ES92114281T patent/ES2168254T3/es not_active Expired - Lifetime
- 1992-08-21 DK DK92114281T patent/DK0536515T3/da active
- 1992-08-21 DE DE200612000058 patent/DE122006000058I2/de active Active
- 1992-08-21 DE DE69232302T patent/DE69232302T4/de not_active Expired - Lifetime
- 1992-08-21 DE DE1992632302 patent/DE122006000058I1/de active Pending
- 1992-08-27 TW TW081106768A patent/TW275616B/zh not_active IP Right Cessation
- 1992-09-29 MX MX9205532A patent/MX9205532A/es unknown
- 1992-09-30 CZ CS922984A patent/CZ284159B6/cs not_active IP Right Cessation
- 1992-09-30 CZ CZ973093A patent/CZ284209B6/cs not_active IP Right Cessation
- 1992-09-30 SK SK2984-92A patent/SK280837B6/sk not_active IP Right Cessation
- 1992-09-30 SK SK1149-99A patent/SK284826B6/sk not_active IP Right Cessation
- 1992-09-30 HU HU9203110A patent/HU219973B/hu unknown
- 1992-10-01 IL IL11959092A patent/IL119590A/xx not_active IP Right Cessation
- 1992-10-01 NZ NZ244585A patent/NZ244585A/en not_active IP Right Cessation
- 1992-10-01 IL IL10332092A patent/IL103320A/en not_active IP Right Cessation
- 1992-10-02 CA CA002079692A patent/CA2079692C/en not_active Expired - Lifetime
- 1992-10-02 PL PL92310717A patent/PL172282B1/pl unknown
- 1992-10-02 KR KR1019920018122A patent/KR100269072B1/ko not_active IP Right Cessation
- 1992-10-02 NO NO923857A patent/NO301472B1/no not_active IP Right Cessation
- 1992-10-02 PL PL92310719A patent/PL176333B1/pl unknown
- 1992-10-02 PL PL92310718A patent/PL175957B1/pl unknown
- 1992-10-02 PL PL92296143A patent/PL173311B1/pl unknown
- 1992-10-02 ZA ZA927607A patent/ZA927607B/xx unknown
- 1992-10-02 FI FI924454A patent/FI114911B/fi active Protection Beyond IP Right Term
- 1992-10-02 AU AU26183/92A patent/AU654049B2/en not_active Expired
- 1992-10-03 CN CN92112130A patent/CN1048240C/zh not_active Expired - Lifetime
- 1992-10-05 JP JP28811492A patent/JP3186863B2/ja not_active Expired - Lifetime
-
1995
- 1995-04-28 HU HU95P/P00116P patent/HU211172A9/hu active Protection Beyond IP Right Term
-
1996
- 1996-11-10 IL IL11959096A patent/IL119590A0/xx unknown
-
1997
- 1997-05-12 BR BR1100853-9A patent/BR1100853A/pt active IP Right Grant
-
1998
- 1998-11-27 HK HK98112374A patent/HK1011348A1/xx not_active IP Right Cessation
-
2004
- 2004-06-25 CL CL200401623A patent/CL2004001623A1/es unknown
-
2006
- 2006-10-11 LU LU91279C patent/LU91279I2/fr unknown
- 2006-10-23 NL NL300244C patent/NL300244I2/nl unknown
- 2006-11-15 NO NO2006015C patent/NO2006015I2/no unknown
-
2017
- 2017-08-01 NO NO2017037C patent/NO2017037I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL119590A0 (en) | Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates | |
TW222616B (ko) |
Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |