IL119590A - 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates - Google Patents

7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates

Info

Publication number
IL119590A
IL119590A IL11959092A IL11959092A IL119590A IL 119590 A IL119590 A IL 119590A IL 11959092 A IL11959092 A IL 11959092A IL 11959092 A IL11959092 A IL 11959092A IL 119590 A IL119590 A IL 119590A
Authority
IL
Israel
Prior art keywords
substituted
demethyl
intermediates
deoxytetracycline
substituted amino
Prior art date
Application number
IL11959092A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL119590(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL119590A publication Critical patent/IL119590A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Moulding By Coating Moulds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11959092A 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates IL119590A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines

Publications (1)

Publication Number Publication Date
IL119590A true IL119590A (en) 1999-03-12

Family

ID=25092264

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines
IL11959092A IL119590A (en) 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7 - Transformed - 9 - Amino Transformed - 6 - Demethyl - 6 - Deoxytetracyclines

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Country Status (28)

Country Link
EP (1) EP0536515B1 (ja)
JP (1) JP3186863B2 (ja)
KR (1) KR100269072B1 (ja)
CN (1) CN1048240C (ja)
AT (1) ATE211128T1 (ja)
AU (1) AU654049B2 (ja)
BR (1) BR1100853A (ja)
CA (1) CA2079692C (ja)
CL (1) CL2004001623A1 (ja)
CZ (2) CZ309397A3 (ja)
DE (4) DE122006000058I2 (ja)
DK (1) DK0536515T3 (ja)
ES (1) ES2168254T3 (ja)
FI (1) FI114911B (ja)
HK (1) HK1011348A1 (ja)
HU (2) HU219973B (ja)
IL (3) IL103320A (ja)
LU (1) LU91279I2 (ja)
MX (1) MX9205532A (ja)
NL (1) NL300244I1 (ja)
NO (3) NO301472B1 (ja)
NZ (1) NZ244585A (ja)
PL (4) PL175957B1 (ja)
PT (1) PT536515E (ja)
SG (1) SG52361A1 (ja)
SK (2) SK284826B6 (ja)
TW (1) TW275616B (ja)
ZA (1) ZA927607B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
EP0745065A1 (en) * 1994-02-17 1996-12-04 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ATE323671T1 (de) 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
US6642270B2 (en) * 2000-05-15 2003-11-04 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE544745T1 (de) 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
EP1955996A1 (en) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. 7, 9-Substituted tetracycline compounds
ES2338994T3 (es) * 2001-04-24 2010-05-14 Paratek Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida para el tratamiento de la malaria.
EP2329826A1 (en) 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of multiple sclerosis
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP2322501B1 (en) 2002-01-08 2015-08-05 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003075857A2 (en) * 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP2295404A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
SG10201810312UA (en) 2004-05-21 2018-12-28 Harvard College Synthesis of tetracyclines and analogues thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
EP2431469A3 (en) 2006-05-15 2012-05-30 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
PL2225253T3 (pl) 2007-11-29 2012-11-30 Idorsia Pharmaceuticals Ltd Pochodne kwasu fosfonowego i ich zastosowanie jako antagonistów receptora P2Y12
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202021946A (zh) 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
MX358961B (es) * 2008-08-08 2018-09-10 Tetraphase Pharmaceuticals Inc Star Compuestos de tetraciclina sustituidos con fluor en c7.
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof
CA2761241C (en) 2009-05-08 2018-02-27 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
IN2012DN02502A (ja) 2009-08-28 2015-08-28 Tetraphase Pharmaceuticals Inc
AU2011252919B2 (en) 2010-05-12 2017-01-19 Melinta Therapeutics, Inc. Tetracycline compositions
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
NZ705849A (en) 2012-08-31 2018-06-29 Tetraphase Pharmaceuticals Inc Tetracycline compounds
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
US10961190B2 (en) 2016-10-19 2021-03-30 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
LU91279I2 (fr) 2006-12-11
CZ284159B6 (cs) 1998-08-12
NZ244585A (en) 1995-07-26
EP0536515A1 (en) 1993-04-14
AU654049B2 (en) 1994-10-20
SK284826B6 (sk) 2005-12-01
NO2017037I1 (no) 2017-08-01
HK1011348A1 (en) 1999-07-09
PT536515E (pt) 2002-05-31
ATE211128T1 (de) 2002-01-15
HU211172A9 (en) 1995-11-28
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
HUT63145A (en) 1993-07-28
CZ284209B6 (cs) 1998-09-16
CA2079692A1 (en) 1993-04-05
JP3186863B2 (ja) 2001-07-11
DE69232302T2 (de) 2002-08-14
SG52361A1 (en) 1998-09-28
CN1072172A (zh) 1993-05-19
PL173311B1 (pl) 1998-02-27
NO2006015I1 (no) 2006-11-27
CZ298492A3 (en) 1993-05-12
PL172282B1 (pl) 1997-08-29
CA2079692C (en) 2004-06-08
SK298492A3 (en) 1995-03-08
BR1100853A (pt) 1999-12-07
NO2017037I2 (no) 2017-08-01
IL119590A0 (en) 1997-02-18
DE122006000058I1 (de) 2007-01-18
CN1048240C (zh) 2000-01-12
SK114999A3 (en) 2000-07-11
NO301472B1 (no) 1997-11-03
AU2618392A (en) 1993-04-08
ES2168254T3 (es) 2002-06-16
JPH05255219A (ja) 1993-10-05
NO923857D0 (no) 1992-10-02
NO2006015I2 (no) 2011-03-14
NL300244I1 (nl) 2007-01-02
EP0536515B1 (en) 2001-12-19
PL175957B1 (pl) 1999-03-31
TW275616B (ja) 1996-05-11
HU9203110D0 (en) 1992-12-28
IL103320A (en) 1998-12-06
HU219973B (hu) 2001-10-28
FI924454A0 (fi) 1992-10-02
FI114911B (fi) 2005-01-31
PL176333B1 (pl) 1999-05-31
SK280837B6 (sk) 2000-08-14
CZ309397A3 (cs) 1998-09-16
DE69232302T4 (de) 2003-02-13
CL2004001623A1 (es) 2005-06-03
KR930007894A (ko) 1993-05-20
NO923857L (no) 1993-04-05
MX9205532A (es) 1993-04-01
DE122006000058I2 (de) 2007-09-13
FI924454A (fi) 1993-04-05
DK0536515T3 (da) 2002-04-08
PL296143A1 (en) 1993-05-31
IL103320A0 (en) 1993-03-15
DE69232302D1 (de) 2002-01-31
KR100269072B1 (ko) 2000-10-16

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Publication Publication Date Title
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